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PLoS ONE, ISSN 1932-6203, 11/2011, Volume 6, Issue 11, p. e27944
Inflammatory mediators in the tumour microenvironment promote tumour growth, vascular development and enable evasion of anti-tumour immune responses, by... 
MIGRATION | ACTIVATION | FUNCTIONAL MATURATION | ANGIOGENESIS | VEGF | MULTIDISCIPLINARY SCIENCES | MONOCYTE CHEMOATTRACTANT PROTEIN-1 | CXC CHEMOKINES | G-CSF | T-CELLS | ENDOTHELIAL GROWTH-FACTOR | Antigens, CD - immunology | Immunoglobulins - immunology | Membrane Glycoproteins - metabolism | Chemokine CCL2 - immunology | Coculture Techniques | Dendritic Cells - immunology | Humans | Culture Media, Conditioned - pharmacology | Male | Vascular Endothelial Growth Factor A - metabolism | Chemokine CXCL5 - metabolism | Interferon-gamma - metabolism | Chemokine CXCL1 - pharmacology | Lipopolysaccharides - immunology | Antigens, CD - metabolism | Immunoglobulins - metabolism | Chemokine CXCL5 - pharmacology | Flow Cytometry | Female | Chemokine CCL2 - metabolism | Membrane Glycoproteins - immunology | B7-2 Antigen - immunology | Chemokine CXCL1 - metabolism | HLA-DR Antigens - metabolism | Vascular Endothelial Growth Factor A - pharmacology | Colorectal Neoplasms - metabolism | Dendritic Cells - metabolism | Tumor Microenvironment - drug effects | Enzyme-Linked Immunosorbent Assay | Intercellular Adhesion Molecule-1 - immunology | Tissue Culture Techniques | Cells, Cultured | Vascular Endothelial Growth Factor A - immunology | Tumor Microenvironment - immunology | B7-2 Antigen - metabolism | Cell Differentiation - immunology | Chemokine CXCL1 - immunology | Intercellular Adhesion Molecule-1 - metabolism | Colorectal Neoplasms - immunology | Chemokine CCL2 - pharmacology | Cell Differentiation - drug effects | Chemokine CXCL5 - immunology | Interferon-gamma - immunology | Lipopolysaccharides - pharmacology | Aged | HLA-DR Antigens - immunology | Colorectal Neoplasms - pathology | Culture Media, Conditioned - metabolism | Care and treatment | Dendritic cells | Vascular endothelial growth factor | Colorectal cancer | Tumors | CD86 antigen | Colorectal carcinoma | Biochemistry | Metastasis | Kinases | Lipopolysaccharides | Proteins | Angiogenesis | Signal transduction | Lymphocytes | Inhibition | Pretreatment | Conditioning | Antigens | Immune response | Cytokines | Maturation | Secretion | Neutrophils | Interleukin 12 | CD80 antigen | Inflammation | CD83 antigen | Interleukin 10 | Ligands | Histocompatibility antigen HLA | Prostate cancer | Chemokines | Monocyte chemoattractant protein 1 | Cancer | Apoptosis
Journal Article
Cancer Research, ISSN 0008-5472, 07/2011, Volume 71, Issue 14, pp. 4821 - 4833
Journal Article
Cancer Research, ISSN 0008-5472, 11/2012, Volume 72, Issue 22, pp. 5721 - 5732
Journal Article
Nature Medicine, ISSN 1078-8956, 02/2018, Volume 24, Issue 2, pp. 165 - 175
Multiple immune-cell types can infiltrate tumors and promote progression and metastasis through different mechanisms, including immunosuppression. How distinct... 
MEDICINE, RESEARCH & EXPERIMENTAL | METASTASIS | MACROPHAGES | BIOCHEMISTRY & MOLECULAR BIOLOGY | NEUTROPHILS | MYELOID CELLS | CELLULAR SENESCENCE | CELL BIOLOGY | MELANOMA | MICROENVIRONMENT | DOUBLE-BLIND | SUPPRESSOR-CELLS | RESISTANT PROSTATE-CANCER | Humans | Gene Expression Regulation, Neoplastic | Male | Transcriptome - immunology | Tumor Suppressor Protein p53 - genetics | Prostatic Neoplasms - immunology | Prostatic Neoplasms - genetics | PTEN Phosphohydrolase - immunology | Myeloid Cells - immunology | Immunotherapy | Female | Transcription Factors - immunology | Macrophages - immunology | Disease Models, Animal | Promyelocytic Leukemia Protein - genetics | PTEN Phosphohydrolase - genetics | Prostatic Neoplasms - pathology | DNA-Binding Proteins - immunology | Genotype | Transcriptome - genetics | Tumor Suppressor Protein p53 - immunology | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Genetic Heterogeneity | Mice, Knockout | Animals | B-Lymphocytes - immunology | T-Lymphocytes - immunology | Mice | Promyelocytic Leukemia Protein - immunology | Lymphocytes, Tumor-Infiltrating - immunology | Immune response | Physiological aspects | Development and progression | Genetic aspects | Research | Metastasis | Tumors | Medical research | Clinical trials | Genetic diversity | Landscape ecology | Metastases | Biological diversity | Immunosuppression | Immunology | Tumor suppressor genes | Genetics | Qualitative analysis | Prostate cancer | Prostate | PTEN protein | Cancer | Immune system
Journal Article
Molecular Therapy, ISSN 1525-0016, 01/2014, Volume 22, Issue 1, pp. 18 - 27
The tumor microenvironment can promote tumor growth and reduce treatment efficacy. Tumors can occur in many sites in the body, but how surrounding normal... 
MEDICINE, RESEARCH & EXPERIMENTAL | BREAST-CANCER METASTASIS | TOLERANCE | MELANOMA | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | GROWTH | GENES | GENETICS & HEREDITY | REGULATORY T-CELLS | MICE | SUPPRESSOR-CELLS | CARCINOMA | MACROPHAGE MARKERS | CD40 Antigens - antagonists & inhibitors | Receptors, TNF-Related Apoptosis-Inducing Ligand - antagonists & inhibitors | Chemokine CCL2 - immunology | Kidney Neoplasms - immunology | Interleukin-13 - immunology | Male | Kidney Neoplasms - metabolism | Receptors, TNF-Related Apoptosis-Inducing Ligand - immunology | Organ Specificity - immunology | Neoplasms - therapy | Prostate - immunology | Colonic Neoplasms - immunology | Immunotherapy | Neovascularization, Pathologic - immunology | Antibodies, Monoclonal - immunology | Macrophages - immunology | Disease Models, Animal | Gene Expression | Antibodies, Monoclonal - pharmacology | Tumor Necrosis Factor Receptor Superfamily, Member 9 - immunology | Neoplasms - mortality | Treatment Outcome | Tumor Microenvironment - immunology | Macrophages - metabolism | Animals | Antibodies, Monoclonal - administration & dosage | Neoplasms - immunology | Tumor Necrosis Factor Receptor Superfamily, Member 9 - antagonists & inhibitors | Cell Line, Tumor | Kidney Neoplasms - pathology | Mice | Neoplasms - pathology | CD40 Antigens - immunology | Original
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 2010, Volume 5, Issue 9, pp. 1 - 12
Background: Studies of patients with paraneoplastic neurologic disorders (PND) have revealed that apoptotic tumor serves as a potential potent trigger for the... 
MALIGNANT GLIOMA | METASTATIC MELANOMA | PULSED DENDRITIC CELLS | PARANEOPLASTIC CEREBELLAR DEGENERATION | EFFICIENT PRESENTATION | MULTIDISCIPLINARY SCIENCES | APOPTOTIC CELLS | NECROSIS-FACTOR-ALPHA | T-CELLS | CROSS-PRESENTATION | ANTIGEN | Dendritic Cells - immunology | Humans | Middle Aged | Vaccination | Male | Cell- and Tissue-Based Therapy | Prostatic Neoplasms - immunology | Cancer Vaccines - immunology | Cancer Vaccines - therapeutic use | Aged, 80 and over | Cell Line, Tumor | Female | Aged | Dendritic Cells - cytology | Prostate-Specific Antigen - immunology | Dendritic Cells - transplantation | Prostatic Neoplasms - drug therapy | Apoptosis | Medical research | Nervous system diseases | Dendritic cells | Prostate-specific antigen | Clinical trials | Vaccines | T cells | Medicine, Experimental | Product development | Prostate cancer | Tumors | Cell proliferation | Peptides | Laboratories | Hypersensitivity (delayed) | CD8 antigen | Oncology | Lymphocytes T | Metastasis | Immunity | Cancer therapies | Cancer vaccines | Granulocytes | Lymphocytes | Rodents | Immunotherapy | Tumor necrosis factor-TNF | Foxp3 protein | Safety | Antigens | Immunization | Immune response | Statistical analysis | Cytokines | Immunoregulation | Tumor cells | Hypersensitivity | Feasibility studies | Melanoma | T cell receptors | Patients | CD4 antigen | Studies | Immunogenicity | Prostate | Cancer | Prostate-Specific Antigen/immunology | Dendritic Cells/cytology | Cancer Vaccines/therapeutic use | Life Sciences | Prostatic Neoplasms/immunology | Immunology | Cancer Vaccines/immunology | Dendritic Cells/transplantation | Prostatic Neoplasms/drug therapy | Dendritic Cells/immunology
Journal Article
Oncotarget, ISSN 1949-2553, 08/2016, Volume 7, Issue 33, pp. 52810 - 52817
While programmed cell death 1 (PD-1) inhibitors have shown clear anti-tumor efficacy in several solid tumors, prior results in men with metastatic castration... 
Immune response | Immunotherapy | Immunology and Microbiology Section | Enzalutamide | Immunity | PD-1 | Prostate cancer | DOCETAXEL | INFILTRATION | CELL BIOLOGY | CELL LUNG-CANCER | prostate cancer | PEMBROLIZUMAB | MELANOMA | immunotherapy | PD-L1 | NIVOLUMAB | enzalutamide | IPILIMUMAB | ANTIGEN | Phenylthiohydantoin - adverse effects | Hypothyroidism - chemically induced | Humans | Middle Aged | Prostatic Neoplasms, Castration-Resistant - immunology | Antineoplastic Combined Chemotherapy Protocols - adverse effects | Male | Myositis - chemically induced | Programmed Cell Death 1 Receptor - antagonists & inhibitors | Hypothyroidism - immunology | Myositis - immunology | Neoplasm Metastasis | Antibodies, Monoclonal, Humanized - administration & dosage | Aged, 80 and over | Prostatic Neoplasms, Castration-Resistant - prevention & control | Prostate-Specific Antigen - metabolism | Antibodies, Monoclonal, Humanized - adverse effects | Phenylthiohydantoin - immunology | Drug Administration Schedule | Programmed Cell Death 1 Receptor - metabolism | Antineoplastic Combined Chemotherapy Protocols - immunology | Prostatic Neoplasms, Castration-Resistant - metabolism | Remission Induction | Phenylthiohydantoin - analogs & derivatives | Phenylthiohydantoin - administration & dosage | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Aged | Prostate-Specific Antigen - immunology | Antibodies, Monoclonal, Humanized - immunology | Drug Resistance, Neoplasm - drug effects
Journal Article
PLoS ONE, ISSN 1932-6203, 10/2012, Volume 7, Issue 10, p. e47045
High macrophage infiltration has been correlated to improved survival in colorectal cancer (CRC). Tumor associated macrophages (TAMs) play complex roles in... 
CELL LUNG-CANCER | ISLAND METHYLATOR PHENOTYPE | COLON-CANCER | HUMAN PROSTATE-CANCER | MICROSATELLITE INSTABILITY | MULTIDISCIPLINARY SCIENCES | REGULATORY T-CELLS | TUMOR-ASSOCIATED MACROPHAGES | INFILTRATING MACROPHAGES | PATIENT SURVIVAL | ENDOMETRIAL CANCER | Immunohistochemistry | Antigens, CD - immunology | Microsatellite Instability | Prognosis | Rectum - pathology | Colorectal Neoplasms - genetics | Humans | Receptors, Cell Surface - analysis | Colon - immunology | Colorectal Neoplasms - diagnosis | Antigens, CD - analysis | Nitric Oxide Synthase Type II - analysis | DNA Methylation | Nitric Oxide Synthase Type II - immunology | Antigens, Differentiation, Myelomonocytic - immunology | Macrophages - immunology | Macrophages - pathology | Colon - pathology | Rectum - metabolism | Rectum - immunology | Receptors, Cell Surface - immunology | Colon - metabolism | Macrophages - metabolism | Phenotype | Colorectal Neoplasms - immunology | Antigens, Differentiation, Myelomonocytic - analysis | CpG Islands | Colorectal Neoplasms - pathology | Genetic aspects | Research | Macrophages | Analysis | Colorectal cancer | Correlation | Colorectal carcinoma | Microsatellite instability | Cancer therapies | Subgroups | Metastases | Ethics | Genotype & phenotype | Angiogenesis | Surgery | Tumorigenesis | Growth factors | CpG islands | Cell survival | Microsatellites | Stability | Invasiveness | Patients | Survival | Nitric-oxide synthase | Studies | CD163 antigen | Pathology | Screening | Nitric oxide | Medical prognosis | Infiltration | Health risk assessment | Tumors | Cancer | Medical and Health Sciences | Medicin och hälsovetenskap
Journal Article
The Journal of Immunology, ISSN 0022-1767, 10/2000, Volume 165, Issue 7, pp. 3797 - 3803
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 8/2013, Volume 110, Issue 32, pp. 13114 - 13119
Efficient and productive virus infection often requires viral countermeasures that block innate immunity. The IFN-inducible 2',5'-oligoadenylate (2-5A)... 
Coronavirus | Rotavirus | RNA | Liver | Antivirals | Viruses | Amino acids | Mice | Infections | Murine hepatitis virus | Interferon-stiumulated gene | RNA capping enzyme | Nidovirales | Reoviridae | ROTAVIRUS OPEN CORES | PROTEIN | MOUSE HEPATITIS-VIRUS | 2',5'-OLIGOADENYLATE SYNTHETASE | MULTIDISCIPLINARY SCIENCES | interferon-stiumulated gene | 2-5A-DEPENDENT RNASE | MURINE CORONAVIRUS | INTERFERON | PROSTATE-CANCER | INFECTED-CELLS | STRAIN A59 | Endoribonucleases - genetics | Humans | Rotavirus - physiology | Rotavirus - immunology | Molecular Sequence Data | RNA Viruses - physiology | Immunoblotting | Murine hepatitis virus - physiology | Host-Pathogen Interactions - immunology | Murine hepatitis virus - immunology | Rotavirus - metabolism | Macrophages - virology | Oligoribonucleotides - metabolism | RNA Viruses - immunology | Binding Sites - immunology | Capsid Proteins - immunology | RNA Virus Infections - immunology | Macrophages - immunology | Viral Nonstructural Proteins - immunology | 2',5'-Oligoadenylate Synthetase - metabolism | Amino Acid Sequence | Cell Line | Phosphoric Diester Hydrolases - metabolism | Endoribonucleases - metabolism | Capsid Proteins - metabolism | Murine hepatitis virus - metabolism | Cells, Cultured | Viral Nonstructural Proteins - genetics | Phosphoric Diester Hydrolases - genetics | RNA Virus Infections - virology | RNA Viruses - metabolism | Binding Sites - genetics | Mice, Knockout | Phosphoric Diester Hydrolases - immunology | Sequence Homology, Amino Acid | Immunity, Innate - immunology | Macrophages - metabolism | Animals | 2',5'-Oligoadenylate Synthetase - immunology | Adenine Nucleotides - metabolism | Viral Nonstructural Proteins - metabolism | Mutation | Capsid Proteins - genetics | Endoribonucleases - immunology | RNA viruses | Antiviral agents | Immune response | Physiological aspects | Dosage and administration | Research | Phosphodiesterases | Health aspects | Biological Sciences
Journal Article
Molecular Cell, ISSN 1097-2765, 09/2016, Volume 63, Issue 6, pp. 976 - 989
Prostate inflammation has been suggested as an etiology for benign prostatic hyperplasia (BPH). We show that decreased expression of the androgen receptor (AR)... 
microenvironment | androgen receptor | interleukin-1 | inflammation | macrophage | epithelial homeostasis | benign prostatic hyperplasia | INFLAMMATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | GROWTH | FINASTERIDE | PROLIFERATION | MODEL | CANCER | EXPRESSION | TUMORIGENESIS | CELL BIOLOGY | Prostatic Hyperplasia - pathology | Cell Proliferation | Epithelial Cells - metabolism | Interleukin-1alpha - immunology | Prostatic Hyperplasia - immunology | Chemokine CCL2 - immunology | Stromal Cells - pathology | Humans | Male | Interleukin-1beta - genetics | Neutrophil Infiltration | Prostate - metabolism | Leukocyte Common Antigens - immunology | Prostate - pathology | Prostate - immunology | Chemokine CXCL10 - immunology | Interleukin-1alpha - genetics | Macrophages - immunology | Macrophages - pathology | Signal Transduction | Stromal Cells - metabolism | Gene Expression Regulation | Homeostasis - immunology | Interleukin-1beta - immunology | Chemokine CCL2 - genetics | Epithelial Cells - pathology | Stromal Cells - immunology | Inflammation | Prostatic Hyperplasia - genetics | Prostatic Hyperplasia - metabolism | Receptors, Androgen - immunology | Macrophages - metabolism | Animals | Receptors, Androgen - genetics | Chemokine CXCL10 - genetics | Epithelial Cells - immunology | Leukocyte Common Antigens - genetics | Mice | Homeostasis - genetics | Medical colleges | Development and progression | Analysis | Androgen receptor
Journal Article
Journal Article