X
Search Filters
Format Format
Format Format
X
Sort by Item Count (A-Z)
Filter by Count
Journal Article (39505) 39505
Publication (6365) 6365
Book Review (6302) 6302
Book Chapter (713) 713
Conference Proceeding (337) 337
Dissertation (182) 182
Newsletter (154) 154
Reference (39) 39
Government Document (24) 24
Book / eBook (13) 13
Trade Publication Article (7) 7
Web Resource (7) 7
Magazine Article (5) 5
Streaming Video (5) 5
Data Set (4) 4
Newspaper Article (1) 1
Paper (1) 1
more...
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
index medicus (31690) 31690
humans (21166) 21166
animals (16141) 16141
biochemistry & molecular biology (11281) 11281
proteasome endopeptidase complex - metabolism (10715) 10715
proteasome (10042) 10042
cell biology (8373) 8373
proteins (7343) 7343
ubiquitin (7261) 7261
mice (7080) 7080
proteasome endopeptidase complex (5573) 5573
degradation (5559) 5559
apoptosis (5176) 5176
proteolysis (4818) 4818
ubiquitin-proteasome system (4662) 4662
ubiquitin - metabolism (4655) 4655
male (4429) 4429
oncology (4396) 4396
proteasome inhibitors (4230) 4230
research (4126) 4126
cell line, tumor (4037) 4037
female (3884) 3884
expression (3849) 3849
cancer (3847) 3847
ubiquitination (3724) 3724
cell line (3704) 3704
phosphorylation (3585) 3585
article (3377) 3377
bortezomib (3346) 3346
signal transduction (3292) 3292
cysteine endopeptidases - metabolism (3182) 3182
physiological aspects (3104) 3104
multienzyme complexes - metabolism (3093) 3093
protein (2933) 2933
mutation (2920) 2920
activation (2918) 2918
protein binding (2891) 2891
molecular sequence data (2887) 2887
rats (2876) 2876
amino acid sequence (2871) 2871
cells (2834) 2834
proteasomes (2771) 2771
gene expression (2750) 2750
analysis (2679) 2679
oxidative stress (2631) 2631
multidisciplinary sciences (2488) 2488
cells, cultured (2358) 2358
ubiquitin-proteasome pathway (2348) 2348
neurosciences (2290) 2290
autophagy (2246) 2246
genetic aspects (2157) 2157
nf-kappa-b (2156) 2156
pathway (2112) 2112
ubiquitin-protein ligases - metabolism (2106) 2106
proteasome endopeptidase complex - genetics (2053) 2053
biophysics (2047) 2047
gene-expression (2018) 2018
apoptosis - drug effects (1974) 1974
26s proteasome (1947) 1947
biology (1916) 1916
in-vivo (1908) 1908
immunology (1847) 1847
research article (1811) 1811
hela cells (1793) 1793
cell cycle (1780) 1780
blotting, western (1768) 1768
enzymes (1750) 1750
genetics & heredity (1729) 1729
antineoplastic agents - pharmacology (1723) 1723
transfection (1716) 1716
20s proteasome (1704) 1704
health aspects (1646) 1646
inhibition (1634) 1634
pharmacology & pharmacy (1632) 1632
models, biological (1610) 1610
leupeptins - pharmacology (1609) 1609
complex (1586) 1586
hematology (1555) 1555
saccharomyces-cerevisiae (1522) 1522
gene (1497) 1497
down-regulation (1475) 1475
protein folding (1472) 1472
biochemistry (1449) 1449
proteasome inhibitor (1445) 1445
proteins - metabolism (1438) 1438
identification (1418) 1418
middle aged (1416) 1416
ubiquitins - metabolism (1411) 1411
protein structure, tertiary (1408) 1408
in-vitro (1402) 1402
medicine (1375) 1375
molecular biology (1372) 1372
multiple myeloma (1357) 1357
gene expression regulation (1356) 1356
time factors (1319) 1319
transcription (1312) 1312
endoplasmic-reticulum (1311) 1311
dna-binding proteins - metabolism (1303) 1303
genes (1295) 1295
hek293 cells (1287) 1287
more...
Library Location Library Location
Language Language
Language Language
X
Sort by Item Count (A-Z)
Filter by Count
English (39509) 39509
Japanese (283) 283
Chinese (173) 173
French (127) 127
Russian (125) 125
German (104) 104
Korean (40) 40
Polish (39) 39
Spanish (17) 17
Czech (16) 16
Ukrainian (12) 12
Hungarian (5) 5
Italian (3) 3
Portuguese (3) 3
Persian (2) 2
Catalan (1) 1
Dutch (1) 1
Hebrew (1) 1
Malay (1) 1
Swedish (1) 1
Turkish (1) 1
Welsh (1) 1
more...
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


Nature cell biology, ISSN 1465-7392, 07/2017, Volume 19, Issue 8, pp. 1003 - 1003
This corrects the article DOI: 10.1038/ncb3554. 
Proteasomes
Journal Article
Nature, ISSN 0028-0836, 02/2016, Volume 530, Issue 7589, pp. 233 - 236
The proteasome is a multi-component protease complex responsible for regulating key processes such as the cell cycle and antigen presentation(1). Compounds... 
VISUALIZATION | FALCIPARUM MALARIA | MECHANISM | SPECIFICITY | ARTEMISININ RESISTANCE | MULTIDISCIPLINARY SCIENCES | VALIDATION | ELECTRON-MICROSCOPY | IDENTIFICATION | PARASITE | HUMAN 20S PROTEASOME | Plasmodium falciparum - enzymology | Plasmodium - enzymology | Plasmodium chabaudi - enzymology | Species Specificity | Humans | Proteasome Inhibitors - chemistry | Plasmodium - drug effects | Plasmodium falciparum - drug effects | Protein Subunits - metabolism | Dose-Response Relationship, Drug | Artemisinins - pharmacology | Plasmodium chabaudi - physiology | Drug Design | Plasmodium - growth & development | Female | Drug Resistance | Antimalarials - adverse effects | Catalytic Domain | Proteasome Inhibitors - pharmacology | Models, Molecular | Proteasome Endopeptidase Complex - chemistry | Proteasome Inhibitors - toxicity | Proteasome Inhibitors - adverse effects | Antimalarials - pharmacology | Cryoelectron Microscopy | Drug Synergism | Animals | Substrate Specificity - drug effects | Proteasome Endopeptidase Complex - ultrastructure | Antimalarials - chemistry | Plasmodium chabaudi - drug effects | Mice | Mice, Inbred BALB C | Protein Subunits - antagonists & inhibitors | Protein Subunits - chemistry | Antimalarials - toxicity | Enzyme Activation | Plasmodium falciparum - growth & development | Proteasome Endopeptidase Complex - metabolism | Ubiquitin-proteasome system | Plasmodium | Health aspects | Proteins | Malaria | Protease inhibitors | Proteases | Erythrocytes | Ligands | Parasites | Drug dosages | Index Medicus
Journal Article
Journal of Cell Science, ISSN 0021-9533, 07/2018, Volume 131, Issue 14, pp. e1404 - e1404
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 10/2010, Volume 107, Issue 43, pp. 18599 - 18604
Most antigenic peptides presented by MHC class I molecules result from the degradation of intracellular proteins by the proteasome. In lymphoid tissues and... 
T lymphocytes | Antigens | Dendritic cells | HEK293 cells | Liver | Melanoma | Cell lines | Antibodies | Cellular immunity | Tumors | MAGE | Antigenic peptide | Tumor antigen | Immunoproteasome | Antigen processing | immunoproteasome | DENDRITIC CELLS | MULTIDISCIPLINARY SCIENCES | CYTOLYTIC T-LYMPHOCYTES | antigenic peptide | SUBUNIT COMPOSITION | CLEAVAGE | 20S PROTEASOME | tumor antigen | ANGSTROM RESOLUTION | GENERATION | antigen processing | STANDARD PROTEASOME | TUMOR-ASSOCIATED ANTIGEN | Recombinant Proteins - metabolism | Amino Acid Sequence | Antigens, Neoplasm - genetics | Protein Subunits | Humans | Molecular Sequence Data | Proteasome Endopeptidase Complex - chemistry | Recombinant Proteins - genetics | Neoplasm Proteins - metabolism | Mice, Knockout | Histocompatibility Antigens Class I - metabolism | Proteasome Endopeptidase Complex - genetics | Sequence Homology, Amino Acid | Animals | Antigen Presentation | Recombinant Proteins - immunology | Antigens, Neoplasm - metabolism | Cell Line, Tumor | Mice | Proteasome Endopeptidase Complex - metabolism | Neoplasm Proteins - genetics | Proteasome Endopeptidase Complex - classification | Research | Ubiquitin-proteasome system | Properties | Tumor antigens | Methods | Immunological research | Proteins | Molecules | Immunoglobulins | Peptides | Proteases | Cells | Index Medicus | CD8 antigen | Tumor cells | proteasomes | Lymphocytes T | Lymphoid tissue | Small intestine | Kidney | Major histocompatibility complex | Antigen (tumor-associated) | Histocompatibility antigen HLA | Colon | Catalytic subunits | Biological Sciences
Journal Article
Autophagy, ISSN 1554-8627, 07/2015, Volume 11, Issue 7, pp. 1161 - 1178
Multiple myeloma (MM) is the paradigmatic proteasome inhibitor (PI) responsive cancer, but many patients fail to respond. An attractive target to enhance... 
proteasome | multiple myeloma | autophagy | proteasome inhibitors | bortezomib | plasma cells | proteostasis | p62 | SQSTM1 | endoplasmic reticulum | ubiquitin | aggregate | Ubiquitin | Bortezomib | Proteostasis | Multiple myeloma | Plasma cells | Aggregate | Autophagy | Endoplasmic reticulum | P62 | Proteasome inhibitors | Proteasome | SURVIVAL | bafilomycin A | phosphate-buffered saline | CANCER | CELL BIOLOGY | gene ontology | hydroxychloroquine | UPR | immunoprecipitation | UPS | plasma cell | PBS | antibody | ERGIC | Rapa | STRESS-RESPONSE | allophycocyanin | pAb | unfolded protein response | EXTENDED FOLLOW-UP | amc | HCQ | DISEASE | Btz | DEFICIENT MICE | Baf A1 | proteasome inhibitor | polyclonal antibody | immunoglobulin | IMMUNOGLOBULIN PRODUCTION | stable isotope labeling in cell culture | SILAC | 7-amino-4-methylcoumarin | bone marrow | PLASMA-CELLS | LC-MS | ubiquitin-proteasome system | APC | liquid chromatography-tandem mass spectrometry | DIFFERENTIATION | ER-Golgi intermediate compartment | rapamycin | Cell Survival - drug effects | Proteasome Inhibitors - pharmacology | Sequestosome-1 Protein | Humans | Endoplasmic Reticulum - metabolism | Multiple Myeloma - metabolism | Autophagy - drug effects | Endoplasmic Reticulum - ultrastructure | Proteolysis - drug effects | Multiple Myeloma - pathology | Protein Binding - drug effects | Cytoprotection - drug effects | Cell Line, Tumor | Homeostasis - drug effects | Proteasome Endopeptidase Complex - metabolism | Adaptor Proteins, Signal Transducing - metabolism | Ubiquitinated Proteins - metabolism | Protein Aggregates - drug effects | Index Medicus
Journal Article
Veterinary Immunology and Immunopathology, ISSN 0165-2427, 07/2015, Volume 166, Issue 1-2, pp. 43 - 49
Journal Article
American Journal of Physiology - Lung Cellular and Molecular Physiology, ISSN 1040-0605, 11/2012, Volume 303, Issue 9, pp. 814 - 823
Cigarette smoke mediates DNA damage, lipid peroxidation, and modification and misfolding of proteins, thereby inducing severe cellular damage. The ubiquitin... 
Oxidative stress | Chronic obstructive pulmonary disease | Protein quality control | Ubiquitin proteasome system | Cigarette smoke | SYSTEM | PHYSIOLOGY | UBIQUITIN | ubiquitin proteasome system | ANTIGEN PRESENTATION | cigarette smoke | 20S PROTEASOME | CARDIOMYOPATHIES | OBSTRUCTIVE PULMONARY-DISEASE | RESPIRATORY SYSTEM | protein quality control | DEGRADATION | INHIBITORS | PROTEINS | oxidative stress | chronic obstructive pulmonary disease | Smoking - adverse effects | Protein Carbonylation | Oxidative Stress | Apoptosis - drug effects | Humans | Smoke | Polyubiquitin | Lung - enzymology | Protein Processing, Post-Translational - drug effects | Plant Preparations - pharmacology | Female | Ubiquitinated Proteins - metabolism | Gene Expression | Oxidation-Reduction | Proteasome Inhibitors - pharmacology | Cell Survival | Mice, Inbred C57BL | Alveolar Epithelial Cells - metabolism | Alveolar Epithelial Cells - drug effects | Proteasome Inhibitors - toxicity | Proteasome Endopeptidase Complex - physiology | Tobacco - toxicity | Proteasome Endopeptidase Complex - genetics | Plant Preparations - toxicity | Animals | Lung - drug effects | Cell Line, Tumor | Mice | Proteasome Endopeptidase Complex - metabolism | Alveolar Epithelial Cells - physiology | Glutathione - blood | Physiological aspects | Lungs | Ubiquitin-proteasome system | Health aspects | DNA damage | Rodents | Lipids | Oxidation | Cells | Smoking | Index Medicus
Journal Article
Nature, ISSN 0028-0836, 2013, Volume 497, Issue 7450, pp. 512 - 516
The proteasomal ATPase ring, comprising Rpt1-Rpt6, associates with the heptameric alpha-ring of the proteasome core particle (CP) in the mature proteasome,... 
REGULATORY PARTICLE | CORE | STRUCTURAL BASIS | PATHWAY | MULTIDISCIPLINARY SCIENCES | YEAST 26S PROTEASOME | GATE | S PROTEASOME | 20S PROTEASOMES | ATPASES | SUBUNIT | Physiological aspects | Ubiquitin-proteasome system | Brewer's yeast | Adenosine triphosphatase | Peptides | Enzymes | Yeast | Index Medicus | proteasome | chaperone | single particle cryoEM | ATPase
Journal Article
British Journal of Haematology, ISSN 0007-1048, 09/2016, Volume 174, Issue 5, pp. 711 - 720
Journal Article
Nature Structural and Molecular Biology, ISSN 1545-9993, 07/2013, Volume 20, Issue 7, pp. 781 - 788
The 26S proteasome is the major eukaryotic ATP-dependent protease, responsible for regulating the proteome through degradation of ubiquitin-tagged substrates.... 
REGULATORY PARTICLE | TRANSLOCATION | RECOGNITION | MECHANISM | BIOCHEMISTRY & MOLECULAR BIOLOGY | ATPASES | CELL BIOLOGY | BIOPHYSICS | STRUCTURAL BASIS | MOLECULAR ARCHITECTURE | NEW-GENERATION | DEUBIQUITINATION | SUBUNIT | Protein Structure, Tertiary | Saccharomyces cerevisiae Proteins - ultrastructure | Endopeptidases - metabolism | Catalytic Domain | Mutagenesis, Site-Directed | Saccharomyces cerevisiae - genetics | Models, Molecular | Proteasome Endopeptidase Complex - chemistry | Substrate Specificity | Structure-Activity Relationship | Saccharomyces cerevisiae Proteins - genetics | Cryoelectron Microscopy | Proteasome Endopeptidase Complex - genetics | Proteasome Endopeptidase Complex - ultrastructure | Proteolysis | Adenosine Triphosphate - metabolism | Saccharomyces cerevisiae Proteins - metabolism | Protein Binding | Saccharomyces cerevisiae - enzymology | Protein Conformation | Proteasome Endopeptidase Complex - metabolism | Ubiquitinated Proteins - metabolism | Saccharomyces cerevisiae Proteins - chemistry | Hydrolysis | Proteases | Physiological aspects | Genetic aspects | Research | Structure | Ubiquitin-proteasome system | Protease inhibitors | Mutagenesis | Molecular biology | Proteomics | Index Medicus | 26S proteasome | 19S regulatory particle | Rpn11 | UPS | deubiquitination | AAA+ ATPase | cryo-EM | protein translocation
Journal Article