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1. Full Text Medicinal attributes of 1,2,3-triazoles: Current developments
by Dheer, Divya and Singh, Virender and Shankar, Ravi
Bioorganic chemistry, ISSN 0045-2068, 04/2017, Volume 71, pp. 30 - 54
1,3-Dipolar cycloaddition | Multicomponent reaction | 1,2,3-Triazole | Alkyne–azide coupling reaction | Biochemistry & Molecular Biology | Physical Sciences | Chemistry | Chemistry, Organic | Life Sciences & Biomedicine | Science & Technology | Triazoles - chemistry | Anti-Infective Agents - pharmacology | Antineoplastic Agents - chemical synthesis | Humans | Drug Discovery - methods | Azides - chemistry | HIV Protease Inhibitors - pharmacology | Anti-Infective Agents - chemistry | Triazoles - chemical synthesis | Antineoplastic Agents - pharmacology | Anti-Inflammatory Agents - pharmacology | Click Chemistry - methods | Models, Molecular | HIV Protease Inhibitors - chemistry | Alkynes - chemistry | Cyclooxygenase Inhibitors - chemistry | Antineoplastic Agents - chemistry | Anti-Infective Agents - chemical synthesis | Cycloaddition Reaction - methods | Cyclooxygenase Inhibitors - pharmacology | Triazoles - pharmacology | Animals | Anti-Inflammatory Agents - chemistry | Cyclooxygenase Inhibitors - chemical synthesis | Anti-Inflammatory Agents - chemical synthesis | HIV Protease Inhibitors - chemical synthesis | Receptor, Cannabinoid, CB1 - antagonists & inhibitors | Triazoles | COX-2 inhibitors | Protease inhibitors | Proteases | Index Medicus
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2. Full Text Structure of M-pro from SARS-CoV-2 and discovery of its inhibitors
by Jin, Zhenming and Du, Xiaoyu and Xu, Yechun and Deng, Yongqiang and Liu, Meiqin and Zhao, Yao and Zhang, Bing and Li, Xiaofeng and Zhang, Leike and Peng, Chao and Duan, Yinkai and Yu, Jing and Wang, Lin and Yang, Kailin and Liu, Fengjiang and Jiang, Rendi and Yang, Xinglou and You, Tian and Liu, Xiaoce and Yang, Xiuna and Bai, Fang and Liu, Hong and Liu, Xiang and Guddat, Luke W and Xu, Wenqing and Xiao, Gengfu and Qin, Chengfeng and Shi, Zhengli and Jiang, Hualiang and Rao, Zihe and Yang, Haitao
Nature (London), ISSN 0028-0836, 06/2020, Volume 582, Issue 7811, p. 289
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Cysteine Endopeptidases - chemistry | Protein Structure, Tertiary | Antiviral Agents - pharmacology | Pandemics | Humans | Betacoronavirus - drug effects | Models, Molecular | Protease Inhibitors - chemistry | Coronavirus 3C Proteases | Drug Discovery - methods | COVID-19 | Protease Inhibitors - pharmacology | SARS-CoV-2 | Viral Nonstructural Proteins - chemistry | Coronavirus Infections - virology | Antiviral Agents - chemistry | Betacoronavirus - chemistry | Drug Design | Pneumonia, Viral - enzymology | Cells, Cultured - virology | Drug Evaluation, Preclinical | Viral Nonstructural Proteins - antagonists & inhibitors | Pneumonia, Viral - virology | Coronavirus Infections - enzymology
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3. Full Text Crystal structure of SARS-CoV-2 main protease provides a basis for design of improved alpha-ketoamide inhibitors
by Zhang, Linlin and Lin, Daizong and Sun, Xinyuanyuan and Curth, Ute and Drosten, Christian and Sauerhering, Lucie and Becker, Stephan and Rox, Katharina and Hilgenfeld, Rolf
Science (American Association for the Advancement of Science), ISSN 0036-8075, 04/2020, Volume 368, Issue 6489, pp. 409 - 412
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Cysteine Endopeptidases - chemistry | Antiviral Agents - pharmacokinetics | Protease Inhibitors - pharmacokinetics | Humans | Protein Multimerization | Betacoronavirus - enzymology | Half-Life | Coronavirus 3C Proteases | Crystallography, X-Ray | Antiviral Agents - metabolism | Protease Inhibitors - pharmacology | SARS-CoV-2 | Viral Nonstructural Proteins - chemistry | Cysteine Endopeptidases - metabolism | Antiviral Agents - chemistry | Drug Design | Protein Domains | Amides - metabolism | Lung - metabolism | Binding Sites | Amides - pharmacology | Virus Replication - drug effects | Antiviral Agents - pharmacology | Betacoronavirus - drug effects | Models, Molecular | Protease Inhibitors - chemistry | Protease Inhibitors - metabolism | Animals | Amides - chemistry | Cell Line, Tumor | Viral Nonstructural Proteins - metabolism | Mice | Pyridones - chemistry | Tropism | Enzymes | Pandemics | Severe acute respiratory syndrome | Proteinase | Viral diseases | Viruses | Coronaviruses | Lead compounds | Ribonucleic acid--RNA | Drug development | Severe acute respiratory syndrome coronavirus 2 | COVID-19 | Proteins | Inhibitors | Protease | Respiratory diseases | Polyproteins | Pharmacokinetics | Protein structure | Public health | Crystal structure | Life cycles | Index Medicus
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4. Full Text γ-Secretase inhibitors and modulators
by Golde, Todd E and Koo, Edward H and Felsenstein, Kevin M and Osborne, Barbara A and Miele, Lucio
Biochimica et biophysica acta. Biomembranes, ISSN 0005-2736, 12/2013, Volume 1828, Issue 12, pp. 2898 - 2907
γ-Secretase inhibitor | Alzheimer's disease | γ-Secretase modulator | Cancer | Biochemistry & Molecular Biology | Biophysics | Life Sciences & Biomedicine | Science & Technology | Amyloid beta-Protein Precursor - chemistry | Humans | Substrate Specificity | Structure-Activity Relationship | Protein Subunits - metabolism | Alzheimer Disease - pathology | Protease Inhibitors - pharmacology | Proteolysis | Amyloid beta-Protein Precursor - metabolism | Drug Design | Binding Sites | Signal Transduction | Alzheimer Disease - drug therapy | Neoplasms - enzymology | Protease Inhibitors - chemistry | Clinical Trials as Topic | Alzheimer Disease - enzymology | Amyloid Precursor Protein Secretases - chemistry | Neoplasms - drug therapy | Amyloid Precursor Protein Secretases - metabolism | Protein Binding | Protein Subunits - antagonists & inhibitors | Protein Subunits - chemistry | Amyloid Precursor Protein Secretases - antagonists & inhibitors | Neoplasms - pathology | Index Medicus
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5. Full Text In Silico Evaluation of the Effectivity of Approved Protease Inhibitors against the Main Protease of the Novel SARS-CoV-2 Virus
by Eleftheriou, Phaedra and Amanatidou, Dionysia and Petrou, Anthi and Geronikaki, Athina
Molecules (Basel, Switzerland), ISSN 1420-3049, 06/2020, Volume 25, Issue 11, p. 2529
Biochemistry & Molecular Biology | Physical Sciences | Chemistry | Life Sciences & Biomedicine | Chemistry, Multidisciplinary | Science & Technology | Dipeptidyl Peptidase 4 - metabolism | Coronavirus Infections - drug therapy | Humans | Pneumonia, Viral - drug therapy | Thrombin - antagonists & inhibitors | Hepacivirus - genetics | Hepacivirus - chemistry | Dipeptidyl-Peptidase IV Inhibitors - pharmacology | COVID-19 | SARS-CoV-2 | Anticoagulants - chemistry | Antiviral Agents - chemistry | Binding Sites | Amino Acid Sequence | Antiviral Agents - pharmacology | Protease Inhibitors - chemistry | Dipeptidyl-Peptidase IV Inhibitors - chemistry | Factor Xa - metabolism | Thrombin - genetics | Thrombin - chemistry | Cysteine Endopeptidases - genetics | Protein Conformation | Viral Nonstructural Proteins - metabolism | Molecular Docking Simulation | Viral Nonstructural Proteins - antagonists & inhibitors | Betacoronavirus - genetics | Cysteine Endopeptidases - chemistry | Factor Xa - chemistry | Pandemics | Dipeptidyl Peptidase 4 - chemistry | Betacoronavirus - enzymology | Substrate Specificity | Coronavirus 3C Proteases | Protease Inhibitors - pharmacology | Thermodynamics | Viral Nonstructural Proteins - chemistry | Cysteine Endopeptidases - metabolism | Betacoronavirus - chemistry | Protein Interaction Domains and Motifs | Factor Xa - genetics | Betacoronavirus - drug effects | Viral Nonstructural Proteins - genetics | Dipeptidyl Peptidase 4 - genetics | Hepacivirus - enzymology | Sequence Alignment | Anticoagulants - pharmacology | Protein Binding | Structural Homology, Protein | Thrombin - metabolism | Disease | Viral diseases | Coagulation | Clinical trials | Thrombin | Viruses | Amino acids | Drug development | Proteins | Protease | Docking | Hypertension | Anticoagulants | Antiretroviral drugs | Antiviral agents | Enzymes | Severe acute respiratory syndrome | Diabetes mellitus | Proteinase inhibitors | Coagulants | RNA polymerase | Coronaviruses | Severe acute respiratory syndrome coronavirus 2 | Protease inhibitors | Respiratory diseases | Diabetes | Coagulation factor Xa | Index Medicus | protease inhibitors | coronavirus | HCV protease inhibitors | a-thrombin inhibitors | DPP-4 inhibitors
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6. Full Text Organic Carbamates in Drug Design and Medicinal Chemistry
by Ghosh, Arun K and Brindisi, Margherita
Journal of medicinal chemistry, ISSN 0022-2623, 04/2015, Volume 58, Issue 7, pp. 2895 - 2940
Pharmacology & Pharmacy | Life Sciences & Biomedicine | Chemistry, Medicinal | Science & Technology | Antiviral Agents - pharmacology | Chemistry Techniques, Synthetic | Chemistry, Pharmaceutical - methods | Hepatitis C - drug therapy | Drug Stability | Humans | HIV Protease | HIV Protease Inhibitors - chemistry | Carbamates - chemistry | HIV Protease Inhibitors - pharmacology | Carbamates - chemical synthesis | Serine Proteinase Inhibitors - chemistry | Antiviral Agents - chemistry | Cysteine Proteinase Inhibitors - pharmacology | Drug Design | Prodrugs - chemical synthesis | Cysteine Proteinase Inhibitors - chemistry | Amyloid Precursor Protein Secretases - antagonists & inhibitors | Viral Nonstructural Proteins - antagonists & inhibitors | Serine Proteinase Inhibitors - pharmacology | Carbamates - pharmacology | Index Medicus
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