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1. Full Text Radiation Dose–Volume Effects in Radiation-Induced Rectal Injury
by Michalski, Jeff M., M.D and Gay, Hiram, M.D and Jackson, Andrew, M.D and Tucker, Susan L., Ph.D and Deasy, Joseph O., Ph.D
International Journal of Radiation Oncology, Biology, Physics, ISSN 0360-3016, 2010, Volume 76, Issue 3, pp. S123 - S129
The available dose/volume/outcome data for rectal injury were reviewed. The volume of rectum receiving ≥60Gy is consistently associated with the risk of Grade... 
Radiology | Hematology, Oncology and Palliative Medicine | Radiation injury | Rectum | NTCP | MULTICENTER | ONCOLOGY-GROUP | LOCALIZED PROSTATE-CANCER | TISSUE COMPLICATION PROBABILITY | TRIAL | IRRADIATION | LATE TOXICITY | ONCOLOGY | CONFORMAL RADIOTHERAPY | HISTOGRAMS | QUALITY-OF-LIFE | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | Radiography | Radiotherapy Dosage | Rectum - diagnostic imaging | Gastrointestinal Hemorrhage - etiology | Models, Biological | Humans | Radiotherapy, Conformal - adverse effects | Risk | Rectum - radiation effects | Models, Statistical | Radiation Injuries - complications | Forecasting | Medical colleges | Analysis | Oncology, Experimental | Radiation | Research | Prostate cancer | Cancer | Index Medicus | GASTROINTESTINAL TRACT | LARGE INTESTINE | BEAMS | DIGESTIVE SYSTEM | RADIATION EFFECTS | PROTON BEAMS | MALE GENITALS | RADIATION DOSES | THREE-DIMENSIONAL CALCULATIONS | MEDICINE | PARTICLE BEAMS | RADIATION DOSE DISTRIBUTIONS | HEALTH HAZARDS | THERAPY | GLANDS | BIOLOGICAL EFFECTS | RADIOLOGY AND NUCLEAR MEDICINE | BIOLOGICAL RADIATION EFFECTS | NUCLEON BEAMS | RADIOTHERAPY | RADIOLOGY | PROSTATE | INJURIES | NEOPLASMS | RECTUM | TOXICITY | INTESTINES | RADIATION INJURIES | NUCLEAR MEDICINE | ORGANS | DISEASES | DOSES | BODY | HAZARDS
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2. Full Text Radiation and checkpoint blockade immunotherapy: radiosensitisation and potential mechanisms of synergy
by Sharabi, Andrew B, Dr and Lim, Michael, MD and DeWeese, Theodore L, Prof and Drake, Charles G, Prof
Lancet Oncology, The, ISSN 1470-2045, 2015, Volume 16, Issue 13, pp. e498 - e509
Summary Checkpoint blockade immunotherapy has received mainstream attention as a result of striking and durable clinical responses in some patients with... 
Hematology, Oncology and Palliative Medicine | MHC CLASS-I | BREAST-CANCER | CALRETICULIN EXPOSURE | DENDRITIC CELLS | ONCOLOGY | ANTITUMOR IMMUNE-RESPONSES | ADVANCED MELANOMA | PROSTATE-CANCER | TUMOR-CELLS | IONIZING-RADIATION | CD8(+) T-CELLS | Cell Death - radiation effects | Immunotherapy - methods | Dendritic Cells - immunology | Humans | Radiation Tolerance | Antibodies, Monoclonal - therapeutic use | Molecular Targeted Therapy | Radiation-Sensitizing Agents - therapeutic use | CD8-Positive T-Lymphocytes - radiation effects | Neoplasms - therapy | Dendritic Cells - drug effects | Cell Death - drug effects | Signal Transduction - radiation effects | Cytotoxicity, Immunologic - drug effects | Chemoradiotherapy - methods | Treatment Outcome | Lymphocytes, Tumor-Infiltrating - drug effects | Radiation Dosage | Dendritic Cells - diagnostic imaging | Radiography | Animals | Signal Transduction - drug effects | Neoplasms - immunology | CD8-Positive T-Lymphocytes - drug effects | CD8-Positive T-Lymphocytes - immunology | Neoplasms - pathology | Cytotoxicity, Immunologic - radiation effects | Lymphocytes, Tumor-Infiltrating - radiation effects | Lymphocytes, Tumor-Infiltrating - immunology | Chemotherapy | Lung cancer | Analysis | Immunotherapy | Melanoma | Radiation | Lymphomas | Cancer
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3. Full Text Abscopal effects of radiation therapy: A clinical review for the radiobiologist
by Siva, Shankar and MacManus, Michael P and Martin, Roger F and Martin, Olga A
Cancer Letters, ISSN 0304-3835, 2013, Volume 356, Issue 1, pp. 82 - 90
Abstract An “abscopal” effect occurs when localized irradiation perturbs the organism as a whole, with consequences that can be either beneficial or... 
Hematology, Oncology and Palliative Medicine | Normal tissue effects | Cytokines | Radiotherapy | Abscopal effects | Tumors | Immune system | DNA-DAMAGE | DOUBLE-STRAND BREAKS | TUMOR-CELLS | SPONTANEOUS REGRESSION | CELL LUNG-CANCER | INDUCED BYSTANDER | ONCOLOGY | PROSTATE-CANCER | IN-VIVO | IONIZING-RADIATION | PRIMARY HUMAN FIBROBLASTS | Bystander Effect - radiation effects | Cell Transformation, Neoplastic - radiation effects | Genomic Instability - radiation effects | Apoptosis - radiation effects | Humans | Middle Aged | Male | Inflammation - immunology | Neoplasm Metastasis | Adult | Female | Neoplasms - radiotherapy | Aged | Cytokines - immunology | Radiation | Liver cancer | Hematology | Melanoma | Breast cancer | Lymphomas | Radiation therapy | Metastasis | Patients | Age | Skin cancer
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4. Full Text Microbubble-based enhancement of radiation effect: Role of cell membrane ceramide metabolism
by Al-Mahrouki, Azza and Giles, Anoja and Hashim, Amr and Kim, Hyunjung Christina and El-Falou, Ahmad and Rowe-Magnus, Dean and Farhat, Golnaz and Czarnota, Gregory J
PLoS ONE, ISSN 1932-6203, 07/2017, Volume 12, Issue 7, p. e0181951
Ultrasound (US) stimulated microbubbles (MB) is a new treatment approach that sensitizes cancer cells to radiation (XRT). The molecular pathways in this... 
SYNTHASE | APOPTOSIS | IN-VITRO | THERAPY | TRIGGERED DRUG | MULTIDISCIPLINARY SCIENCES | GENE-EXPRESSION | FREQUENCY POWER DOPPLER | SPHINGOLIPIDS | ULTRASOUND-STIMULATED MICROBUBBLES | CANCER | Immunohistochemistry | Prostatic Neoplasms - metabolism | Sonication | Ganglioside Galactosyltransferase - genetics | Prostatic Neoplasms - radiotherapy | Apoptosis - radiation effects | Ganglioside Galactosyltransferase - metabolism | Humans | Gene Expression Regulation, Neoplastic | Apoptosis - genetics | Male | Prostatic Neoplasms - genetics | RNA Interference | Microbubbles | Cell Membrane - metabolism | Signal Transduction - radiation effects | Cell Membrane - radiation effects | Ceramides - metabolism | Signal Transduction - genetics | Mice, SCID | Reverse Transcriptase Polymerase Chain Reaction | Cell Survival - radiation effects | Xenograft Model Antitumor Assays | Animals | Cell Line, Tumor | Ultrasonics - methods | Physiological aspects | Cell membranes | Research | Genetically modified organisms | Glycosyltransferases | Radiation | Health sciences | Regulations | Glycosyltransferase | Oncology | Lipids | Acoustics | Metastasis | Assaying | Doppler effect | Oxygen content | Cancer therapies | Signal transduction | Control | Ultrasonic imaging | Reduction | Pathways | Xenografts | Ceramide | Damage | Ultrasound | Drug dosages | Genetic modification | Departments | Cell survival | Saturation | Histology | Breast cancer | Biophysics | Metabolism | Signaling | Cell death | Disruption | Galactose | In vitro methods and tests | Endoplasmic reticulum | Prostate | Tumors | Apoptosis | Cancer
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5. Full Text Preliminary Toxicity Analysis of 3-Dimensional Conformal Radiation Therapy Versus Intensity Modulated Radiation Therapy on the High-Dose Arm of the Radiation Therapy Oncology Group 0126 Prostate Cancer Trial
by Michalski, Jeff M., MD and Yan, Yan, MD, MS and Watkins-Bruner, Deborah, PhD and Bosch, Walter R., DSc and Winter, Kathryn, MS and Galvin, James M., DSc and Bahary, Jean-Paul, MD and Morton, Gerard C., MB and Parliament, Matthew B., MD and Sandler, Howard M., MD
International Journal of Radiation Oncology, Biology, Physics, ISSN 0360-3016, 2013, Volume 87, Issue 5, pp. 932 - 938
Purpose To give a preliminary report of clinical and treatment factors associated with toxicity in men receiving high-dose radiation therapy (RT) on a phase 3... 
Radiology | Hematology, Oncology and Palliative Medicine | ONCOLOGY | RECTAL TOXICITY | VOLUME | ESCALATION TRIAL | RANDOMIZED CONTROLLED-TRIAL | RADIOTHERAPY | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | Radiotherapy Dosage | Organs at Risk - radiation effects | Prostatic Neoplasms - pathology | Prostatic Neoplasms - radiotherapy | Age Factors | Humans | Radiotherapy, Intensity-Modulated - methods | Prostate - radiation effects | Logistic Models | Male | Rectum - radiation effects | Radiation Injuries - complications | Tumor Burden | Urinary Bladder - radiation effects | Quality Assurance, Health Care | Radiotherapy, Intensity-Modulated - adverse effects | Analysis of Variance | Seminal Vesicles - radiation effects | Radiation Injuries - pathology | Radiotherapy, Conformal - adverse effects | Continental Population Groups | Radiotherapy, Conformal - methods | Clinical trials | Sects | Radiotherapy | Nuclear radiation | Prostate cancer | Analysis | Index Medicus | PROSTATE | DISEASE INCIDENCE | NEOPLASMS | RECTUM | RADIOLOGY AND NUCLEAR MEDICINE | RADIATION DOSES | TOXICITY | BLADDER | PLANNING
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6. Full Text Acquisition of epithelial-mesenchymal transition and cancer stem cell phenotypes is associated with activation of the PI3K/Akt/mTOR pathway in prostate cancer radioresistance
by Chang, L and Graham, PH and Hao, J and Ni, J and Bucci, J and Cozzi, PJ and Kearsley, JH and Li, Y
CELL DEATH & DISEASE, ISSN 2041-4889, 10/2013, Volume 4, Issue 10, pp. e875 - e875
Radioresistance is a major challenge in prostate cancer (CaP) radiotherapy (RT). In this study, we investigated the role and association of... 
BEZ235 | RADIATION SENSITIVITY | IDENTIFICATION | EMT | PI3K/Akt/mTOR | CELL BIOLOGY | CSC | IN-VITRO | radiation therapy | PROTEASOME | RESISTANCE | INHIBITOR | Prostate cancer | radioresistance | Prostatic Neoplasms - radiotherapy | Epithelial-Mesenchymal Transition - radiation effects | TOR Serine-Threonine Kinases - metabolism | Apoptosis - drug effects | Apoptosis - radiation effects | Neoplastic Stem Cells - drug effects | Humans | Spheroids, Cellular - pathology | Epithelial-Mesenchymal Transition - drug effects | Male | Phosphatidylinositol 3-Kinases - metabolism | Spheroids, Cellular - radiation effects | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Quinolines - pharmacology | Radiation Tolerance - radiation effects | TOR Serine-Threonine Kinases - antagonists & inhibitors | Neoplastic Stem Cells - pathology | Spheroids, Cellular - drug effects | Imidazoles - therapeutic use | Signal Transduction - radiation effects | Proto-Oncogene Proteins c-akt - metabolism | Prostatic Neoplasms - drug therapy | Prostatic Neoplasms - pathology | Reproducibility of Results | Neoplasm Invasiveness | Imidazoles - pharmacology | Enzyme Activation - drug effects | Enzyme Activation - radiation effects | Radiation Tolerance - drug effects | Phenotype | Animals | Cell Cycle Checkpoints - radiation effects | Signal Transduction - drug effects | Cell Cycle Checkpoints - drug effects | Models, Biological | Cell Line, Tumor | Prostatic Neoplasms - enzymology | Quinolines - therapeutic use | Neoplastic Stem Cells - enzymology | PI3K | mTOR | Akt | Original
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7. Full Text Managing the Adverse Effects of Radiation Therapy
by Berkey, Franklin J., DO
American Family Physician, ISSN 0002-838X, 2010, Volume 82, Issue 4, pp. 381 - 388
Nearly two thirds of patients with cancer will undergo radiation therapy as part of their treatment plan. Given the increased use of radiation therapy and the... 
Internal Medicine | HEMORRHAGIC CYSTITIS | MEDICINE, GENERAL & INTERNAL | PRACTICE GUIDELINE | INDUCED EMESIS | PROSTATE-CANCER | DOUBLE-BLIND | CARDIOVASCULAR-DISEASE | RANDOMIZED-TRIAL | PRIMARY HEALTH CARE | ERECTILE DYSFUNCTION | AMERICAN-SOCIETY | SKIN REACTIONS | Fatigue - drug therapy | Humans | Risk Factors | Sexual Dysfunction, Physiological - drug therapy | Fatigue - etiology | Gastrointestinal Tract - radiation effects | Male | Dermatologic Agents - therapeutic use | Radiotherapy - adverse effects | Vomiting - drug therapy | Depression - etiology | Depression - drug therapy | Dermatitis - etiology | Neoplasms - complications | Cardiovascular System - radiation effects | Sexual Dysfunction, Physiological - etiology | Antiemetics - therapeutic use | Vomiting - etiology | Female | Lung - radiation effects | Neoplasms - radiotherapy | Dermatitis - drug therapy | Complications and side effects | Usage | Care and treatment | Depression, Mental | Skin | Inflammation | Diagnosis | Radiotherapy | Dermatitis | Risk factors | Cancer
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8. Full Text Effects of radiation on normal tissue: consequences and mechanisms
by Stone, Helen B and Coleman, C Norman and Anscher, Mitchell S and McBride, William H
Lancet Oncology, ISSN 1470-2045, 2003, Volume 4, Issue 9, pp. 529 - 536
The use of radiation therapy to treat cancer inevitably involves exposure of normal tissues. As a result, patients may experience symptoms associated with... 
APOPTOSIS | INDUCED PULMONARY FIBROSIS | THERAPY | ONCOLOGY | CONFORMAL RADIOTHERAPY | PROSTATE-CANCER | GASTROINTESTINAL-TRACT | INDUCED LUNG INJURY | CONVERTING ENZYME-INHIBITORS | DAMAGE | GROWTH-FACTOR BETA-1 | Animals | Radiation Injuries - prevention & control | Humans | Radiation-Protective Agents - therapeutic use | Neoplasms - radiotherapy | Radiation Injuries - pathology | Radiotherapy - adverse effects | Radiation Injuries - etiology | Radiation | Radiogenetics
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9. Full Text Radiation Dose–Volume Effects of the Urinary Bladder
by Viswanathan, Akila N., M.D., M.P.H and Yorke, Ellen D., Ph.D and Marks, Lawrence B., M.D and Eifel, Patricia J., M.D and Shipley, William U., M.D
International Journal of Radiation Oncology, Biology, Physics, ISSN 0360-3016, 2010, Volume 76, Issue 3, pp. S116 - S122
An in-depth overview of the normal-tissue radiation tolerance of the urinary bladder is presented. The most informative studies consider whole-organ... 
Radiology | Hematology, Oncology and Palliative Medicine | toxicity | Bladder dose | LATE COMPLICATIONS | RADICAL HYSTERECTOMY | LOCALIZED PROSTATE-CANCER | ICRU REFERENCE | RANDOMIZED-TRIAL | CERVICAL-CANCER | UTERINE CERVIX | ONCOLOGY | CONCOMITANT BOOST | TRANSITIONAL CELL-CARCINOMA | 3-DIMENSIONAL CONFORMAL RADIOTHERAPY | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | Radiotherapy Dosage | Prostatic Neoplasms - radiotherapy | Movement | Uterine Cervical Neoplasms - radiotherapy | Humans | Radiation Tolerance | Male | Prostatectomy - adverse effects | Radiation Injuries - complications | Forecasting | Urinary Bladder - radiation effects | Radiography | Urinary Bladder Neoplasms - radiotherapy | Models, Biological | Urinary Bladder - diagnostic imaging | Female | Hysterectomy - adverse effects | Analysis | Radiation | INJURIES | RADIATION EFFECTS | RADIATION DOSES | TOXICITY | RADIATION INJURIES | IRRADIATION | ORGANS | URINARY TRACT | DISEASES | BIOLOGICAL EFFECTS | DOSES | RADIOLOGY AND NUCLEAR MEDICINE | BIOLOGICAL RADIATION EFFECTS | BLADDER | NONUNIFORM IRRADIATION | BODY
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10. Full Text Ipilimumab with stereotactic ablative radiation therapy: Phase i results and immunologic correlates from peripheral T cells
by Tang, Chad and Welsh, James W and De Groot, Patricia and Massarelli, Erminia and Chang, Joe Y and Hess, Kenneth R and Basu, Sreyashi and Curran, Michael A and Cabanillas, Maria E and Subbiah, Vivek and Fu, Siqing and Tsimberidou, Apostolia M and Karp, Daniel and Gomez, Daniel R and Diab, Adi and Komaki, Ritsuko and Heymach, John V and Sharma, Padmanee and Naing, Aung and Hong, David S
Clinical Cancer Research, ISSN 1078-0432, 03/2017, Volume 23, Issue 6, pp. 1388 - 1396
Purpose: Little prospective data are available on clinical outcomes and immune correlates from combination radiation and immunotherapy. We conducted a phase I... 
TRIAL | CTLA-4 BLOCKADE | LUNG-CANCER | MELANOMA | SOLID TUMORS | ONCOLOGY | IMMUNOTHERAPY | EARLY-STAGE | RADIOTHERAPY | RESISTANT PROSTATE-CANCER | COMBINATION | Lung Neoplasms - drug therapy | Liver - pathology | Humans | Middle Aged | CD4-Positive T-Lymphocytes - radiation effects | Lung Neoplasms - radiotherapy | Liver - radiation effects | Lung Neoplasms - pathology | Male | Radiosurgery - adverse effects | CD8-Positive T-Lymphocytes - radiation effects | Flow Cytometry | Aged, 80 and over | Adult | Female | Liver Neoplasms - pathology | Lung - radiation effects | Ipilimumab - administration & dosage | Lung - pathology | Liver Neoplasms - drug therapy | Treatment Outcome | Combined Modality Therapy | Ipilimumab - adverse effects | CD8-Positive T-Lymphocytes - drug effects | Liver Neoplasms - radiotherapy | Lung - drug effects | Aged | Biomarkers, Tumor - genetics | CD4-Positive T-Lymphocytes - drug effects | Flow cytometry | Toxicity | CD8 antigen | Liver | Radiation | Activation | Lymphocytes T | T cell receptors | Radiation therapy | Patients | CD4 antigen | Liver cancer | Cytometry | Cell activation | Lungs | Experimental design | Lymphocytes | Immunotherapy | ICOS protein | Irradiation | Cancer | Index Medicus | trial correlates | Stereotactic ablative radiation therapy | immunotherapy | ipilimumab
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11. Full Text PI3K/Akt/mTOR pathway inhibitors enhance radiosensitivity in radioresistant prostate cancer cells through inducing apoptosis, reducing autophagy, suppressing NHEJ and HR repair pathways
by Chang, L and Graham, P.H and Hao, J and Ni, J and Bucci, J and Cozzi, P.J and Kearsley, J.H and Li, Y
Cell Death and Disease, ISSN 2041-4889, 01/2014, Volume 5, Issue 10, pp. e1437 - e1437
The PI3K/Akt/mTOR pathway has a central role in cancer metastasis and radiotherapy. To develop effective therapeutics to improve radiosensitivity,... 
TRANSITION | ACTIVATION | DUAL PI3K/MTOR INHIBITOR | DOUBLE-STRAND BREAKS | CYCLIN-DEPENDENT KINASE | TOXICITY | LINES | RADIATION-THERAPY | P53 | CELL BIOLOGY | Prostatic Neoplasms - radiotherapy | Homologous Recombination - drug effects | TOR Serine-Threonine Kinases - metabolism | Apoptosis - drug effects | Apoptosis - radiation effects | DNA End-Joining Repair - radiation effects | Humans | Male | Phosphatidylinositol 3-Kinases - metabolism | Prostatic Neoplasms - physiopathology | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Autophagy | Proto-Oncogene Proteins c-akt - genetics | Radiation Tolerance - radiation effects | TOR Serine-Threonine Kinases - antagonists & inhibitors | Prostatic Neoplasms - genetics | TOR Serine-Threonine Kinases - genetics | Signal Transduction - radiation effects | Proto-Oncogene Proteins c-akt - metabolism | Prostatic Neoplasms - drug therapy | DNA End-Joining Repair - drug effects | Homologous Recombination - radiation effects | Cell Cycle - radiation effects | Enzyme Inhibitors - pharmacology | Phosphatidylinositol 3-Kinases - genetics | Radiation Tolerance - drug effects | Signal Transduction - drug effects | Cell Line, Tumor | Cell Cycle - drug effects | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | Original
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