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Nature medicine, ISSN 1546-170X, 10/2015, Volume 21, Issue 11, pp. 1262 - 1271
Cancer-associated muscle weakness is a poorly understood phenomenon, and there is no effective treatment. Here we find that seven different mouse models of... 
Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Cell Biology | Research & Experimental Medicine | Neoplasms - metabolism | Prostatic Neoplasms - metabolism | Up-Regulation | Calcium - metabolism | Humans | Lung Neoplasms - metabolism | NADPH Oxidases - metabolism | Bone Neoplasms - secondary | Lung Neoplasms - pathology | Male | Muscle, Skeletal - metabolism | Osteolysis - etiology | Ryanodine Receptor Calcium Release Channel - metabolism | X-Ray Microtomography | Bone Neoplasms - metabolism | Breast Neoplasms - metabolism | Neoplasms - complications | MCF-7 Cells | Osteolysis - diagnostic imaging | Muscle Proteins - metabolism | NADPH Oxidases - genetics | Female | Camurati-Engelmann Syndrome - metabolism | Muscle Strength | Calcium Signaling | Disease Models, Animal | Muscle Weakness - etiology | Prostatic Neoplasms - pathology | Oxidation-Reduction | Bone Neoplasms - diagnostic imaging | NADPH Oxidase 4 | Mice, SCID | Multiple Myeloma - metabolism | Absorptiometry, Photon | Osteolysis - metabolism | Multiple Myeloma - pathology | Animals | Muscle Contraction | Breast Neoplasms - pathology | Mice, Nude | Muscle Weakness - metabolism | Cell Line, Tumor | Mice | Neoplasms - pathology | Transforming Growth Factor beta - metabolism | Index Medicus
Journal Article
PloS one, ISSN 1932-6203, 06/2017, Volume 12, Issue 6, pp. e0179610 - e0179610
Objective To assess the prognostic roles of BAP1, PBRM1, pS6, PTEN, TGase2, PD-L1, CA9, PSMA, and Ki-67 tissue biomarkers in localized renal cell carcinoma... 
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Immunohistochemistry | Prognosis | Tissue Array Analysis | Humans | Middle Aged | Ki-67 Antigen - metabolism | Male | Kidney Neoplasms - metabolism | Porphyrins - metabolism | Neoplasm Recurrence, Local - mortality | Neoplasm Recurrence, Local - pathology | Glutamate Carboxypeptidase II - metabolism | Neoplasm Grading | Antigens, Neoplasm - metabolism | Antigens, Surface - metabolism | Biomarkers, Tumor - metabolism | Ubiquitin Thiolesterase - metabolism | Adult | Female | Carbonic Anhydrase IX - metabolism | Retrospective Studies | Tumor Suppressor Proteins - metabolism | Neoplasm Recurrence, Local - metabolism | Carcinoma, Renal Cell - pathology | PTEN Phosphohydrolase - metabolism | Nuclear Proteins - metabolism | Survival Rate | Kidney Neoplasms - mortality | Transcription Factors - metabolism | Carcinoma, Renal Cell - metabolism | Carcinoma, Renal Cell - mortality | Disease-Free Survival | B7-H1 Antigen - metabolism | Transglutaminases - metabolism | Sulfonamides - metabolism | Kidney Neoplasms - pathology | Aged | Neoplasm Staging | GTP-Binding Proteins - metabolism | Genetic aspects | Carcinoma, Renal cell | Research | Biological markers | Biometrics | Metastasis | Kinases | Epidemiology | Cancer therapies | Urology | Proteins | Nephrectomy | Quality | Growth factors | Age | Antigens | Markers | Hazards | Patients | Survival | Disease prevention | Hospitals | Medical prognosis | PD-L1 protein | Biomarkers | Death | Mutation | Diabetes | Prostate cancer | PTEN protein | Clear cell-type renal cell carcinoma | Kidney transplantation | Tumors | Index Medicus
Journal Article
PloS one, ISSN 1932-6203, 04/2012, Volume 7, Issue 4, pp. e34653 - e34653
Background: Shedding microvesicles are membrane released vesicles derived directly from the plasma membrane. Exosomes are released membrane vesicles of late... 
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Exosomes - metabolism | Cell Line | NIH 3T3 Cells | Microscopy, Electron, Transmission - methods | Secretory Vesicles - metabolism | DNA - metabolism | RNA, Messenger - metabolism | Clathrin - metabolism | Animals | Cell Nucleus - metabolism | Biological Transport | Myocytes, Cardiac - metabolism | Cytosol - metabolism | Cell Membrane - metabolism | Membrane Proteins - metabolism | Mice | Annexin A2 - metabolism | Caveolin 3 - metabolism | Fibroblasts - metabolism | RNA - metabolism | Clathrin | RNA | Genes | Hostages | Nucleotide sequencing | Gene expression | DNA sequencing | Heart | Flow cytometry | Sperm | Centrifugation | Lung cancer | Ultracentrifugation | Biochemistry | Exosomes | Cytosol | Nuclei | Muscular dystrophy | Gene sequencing | Vesicles | Rodents | Penicillin | Fibroblasts | Public health | Deoxyribonucleic acid--DNA | Differential media | Messages | Nucleotide sequence | Caveolin | Membrane vesicles | Cardiomyocytes | Electron microscopy | Metabolism | Ribonucleic acid--RNA | Medicine | Polymerase | DNA nucleotidylexotransferase | Cytometry | Hospitals | Transmission electron microscopy | MicroRNAs | Biochemical characteristics | Clinical medicine | Mutation | Prostate | Index Medicus | Deoxyribonucleic acid | Ribonucleic acid | DNA | Media (differential)
Journal Article
Molecular carcinogenesis, ISSN 0899-1987, 02/2014, Volume 53, Issue 2, pp. 85 - 97
As a link between inflammation and cancer has been reported in many studies, we established an in vitro model of prostatic inflammation to investigate the loss... 
androgen | loss of p53 | inflammation | DNA damage | ROS | prostate | NFkB | Loss of p53 | Androgen | Inflammation | Prostate | Biochemistry & Molecular Biology | Oncology | Life Sciences & Biomedicine | Science & Technology | Proto-Oncogene Proteins c-mdm2 - genetics | Reactive Oxygen Species - metabolism | Apoptosis - drug effects | Antioxidants - metabolism | Homeodomain Proteins - metabolism | Humans | Transcriptional Activation - drug effects | Tumor Necrosis Factor-alpha - genetics | Apoptosis - genetics | Male | NF-kappa B - metabolism | Interleukin-1beta - genetics | Prostatitis - metabolism | Inflammation - metabolism | Matrix Metalloproteinase 9 - metabolism | Phosphorylation - genetics | Acetylcysteine - analogs & derivatives | Interleukin-1beta - metabolism | Matrix Metalloproteinase 9 - genetics | U937 Cells | Prostate-Specific Antigen - metabolism | Phosphorylation - drug effects | Interleukin-6 - metabolism | Prostate-Specific Antigen - genetics | Glutathione Peroxidase - metabolism | Lysine - analogs & derivatives | Interleukin-6 - genetics | Down-Regulation - genetics | Glutathione Peroxidase - genetics | Prostatitis - drug therapy | Androgens - genetics | Macrophages - metabolism | Receptors, Androgen - genetics | Signal Transduction - drug effects | Cell Line, Tumor | Androgens - metabolism | Tumor Necrosis Factor-alpha - metabolism | Prostatic Neoplasms - metabolism | Receptors, Androgen - metabolism | I-kappa B Proteins - metabolism | I-kappa B Proteins - genetics | Prostatitis - pathology | Tumor Suppressor Protein p53 - genetics | Cell Differentiation - genetics | Prostatic Neoplasms - genetics | Inflammation Mediators - metabolism | Proto-Oncogene Proteins c-mdm2 - metabolism | Prostatic Neoplasms - pathology | Kallikreins - genetics | Tumor Suppressor Protein p53 - metabolism | Antioxidants - pharmacology | Transcription Factors - genetics | Down-Regulation - drug effects | Homeodomain Proteins - genetics | Transcription Factors - metabolism | Up-Regulation - drug effects | Lysine - pharmacology | NF-kappa B - genetics | Cell Differentiation - drug effects | Acetylcysteine - pharmacology | Inflammation - genetics | Macrophages - drug effects | Kallikreins - metabolism | Ubiquitin | Analysis | Kallikrein | Hormones, Sex | Tumor proteins | Mitogens | Androgens | Cytokines | Molecular biology | Gene expression | Prostate cancer | Index Medicus
Journal Article
PloS one, ISSN 1932-6203, 12/2018, Volume 13, Issue 12, pp. e0208756 - e0208756
Journal Article
NeuroImage (Orlando, Fla.), ISSN 1053-8119, 04/2019, Volume 189, pp. 171 - 179
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 07/2009, Volume 106, Issue 30, pp. 12465 - 12470
Chromosomal rearrangements involving erythroblast transformation specific (ETS) family transcription factors were recently defined as the most common genetic... 
Adenocarcinoma | Prostate gland | Epithelial cells | Cell lines | Mice | Lesions | Prostate | Prostate cancer | Cells | Tissue grafting | PTEN | AKT | ERG | Androgen receptor | Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Immunohistochemistry | Transcriptional Regulator ERG | Oncogene Proteins - genetics | Prostatic Neoplasms - metabolism | Prostatic Intraepithelial Neoplasia - pathology | Epithelial Cells - metabolism | Proto-Oncogene Proteins c-ets - genetics | Hyperplasia | Male | Phosphatidylinositol 3-Kinases - metabolism | Prostate - metabolism | Tumor Suppressor Protein p53 - genetics | DNA-Binding Proteins - metabolism | Prostate - pathology | Prostatic Neoplasms - genetics | Proto-Oncogene Proteins c-ets - metabolism | Prostatic Intraepithelial Neoplasia - metabolism | Prostatic Neoplasms - pathology | Signal Transduction | Mice, Inbred C57BL | Cells, Cultured | Oncogene Proteins - metabolism | Tumor Suppressor Protein p53 - metabolism | Epithelial Cells - pathology | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Proto-Oncogene Proteins c-myc - metabolism | Blotting, Western | Transcription Factors - metabolism | Integrin alpha6 - metabolism | Animals | Cell Transformation, Neoplastic | Proto-Oncogene Proteins c-jun - metabolism | Keratin-5 - metabolism | Luminescent Proteins - genetics | Mutation | Prostatic Intraepithelial Neoplasia - genetics | Luminescent Proteins - metabolism | Androgens | Physiological aspects | Development and progression | Genetic aspects | Cellular signal transduction | DNA binding proteins | Research | Index Medicus | Biological Sciences | prostate cancer | androgen receptor
Journal Article
European urology, ISSN 0302-2838, 01/2015, Volume 67, Issue 1, pp. 53 - 60
Abstract Background Enzalutamide is a novel antiandrogen with proven efficacy in metastatic castration-resistant prostate cancer (mCRPC). Objective To evaluate... 
Urology | Castration-resistant prostate cancer | Primary resistance to enzalutamide | Androgen signaling inhibition | Bone metastasis | Bone tumor microenvironment | Adaptive feedback mechanism | Androgen receptor | Predictors of outcome | Enzalutamide | Tissue-based research | Life Sciences & Biomedicine | Urology & Nephrology | Science & Technology | Prospective Studies | Phenylthiohydantoin - therapeutic use | Humans | Middle Aged | Receptors, Androgen - metabolism | Retroviridae Proteins, Oncogenic - metabolism | Bone Neoplasms - secondary | Cytoplasm - metabolism | Drug Resistance, Neoplasm | Ki-67 Antigen - metabolism | Male | Antineoplastic Agents - therapeutic use | Receptors, Glucocorticoid - metabolism | Prostatic Neoplasms, Castration-Resistant - pathology | Bone Neoplasms - metabolism | Cell Nucleus - metabolism | Protein Isoforms - metabolism | Bone Marrow - metabolism | Aged, 80 and over | Adult | Bone Neoplasms - drug therapy | Testosterone - blood | Gene Dosage | Prostatic Neoplasms, Castration-Resistant - drug therapy | Prostatic Neoplasms, Castration-Resistant - metabolism | Bone Marrow Neoplasms - secondary | Phenylthiohydantoin - analogs & derivatives | Prostate-Specific Antigen - blood | Receptors, Androgen - genetics | Signal Transduction - drug effects | Bone Marrow Neoplasms - metabolism | Aged | Bone Marrow Neoplasms - drug therapy | Steroid 17-alpha-Hydroxylase - metabolism | Prostate cancer | Metastasis | Index Medicus | Bone marrow biopsy | Androgen | Antiandrogens
Journal Article