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Nature Medicine, ISSN 1078-8956, 11/2015, Volume 21, Issue 11, pp. 1262 - 1271
Cancer-associated muscle weakness is a poorly understood phenomenon, and there is no effective treatment. Here we find that seven different mouse models of... 
MEDICINE, RESEARCH & EXPERIMENTAL | CANCER CACHEXIA | CELLS | INTRACELLULAR CALCIUM | BIOCHEMISTRY & MOLECULAR BIOLOGY | RELEASE | CELL BIOLOGY | DYSTROPHIC MUSCLE | GROWTH-FACTOR-BETA | HORMONE-RELATED PROTEIN | RYANODINE RECEPTOR | CAMURATI-ENGELMANN-DISEASE | IN-VIVO | Neoplasms - metabolism | Prostatic Neoplasms - metabolism | Up-Regulation | Calcium - metabolism | Humans | Lung Neoplasms - metabolism | NADPH Oxidases - metabolism | Bone Neoplasms - secondary | Lung Neoplasms - pathology | Male | Muscle, Skeletal - metabolism | Osteolysis - etiology | Ryanodine Receptor Calcium Release Channel - metabolism | X-Ray Microtomography | Bone Neoplasms - metabolism | Breast Neoplasms - metabolism | Neoplasms - complications | MCF-7 Cells | Osteolysis - diagnostic imaging | Muscle Proteins - metabolism | NADPH Oxidases - genetics | Female | Camurati-Engelmann Syndrome - metabolism | Muscle Strength | Calcium Signaling | Disease Models, Animal | Muscle Weakness - etiology | Prostatic Neoplasms - pathology | Oxidation-Reduction | Bone Neoplasms - diagnostic imaging | NADPH Oxidase 4 | Mice, SCID | Multiple Myeloma - metabolism | Absorptiometry, Photon | Osteolysis - metabolism | Multiple Myeloma - pathology | Animals | Muscle Contraction | Breast Neoplasms - pathology | Mice, Nude | Muscle Weakness - metabolism | Cell Line, Tumor | Mice | Neoplasms - pathology | Transforming Growth Factor beta - metabolism | Index Medicus
Journal Article
European Urology, ISSN 0302-2838, 2014, Volume 67, Issue 1, pp. 53 - 60
Abstract Background Enzalutamide is a novel antiandrogen with proven efficacy in metastatic castration-resistant prostate cancer (mCRPC). Objective To evaluate... 
Urology | Castration-resistant prostate cancer | Primary resistance to enzalutamide | Androgen signaling inhibition | Bone metastasis | Bone tumor microenvironment | Adaptive feedback mechanism | Androgen receptor | Predictors of outcome | Enzalutamide | Tissue-based research | TESTOSTERONE | CHEMOTHERAPY | RECEPTOR SPLICE VARIANTS | THERAPY | DEPRIVATION | CLINICAL-TRIALS | UROLOGY & NEPHROLOGY | INCREASED SURVIVAL | PROGRESSION | ABIRATERONE | Prospective Studies | Phenylthiohydantoin - therapeutic use | Humans | Middle Aged | Receptors, Androgen - metabolism | Retroviridae Proteins, Oncogenic - metabolism | Bone Neoplasms - secondary | Cytoplasm - metabolism | Drug Resistance, Neoplasm | Ki-67 Antigen - metabolism | Male | Antineoplastic Agents - therapeutic use | Receptors, Glucocorticoid - metabolism | Prostatic Neoplasms, Castration-Resistant - pathology | Bone Neoplasms - metabolism | Cell Nucleus - metabolism | Protein Isoforms - metabolism | Bone Marrow - metabolism | Aged, 80 and over | Adult | Bone Neoplasms - drug therapy | Testosterone - blood | Gene Dosage | Prostatic Neoplasms, Castration-Resistant - drug therapy | Prostatic Neoplasms, Castration-Resistant - metabolism | Bone Marrow Neoplasms - secondary | Phenylthiohydantoin - analogs & derivatives | Prostate-Specific Antigen - blood | Receptors, Androgen - genetics | Signal Transduction - drug effects | Bone Marrow Neoplasms - metabolism | Aged | Bone Marrow Neoplasms - drug therapy | Steroid 17-alpha-Hydroxylase - metabolism | Prostate cancer | Metastasis | Index Medicus | Bone marrow biopsy | Androgen | Antiandrogens
Journal Article
Journal Article
Nature, ISSN 0028-0836, 07/2017, Volume 547, Issue 7664, pp. 453 - 457
Plasticity of the cell state has been proposed to drive resistance to multiple classes of cancer therapies, thereby limiting their effectiveness(1-4). A... 
EPITHELIAL-MESENCHYMAL TRANSITION | METABOLISM | MULTIDISCIPLINARY SCIENCES | PROSTATE-CANCER | HUMAN-MELANOMA CELLS | SENSITIVITY | DEATH | INHIBITOR | EXPRESSION | SIGNATURE | REVEALS | Prostatic Neoplasms - metabolism | Cadherins - metabolism | Humans | Mesoderm - drug effects | Melanoma - enzymology | Male | Lipid Peroxides - metabolism | Zinc Finger E-box-Binding Homeobox 1 - genetics | Neoplasms - genetics | Mesoderm - enzymology | Cell Death | Epithelial-Mesenchymal Transition | Lipid Peroxidation - drug effects | Cell Transdifferentiation | Prostatic Neoplasms - drug therapy | Melanoma - metabolism | Glutathione Peroxidase - metabolism | Prostatic Neoplasms - pathology | Reproducibility of Results | Neoplasms - enzymology | Melanoma - pathology | Iron - metabolism | Neoplasms - drug therapy | Cell Lineage | Drug Resistance, Neoplasm - genetics | Proto-Oncogene Proteins B-raf - genetics | Melanoma - drug therapy | Proteomics | Cell Line, Tumor | Prostatic Neoplasms - enzymology | Mesoderm - metabolism | Neoplasms - pathology | Mesoderm - pathology | Peroxidase | Research | Chemical properties | Chemical synthesis | Analysis | Cancer cells | Therapy | Biotechnology | Carcinoma | Mesenchyme | Genes | Lipid peroxidation | Lipids | Iron | Genomes | Phospholipids | Kinases | Cancer therapies | Proteins | Organoids | Dissipation | Peroxides | Lipid metabolism | Glutathione | Transfer RNA | Peroxidation | Glutathione peroxidase | Enzymes | Mortality | Melanoma | Selenocysteine | Tumor cell lines | Metabolism | Substrates | Cell death | Lipoxygenase | Prostate cancer | Prostate | Tumors | Apoptosis | Cancer | Index Medicus
Journal Article
Science, ISSN 0036-8075, 12/2008, Volume 322, Issue 5908, pp. 1695 - 1699
Enhancer of zeste homolog 2 (EZH2) is a mammalian histone methyltransferase that contributes to the epigenetic silencing of target genes and regulates the... 
Cell growth | MicroRNA | Epithelial cells | Genomics | Stem cells | Cell lines | Small interfering RNA | Reports | Prostate cancer | Cancer | Tumors | MOUSE DEVELOPMENT | DEVELOPMENTAL REGULATORS | MULTIDISCIPLINARY SCIENCES | EMBRYONIC STEM-CELLS | IN-VIVO | H3 LYSINE-27 METHYLATION | ZESTE HOMOLOG-2 | ENHANCER | TARGETS | POLYCOMB | EXPRESSION | Neoplasms - metabolism | Prostatic Neoplasms - metabolism | RNA, Small Interfering - genetics | Epigenesis, Genetic | Humans | Gene Expression Regulation, Neoplastic | Stomach Neoplasms - metabolism | Male | MicroRNAs - metabolism | Breast Neoplasms - metabolism | DNA-Binding Proteins - metabolism | Neoplasm Metastasis | Prostatic Neoplasms - genetics | Neoplasms - genetics | Female | Lysine - metabolism | 3' Untranslated Regions | Stomach Neoplasms - genetics | Promoter Regions, Genetic | Prostatic Neoplasms - pathology | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Disease Progression | Enhancer of Zeste Homolog 2 Protein | Transcription Factors - metabolism | Polycomb Repressive Complex 2 | Algorithms | Breast Neoplasms - genetics | Cell Line, Tumor | MicroRNAs - genetics | Histones - metabolism | Genome, Human | Methylation | Methyltransferases | RNA | Physiological aspects | Genetic aspects | Research | Health aspects | Oncology | Gene expression | Ribonucleic acid--RNA | Index Medicus
Journal Article
Cancer Cell, ISSN 1535-6108, 05/2012, Volume 21, Issue 5, pp. 642 - 654
Recent studies underscore the importance of myeloid cells in rendering distant organs hospitable for disseminating tumor cells to colonize. However, what... 
LUNG METASTASIS | STAT3 ACTIVATION | IMMUNE CELLS | ONCOLOGY | INFLAMMATION | IN-VIVO | NICHE | DEPENDENT TUMOR ANGIOGENESIS | CANCER | TUMORIGENESIS | PROGRESSION | CELL BIOLOGY | Neoplasms - metabolism | Prostatic Neoplasms - metabolism | Cell Proliferation | Lymph Nodes - pathology | Receptors, Lysosphingolipid - deficiency | Humans | Lung Neoplasms - metabolism | Tumor Microenvironment | Male | Prostatic Neoplasms - genetics | Lung Neoplasms - secondary | RNA Interference | Time Factors | STAT3 Transcription Factor - deficiency | Urinary Bladder Neoplasms - pathology | Receptors, Lysosphingolipid - genetics | Receptors, Lysosphingolipid - metabolism | Urinary Bladder Neoplasms - metabolism | STAT3 Transcription Factor - genetics | STAT3 Transcription Factor - metabolism | Melanoma - metabolism | Skin Neoplasms - pathology | Prostatic Neoplasms - pathology | Transduction, Genetic | Signal Transduction | Cell Survival | Neoplasm Invasiveness | Lymph Nodes - metabolism | Lymphatic Metastasis | Melanoma - secondary | Mice, Knockout | Skin Neoplasms - metabolism | Animals | Cell Line, Tumor | CpG Islands | Myeloid Cells - metabolism | Mice | Myeloid Cells - pathology | Neoplasms - pathology | Cell Movement | Analysis | Oncology, Experimental | Transplantation | Metastasis | Research | Hematopoietic stem cells | Tumors | Cancer | Index Medicus
Journal Article
Cancer Research, ISSN 0008-5472, 04/2011, Volume 71, Issue 7, pp. 2600 - 2610
Journal Article
Nature, ISSN 0028-0836, 08/2010, Volume 466, Issue 7308, pp. 869 - 873
Journal Article
Nature, ISSN 0028-0836, 02/2018, Volume 554, Issue 7692, pp. 378 - 381
Journal Article
PLoS ONE, ISSN 1932-6203, 11/2011, Volume 6, Issue 11, pp. e27970 - e27970
Background: Although androgens are depleted in castration resistant prostate cancer (CRPC), metastases still express nuclear androgen receptor (AR) and... 
STEROIDOGENESIS | THERAPY | TESTOSTERONE | EPIDERMAL-GROWTH-FACTOR | BIOLOGY | GENE-EXPRESSION | FACTOR-I | BONE | CELL-LINES | SPLICE VARIANTS | PROGRESSION | Neoplasms, Hormone-Dependent - metabolism | Prostatic Neoplasms - metabolism | Prostatic Hyperplasia - pathology | Prognosis | Alternative Splicing | Humans | Middle Aged | Receptors, Androgen - metabolism | Gene Expression Regulation, Neoplastic | Bone Neoplasms - secondary | Male | Immunoenzyme Techniques | Prostate - metabolism | Bone Neoplasms - metabolism | Neoplasms, Hormone-Dependent - genetics | Prostate - pathology | Prostatic Neoplasms - genetics | Castration | Aged, 80 and over | Adult | Bone Neoplasms - genetics | Real-Time Polymerase Chain Reaction | Soft Tissue Neoplasms - genetics | Prostatic Neoplasms - pathology | Soft Tissue Neoplasms - secondary | RNA, Messenger - genetics | Soft Tissue Neoplasms - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Prostatic Hyperplasia - genetics | Blotting, Western | Prostatic Hyperplasia - metabolism | Receptors, Androgen - genetics | Neoplasms, Hormone-Dependent - pathology | Cell Line, Tumor | Aged | Proteins | Viral antibodies | Antibodies | Androgens | Metastasis | Prostate cancer | Alternative splicing | Phosphorylation | Staining | Kinases | Tissues | Urology | Metastases | Angiogenesis | Xenografts | Localization | Medical research | Lymphatic system | Immunoglobulins | Review boards | C-Terminus | Gene expression | Polymerase chain reaction | Chemotherapy | Ligands | Immunoreactivity | Prostate | Cancer | Index Medicus
Journal Article