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BIOCHEMICAL PHARMACOLOGY, ISSN 0006-2952, 07/2015, Volume 96, Issue 1, pp. 1 - 9
Proteasome inhibitors have a 20 year history in cancer therapy. The first proteasome inhibitor, bortezomib (Velcade, PS-341), a break-through multiple myeloma... 
MULTIPLE-MYELOMA | IXAZOMIB | CELLS | Bortezomib | MLN9708 | CEP-18770 | ANTITUMOR-ACTIVITY | PS-341 | THERAPY | Ixazomib citrate | PHASE-I TRIAL | Carfilzomib | PHARMACOLOGY & PHARMACY | TUMOR-GROWTH | Proteasome
Journal Article
BJU International, ISSN 1464-4096, 04/2018, Volume 121, Issue 4, pp. 600 - 609
Journal Article
Nature, ISSN 0028-0836, 02/2016, Volume 530, Issue 7589, pp. 233 - 236
The proteasome is a multi-component protease complex responsible for regulating key processes such as the cell cycle and antigen presentation(1). Compounds... 
VISUALIZATION | FALCIPARUM MALARIA | MECHANISM | SPECIFICITY | ARTEMISININ RESISTANCE | MULTIDISCIPLINARY SCIENCES | VALIDATION | ELECTRON-MICROSCOPY | IDENTIFICATION | PARASITE | HUMAN 20S PROTEASOME | Plasmodium falciparum - enzymology | Plasmodium - enzymology | Plasmodium chabaudi - enzymology | Species Specificity | Humans | Proteasome Inhibitors - chemistry | Plasmodium - drug effects | Plasmodium falciparum - drug effects | Protein Subunits - metabolism | Dose-Response Relationship, Drug | Artemisinins - pharmacology | Plasmodium chabaudi - physiology | Drug Design | Plasmodium - growth & development | Female | Drug Resistance | Antimalarials - adverse effects | Catalytic Domain | Proteasome Inhibitors - pharmacology | Models, Molecular | Proteasome Endopeptidase Complex - chemistry | Proteasome Inhibitors - toxicity | Proteasome Inhibitors - adverse effects | Antimalarials - pharmacology | Cryoelectron Microscopy | Drug Synergism | Animals | Substrate Specificity - drug effects | Proteasome Endopeptidase Complex - ultrastructure | Antimalarials - chemistry | Plasmodium chabaudi - drug effects | Mice | Mice, Inbred BALB C | Protein Subunits - antagonists & inhibitors | Protein Subunits - chemistry | Antimalarials - toxicity | Enzyme Activation | Plasmodium falciparum - growth & development | Proteasome Endopeptidase Complex - metabolism | Ubiquitin-proteasome system | Plasmodium | Health aspects | Proteins | Malaria | Protease inhibitors | Proteases | Erythrocytes | Ligands | Parasites | Drug dosages | Index Medicus
Journal Article
Biochemical Journal, ISSN 0264-6021, 09/2013, Volume 454, Issue 2, pp. 201 - 208
NAC (N-acetyl-L-cysteine) is commonly used to identify and test ROS (reactive oxygen species) inducers, and to inhibit ROS. In the present study, we identified... 
Catalase | N-acetyl-L-cysteine (NAC) | Proteasome inhibitor | Reactive oxygen species (ROS) | Forkhead box protein M1 (FOXM1) | CANCER-CELLS | TARGET | APOPTOSIS | OXIDATIVE STRESS | PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | reactive oxygen species (ROS) | ENDOPLASMIC-RETICULUM STRESS | BORTEZOMIB | FOXM1 | INACTIVATION | proteasome inhibitor | LACTACYSTIN | catalase | Free Radical Scavengers - pharmacology | Oxidants - pharmacology | Reactive Oxygen Species - metabolism | Apoptosis - drug effects | Humans | Acetylcysteine - metabolism | Proteasome Inhibitors - chemistry | Proteasome Inhibitors - metabolism | Viral Proteins - metabolism | Antineoplastic Agents, Phytogenic - antagonists & inhibitors | Chromans - metabolism | Proteasome Endopeptidase Complex - drug effects | Chromans - pharmacology | Dioxolanes - pharmacology | Forkhead Transcription Factors - metabolism | Forkhead Transcription Factors - antagonists & inhibitors | Ubiquitinated Proteins - metabolism | Recombinant Proteins - metabolism | Recombinant Proteins - antagonists & inhibitors | Free Radical Scavengers - metabolism | Proteasome Inhibitors - pharmacology | Catalase - genetics | Chromans - antagonists & inhibitors | Hydrogen Peroxide - pharmacology | Viral Proteins - genetics | Oxidants - antagonists & inhibitors | Dioxolanes - antagonists & inhibitors | Forkhead Transcription Factors - genetics | Catalase - metabolism | Reactive Oxygen Species - antagonists & inhibitors | Protein Stability - drug effects | Acetylcysteine - pharmacology | Cell Line, Tumor | Cytomegalovirus - enzymology | Proteasome Endopeptidase Complex - metabolism | Antineoplastic Agents, Phytogenic - pharmacology | Forkhead Box Protein M1 | Hydrogen Peroxide - antagonists & inhibitors | Index Medicus | N-acetyl-l-cysteine (NAC)
Journal Article
Biochemical Pharmacology, ISSN 0006-2952, 07/2015, Volume 96, Issue 1, pp. 1 - 9
Proteasome inhibitors have a 20 year history in cancer therapy. The first proteasome inhibitor, bortezomib (Velcade, PS-341), a break-through multiple myeloma... 
Carfilzomib | Bortezomib | MLN9708 | Ixazomib citrate | Proteasome | Antineoplastic Agents - pharmacology | Antineoplastic Agents - therapeutic use | Proteasome Inhibitors - pharmacology | Humans | Proteasome Inhibitors - therapeutic use | Neoplasms - drug therapy | Index Medicus
Journal Article
Angewandte Chemie - International Edition, ISSN 1433-7851, 05/2016, Volume 55, Issue 19, pp. 5745 - 5748
Elevated expression of the immunoproteasome has been associated with autoimmune diseases, inflammatory diseases, and various types of cancer. Selective... 
inhibitors | immunoproteasome | irreversible inhibition | drug design | small-molecule inhibitors | ACTIVE-SITE | CONSTITUTIVE PROTEASOME | RESISTANCE | COVALENT DRUGS | LIGAND | CHEMISTRY, MULTIDISCIPLINARY | Chymotrypsin | Enzyme inhibitors | Rodents | Index Medicus
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 07/2018, Volume 128, Issue 7, pp. 2760 - 2762
Journal Article
International Journal of Cancer, ISSN 0020-7136, 08/2015, Volume 137, Issue 3, pp. 686 - 697
Around 70% of breast cancers express the estrogen receptor α (ERα) and depend on estrogen for growth, survival and disease progression. The presence of hormone... 
Her2 inhibition | proteasome inhibition | estrogen receptor alpha inhibition | SURVIVAL | ACTIVATION | TAMOXIFEN | ER-ALPHA | ENDOCRINE TREATMENT | REPRESSION | ONCOLOGY | GROWTH | GENE-EXPRESSION | RESISTANCE | PROMOTES | Receptors, Estrogen - metabolism | Prognosis | TOR Serine-Threonine Kinases - metabolism | Humans | Receptor, ErbB-2 - metabolism | Antineoplastic Agents - therapeutic use | Phosphatidylinositol 3-Kinases - metabolism | Pyrazines - therapeutic use | Boronic Acids - therapeutic use | Tumor Suppressor Protein p53 - genetics | Breast Neoplasms - metabolism | Neoplasm Metastasis | Receptor, Epidermal Growth Factor - metabolism | Estrogen Receptor alpha - metabolism | Female | Antineoplastic Agents - pharmacology | Cell Death - drug effects | Gene Expression Regulation, Neoplastic - drug effects | Proto-Oncogene Proteins c-akt - metabolism | Disease Models, Animal | Bortezomib | Receptors, Estrogen - genetics | Proteasome Inhibitors - pharmacology | Signal Transduction | Tumor Suppressor Protein p53 - metabolism | Breast Neoplasms - drug therapy | Proteasome Inhibitors - therapeutic use | Xenograft Model Antitumor Assays | Animals | Breast Neoplasms - pathology | Cell Line, Tumor | Breast Neoplasms - mortality | Pyrazines - pharmacology | Boronic Acids - pharmacology | Mitogen-Activated Protein Kinases - metabolism | Estrogen | Phenols | Development and progression | Breast cancer | Hormones | Tumor proteins | Medical prognosis | Mortality | Endocrine therapy | Mammography | Kinases | Cancer therapies | Tumors | Index Medicus
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 05/2011, Volume 286, Issue 21, pp. 18633 - 18640
Journal Article
Journal of Cell Communication and Signaling, ISSN 1873-9601, 6/2011, Volume 5, Issue 2, pp. 101 - 110
Journal Article
Nature, ISSN 0028-0836, 10/2009, Volume 461, Issue 7264, pp. 621 - 626
Journal Article