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1. Full Text Cytochrome P450 3A4, 3A5, and 2C8 expression in breast, prostate, lung, endometrial, and ovarian tumors : relevance for resistance to taxanes
by van Eijk, Maarten and Boosman, René J and Schinkel, Alfred H and Huitema, Alwin D R and Beijnen, Jos H
Cancer chemotherapy and pharmacology, ISSN 0344-5704, 2019, Volume 84, Issue 3, pp. 487 - 499
Intratumoral | Ritonavir | Paclitaxel | Docetaxel | CYP | Review | Journal Article | Medicine & Public Health | Oncology | Cancer Research | Pharmacology/Toxicology | Pharmacology & Pharmacy | Life Sciences & Biomedicine | Science & Technology | Lung Neoplasms - drug therapy | Taxoids - pharmacology | Humans | Ovarian Neoplasms - pathology | Drug Resistance, Neoplasm | Lung Neoplasms - pathology | Male | Breast Neoplasms - enzymology | Female | Antineoplastic Agents - pharmacology | Cytochrome P-450 CYP2C8 - metabolism | Ovarian Neoplasms - drug therapy | Prostatic Neoplasms - drug therapy | Prostatic Neoplasms - pathology | Endometrial Neoplasms - enzymology | Lung Neoplasms - enzymology | Neoplasms - enzymology | Breast Neoplasms - drug therapy | Ovarian Neoplasms - enzymology | Neoplasms - drug therapy | Breast Neoplasms - pathology | Cytochrome P-450 CYP3A - metabolism | Prostatic Neoplasms - enzymology | Endometrial Neoplasms - drug therapy | Endometrial Neoplasms - pathology | Neoplasms - pathology | Antimitotic agents | Protease inhibitors | Proteases | Pharmacy | Cytochrome P-450 | Physiological aspects | Drugstores | Antineoplastic agents | Ovarian cancer | Cytochrome | Enzymes | Cytochrome P450 | Proteinase inhibitors | Taxane | Metabolism | Anticancer properties | Antitumor agents | Lungs | Drug metabolism | Breast | Solid tumors | Taxanes | Prostate | Endometrium | Tumors | Cytochromes P450 | Index Medicus
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2. Full Text The deficiency of Akt1 is sufficient to suppress tumor development in Pten+/- mice
by Chen, Mei-Ling and Xu, Pei-Zhang and Peng, Xiao-Ding and Chen, William S and Guzman, Grace and Yang, Ximing and Di Cristofano, Antonio and Pandolfi, Pier Paolo and Hay, Nissim
Genes & development, ISSN 0890-9369, 06/2006, Volume 20, Issue 12, pp. 1569 - 1574
Intestinal polyps | PIN | Endometrium carcinoma | Thyroid and adrenal tumors | Cancer therapy | Genetics & Heredity | Life Sciences & Biomedicine | Developmental Biology | Science & Technology | Cell Biology | Prostatic Intraepithelial Neoplasia - pathology | Thyroid Neoplasms - enzymology | Proto-Oncogene Proteins c-akt - deficiency | Male | Intestinal Polyps - enzymology | Proto-Oncogene Proteins c-akt - genetics | Adrenal Gland Neoplasms - enzymology | Prostatic Neoplasms - genetics | Endometrial Neoplasms - genetics | Neoplasms - genetics | Female | Pseudolymphoma - genetics | Pseudolymphoma - enzymology | Adrenal Gland Neoplasms - pathology | PTEN Phosphohydrolase - genetics | Prostatic Neoplasms - pathology | Endometrial Neoplasms - enzymology | Neoplasms - enzymology | PTEN Phosphohydrolase - metabolism | Pseudolymphoma - pathology | Thyroid Neoplasms - genetics | Animals | Prostatic Intraepithelial Neoplasia - enzymology | Intestinal Polyps - pathology | Prostatic Neoplasms - enzymology | Endometrial Neoplasms - pathology | Heterozygote | Mice | Prostatic Intraepithelial Neoplasia - genetics | Neoplasms - pathology | Adrenal Gland Neoplasms - genetics | Thyroid Neoplasms - pathology | Index Medicus | Research Communication | thyroid and adrenal tumors | intestinal polyps | endometrium carcinoma
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3. Full Text Asparagine bioavailability governs metastasis in a model of breast cancer
by Knott, Simon R.V and Wagenblast, Elvin and Khan, Showkhin and Kim, Sun Y and Soto, Mar and Wagner, Michel and Turgeon, Marc-Olivier and Fish, Lisa and Erard, Nicolas and Gable, Annika L and MacEli, Ashley R and DIckopf, Steffen and Papachristou, Evangelia K and D'Santos, Clive S and Carey, Lisa A and Wilkinson, John E and Harrell, J. Chuck and Perou, Charles M and Goodarzi, Hani and Poulogiannis, George and Hannon, Gregory J
Nature (London), ISSN 0028-0836, 02/2018, Volume 554, Issue 7692, pp. 378 - 381
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Prostatic Neoplasms - metabolism | Prognosis | Humans | Lung Neoplasms - metabolism | Biological Availability | Lung Neoplasms - pathology | Male | Epithelial-Mesenchymal Transition - genetics | Breast Neoplasms - metabolism | Breast Neoplasms - enzymology | Prostatic Neoplasms - genetics | Lung Neoplasms - secondary | RNA Interference | Neoplasm Invasiveness - pathology | Female | Asparaginase - therapeutic use | Aspartate-Ammonia Ligase - metabolism | Disease Models, Animal | Asparagine - deficiency | Prostatic Neoplasms - pathology | Reproducibility of Results | Asparaginase - metabolism | Lung Neoplasms - enzymology | Aspartate-Ammonia Ligase - genetics | Disease Progression | Animals | Breast Neoplasms - genetics | Breast Neoplasms - pathology | Neoplasm Metastasis - pathology | Asparagine - metabolism | Cell Line, Tumor | Prostatic Neoplasms - enzymology | Mice | Oncology, Experimental | Asparagine | Breast cancer | Cancer invasiveness | Research | Metastasis | Cancer | Mesenchyme | Invasiveness | RNA-mediated interference | L-asparaginase | Amino acids | Genomes | Bioavailability | Gene expression | Ribonucleic acid--RNA | Patients | Metastases | Proteins | Aspartate-ammonia ligase | Diet | Asparaginase | Tumors | Index Medicus
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4. Full Text Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway
by Viswanathan, Vasanthi S and Ryan, Matthew J and Dhruv, Harshil D and Gill, Shubhroz and Eichhoff, Ossia M and Seashore-Ludlow, Brinton and Kaffenberger, Samuel D and Eaton, John K and Shimada, Kenichi and Aguirre, Andrew J and Viswanathan, Srinivas R and Chattopadhyay, Shrikanta and Tamayo, Pablo and Yang, Wan Seok and Rees, Matthew G and Chen, Sixun and Boskovic, Zarko V and Javaid, Sarah and Huang, Cherrie and Wu, Xiaoyun and Tseng, Yuen-Yi and Roider, Elisabeth M and Gao, Dong and Cleary, James M and Wolpin, Brian M and Mesirov, Jill P and Haber, Daniel A and Engelman, Jeffrey A and Boehm, Jesse S and Kotz, Joanne D and Hon, Cindy S and Chen, Yu and Hahn, William C and Levesque, Mitchell P and Doench, John G and Berens, Michael E and Shamji, Alykhan F and Clemons, Paul A and Stockwell, Brent R and Schreiber, Stuart L
Nature (London), ISSN 0028-0836, 07/2017, Volume 547, Issue 7664, pp. 453 - 457
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Prostatic Neoplasms - metabolism | Cadherins - metabolism | Humans | Mesoderm - drug effects | Melanoma - enzymology | Male | Lipid Peroxides - metabolism | Zinc Finger E-box-Binding Homeobox 1 - genetics | Neoplasms - genetics | Mesoderm - enzymology | Cell Death | Epithelial-Mesenchymal Transition | Lipid Peroxidation - drug effects | Cell Transdifferentiation | Prostatic Neoplasms - drug therapy | Melanoma - metabolism | Glutathione Peroxidase - metabolism | Prostatic Neoplasms - pathology | Reproducibility of Results | Neoplasms - enzymology | Melanoma - pathology | Iron - metabolism | Neoplasms - drug therapy | Cell Lineage | Drug Resistance, Neoplasm - genetics | Proto-Oncogene Proteins B-raf - genetics | Melanoma - drug therapy | Proteomics | Cell Line, Tumor | Prostatic Neoplasms - enzymology | Mesoderm - metabolism | Neoplasms - pathology | Mesoderm - pathology | Peroxidase | Research | Chemical properties | Chemical synthesis | Analysis | Cancer cells | Therapy | Biotechnology | Carcinoma | Mesenchyme | Genes | Lipid peroxidation | Lipids | Iron | Genomes | Phospholipids | Kinases | Cancer therapies | Proteins | Organoids | Dissipation | Peroxides | Lipid metabolism | Glutathione | Transfer RNA | Peroxidation | Glutathione peroxidase | Enzymes | Mortality | Melanoma | Selenocysteine | Tumor cell lines | Metabolism | Substrates | Cell death | Lipoxygenase | Prostate cancer | Prostate | Tumors | Apoptosis | Cancer | Index Medicus
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5. Full Text Five different anti-prostate-specific membrane antigen (PSMA) antibodies confirm PSMA expression in tumor-associated neovasculature
by Chang, Sam S and Reuter, Victor E and Heston, W.D.W and Bander, Neil H and Grauer, Lana S and Gaudin, Paul B
Cancer research (Chicago, Ill.), ISSN 0008-5472, 07/1999, Volume 59, Issue 13, pp. 3192 - 3198
Life Sciences & Biomedicine | Oncology | Science & Technology | Tumors of the urinary system | Urinary tract. Prostate gland | Nephrology. Urinary tract diseases | Biological and medical sciences | Medical sciences | Humans | Urinary Bladder Neoplasms - enzymology | Male | Testicular Neoplasms - enzymology | Testicular Neoplasms - pathology | Neovascularization, Pathologic - enzymology | Breast Neoplasms - enzymology | Transfection | Carboxypeptidases - immunology | Urinary Bladder Neoplasms - pathology | Carcinoma, Renal Cell - enzymology | Female | Antigens, Neoplasm - analysis | Tumor Cells, Cultured | Carcinoma, Renal Cell - blood supply | Prostatic Neoplasms - blood supply | Antigens, Neoplasm - genetics | Prostatic Neoplasms - pathology | Carcinoma, Renal Cell - pathology | Neoplasms - enzymology | Neoplasms - blood supply | Carboxypeptidases - genetics | Antibodies, Monoclonal | Breast Neoplasms - blood supply | Urinary Bladder Neoplasms - blood supply | Breast Neoplasms - pathology | Testicular Neoplasms - blood supply | Prostatic Neoplasms - enzymology | Antigens, Surface | Prostate - enzymology | Neoplasms - pathology | Carboxypeptidases - analysis | Glutamate Carboxypeptidase II | Index Medicus
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6. Full Text Kallikrein-related peptidases in prostate, breast, and ovarian cancers: from pathobiology to clinical relevance
by Avgeris, Margaritis and Mavridis, Konstantinos and Scorilas, Andreas
Biological chemistry, ISSN 1431-6730, 05/2012, Volume 393, Issue 5, pp. 301 - 317
epithelial-mesenchymal transition | extracellular matrix proteases | KLK | biomarkers | serine proteases | PSA | Biomarkers | Epithelial-mesenchymal transition | Serine proteases | Extracellular matrix proteases | Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Prostatic Neoplasms - pathology | Ovarian Neoplasms - diagnosis | Humans | Ovarian Neoplasms - pathology | Neoplasms - enzymology | Male | Neoplasms - diagnosis | Prostatic Neoplasms - diagnosis | Ovarian Neoplasms - enzymology | Prostatic Neoplasms - therapy | Breast Neoplasms - therapy | Breast Neoplasms - enzymology | Neoplasms - therapy | Breast Neoplasms - pathology | Ovarian Neoplasms - therapy | Prostatic Neoplasms - enzymology | Female | Breast Neoplasms - diagnosis | Neoplasms - pathology | Kallikreins - metabolism | Kallikrein | Development and progression | Breast cancer | Research | Properties | Prostate cancer | Clinical pathology | Ovarian cancer | Index Medicus
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7. Full Text Aldehyde dehydrogenase 3A1 associates with prostate tumorigenesis
by Yan, J and De Melo, J and Cutz, J.-C and Aziz, T and Tang, D
British journal of cancer, ISSN 0007-0920, 05/2014, Volume 110, Issue 10, pp. 2593 - 2603
Life Sciences & Biomedicine | Oncology | Science & Technology | Tumors of the urinary system | Urinary tract. Prostate gland | Nephrology. Urinary tract diseases | Biological and medical sciences | Multiple tumors. Solid tumors. Tumors in childhood (general aspects) | Medical sciences | Tumors | Neoplasm Transplantation | Prostatic Intraepithelial Neoplasia - pathology | Adenocarcinoma - pathology | Aldehyde Dehydrogenase - analysis | Humans | Aldehyde Dehydrogenase - biosynthesis | Gene Expression Regulation, Neoplastic | Bone Neoplasms - secondary | Male | Lung Neoplasms - secondary | Neoplasms, Hormone-Dependent - enzymology | Neoplasm Proteins - genetics | Prostatic Neoplasms - pathology | Bone Neoplasms - enzymology | Lung Neoplasms - enzymology | Neoplasm Proteins - biosynthesis | Adenocarcinoma - enzymology | Enzyme Induction | Aldehyde Dehydrogenase - genetics | Lymphatic Metastasis | Mice, SCID | Disease Progression | Androgens | Animals | Cell Transformation, Neoplastic | Neoplasms, Hormone-Dependent - pathology | Prostatic Intraepithelial Neoplasia - enzymology | Epithelial Cells - enzymology | Cell Line, Tumor | Prostatic Neoplasms - enzymology | Mice, Inbred NOD | Neoplasm Proteins - analysis | Mice | Neoplastic Stem Cells - enzymology | Cell Line, Transformed | Index Medicus | aldehyde dehydrogenase 3A1 | prostate cancer | prostate cancer stem cells | Molecular Diagnostics
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8. Full Text MnSOD upregulation sustains the Warburg effect via mitochondrial ROS and AMPK-dependent signalling in cancer
by Hart, Peter C and Mao, Mao and De Abreu, Andre Luelsdorf P and Ansenberger-Fricano, Kristine and Ekoue, Dede N and Ganini, Douglas and Kajdacsy-Balla, Andre and Diamond, Alan M and Minshall, Richard D and Consolaro, Marcia E. L and Santos, Janine H and Bonini, Marcelo G
Nature communications, ISSN 2041-1723, 2015, Volume 6, Issue 1, pp. 6053 - 6053
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Mitochondria - enzymology | RNA, Small Interfering - genetics | AMP-Activated Protein Kinases - metabolism | Colonic Neoplasms - genetics | Superoxide Dismutase - genetics | Reactive Oxygen Species - metabolism | Humans | Transcriptional Activation | Gene Expression Regulation, Neoplastic | Phosphofructokinase-1 - genetics | Superoxide Dismutase - antagonists & inhibitors | Male | Glycolysis - genetics | Breast Neoplasms - enzymology | Prostatic Neoplasms - genetics | Mitochondria - genetics | Female | Hexokinase - genetics | Superoxide Dismutase - metabolism | Prostatic Neoplasms - pathology | Oxidation-Reduction | Pyruvate Kinase - metabolism | Signal Transduction | AMP-Activated Protein Kinases - antagonists & inhibitors | Hydrogen Peroxide - metabolism | Breast Neoplasms - genetics | Breast Neoplasms - pathology | Colonic Neoplasms - pathology | Cell Line, Tumor | Prostatic Neoplasms - enzymology | Colonic Neoplasms - enzymology | Hexokinase - metabolism | Neoplasm Staging | Phosphofructokinase-1 - metabolism | Pyruvate Kinase - genetics | AMP-Activated Protein Kinases - genetics | RNA, Small Interfering - metabolism | Index Medicus
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