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Nucleic Acids Research, ISSN 0305-1048, 2016, Volume 44, Issue 1, pp. D343 - D350
Journal Article
Drug Metabolism and Disposition, ISSN 0090-9556, 02/2013, Volume 41, Issue 2, pp. 353 - 361
Dolutegravir (DTG; S/GSK1349572) is a potent HIV-1 integrase inhibitor with a distinct resistance profile and a once-daily dose regimen that does not require... 
SERUM CREATININE LEVELS | IMMUNODEFICIENCY-VIRUS-INFECTION | HUMAN HEPATOCYTES | HEALTHY-SUBJECTS | CYTOCHROME-P450 ENZYMES | GLOMERULAR-FILTRATION | PHARMACOLOGY & PHARMACY | GASTROINTESTINAL PH | MULTIDRUG-RESISTANCE | BOOSTED PROTEASE INHIBITORS | P-GLYCOPROTEIN | ATP Binding Cassette Transporter, Sub-Family G, Member 2 | HIV Integrase Inhibitors - pharmacology | Heterocyclic Compounds, 3-Ring - metabolism | Cricetulus | Cytochrome P-450 Enzyme Inhibitors | Heterocyclic Compounds, 3-Ring - pharmacology | Humans | ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism | Cytochrome P-450 Enzyme System - metabolism | Membrane Transport Proteins - drug effects | Male | Neoplasm Proteins - antagonists & inhibitors | ATP-Binding Cassette, Sub-Family B, Member 1 - antagonists & inhibitors | Neoplasm Proteins - metabolism | Organic Anion Transporters - metabolism | Glucuronosyltransferase - genetics | Drug Interactions | Transfection | Membrane Transport Proteins - genetics | Microsomes, Liver - drug effects | Madin Darby Canine Kidney Cells | ATP-Binding Cassette Transporters - metabolism | Female | Membrane Transport Proteins - metabolism | Microsomes, Liver - enzymology | Hepatocytes - drug effects | CHO Cells | Cricetinae | Organic Anion Transporters - antagonists & inhibitors | Isoenzymes | Enzyme Induction | HIV Integrase Inhibitors - metabolism | Multidrug Resistance-Associated Proteins - antagonists & inhibitors | Animals | Glucuronosyltransferase - metabolism | Dogs | Cytochrome P-450 Enzyme System - genetics | Glucuronosyltransferase - antagonists & inhibitors | ATP Binding Cassette Transporter, Sub-Family B | Multidrug Resistance-Associated Proteins - metabolism | ATP-Binding Cassette Transporters - antagonists & inhibitors | Hepatocytes - enzymology
Journal Article
Journal Article
PLoS Pathogens, ISSN 1553-7366, 07/2012, Volume 8, Issue 7, p. 22
Hepatitis C virus (HCV) infects over 170 million people worldwide and is the leading cause of chronic liver diseases, including cirrhosis, liver failure, and... 
WILD-TYPE | TELAPREVIR | RAPID VIRAL RESPONSE | ENZYMATIC-ACTIVITIES | PRECLINICAL PROFILE | MICROBIOLOGY | DISCOVERY | INTERFERON | REPLICATION | VIROLOGY | ANTIVIRAL EFFICACY | BOCEPREVIR | PARASITOLOGY | Hepatitis C - drug therapy | Proline - metabolism | Humans | Hepacivirus - genetics | Structure-Activity Relationship | Antiviral Agents - metabolism | Protease Inhibitors - pharmacology | Indoles - metabolism | Viral Nonstructural Proteins - chemistry | Antiviral Agents - chemistry | Lactams - pharmacology | Proline - pharmacology | Indoles - pharmacology | Protease Inhibitors - therapeutic use | Oligopeptides - chemistry | Hepacivirus - drug effects | Protein Structure, Tertiary | Antiviral Agents - pharmacology | Proline - analogs & derivatives | Sulfonamides - chemistry | Models, Molecular | Protease Inhibitors - chemistry | Protease Inhibitors - metabolism | Oligopeptides - metabolism | Sulfonamides - pharmacology | Lactams - metabolism | Proline - chemistry | Drug Resistance, Viral - genetics | Hepatitis C - virology | Sulfonamides - metabolism | Oligopeptides - pharmacology | Viral Nonstructural Proteins - antagonists & inhibitors | Indoles - chemistry | Lactams - chemistry | Virus diseases | Viral drug resistance | Research | Protease inhibitors | Properties | Observations | Hepatitis | Liver cancer | Liver diseases | Ligands | Genetic diversity | Drug resistance | Pharmaceutical industry | Cancer therapies | Viral infections
Journal Article
Journal Article