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Journal Article
Molecular and Cellular Biology, ISSN 0270-7306, 02/2005, Volume 25, Issue 3, pp. 1025 - 1040
Journal Article
Autophagy, ISSN 1554-8627, 08/2014, Volume 10, Issue 8, pp. 1380 - 1390
Journal Article
Journal Article
Journal Article
Nature Medicine, ISSN 1078-8956, 12/2011, Volume 17, Issue 12, pp. 1636 - 1640
Ubiquitin-tagged substrates are degraded by the 26S proteasome, which is a multisubunit complex comprising a proteolytic 20S core particle capped by 19S... 
MEDICINE, RESEARCH & EXPERIMENTAL | APOPTOSIS | PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | BORTEZOMIB | 26S PROTEASOME | CELL-DEATH | P53 | CELL BIOLOGY | UBIQUITINATION | ROLES | DEGRADATION | EXPRESSION | Tumor Suppressor Protein p53 - antagonists & inhibitors | Humans | Ubiquitin - metabolism | Breast Neoplasms | Protease Inhibitors - pharmacology | Multiple Myeloma - drug therapy | Ubiquitination | Proteasome Endopeptidase Complex - drug effects | Microarray Analysis | Ubiquitin Thiolesterase - metabolism | Female | Antineoplastic Agents - pharmacology | Ubiquitin Thiolesterase - antagonists & inhibitors | Disease Models, Animal | Bortezomib | Tumor Suppressor Protein p53 - metabolism | bcl-2-Associated X Protein - metabolism | Carboxypeptidases - antagonists & inhibitors | Mice, SCID | Piperidones - pharmacology | Ubiquitin Thiolesterase - genetics | bcl-2-Associated X Protein - antagonists & inhibitors | Gene Expression Regulation, Enzymologic | Animals | Cell Line, Tumor | Carboxypeptidases - metabolism | Mice | Mice, Inbred BALB C | Proteasome Endopeptidase Complex - metabolism | Proteasome Inhibitors | Pyrazines - pharmacology | Apoptosis | Boronic Acids - pharmacology | Physiological aspects | Care and treatment | Research | Ubiquitin-proteasome system | Cancer | Proteins | Inhibitor drugs | Molecular biology | Medical and Health Sciences | Medicin och hälsovetenskap
Journal Article
Nature, ISSN 0028-0836, 10/2009, Volume 461, Issue 7264, pp. 614 - 620
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 08/2017, Volume 23, Issue 16, pp. 4817 - 4830
Purpose: EZH2 and EZH1, the catalytic components of polycomb repressive complex 2 (PRC2), trigger trimethylation of H3K27 (H3K27me3) to repress the... 
MULTIPLE-MYELOMA | APOPTOSIS | STEM-CELLS | ONCOLOGY | NUCLEAR RECEPTORS | B-CELL LYMPHOMAS | PROSTATE-CANCER | THERAPEUTIC TARGET | GROWTH | ACUTE MYELOID-LEUKEMIA | SOMATIC MUTATIONS | Polycomb Repressive Complex 2 - antagonists & inhibitors | Enhancer of Zeste Homolog 2 Protein - antagonists & inhibitors | Polycomb Repressive Complex 2 - genetics | Humans | Male | Bortezomib - pharmacology | Antineoplastic Combined Chemotherapy Protocols - pharmacology | Pyridones - administration & dosage | Multiple Myeloma - drug therapy | Gene Expression Regulation, Neoplastic - drug effects | Enhancer of Zeste Homolog 2 Protein - genetics | Enhancer of Zeste Homolog 2 Protein - metabolism | Proteasome Inhibitors - pharmacology | Proteasome Inhibitors - administration & dosage | Cells, Cultured | Mice, SCID | Multiple Myeloma - metabolism | Mice, Knockout | Drug Synergism | Xenograft Model Antitumor Assays | Animals | Bortezomib - administration & dosage | Cell Line, Tumor | Mice, Inbred NOD | Proteasome Endopeptidase Complex - metabolism | Polycomb Repressive Complex 2 - metabolism | Multiple Myeloma - genetics | Pyridones - pharmacology | Therapy | Biotechnology | Transcription | Pathogenesis | Multiple myeloma | Myc protein | E2F protein | Xenografts | Catalysis | Inhibition | Sensitizing | Bortezomib | Tumor cell lines | Ribonucleic acid--RNA | Proteasome inhibitors | Polycomb group proteins | Inhibitors | Protease inhibitors | Experimental design | Derepression | Cell lines | Epigenetics | Tumor suppressor genes | Methylation | Prostate cancer | Prostate | Tumors | Cancer
Journal Article
EMBO reports, ISSN 1469-221X, 10/2012, Volume 13, Issue 10, pp. 900 - 908
The Rho‐associated (ROCK) serine/threonine kinases have emerged as central regulators of the actomyosin cytoskeleton, their main purpose being to promote... 
actin | cancer | ROCK | inhibitor | cytoskeleton | SIGNALING COOPERATE | PROTEIN-KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | PANCREATIC-CANCER | DOWN-REGULATION | TUMOR-CELLS | VENTRAL BODY-WALL | SOMATIC MUTATIONS | CHRONIC MYELOID-LEUKEMIA | CELL BIOLOGY |