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anaphase-promoting complex (1) 1
apc (1) 1
apc/c, anaphase-promoting complex/cyclosome (1) 1
asb, ankyrin repeat and socs-box (1) 1
assembly (1) 1
aux, auxin (1) 1
bcr, btb–cul3–rbx1 (1) 1
biochemistry & molecular biology (1) 1
bp, β-propeller (1) 1
broad complex (1) 1
btb, bric-a-brac (1) 1
btb, bric-a-brac/tramtrack/broad complex (1) 1
c, anaphase-promoting complex (1) 1
cancer-therapy (1) 1
cand1, cullin-associated nedd8-dissociated protein 1 (1) 1
cbfβ, core binding factor β (1) 1
cdc, cell division cycle (1) 1
cell-cycle (1) 1
cks1, cyclin-dependent protein kinase regulatory subunit 1 (1) 1
coi1, coronatine-insensitive protein 1 (1) 1
cop9 signalosome (1) 1
cpd, compound (1) 1
cph, conserved within cul7, parc and herc2 (1) 1
crbn, cereblon (1) 1
crl, cullin–ring e3 ubiquitin ligase (1) 1
csa, cockayne syndrome a (1) 1
csn, cop9 signalosome complex (1) 1
ctd, c-terminal domain (1) 1
cul, cullin (1) 1
cullin proteins - antagonists & inhibitors (1) 1
cullin proteins - chemistry (1) 1
cullin proteins - genetics (1) 1
cyclosome (1) 1
dcaf, ddb1–cul4a-associated factor (1) 1
ddb, damage-specific dna-binding protein (1) 1
drug design (1) 1
drug discovery - methods (1) 1
elobc, elonginb–elonginc complex (1) 1
f-box proteins (1) 1
fbw (1) 1
fbw/fbxw, f-box/wd repeat-containing protein (1) 1
fbxl, f-box (1) 1
fbxl, f-box/leucine-rich motif-containing protein (1) 1
fbxo, f-box (1) 1
fbxo, f-box/other domain-containing protein (1) 1
fbxw, f-box (1) 1
fp, fluorescence polarization (1) 1
ghr, growth hormone receptor (1) 1
hect, homologous with e6-associated protein c-terminus (1) 1
herc2, hect domain- and rld domain-containing e3 ubiquitin protein ligase 2 (1) 1
hif-1α, hypoxia-inducible factor 1α (1) 1
humans (1) 1
iaa, indole-3-acetic acid (1) 1
index medicus (1) 1
itc, isothermal titration calorimetry (1) 1
iκb, inhibitor of nf-κb (1) 1
ja-ile, jasmonoyl-isoleucine (1) 1
jaz1, jasmonate (1) 1
jaz1, jasmonate/zim domain protein 1 (1) 1
kappa-b-alpha (1) 1
keap1, kelch-like enoyl-coa hydratase-associated protein 1 (1) 1
klhl, kelch-like protein (1) 1
leucine-rich motif-containing protein (1) 1
math, meprin and traf homology (1) 1
mel26, maternal effect lethal 26 (1) 1
models, molecular (1) 1
molecular structure (1) 1
mtor, mammalian target of rapamycin (1) 1
nae, nedd8-activating enzyme (1) 1
nedd, neural-precursor-cell-expressed developmentally down-regulated (1) 1
nf-κb, nuclear factor κb (1) 1
nrf2, nuclear factor-erythroid 2-related factor 2 (1) 1
ntd, n-terminal domain (1) 1
other domain-containing protein (1) 1
parc, p53-associated parkin-like cytoplasmic protein (1) 1
poz, pox virus and zinc finger (1) 1
ppi, protein–protein interaction (1) 1
protac, proteolysis-targeting chimaeric molecule (1) 1
proteasome inhibitors - chemistry (1) 1
proteasome inhibitors - pharmacology (1) 1
proteasome system (1) 1
protein structure, quaternary (1) 1
protein structure, tertiary (1) 1
protein subunits (1) 1
rbx1, ring-box protein 1 (1) 1
review (1) 1
review article (1) 1
ring, really interesting new gene (1) 1
scf, skp1–cdc53–f-box cdc4 (1) 1
sh2, src homology 2 (1) 1
skp2, s-phase kinase-associated protein 2 (1) 1
small molecule (1) 1
smer3, small-molecule enhancer of rapamycin 3 (1) 1
socs, suppressor of cytokine signalling (1) 1
socs-box (1) 1
spop, speckle-type poz protein (1) 1
stat, signal transducer and activator of transcription (1) 1
structure (1) 1
structure-based design (1) 1
substrate-assisted inhibition (1) 1
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Biochemical Journal, ISSN 0264-6021, 05/2015, Volume 467, Issue 3, pp. 365 - 386
In the last decade, the ubiquitin-proteasome system has emerged as a valid target for the development of novel therapeutics. E3 ubiquitin ligases are... 
Ubiquitin | Ubiquitination | Small molecule | Structure | Structure-based design | Assembly | small molecule | ANAPHASE-PROMOTING COMPLEX | SOCS-BOX | BIOCHEMISTRY & MOLECULAR BIOLOGY | F-BOX PROTEINS | KAPPA-B-ALPHA | structure | structure-based design | ubiquitin | CANCER-THERAPY | ubiquitination | COP9 SIGNALOSOME | assembly | TUMOR-SUPPRESSOR PROTEIN | SUBSTRATE-ASSISTED INHIBITION | CELL-CYCLE | PROTEASOME SYSTEM | Protein Structure, Tertiary | Protein Subunits | Cullin Proteins - antagonists & inhibitors | Proteasome Inhibitors - pharmacology | Humans | Models, Molecular | Proteasome Inhibitors - chemistry | Drug Discovery - methods | Cullin Proteins - chemistry | Cullin Proteins - genetics | Drug Design | Protein Structure, Quaternary | Molecular Structure | MEL26, maternal effect lethal 26 | HECT, homologous with E6-associated protein C-terminus | DCAF, DDB1–Cul4A-associated factor | CPH, conserved within Cul7, PARC and HERC2 | CSA, Cockayne syndrome A | NAE, NEDD8-activating enzyme | Rbx1, RING-box protein 1 | PPI, protein–protein interaction | C, anaphase-promoting complex | SV5, simian virus 5 | Fbxw, F-box | Skp2, S-phase kinase-associated protein 2 | IAA, indole-3-acetic acid | Cpd, compound | Fbw | SMER3, small-molecule enhancer of rapamycin 3 | mTOR, mammalian target of rapamycin | HERC2, HECT domain- and RLD (regulator of chromosome condensation 1 protein-like domain) domain-containing E3 ubiquitin protein ligase 2 | IκB, inhibitor of NF-κB | UPS, ubiquitin–proteasome system | Nrf2, nuclear factor-erythroid 2-related factor 2 | Protac, proteolysis-targeting chimaeric molecule | WD repeat-containing protein | ZIM (zinc finger expressed in inflorescence) domain protein 1 | NF-κB, nuclear factor κB | leucine-rich motif-containing protein | CTD, C-terminal domain | Ub, ubiquitin | Vif, virion infectivity factor | NTD, N-terminal domain | GHR, growth hormone receptor | CRBN, cereblon | HIF-1α, hypoxia-inducible factor 1α | SH2, Src homology 2 | BP, β-propeller | UBL, ubiquitin-like protein | FP, fluorescence polarization | Cks1, cyclin-dependent protein kinase regulatory subunit 1 | CSN, COP9 (constitutive photomorphogenesis 9) signalosome complex | ITC, isothermal titration calorimetry | RING, really interesting new gene | Ubc12, ubiquitin-conjugating enzyme 12 | KLHL, Kelch-like protein | Review | VPRBP, Vpr-binding protein | SCF, Skp1–Cdc53–F-box Cdc4 | POZ, pox virus and zinc finger | JAZ1, jasmonate | Keap1, Kelch-like enoyl-CoA hydratase-associated protein 1 | PARC, p53-associated parkin-like cytoplasmic protein | DDB, damage-specific DNA-binding protein | JA-Ile, jasmonoyl-isoleucine | Fbxl, F-box | MATH, meprin and TRAF (tumour necrosis factor receptor-associated factor) homology | CRL, Cullin–RING E3 ubiquitin ligase | other domain-containing protein | COI1, coronatine-insensitive protein 1 | EloBC, ElonginB–ElonginC complex | broad complex | VHL, von Hippel–Lindau | Vpr, viral protein R | Aux, auxin | STAT, signal transducer and activator of transcription | CAND1, Cullin-associated NEDD8-dissociated protein 1 | Fbxo, F-box | TIR1, transport inhibitor response 1 | CBFβ, core binding factor β | BCR, BTB–Cul3–Rbx1 | cyclosome | SOCS, suppressor of cytokine signalling | NEDD, neural-precursor-cell-expressed developmentally down-regulated | BTB, bric-a-brac | APC | Cdc, cell division cycle | Cul, Cullin | SPOP, speckle-type POZ protein | β-TrCP, β-transducin repeat-containing protein | tramtrack | ASB, ankyrin repeat and SOCS-box
Journal Article
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