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1. Full Text Aire-Dependent Thymic Development of Tumor-Associated Regulatory T Cells
by Sven Malchow and Daniel S. Leventhal and Saki Nishi and Benjamin I. Fischer and Lynn Shen and Gladell P. Paner and Ayelet S. Amit and Chulho Kang and Jenna E. Geddes and James P. Allison and Nicholas D. Socci and Peter A. Savage
Science, ISSN 0036-8075, 3/2013, Volume 339, Issue 6124, pp. 1219 - 1224
Despite considerable interest in the modulation of tumor-associated Foxp3 + regulatory T cells (T regs ) for therapeutic benefit, little is known about the... 
T lymphocytes | Antigens | Percentages | REPORTS | Anatomy | Prostate cancer | Prostate | Lymph nodes | T cell antigen receptors | Tumors | Cancer | POPULATION | MULTIDISCIPLINARY SCIENCES | PROSTATE-CANCER | GENES | SELF-ANTIGEN | SELECTION | EXPRESSION | REPERTOIRES | TRANSGENIC MICE | Antigens, Polyomavirus Transforming - genetics | Immune Tolerance | Male | Mice, Transgenic | Transcription Factors - genetics | Homeodomain Proteins - genetics | Prostatic Neoplasms - immunology | T-Lymphocytes, Regulatory - immunology | Animals | Prostate - immunology | Autoantigens - immunology | CD4 Antigens - analysis | Forkhead Transcription Factors - analysis | Female | Thymus Gland - growth & development | Thymus Gland - immunology | Mice | Prostate-Specific Antigen - immunology | Transcription Factors - immunology | T cells | Properties | Growth | T cell receptors | Rodents | Origins | Government regulations | Organs | Females
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2. Full Text Overall Survival Analysis of a Phase II Randomized Controlled Trial of a Poxviral-Based PSA-Targeted Immunotherapy in Metastatic Castration-Resistant Prostate Cancer
by Philip W. Kantoff and Thomas J. Schuetz and Brent A. Blumenstein and L. Michael Glode and David L. Bilhartz and Michael Wyand and Kelledy Manson and Dennis L. Panicali and Reiner Laus and Jeffrey Schlom and William L. Dahut and Philip M. Arlen and James L. Gulley and Wayne R. Godfrey
Journal of Clinical Oncology, ISSN 0732-183X, 03/2010, Volume 28, Issue 7, pp. 1099 - 1105
Purpose Therapeutic prostate-specific antigen (PSA)-targeted poxviral vaccines for prostate cancer have been well tolerated. PROSTVAC-VF treatment was... 
THERAPY | COLONY-STIMULATING FACTOR | ONCOLOGY | CLINICAL-TRIALS | COSTIMULATORY MOLECULES | ANTIGEN | VACCINES | Prostatic Neoplasms - pathology | Immunization | Double-Blind Method | Genetic Vectors - immunology | Humans | Middle Aged | Male | Vaccines, Synthetic - immunology | Poxviridae - immunology | Prostatic Neoplasms - mortality | Orchiectomy | Prostatic Neoplasms - therapy | Cancer Vaccines - immunology | Neoplasm Metastasis | Aged, 80 and over | Prostate-Specific Antigen - antagonists & inhibitors | Aged | Prostate-Specific Antigen - immunology | Guc7 | Original Reports
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3. Full Text Early evidence of anti-PD-1 activity in enzalutamide-resistant prostate cancer
by Graff, Julie N and Alumkal, Joshi J and Drake, Charles G and Thomas, George V and Redmond, William L and Farhad, Mohammad and Cetnar, Jeremy P and Ey, Frederick S and Bergan, Raymond C and Slottke, Rachel and Beer, Tomasz M
Oncotarget, ISSN 1949-2553, 08/2016, Volume 7, Issue 33, pp. 52810 - 52817
While programmed cell death 1 (PD-1) inhibitors have shown clear anti-tumor efficacy in several solid tumors, prior results in men with metastatic castration... 
Immune response | Immunotherapy | Immunology and Microbiology Section | Enzalutamide | Immunity | PD-1 | Prostate cancer | DOCETAXEL | INFILTRATION | CELL BIOLOGY | CELL LUNG-CANCER | prostate cancer | PEMBROLIZUMAB | MELANOMA | immunotherapy | PD-L1 | NIVOLUMAB | enzalutamide | IPILIMUMAB | ANTIGEN | Phenylthiohydantoin - adverse effects | Hypothyroidism - chemically induced | Humans | Middle Aged | Prostatic Neoplasms, Castration-Resistant - immunology | Antineoplastic Combined Chemotherapy Protocols - adverse effects | Male | Myositis - chemically induced | Programmed Cell Death 1 Receptor - antagonists & inhibitors | Hypothyroidism - immunology | Myositis - immunology | Neoplasm Metastasis | Antibodies, Monoclonal, Humanized - administration & dosage | Aged, 80 and over | Prostatic Neoplasms, Castration-Resistant - prevention & control | Prostate-Specific Antigen - metabolism | Antibodies, Monoclonal, Humanized - adverse effects | Phenylthiohydantoin - immunology | Drug Administration Schedule | Programmed Cell Death 1 Receptor - metabolism | Antineoplastic Combined Chemotherapy Protocols - immunology | Prostatic Neoplasms, Castration-Resistant - metabolism | Remission Induction | Phenylthiohydantoin - analogs & derivatives | Phenylthiohydantoin - administration & dosage | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Aged | Prostate-Specific Antigen - immunology | Antibodies, Monoclonal, Humanized - immunology | Drug Resistance, Neoplasm - drug effects
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4. Full Text Ipilimumab and a poxviral vaccine targeting prostate-specific antigen in metastatic castration-resistant prostate cancer: a phase 1 dose-escalation trial
by Madan, Ravi A, MD and Mohebtash, Mahsa, MD and Arlen, Philip M, MD and Vergati, Matteo, MD and Rauckhorst, Myrna, RN and Steinberg, Seth M, PhD and Tsang, Kwong Y, PhD and Poole, Diane J and Parnes, Howard L, MD and Wright, John J, MD PhD and Dahut, William L, MD and Schlom, Jeffrey, PhD and Gulley, James L, Dr
Lancet Oncology, The, ISSN 1470-2045, 2012, Volume 13, Issue 5, pp. 501 - 508
Summary Background Therapeutic cancer vaccines have shown activity in metastatic castration-resistant prostate cancer (mCRPC), and methods are being assessed... 
Hematology, Oncology and Palliative Medicine | SURVIVAL | ONCOLOGY | IMMUNOTHERAPY | AUTOIMMUNITY | SAFETY | CTLA-4 | BLOCKADE | Antigens, CD - immunology | Viral Vaccines - therapeutic use | Humans | Ipilimumab | Middle Aged | Antibodies, Monoclonal - therapeutic use | Immunotherapy, Active | Male | Antineoplastic Agents - therapeutic use | Poxviridae - immunology | Orchiectomy | Prostatic Neoplasms - immunology | Prostatic Neoplasms - therapy | Dose-Response Relationship, Drug | Cancer Vaccines - immunology | Cancer Vaccines - therapeutic use | Prostatic Neoplasms - secondary | Aged, 80 and over | Aged | Prostate-Specific Antigen - immunology | Viral Vaccines - immunology | Antigens | Care and treatment | Oncology, Experimental | Clinical trials | Vaccines | Research | Metastasis | T cells | Cancer vaccines | Monoclonal antibodies | Product development | Prostate cancer | Cancer | Protein binding
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5. Full Text 3D label-free prostate specific antigen (PSA) immunosensor based on graphene–gold composites
by Jang, Hee Dong and Kim, Sun Kyung and Chang, Hankwon and Choi, Jeong-Woo
Biosensors and Bioelectronics, ISSN 0956-5663, 01/2015, Volume 63, pp. 546 - 551
Highly sensitive and label-free detection of the prostate specific antigen (PSA) remains a challenge in the diagnosis of prostate cancer. Here, a novel... 
Aerosol spray pyrolysis | Crumpled graphene–gold composite | Label-free immunosensor | Prostate specific antigen (PSA) | Crumpled graphene-gold composite | ELECTROCHEMISTRY | CHEMISTRY, ANALYTICAL | NANOSCIENCE & NANOTECHNOLOGY | GRAPHITE OXIDE | PLATFORM | NANOPARTICLES | BIOPHYSICS | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | IMMUNOASSAY | NANOCOMPOSITE | DOPED GRAPHENE | FREE ELECTROCHEMICAL IMMUNOSENSOR | Gold - chemistry | Immunoassay - instrumentation | Nanocomposites - chemistry | Antibodies - chemistry | Metal Nanoparticles - chemistry | Oxides - chemistry | Equipment Design | Prostate-Specific Antigen - analysis | Conductometry - instrumentation | Staining and Labeling | Antibodies - immunology | Biosensing Techniques - instrumentation | Nanocomposites - ultrastructure | Prostate-Specific Antigen - immunology | Graphite - chemistry | Prostate-Specific Antigen - chemistry | Equipment Failure Analysis | Pyrolysis | Composite materials industry | Graphene | Prostate-specific antigen | Graphite | Prostate cancer | Electric properties | Electrodes | Antigens | Gold | Immunosensors | Biosensors | Prostate | Three dimensional
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6. Full Text Exosome targeting of tumor antigens expressed by cancer vaccines can improve antigen immunogenicity and therapeutic efficacy
by Rountree, Ryan B and Mandl, Stefanie J and Nachtwey, James M and Dalpozzo, Katie and Do, Lisa and Lombardo, John R and Schoonmaker, Peter L and Brinkmann, Kay and Dirmeier, Ulrike and Laus, Reiner and Delcayre, Alain
Cancer Research, ISSN 0008-5472, 08/2011, Volume 71, Issue 15, pp. 5235 - 5244
MVA-BN-PRO (BN ImmunoTherapeutics) is a candidate immunotherapy product for the treatment of prostate cancer. It encodes 2 tumor-associated antigens,... 
CELLS | ONCOLOGY | MEMBRANE-VESICLES | IMMUNOTHERAPY | RECOMBINANT | IMMUNE-RESPONSES | MICE | RESISTANT PROSTATE-CANCER | SIPULEUCEL-T | PSA | Adenocarcinoma - pathology | Humans | Male | Th1 Cells - immunology | Vaccinia virus - immunology | Drug Delivery Systems | Prostatic Neoplasms - immunology | Prostatic Neoplasms - therapy | Protein Tyrosine Phosphatases - immunology | Cancer Vaccines - therapeutic use | Milk Proteins - immunology | Exosomes - immunology | Immunotherapy, Active - methods | Antibodies, Neoplasm - biosynthesis | Milk Proteins - pharmacokinetics | Protein Structure, Tertiary | Prostate-Specific Antigen - administration & dosage | Prostatic Neoplasms - pathology | Antigens, Neoplasm - immunology | Adenocarcinoma - immunology | Cancer Vaccines - administration & dosage | Mice, Inbred C57BL | Xenograft Model Antitumor Assays | Cancer Vaccines - immunology | Vaccines, Attenuated - immunology | Animals | Adenocarcinoma - therapy | Acid Phosphatase | Mice | Mice, Inbred BALB C | Prostate-Specific Antigen - immunology | Antigens, Surface - immunology
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7. Full Text Ultrasensitive Electrochemical Detection of Prostate-Specific Antigen by Using Antibodies Anchored on a DNA Nanostructural Scaffold
by Chen, Xiaoqing and Zhou, Guobao and Song, Ping and Wang, Jingjing and Gao, Jimin and Lu, Jianxin and Fan, Chunhai and Zuo, Xiaolei
Analytical Chemistry, ISSN 0003-2700, 08/2014, Volume 86, Issue 15, pp. 7337 - 7342
The high occurrence of prostate cancer in men makes the prostate-specific antigen (PSA) screening test really important. More importantly, the recurrence rate... 
REDEFINES UNDETECTABLE PSA | CHEMISTRY, ANALYTICAL | ELECTRON-TRANSFER | BIOCHEMICAL RECURRENCE | CONSTRUCTION | BINDING | PROMISING PLASMA BIOMARKERS | ASSAY REVEALS PROSTASOMES | IMMOBILIZATION | SURFACES | DNA - chemistry | Limit of Detection | Base Sequence | Humans | Antibodies - immunology | Molecular Sequence Data | Electrochemical Techniques - methods | Prostate-Specific Antigen - immunology | Nanostructures | Prostate-Specific Antigen - analysis | Measurement | Chemical detectors | Usage | Research | Nucleotide sequencing | Enzyme kinetics | Surface energy | DNA sequencing
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8. Full Text Efficacy Against Human Prostate Cancer by Prostate-specific Membrane Antigen-specific, Transforming Growth Factor-β Insensitive Genetically Targeted CD8+ T-cells Derived from Patients with Metastatic Castrate-resistant Disease
by Zhang, Qiang and Zhang, Weipeng and Helfand, Brian T and Carneiro, Benedito A and Qin, Weijun and Yang, Ximing J and Lee, Chung and Giles, Francis J and Cristofanilli, Massimo and Kuzel, Timothy M
European Urology, ISSN 0302-2838, 05/2018, Volume 73, Issue 5, pp. 648 - 652
Current immunotherapy has limited efficacy on metastatic castrate-resistant prostate cancer (mCRPC). We therefore sought to improve the antitumor ability of... 
mCRPC | TGF-β | PSMA | Prostate cancer | CD8+ T-cells | T-cells | CD8 | TGF-beta | IMMUNOTHERAPY | UROLOGY & NEPHROLOGY | RECEPTOR | CD8(+) T-cells | Transforming Growth Factor beta - immunology | Glutamate Carboxypeptidase II - immunology | Immunotherapy - methods | Humans | Male | Treatment Outcome | Prostatic Neoplasms, Castration-Resistant - pathology | Neoplasm Metastasis | Animals | Transforming Growth Factor beta - drug effects | Mice, Nude | CD8-Positive T-Lymphocytes - drug effects | Glutamate Carboxypeptidase II - drug effects | Cell Line, Tumor | Prostate-Specific Antigen - drug effects | Prostatic Neoplasms, Castration-Resistant - therapy | Mice | Prostate-Specific Antigen - immunology | CD8-Positive T-Lymphocytes - immunology | Antigens, Surface - drug effects | Antigens, Surface - immunology | Molecular Targeted Therapy - methods | Disease Models, Animal | TGF
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9. Full Text Chemotherapy‐induced immunogenic modulation of tumor cells enhances killing by cytotoxic T lymphocytes and is distinct from immunogenic cell death
by Hodge, James W and Garnett, Charlie T and Farsaci, Benedetto and Palena, Claudia and Tsang, Kwong‐Yok and Ferrone, Soldano and Gameiro, Sofia R
International Journal of Cancer, ISSN 0020-7136, 08/2013, Volume 133, Issue 3, pp. 624 - 636
Certain chemotherapeutic regimens trigger cancer cell death while inducing dendritic cell maturation and subsequent immune responses. However,... 
calreticulin | immunogenic modulation | docetaxel | antigen‐processing machinery | T‐cell response | immunogenic cell death | antigen-processing machinery | T-cell response | CANCER-CELLS | DEFINITION | RECOGNITION | VACCINE | COMBINATION | CALRETICULIN EXPOSURE | ONCOLOGY | RESISTANCE | EXPRESSION | Taxoids - pharmacology | Apoptosis - drug effects | Dendritic Cells - immunology | Humans | Male | Adenosine Triphosphate - biosynthesis | Prostatic Neoplasms - therapy | Breast Neoplasms - therapy | HMGB1 Protein - biosynthesis | T-Lymphocytes, Cytotoxic - drug effects | Colorectal Neoplasms - therapy | RNA Interference | Immunotherapy | Female | Antineoplastic Agents - pharmacology | eIF-2 Kinase - genetics | T-Lymphocytes, Cytotoxic - immunology | Carcinoembryonic Antigen - immunology | Apoptosis - immunology | T-Lymphocytes, Cytotoxic - metabolism | Calreticulin - analysis | Mucin-1 - immunology | Cell Line, Tumor | Prostate-Specific Antigen - immunology | RNA, Small Interfering | Cytotoxicity, Immunologic | Chemotherapy | Immune response | Chromosomal proteins | Dendritic cells | Cell death | Analysis | Docetaxel | Biochemistry | T cells | Tumors | Cancer | Cytotoxicity | Immunology | Lymphocytes | Apoptosis
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10. Full Text Ultrasensitive electrochemical detection of prostate-specific antigen (PSA) using gold-coated magnetic nanoparticles as 'dispersible electrodes
by Chuah, Kyloon and Lai, Leo M. H and Goon, Ian Y and Parker, Stephen G and Amal, Rose and Justin Gooding, J
Chemical Communications, ISSN 1359-7345, 04/2012, Volume 48, Issue 29, pp. 3503 - 3505
Herein, we demonstrate the use of modified gold-coated magnetic nanoparticles as 'dispersible electrodes' which act as selective capture vehicles for... 
ASSAY | BIOSENSORS | CHANNEL | CHEMISTRY, MULTIDISCIPLINARY | Gold - chemistry | Microscopy, Electron, Transmission | Microscopy, Electron, Scanning | Nanoparticles - chemistry | Biosensing Techniques | Nanoparticles - ultrastructure | Electrochemistry | Prostate-Specific Antigen - immunology | Ferrosoferric Oxide - chemistry | Prostate-Specific Antigen - analysis | Antibodies, Monoclonal - immunology
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11. Full Text Reassessing target antigens for adoptive T-cell therapy
by Hinrichs, Christian S and Restifo, Nicholas P
Nature Biotechnology, ISSN 1087-0156, 11/2013, Volume 31, Issue 11, pp. 999 - 1008
Adoptive T-cell therapy can target and kill widespread malignant cells thereby inducing durable clinical responses in melanoma and selected other malignances.... 
HUMAN-LYMPHOCYTES | CARBONIC-ANHYDRASE-IX | CANCER REGRESSION | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | PROSTATE-SPECIFIC ANTIGEN | TYROSINE KINASE | TELOMERASE ACTIVITY | NAIVE RATHER | NORMAL-TISSUES | ANTITUMOR-ACTIVITY | TUMOR GENE WT1 | Immunotherapy, Adoptive - adverse effects | Cell- and Tissue-Based Therapy - methods | Immunotherapy, Adoptive - methods | Humans | Autoimmune Diseases - immunology | Cross Reactions - immunology | Drug Delivery Systems | Models, Immunological | Neoplasms - therapy | Animals | Neoplasms - immunology | Antigens - immunology | T-Lymphocytes - immunology | Cell- and Tissue-Based Therapy - adverse effects | Care and treatment | Immunotherapy | Cellular therapy | Research | T cells | Testing | Cancer | Antigens | T cell receptors | Cancer therapies | Melanoma
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12. Full Text Multiplexed Detection of Tumor Markers with Multicolor Polymer Dot-Based Immunochromatography Test Strip
by Fang, Chia-Chia and Chou, Chia-Cheng and Yang, Yong-Quan and Wei-Kai, Tsai and Wang, Yeng-Tseng and Chan, Yang-Hsiang
Analytical Chemistry, ISSN 0003-2700, 02/2018, Volume 90, Issue 3, pp. 2134 - 2140
There have been ongoing efforts to develop more sensitive and fast quantitative screening of cancer markers by use of fluorometric immunochromatographic test... 
NANOPARTICLES | CHEMISTRY, ANALYTICAL | QUANTITATIVE DETECTION | ACTIVATION | DESIGN | FLUORESCENCE | DIAGNOSTICS RECENT DEVELOPMENTS | SENSOR | POINT | SEMICONDUCTING POLYMER | QUANTUM DOTS | Limit of Detection | Nanoparticles - chemistry | Carcinoembryonic Antigen - blood | Carcinoembryonic Antigen - immunology | Humans | Prostate-Specific Antigen - blood | alpha-Fetoproteins - analysis | Biomarkers, Tumor - blood | Immunoconjugates - immunology | Animals | alpha-Fetoproteins - immunology | Chickens | Polymers - chemistry | Mice | Prostate-Specific Antigen - immunology | Biomarkers, Tumor - immunology | Chromatography, Affinity - methods | Alpha fetoproteins | Tumor markers | Prostate-specific antigen | Analysis
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13. Full Text Cancer Biomarker Detection in Serum Samples Using Surface Plasmon Resonance and Quartz Crystal Microbalance Sensors with Nanoparticle Signal Amplification
by Uludag, Yildiz and Tothill, Ibtisam E
Analytical Chemistry, ISSN 0003-2700, 07/2012, Volume 84, Issue 14, pp. 5898 - 5904
Early detection of cancer is vital for the successful treatment of the disease. Hence, a rapid and sensitive diagnosis is essential before the cancer is spread... 
CHEMISTRY, ANALYTICAL | FILMS | IMMUNOASSAY | PROSTATE-SPECIFIC ANTIGEN | SIZE | Gold - chemistry | Humans | Metal Nanoparticles - chemistry | Surface Plasmon Resonance - methods | Prostate-Specific Antigen - blood | Biomarkers, Tumor - blood | Quartz Crystal Microbalance Techniques - methods | alpha 1-Antichymotrypsin - metabolism | Biomarkers, Tumor - metabolism | Immunoassay - methods | Prostate-Specific Antigen - immunology | Prostate-Specific Antigen - metabolism | Biomarkers, Tumor - immunology | Usage | Tumor markers | Research | Diagnosis | Biological assay | Methods | Cancer | Immune system | Testing
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14. Full Text Two-dimensional layered MoS2 biosensors enable highly sensitive detection of biomolecules
by Lee, Joonhyung and Dak, Piyush and Lee, Yeonsung and Park, Heekyeong and Choi, Woong and Alam, Muhammad A and Kim, Sunkook
Scientific Reports, ISSN 2045-2322, 2014, Volume 4, Issue 1, p. 7352
We present a MoS2 biosensor to electrically detect prostate specific antigen (PSA) in a highly sensitive and label-free manner. Unlike previous MoS2-FET-based... 
LARGE-AREA | FIELD-EFFECT-TRANSISTOR | MULTIDISCIPLINARY SCIENCES | GROWTH | GRAPHENE | PROTEINS | BLOOD | Molybdenum - chemistry | Humans | Male | Prostatic Neoplasms - diagnosis | Disulfides - immunology | Disulfides - chemistry | Sensitivity and Specificity | Equipment Design - methods | Immunoassay - methods | Biosensing Techniques - methods | Prostate-Specific Antigen - immunology | Prostate-Specific Antigen - chemistry | Hydrogen-Ion Concentration | Molybdenum - immunology | Antigens | Sensors | Hydrophobicity | Biosensors | pH effects | Prostate
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15. Full Text A National Multicenter Phase 2 Study of Prostate-specific Antigen (PSA) Pox Virus Vaccine with Sequential Androgen Ablation Therapy in Patients with PSA Progression: ECOG 9802
by DiPaola, Robert S and Chen, Yu-Hui and Bubley, Glenn J and Stein, Mark N and Hahn, Noah M and Carducci, Michael A and Lattime, Edmund C and Gulley, James L and Arlen, Philip M and Butterfield, Lisa H and Wilding, George
European Urology, ISSN 0302-2838, 2014, Volume 68, Issue 3, pp. 365 - 371
Abstract Background E9802 was a phase 2 multi-institution study conducted to evaluate the safety and effectiveness of vaccinia and fowlpox prostate-specific... 
Urology | Pox virus | Vaccine | Prostate cancer | PSA | SURVIVAL | TRIAL | DEPRIVATION THERAPY | IMPACT | ONCOLOGY-GROUP | IMMUNOTHERAPY | UROLOGY & NEPHROLOGY | CANCER | Kallikreins - immunology | Humans | Middle Aged | Fowlpox virus - immunology | Male | Combined Modality Therapy | Granulocyte-Macrophage Colony-Stimulating Factor - therapeutic use | Disease Progression | Prostate-Specific Antigen - blood | Vaccinia virus - immunology | Cancer Vaccines - immunology | Cancer Vaccines - therapeutic use | Androgen Antagonists - therapeutic use | Prostatectomy | Aged | Kallikreins - blood | Prostate-Specific Antigen - immunology | Prostatic Neoplasms - drug therapy | Medicine, Experimental | Antigens | Medical research | Vaccines | Index Medicus
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