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The New England journal of medicine, ISSN 1533-4406, 2017, Volume 377, Issue 4, pp. 338 - 351
Journal Article
Nature cell biology, ISSN 1476-4679, 2018, Volume 20, Issue 8, pp. 954 - 965
BRCA1 deficiencies cause breast, ovarian, prostate and other cancers, and render tumours hypersensitive to poly(ADP-ribose) polymerase (PARP) inhibitors. To... 
PATHWAY CHOICE | STRAND BREAK REPAIR | RESECTION | DAMAGE-RESPONSE | 53BP1 | CLASS-SWITCH RECOMBINATION | FANCONI-ANEMIA | DIFFERENTIAL EXPRESSION ANALYSIS | POLYMERASE-ZETA | TELOMERES | CELL BIOLOGY | Osteosarcoma - drug therapy | Mad2 Proteins - metabolism | Humans | Multiprotein Complexes | Ovarian Neoplasms - pathology | Bone Neoplasms - pathology | DNA Breaks, Double-Stranded | Bone Neoplasms - metabolism | Breast Neoplasms - metabolism | Dose-Response Relationship, Drug | Ovarian Neoplasms - genetics | Telomere-Binding Proteins - genetics | DNA End-Joining Repair | HEK293 Cells | Female | Bone Neoplasms - genetics | Ovarian Neoplasms - metabolism | Bone Neoplasms - drug therapy | BRCA1 Protein - deficiency | Telomere-Binding Proteins - metabolism | Ovarian Neoplasms - drug therapy | Osteosarcoma - metabolism | DNA-Binding Proteins | Tumor Suppressor p53-Binding Protein 1 - metabolism | Recombinational DNA Repair | Tumor Suppressor p53-Binding Protein 1 - genetics | Cisplatin - pharmacology | Breast Neoplasms - drug therapy | Proteins - genetics | Xenograft Model Antitumor Assays | BRCA1 Protein - genetics | Poly(ADP-ribose) Polymerase Inhibitors - pharmacology | Drug Resistance, Neoplasm - genetics | Animals | Breast Neoplasms - genetics | Proteins - metabolism | Breast Neoplasms - pathology | Mad2 Proteins - genetics | Cell Line, Tumor | Mice | Osteosarcoma - genetics | Cell Cycle Proteins | Osteosarcoma - pathology | Care and treatment | DNA | Cancer cells | Breast cancer | Genetic aspects | Research | Gene expression | Single-stranded DNA | DNA damage | Homologous recombination | Poly(ADP-ribose) | Homology | Genomes | Inactivation | Proteins | Ribose | Null cells | Deoxyribonucleic acid--DNA | BRCA2 protein | CRISPR | Deactivation | BRCA1 protein | Poly(ADP-ribose) polymerase | Adenosine diphosphate | Oligosaccharides | Double-strand break repair | Screens | Cisplatin | Inhibitors | Prostate | Viability | Tumors | Telomere-Binding Proteins / metabolism | Osteosarcoma / genetics | Telomere-Binding Proteins / genetics | BRCA1 Protein / genetics | Cellular Biology | Genetics | Proteins / genetics | Osteosarcoma / drug therapy | Ovarian Neoplasms / genetics | Mad2 Proteins / genetics | Proteins / metabolism | Breast Neoplasms / drug therapy | Breast Neoplasms / metabolism | Tumor Suppressor p53-Binding Protein 1 / genetics | BRCA1 Protein / deficiency | Ovarian Neoplasms / metabolism | Mad2 Proteins / metabolism | Breast Neoplasms / pathology | Bone Neoplasms / genetics | Ovarian Neoplasms / pathology | Bone Neoplasms / pathology | Life Sciences | Bone Neoplasms / drug therapy | Ovarian Neoplasms / drug therapy | Osteosarcoma / metabolism | Biochemistry, Molecular Biology | Breast Neoplasms / genetics | Drug Resistance, Neoplasm / genetics | Osteosarcoma / pathology | Bone Neoplasms / metabolism | Poly(ADP-ribose) Polymerase Inhibitors / pharmacology | Cisplatin / pharmacology | Molecular biology | Tumor Suppressor p53-Binding Protein 1 / metabolism | Cancer
Journal Article
European urology, ISSN 0302-2838, 2014, Volume 65, Issue 2, pp. 270 - 273
Journal Article
Journal of clinical oncology, ISSN 1527-7755, 2010, Volume 28, Issue 19, pp. 3167 - 3175
Journal Article
Journal of clinical oncology, ISSN 1527-7755, 2015, Volume 33, Issue 3, pp. 244 - 250
Journal Article
International journal of radiation oncology, biology, physics, ISSN 0360-3016, 2012, Volume 83, Issue 2, pp. 720 - 726
Purpose To analyze the effect of reduced-dose radiotherapy on local control in children with low-risk rhabdomyosarcoma (RMS... 
Radiology | Hematology, Oncology and Palliative Medicine | Radiotherapy | Local control | Low risk | Rhabdomyosarcoma | PARAMENINGEAL RHABDOMYOSARCOMA | INTERNATIONAL SOCIETY | INTERGROUP-RHABDOMYOSARCOMA | NONMETASTATIC RHABDOMYOSARCOMA | SURGICAL-MANAGEMENT | FAILURE | RADIATION-THERAPY | STUDY-IV | GROUP-III PATIENTS | ONCOLOGY | PATIENT | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | Lymph Node Excision | Prostatic Neoplasms - radiotherapy | Age Factors | Humans | Child, Preschool | Infant | Male | Rhabdomyosarcoma, Embryonal - surgery | Neoplasm, Residual | Young Adult | Rhabdomyosarcoma, Embryonal - secondary | Treatment Failure | Adult | Female | Urogenital Neoplasms - drug therapy | Orbital Neoplasms - surgery | Child | Infant, Newborn | Orbital Neoplasms - radiotherapy | Prostatic Neoplasms - drug therapy | Rhabdomyosarcoma, Embryonal - pathology | Quality Control | Prostatic Neoplasms - pathology | Drug Administration Schedule | Prostatic Neoplasms - surgery | Head and Neck Neoplasms - drug therapy | Orbital Neoplasms - pathology | Urogenital Neoplasms - pathology | Orbital Neoplasms - drug therapy | Lymphatic Metastasis | Rhabdomyosarcoma, Embryonal - drug therapy | Tumor Burden | Head and Neck Neoplasms - pathology | Head and Neck Neoplasms - radiotherapy | Radiotherapy Dosage - standards | Urogenital Neoplasms - radiotherapy | Adolescent | Combined Modality Therapy - methods | Urogenital Neoplasms - surgery | Rhabdomyosarcoma, Embryonal - radiotherapy | Second-Look Surgery | Head and Neck Neoplasms - surgery | SURGERY | PATIENTS | NEOPLASMS | LYMPH NODES | FAILURES | RADIOLOGY AND NUCLEAR MEDICINE | ENDOXAN | RADIATION DOSES | RADIOTHERAPY | CHILDREN | CONTROL | HAZARDS | Low-risk | Local Control
Journal Article
Journal Article
Cancer chemotherapy and pharmacology, ISSN 1432-0843, 2019, Volume 84, Issue 3, pp. 487 - 499
.... While their function in hepatic metabolism of taxanes is well established, expression of these enzymes in solid tumors may play a role in the in situ metabolism of drugs as well, potentially... 
Intratumoral | Ritonavir | Paclitaxel | Docetaxel | CYP | Review | Journal Article | Medicine & Public Health | Oncology | Cancer Research | Pharmacology/Toxicology | PREGNANE-X RECEPTOR | IMMUNOHISTOCHEMICAL LOCALIZATION | DOCETAXEL RESISTANCE | CYP3A4 EXPRESSION | TARGETED THERAPIES | MESSENGER-RNA | ONCOLOGY | P450-MEDIATED METABOLISM | BIOLOGICAL-ACTIVITY | PHARMACOLOGY & PHARMACY | HIV-1 PROTEASE INHIBITOR | METABOLIZING-ENZYMES | Lung Neoplasms - drug therapy | Taxoids - pharmacology | Humans | Ovarian Neoplasms - pathology | Drug Resistance, Neoplasm | Lung Neoplasms - pathology | Male | Breast Neoplasms - enzymology | Female | Antineoplastic Agents - pharmacology | Cytochrome P-450 CYP2C8 - metabolism | Ovarian Neoplasms - drug therapy | Prostatic Neoplasms - drug therapy | Prostatic Neoplasms - pathology | Endometrial Neoplasms - enzymology | Lung Neoplasms - enzymology | Neoplasms - enzymology | Breast Neoplasms - drug therapy | Ovarian Neoplasms - enzymology | Neoplasms - drug therapy | Breast Neoplasms - pathology | Cytochrome P-450 CYP3A - metabolism | Prostatic Neoplasms - enzymology | Endometrial Neoplasms - drug therapy | Endometrial Neoplasms - pathology | Neoplasms - pathology | Antimitotic agents | Protease inhibitors | Proteases | Pharmacy | Cytochrome P-450 | Physiological aspects | Drugstores | Antineoplastic agents | Ovarian cancer | Cytochrome | Enzymes | Cytochrome P450 | Proteinase inhibitors | Taxane | Metabolism | Anticancer properties | Antitumor agents | Lungs | Drug metabolism | Breast | Solid tumors | Taxanes | Prostate | Endometrium | Tumors | Cytochromes P450
Journal Article
Cancer letters, ISSN 0304-3835, 2007, Volume 251, Issue 1, pp. 132 - 145
...1 Introduction Betulinic acid (BA) is a plant-derived pentacyclic lupine-type triterpene, which was discovered in a National Cancer Institute drug screening... 
Hematology, Oncology and Palliative Medicine | Chemotherapy | Lung cancer | Betulinic acid | Colorectal cancer | Breast cancer | Prostate cancer | Cervical cancer | Apoptosis | ACTIVATION | colorectal cancer | INDUCED APOPTOSIS | breast cancer | apoptosis | TUMOR-CELLS | betulinic acid | IDENTIFICATION | cervical cancer | chemotherapy | CYTOTOXIC ACTIVITY | lung cancer | prostate cancer | ONCOLOGY | HUMAN-MELANOMA CELLS | SERINE-PROTEASE | INDUCED DEATH | INHIBITOR | DERIVATIVES | Neoplasms - metabolism | Lung Neoplasms - drug therapy | Prostatic Neoplasms - metabolism | Triterpenes - pharmacology | Apoptosis - drug effects | Humans | Lung Neoplasms - metabolism | Lung Neoplasms - pathology | Male | Uterine Cervical Neoplasms - pathology | Breast Neoplasms - metabolism | Dose-Response Relationship, Drug | Uterine Cervical Neoplasms - metabolism | Colorectal Neoplasms - drug therapy | Female | Colorectal Neoplasms - metabolism | Prostatic Neoplasms - drug therapy | Cell Survival - drug effects | Prostatic Neoplasms - pathology | Jurkat Cells | Cells, Cultured | Uterine Cervical Neoplasms - drug therapy | Breast Neoplasms - drug therapy | Blotting, Western | Neoplasms - drug therapy | Poly(ADP-ribose) Polymerases - metabolism | Breast Neoplasms - pathology | Cell Line, Tumor | Antineoplastic Agents, Phytogenic - pharmacology | Colorectal Neoplasms - pathology | Neoplasms - pathology | Cancer
Journal Article
BMC research notes, ISSN 1756-0500, 2016, Volume 9, Issue 1, p. 143
Journal Article