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1. Full Text Conformational switching of the 26S proteasome enables substrate degradation
by Matyskiela, Mary E and Lander, Gabriel C and Martin, Andreas
Nature structural & molecular biology, ISSN 1545-9993, 07/2013, Volume 20, Issue 7, pp. 781 - 788
Biochemistry & Molecular Biology | Biophysics | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Protein Structure, Tertiary | Saccharomyces cerevisiae Proteins - ultrastructure | Endopeptidases - metabolism | Catalytic Domain | Mutagenesis, Site-Directed | Saccharomyces cerevisiae - genetics | Models, Molecular | Proteasome Endopeptidase Complex - chemistry | Substrate Specificity | Structure-Activity Relationship | Saccharomyces cerevisiae Proteins - genetics | Cryoelectron Microscopy | Proteasome Endopeptidase Complex - genetics | Proteasome Endopeptidase Complex - ultrastructure | Proteolysis | Adenosine Triphosphate - metabolism | Saccharomyces cerevisiae Proteins - metabolism | Protein Binding | Saccharomyces cerevisiae - enzymology | Protein Conformation | Proteasome Endopeptidase Complex - metabolism | Ubiquitinated Proteins - metabolism | Saccharomyces cerevisiae Proteins - chemistry | Hydrolysis | Proteases | Physiological aspects | Genetic aspects | Research | Structure | Ubiquitin-proteasome system | Protease inhibitors | Mutagenesis | Molecular biology | Proteomics | Index Medicus | 26S proteasome | 19S regulatory particle | Rpn11 | UPS | deubiquitination | AAA+ ATPase | cryo-EM | protein translocation
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2. Full Text Characterization of Fully Recombinant Human 20S and 20S-PA200 Proteasome Complexes
by Toste Rêgo, Ana and da Fonseca, Paula C.A
Molecular cell, ISSN 1097-2765, 10/2019, Volume 76, Issue 1, pp. 138 - 147.e5
proteasome | 20S-PA200 | PA200 | recombinant | regulator | atomic model | human | cryo-EM | structure | Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Recombinant Proteins - metabolism | Recombinant Proteins - ultrastructure | Allosteric Regulation | Humans | Nuclear Proteins - ultrastructure | Models, Molecular | Nuclear Proteins - metabolism | Structure-Activity Relationship | Spodoptera | Proteasome Endopeptidase Complex - genetics | Sf9 Cells | Animals | Proteasome Endopeptidase Complex - ultrastructure | Proteolysis | Protein Binding | Protein Conformation | Proteasome Endopeptidase Complex - metabolism | Inositol Phosphates - metabolism | Nuclear Proteins - genetics | Binding Sites | Index Medicus
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3. Full Text Multiple Associated Proteins Regulate Proteasome Structure and Function
by Leggett, David S and Hanna, John and Borodovsky, Anna and Crosas, Bernat and Schmidt, Marion and Baker, Rohan T and Walz, Thomas and Ploegh, Hidde and Finley, Daniel
Molecular cell, ISSN 1097-2765, 2002, Volume 10, Issue 3, pp. 495 - 507
Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Cysteine Endopeptidases - chemistry | Ligases - isolation & purification | Ligases - genetics | Multienzyme Complexes - metabolism | Proteasome Endopeptidase Complex | Recombinant Fusion Proteins - metabolism | Protein Subunits - metabolism | Saccharomyces cerevisiae - metabolism | Salts - chemistry | Cysteine Endopeptidases - metabolism | Protein Subunits - isolation & purification | Adenosine Triphosphate - metabolism | Saccharomyces cerevisiae Proteins - isolation & purification | Binding Sites | Endopeptidases - isolation & purification | Protein Subunits - genetics | Multienzyme Complexes - ultrastructure | Endopeptidases - metabolism | Ligases - metabolism | Saccharomyces cerevisiae Proteins - genetics | Canavanine - metabolism | Multienzyme Complexes - chemistry | Proteins - genetics | Ubiquitin-Protein Ligases | Endopeptidases - genetics | Proteins - metabolism | Cysteine Endopeptidases - isolation & purification | Saccharomyces cerevisiae Proteins - metabolism | Protein Binding | Recombinant Fusion Proteins - genetics | Cysteine Endopeptidases - ultrastructure | Multienzyme Complexes - isolation & purification | Index Medicus
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4. Full Text Ubp6 deubiquitinase controls conformational dynamics and substrate degradation of the 26S proteasome
by Bashore, Charlene and Dambacher, Corey M and Goodall, Ellen A and Matyskiela, Mary E and Lander, Gabriel C and Martin, Andreas
Nature structural & molecular biology, ISSN 1545-9993, 09/2015, Volume 22, Issue 9, pp. 712 - 719
Biochemistry & Molecular Biology | Biophysics | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Multienzyme Complexes - ultrastructure | Saccharomyces cerevisiae - metabolism | Endopeptidases - metabolism | Endopeptidases - chemistry | Macromolecular Substances - ultrastructure | Saccharomyces cerevisiae Proteins - metabolism | Proteasome Endopeptidase Complex - chemistry | Proteasome Endopeptidase Complex - metabolism | Microscopy, Electron | Saccharomyces cerevisiae - chemistry | Saccharomyces cerevisiae Proteins - chemistry | Physiological aspects | Genetic aspects | Research | Ubiquitin-proteasome system | Proteolysis | Enzymes | Yeast | Microscopy | Proteases | Substrates | Index Medicus
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5. Full Text Cytoplasmic penetration and persistent infection of mammalian cells by polyglutamine aggregates
by Kachirskaia, Ioulia and Heuser, John E and Ren, Pei-Hsien and Melki, Ronald and Kopito, Ron R and Lauckner, Jane E
Nature cell biology, ISSN 1465-7392, 02/2009, Volume 11, Issue 2, pp. 219 - 225
Life Sciences & Biomedicine | Science & Technology | Cell Biology | Prion Diseases - physiopathology | Humans | Cell Communication - physiology | Cytoplasm - metabolism | Cytoplasm - pathology | Peptides - metabolism | Peptides - toxicity | Amyloid - biosynthesis | Disease Transmission, Infectious | Inclusion Bodies - metabolism | Huntington Disease - physiopathology | Cell Line | Neurodegenerative Diseases - pathology | Amyloidosis - pathology | Amyloidosis - physiopathology | Neurodegenerative Diseases - metabolism | Neurofibrils - pathology | Huntington Disease - metabolism | Endocytosis - physiology | Neurodegenerative Diseases - physiopathology | Proteasome Endopeptidase Complex - ultrastructure | Trinucleotide Repeat Expansion - genetics | Proteasome Endopeptidase Complex - metabolism | Amyloidosis - metabolism | Prion Diseases - metabolism | Neurofibrils - metabolism | Amyloid beta-protein | Physiological aspects | Nervous system | Genetic aspects | Degeneration | Research | Glutamine | Index Medicus | Huntington Disease | Neurodegenerative Diseases | Peptides | Neurofibrils | Cell Communication | Proteasome Endopeptidase Complex | Trinucleotide Repeat Expansion | Life Sciences | Prion Diseases | Endocytosis | Inclusion Bodies | Amyloid | Amyloidosis | Cytoplasm
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6. Full Text Structure-and function-based design of Plasmodium-selective proteasome inhibitors
by Li, Hao and O'Donoghue, Anthony J and Van Der Linden, Wouter A and Xie, Stanley C and Yoo, Euna and Foe, Ian T and Tilley, Leann and Craik, Charles S and Da Fonseca, Paula C. A and Bogyo, Matthew
Nature (London), ISSN 0028-0836, 02/2016, Volume 530, Issue 7589, pp. 233 - 236
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Plasmodium falciparum - enzymology | Plasmodium - enzymology | Plasmodium chabaudi - enzymology | Species Specificity | Humans | Proteasome Inhibitors - chemistry | Plasmodium - drug effects | Plasmodium falciparum - drug effects | Protein Subunits - metabolism | Dose-Response Relationship, Drug | Artemisinins - pharmacology | Plasmodium chabaudi - physiology | Drug Design | Plasmodium - growth & development | Female | Drug Resistance | Antimalarials - adverse effects | Catalytic Domain | Proteasome Inhibitors - pharmacology | Models, Molecular | Proteasome Endopeptidase Complex - chemistry | Proteasome Inhibitors - toxicity | Proteasome Inhibitors - adverse effects | Antimalarials - pharmacology | Cryoelectron Microscopy | Drug Synergism | Animals | Substrate Specificity - drug effects | Proteasome Endopeptidase Complex - ultrastructure | Antimalarials - chemistry | Plasmodium chabaudi - drug effects | Mice | Mice, Inbred BALB C | Protein Subunits - antagonists & inhibitors | Protein Subunits - chemistry | Antimalarials - toxicity | Enzyme Activation | Plasmodium falciparum - growth & development | Proteasome Endopeptidase Complex - metabolism | Ubiquitin-proteasome system | Plasmodium | Health aspects | Proteins | Malaria | Protease inhibitors | Proteases | Erythrocytes | Ligands | Parasites | Drug dosages | Index Medicus
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7. Full Text The exocyst subunit Sec3 is regulated by a protein quality control pathway
by Kampmeyer, Caroline and Karakostova, Antonina and Schenstrøm, Signe M and Abildgaard, Amanda B and Lauridsen, Anne-Marie and Jourdain, Isabelle and Hartmann-Petersen, Rasmus
The Journal of biological chemistry, ISSN 0021-9258, 2017, Volume 292, Issue 37, pp. 15240 - 15253
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Schizosaccharomyces - drug effects | Schizosaccharomyces - ultrastructure | Schizosaccharomyces - growth & development | Temperature | HSP70 Heat-Shock Proteins - antagonists & inhibitors | Vesicular Transport Proteins - metabolism | Deubiquitinating Enzymes - antagonists & inhibitors | Ubiquitin-Protein Ligases - antagonists & inhibitors | Recombinant Fusion Proteins - metabolism | Exocytosis - drug effects | Proteolysis - drug effects | Vesicular Transport Proteins - antagonists & inhibitors | Proteasome Endopeptidase Complex - drug effects | Ubiquitination - drug effects | Gene Deletion | Schizosaccharomyces pombe Proteins - metabolism | Deubiquitinating Enzymes - metabolism | Stress, Physiological - drug effects | Schizosaccharomyces pombe Proteins - antagonists & inhibitors | Endopeptidases - metabolism | Microscopy, Electron, Transmission | Schizosaccharomyces pombe Proteins - genetics | Secretory Vesicles - ultrastructure | Endocytosis - drug effects | Vesicular Transport Proteins - genetics | Enzyme Inhibitors - pharmacology | Schizosaccharomyces - physiology | Ubiquitin-Protein Ligases - metabolism | HSP70 Heat-Shock Proteins - genetics | Recombinant Fusion Proteins - chemistry | Deubiquitinating Enzymes - genetics | HSP70 Heat-Shock Proteins - metabolism | Proteasome Endopeptidase Complex - genetics | Endopeptidases - genetics | Proteasome Endopeptidase Complex - ultrastructure | Models, Biological | Protein Stability - drug effects | Secretory Vesicles - drug effects | Secretory Vesicles - physiology | Mutation | Proteasome Endopeptidase Complex - metabolism | Ubiquitin-Protein Ligases - genetics | Index Medicus | proteasome | exocytosis | protein folding | chaperone | ubiquitin | Protein Synthesis and Degradation
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8. Full Text Mechanism of Gate Opening in the 20S Proteasome by the Proteasomal ATPases
by Rabl, Julius and Smith, David M and Yu, Yadong and Chang, Shih-Chung and Goldberg, Alfred L and Cheng, Yifan
Molecular cell, ISSN 1097-2765, 2008, Volume 30, Issue 3, pp. 360 - 368
PROTEINS | Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Archaeal Proteins - metabolism | Peptides - chemistry | Thermoplasma - chemistry | Peptides - genetics | Adenosine Triphosphatases - metabolism | Models, Molecular | Molecular Sequence Data | Thermoplasma - metabolism | Amino Acid Motifs | Cryoelectron Microscopy | Proteasome Endopeptidase Complex - genetics | Animals | Peptides - metabolism | Proteasome Endopeptidase Complex - ultrastructure | Archaeal Proteins - genetics | Protein Conformation | Adenosine Triphosphatases - genetics | Adenosine Triphosphatases - ultrastructure | Archaeal Proteins - ultrastructure | Mutation | Proteasome Endopeptidase Complex - metabolism | Binding Sites | Proteins | Electron microscopy | Cells | Adenosine triphosphatase | Index Medicus | AAA ATPases | Electron cryomicroscopy | protein degradation | proteasomal ATPase | Proteasome
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9. Full Text Proteasome Structure and Assembly
by Budenholzer, Lauren and Cheng, Chin Leng and Li, Yanjie and Hochstrasser, Mark
Journal of molecular biology, ISSN 0022-2836, 11/2017, Volume 429, Issue 22, pp. 3500 - 3524
ubiquitin proteasome system | proteasome | proteasome assembly | protein degradation | Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Cryoelectron Microscopy | Eukaryotic Cells - enzymology | Proteasome Endopeptidase Complex - metabolism | Proteasome Endopeptidase Complex - ultrastructure | Protein Multimerization | Ubiquitin | Proteolysis | Phosphatases | Index Medicus
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