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Nature Medicine, ISSN 1078-8956, 01/2016, Volume 22, Issue 1, pp. 46 - 53
The ubiquitin proteasome system (UPS) degrades misfolded proteins including those implicated in neurodegenerative diseases. We investigated the effects of tau... 
SYSTEM | MEDICINE, RESEARCH & EXPERIMENTAL | KINASE-A | PHOSPHORYLATION | HELICAL FILAMENT-TAU | ALZHEIMERS-DISEASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | UBIQUITINATED PROTEINS ACTIVATE | CELL BIOLOGY | MOUSE MODEL | DEGRADATION | AGGREGATION | TRANSGENIC MICE | Immunoprecipitation | Native Polyacrylamide Gel Electrophoresis | Humans | tau Proteins - metabolism | Cognition Disorders - metabolism | Immunoblotting | Brain - metabolism | Ubiquitination | Proteasome Endopeptidase Complex - drug effects | HEK293 Cells | Behavior, Animal - drug effects | Rolipram - pharmacology | Cyclic AMP - metabolism | Cyclic AMP-Dependent Protein Kinases - drug effects | Disease Models, Animal | Cyclic AMP-Dependent Protein Kinases - metabolism | Mice, Transgenic | Cognition - drug effects | Phosphodiesterase 4 Inhibitors - pharmacology | Brain - drug effects | Tauopathies - metabolism | Animals | Signal Transduction - drug effects | Fluorescent Antibody Technique | Brain - pathology | Mice | Proteasome Endopeptidase Complex - metabolism | In Vitro Techniques | Protein Aggregation, Pathological - metabolism | Prevention | Physiological aspects | Genetic aspects | Cellular signal transduction | Cognition disorders | Research | Ubiquitin-proteasome system | Phosphorylation | Cognition & reasoning | Kinases | Proteases | Protein folding | Neurological disorders
Journal Article
Nature, ISSN 0028-0836, 2014, Volume 508, Issue 7498, pp. 49 - 54
Many aspects of cellular physiology remain unstudied in somatic stem cells, for example, there are almost no data on protein synthesis in any somatic stem... 
PROGENITOR CELLS | MULTIDISCIPLINARY SCIENCES | MTOR PATHWAY | BONE-MARROW | IN-VIVO | DIAMOND-BLACKFAN ANEMIA | PTEN | S19 DEFICIENCY | SELF-RENEWAL | TRANSLATIONAL CONTROL | PROTEASOME ACTIVITY | Cell Proliferation | Leukemia - pathology | Hematopoietic Stem Cells - pathology | Ribosomes - metabolism | Male | Leukemia - metabolism | Genetic Complementation Test | Ribosomal Proteins - metabolism | Flow Cytometry | Proteasome Endopeptidase Complex - drug effects | Time Factors | Cell Transformation, Neoplastic - genetics | Female | Protein Biosynthesis - genetics | Homeostasis - drug effects | Leukemia - genetics | Hematopoietic Stem Cells - drug effects | PTEN Phosphohydrolase - genetics | PTEN Phosphohydrolase - deficiency | Ribosomal Proteins - genetics | Puromycin - metabolism | Hematopoietic Stem Cells - metabolism | Mutation - genetics | Cell Transformation, Neoplastic - metabolism | Animals | Puromycin - analogs & derivatives | Ribosomes - genetics | Hematopoietic Stem Cells - cytology | Protein Biosynthesis - drug effects | Mice | Kinetics | Proteasome Endopeptidase Complex - metabolism | Cell Transformation, Neoplastic - pathology | Homeostasis - genetics | Physiological aspects | Stem cell research | Protein biosynthesis | B cells | Research | Hematopoietic stem cells | Bone marrow | Mutation | Transplants & implants | Protein synthesis | Stem cells
Journal Article
Carcinogenesis, ISSN 0143-3334, 2012, Volume 33, Issue 2, pp. 377 - 384
Journal Article
Journal Article
Nature Cell Biology, ISSN 1465-7392, 08/2016, Volume 18, Issue 8, pp. 897 - 909
Journal Article
Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 05/2012, Volume 56, Issue 5, pp. 2223 - 2230
Journal Article
Nature, ISSN 0028-0836, 08/2016, Volume 537, Issue 7619, pp. 229 - 233
Journal Article
Nature Medicine, ISSN 1078-8956, 02/2018, Volume 24, Issue 2, pp. 186 - 193
The ubiquitin-proteasome system (UPS) comprises a network of enzymes that is responsible for maintaining cellular protein homeostasis. The therapeutic... 
MEDICINE, RESEARCH & EXPERIMENTAL | PROTEIN | MLN4924 | BIOCHEMISTRY & MOLECULAR BIOLOGY | DNA-DAMAGE | KINASE | CELL BIOLOGY | DEGRADATION | SUBSTRATE-ASSISTED INHIBITION | E1 INHIBITOR | NEDD8-ACTIVATING ENZYME | PROTEASOME SYSTEM | MYELOMA | DNA Damage - drug effects | Imides - pharmacology | Small Molecule Libraries - pharmacology | Ubiquitin-Activating Enzymes - genetics | DNA Repair - drug effects | Ubiquitin-Activating Enzymes - chemistry | Ubiquitin - antagonists & inhibitors | Humans | Ubiquitin - chemistry | Proteasome Endopeptidase Complex - chemistry | Ubiquitin - genetics | Sulfonamides - pharmacology | Neoplasms - drug therapy | Proteasome Endopeptidase Complex - genetics | Xenograft Model Antitumor Assays | Animals | Proteasome Endopeptidase Complex - drug effects | Neoplasms - genetics | Ubiquitin-Activating Enzymes - antagonists & inhibitors | Cell Line, Tumor | Nucleosides - pharmacology | Protein Binding | Mice | Neoplasms - pathology | Ubiquitin | Antimitotic agents | Physiological aspects | Genetic aspects | Research | Ubiquitin-proteasome system | Antineoplastic agents | Health aspects | Drugs | Enzymes | Immunomodulation | DNA damage | Homeostasis | Cancer therapies | DNA repair | Modulators | Proteasome inhibitors | Anticancer properties | Molecules | Signaling | Inhibitors | Interrogation | Cell cycle | Xenografts | Proteasomes | Antitumor activity | Conjugation | Deoxyribonucleic acid--DNA | Cancer
Journal Article