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1. Full Text Proteasome inhibitors in cancer therapy
by Manasanch, Elisabet E and Orlowski, Robert Z
Nature reviews. Clinical oncology, ISSN 1759-4774, 07/2017, Volume 14, Issue 7, pp. 417 - 433
Neoplasms - metabolism | Neoplasms - therapy | Humans | Ubiquitin - metabolism | Neoplasms - enzymology | Molecular Targeted Therapy | Proteasome Inhibitors - therapeutic use | Neoplasms - drug therapy | Care and treatment | Innovations | Cancer | Cell proliferation | Ubiquitin | Cell survival | Multiple myeloma | Clinical trials | Homeostasis | Lymphoma | Proteasome inhibitors | Protease inhibitors | Cell death | Tumors | Apoptosis | Index Medicus
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2. Full Text ROS inhibitor N-acetyl-L-cysteine antagonizes the activity of proteasome inhibitors
by Halasi, Marianna and Wang, Ming and Chavan, Tanmay S and Gaponenko, Vadim and Hay, Nissim and Gartel, Andrei L
Biochemical journal, ISSN 0264-6021, 09/2013, Volume 454, Issue 2, pp. 201 - 208
Catalase | N-acetyl-L-cysteine (NAC) | Proteasome inhibitor | Reactive oxygen species (ROS) | Forkhead box protein M1 (FOXM1) | Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Free Radical Scavengers - pharmacology | Oxidants - pharmacology | Reactive Oxygen Species - metabolism | Apoptosis - drug effects | Humans | Acetylcysteine - metabolism | Proteasome Inhibitors - chemistry | Proteasome Inhibitors - metabolism | Viral Proteins - metabolism | Antineoplastic Agents, Phytogenic - antagonists & inhibitors | Chromans - metabolism | Proteasome Endopeptidase Complex - drug effects | Chromans - pharmacology | Dioxolanes - pharmacology | Forkhead Transcription Factors - metabolism | Forkhead Transcription Factors - antagonists & inhibitors | Ubiquitinated Proteins - metabolism | Recombinant Proteins - metabolism | Recombinant Proteins - antagonists & inhibitors | Free Radical Scavengers - metabolism | Proteasome Inhibitors - pharmacology | Catalase - genetics | Chromans - antagonists & inhibitors | Hydrogen Peroxide - pharmacology | Viral Proteins - genetics | Oxidants - antagonists & inhibitors | Dioxolanes - antagonists & inhibitors | Forkhead Transcription Factors - genetics | Catalase - metabolism | Reactive Oxygen Species - antagonists & inhibitors | Protein Stability - drug effects | Acetylcysteine - pharmacology | Cell Line, Tumor | Cytomegalovirus - enzymology | Proteasome Endopeptidase Complex - metabolism | Antineoplastic Agents, Phytogenic - pharmacology | Forkhead Box Protein M1 | Hydrogen Peroxide - antagonists & inhibitors | Index Medicus | N-acetyl-l-cysteine (NAC) | proteasome inhibitor | reactive oxygen species (ROS) | catalase
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3. Full Text Structure-and function-based design of Plasmodium-selective proteasome inhibitors
by Li, Hao and O'Donoghue, Anthony J and Van Der Linden, Wouter A and Xie, Stanley C and Yoo, Euna and Foe, Ian T and Tilley, Leann and Craik, Charles S and Da Fonseca, Paula C. A and Bogyo, Matthew
Nature (London), ISSN 0028-0836, 02/2016, Volume 530, Issue 7589, pp. 233 - 236
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Plasmodium falciparum - enzymology | Plasmodium - enzymology | Plasmodium chabaudi - enzymology | Species Specificity | Humans | Proteasome Inhibitors - chemistry | Plasmodium - drug effects | Plasmodium falciparum - drug effects | Protein Subunits - metabolism | Dose-Response Relationship, Drug | Artemisinins - pharmacology | Plasmodium chabaudi - physiology | Drug Design | Plasmodium - growth & development | Female | Drug Resistance | Antimalarials - adverse effects | Catalytic Domain | Proteasome Inhibitors - pharmacology | Models, Molecular | Proteasome Endopeptidase Complex - chemistry | Proteasome Inhibitors - toxicity | Proteasome Inhibitors - adverse effects | Antimalarials - pharmacology | Cryoelectron Microscopy | Drug Synergism | Animals | Substrate Specificity - drug effects | Proteasome Endopeptidase Complex - ultrastructure | Antimalarials - chemistry | Plasmodium chabaudi - drug effects | Mice | Mice, Inbred BALB C | Protein Subunits - antagonists & inhibitors | Protein Subunits - chemistry | Antimalarials - toxicity | Enzyme Activation | Plasmodium falciparum - growth & development | Proteasome Endopeptidase Complex - metabolism | Ubiquitin-proteasome system | Plasmodium | Health aspects | Proteins | Malaria | Protease inhibitors | Proteases | Erythrocytes | Ligands | Parasites | Drug dosages | Index Medicus
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4. Full Text Nonpeptidic Selective Inhibitors of the Chymotrypsin‐Like (β5 i) Subunit of the Immunoproteasome
by Sosič, Izidor and Gobec, Martina and Brus, Boris and Knez, Damijan and Živec, Matej and Konc, Janez and Lešnik, Samo and Ogrizek, Mitja and Obreza, Aleš and Žigon, Dušan and Janežič, Dušanka and Mlinarič‐Raščan, Irena and Gobec, Stanislav
Angewandte Chemie (International ed.), ISSN 1433-7851, 05/2016, Volume 55, Issue 19, pp. 5745 - 5748
inhibitors | immunoproteasome | irreversible inhibition | drug design | small-molecule inhibitors | Cell Line | Cell Survival - drug effects | Humans | Proteasome Endopeptidase Complex - chemistry | Proteasome Inhibitors - chemistry | Proteasome Inhibitors - metabolism | Structure-Activity Relationship | Oligopeptides - metabolism | Oligopeptides - toxicity | Proteasome Inhibitors - toxicity | Protein Subunits - metabolism | Inhibitory Concentration 50 | Molecular Docking Simulation | Protein Subunits - antagonists & inhibitors | HeLa Cells | Kinetics | Proteasome Endopeptidase Complex - metabolism | Oligopeptides - chemistry | Chymotrypsin | Enzyme inhibitors | Index Medicus
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5. Overview of proteasome inhibitor-based anti-cancer therapies: Perspective on Bortezomib and second generation proteasome inhibitors versus future generation inhibitors of ubiquitin-proteasome system
by Dou, Q. Ping and Zonder, Jeffrey A
Current cancer drug targets, ISSN 1568-0096, 2014, Volume 14, Issue 6, pp. 517 - 536
Bortezomib | Proteasome inhibitor | Multiple myeloma | Carfilzomib | Combination therapy | Immunoproteasomes | Resistance to proteasome inhibitors | Ubiquitin-proteasome pathway | Life Sciences & Biomedicine | Oncology | Science & Technology | Ubiquitin-Specific Proteases - antagonists & inhibitors | Humans | Ubiquitin-Protein Ligases - metabolism | Boronic Acids - adverse effects | Antineoplastic Agents - therapeutic use | Pyrazines - therapeutic use | Boronic Acids - therapeutic use | Molecular Targeted Therapy | Proteasome Inhibitors - adverse effects | Proteasome Inhibitors - therapeutic use | Proteolysis - drug effects | Multiple Myeloma - drug therapy | Multiple Myeloma - pathology | Animals | Ubiquitin-Protein Ligase Complexes - metabolism | Ubiquitination - drug effects | Signal Transduction - drug effects | Antineoplastic Agents - adverse effects | Drug Design | Pyrazines - adverse effects | Proteasome Endopeptidase Complex - metabolism | Multiple Myeloma - enzymology | Ubiquitin-Specific Proteases - metabolism
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6. Full Text The proteasome inhibitor Bortezomib (Velcade) as potential inhibitor of estrogen receptor‐positive breast cancer
by Thaler, Sonja and Thiede, Gitta and Hengstler, Jan G and Schad, Arno and Schmidt, Marcus and Sleeman, Jonathan P
International journal of cancer, ISSN 0020-7136, 08/2015, Volume 137, Issue 3, pp. 686 - 697
Her2 inhibition | proteasome inhibition | estrogen receptor alpha inhibition | Life Sciences & Biomedicine | Oncology | Science & Technology | Receptors, Estrogen - metabolism | Prognosis | TOR Serine-Threonine Kinases - metabolism | Humans | Receptor, ErbB-2 - metabolism | Antineoplastic Agents - therapeutic use | Phosphatidylinositol 3-Kinases - metabolism | Pyrazines - therapeutic use | Boronic Acids - therapeutic use | Tumor Suppressor Protein p53 - genetics | Breast Neoplasms - metabolism | Neoplasm Metastasis | Receptor, Epidermal Growth Factor - metabolism | Estrogen Receptor alpha - metabolism | Female | Antineoplastic Agents - pharmacology | Cell Death - drug effects | Gene Expression Regulation, Neoplastic - drug effects | Proto-Oncogene Proteins c-akt - metabolism | Disease Models, Animal | Bortezomib | Receptors, Estrogen - genetics | Proteasome Inhibitors - pharmacology | Signal Transduction | Tumor Suppressor Protein p53 - metabolism | Breast Neoplasms - drug therapy | Proteasome Inhibitors - therapeutic use | Xenograft Model Antitumor Assays | Animals | Breast Neoplasms - pathology | Cell Line, Tumor | Breast Neoplasms - mortality | Pyrazines - pharmacology | Boronic Acids - pharmacology | Mitogen-Activated Protein Kinases - metabolism | Estrogen | Phenols | Development and progression | Breast cancer | Hormones | Tumor proteins | Medical prognosis | Mortality | Estrogens | Endocrine therapy | Mammography | Kinases | Cancer therapies | Tumors | Index Medicus
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7. Full Text Pevonedistat, a Neuronal Precursor Cell‐Expressed Developmentally Down‐Regulated Protein 8–Activating Enzyme Inhibitor, Is a Potent Inhibitor of Hepatitis B Virus
by Sekiba, Kazuma and Otsuka, Motoyuki and Ohno, Motoko and Yamagami, Mari and Kishikawa, Takahiro and Seimiya, Takahiro and Suzuki, Tatsunori and Tanaka, Eri and Ishibashi, Rei and Funato, Kazuyoshi and Koike, Kazuhiko
Hepatology (Baltimore, Md.), ISSN 0270-9139, 05/2019, Volume 69, Issue 5, pp. 1903 - 1915
Gastroenterology & Hepatology | Life Sciences & Biomedicine | Science & Technology | Ubiquitin | Enzymes | Transcription | Chronic infection | Circular DNA | Proteins | Hepatitis | Ubiquitination | Cell activation | Protein X | Hepatocytes | Proteasomes | Ubiquitin-protein ligase | Hepatitis B | Index Medicus
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8. Full Text Novel investigational drugs active as single agents in multiple myeloma
by D'Agostino, Mattia and Salvini, Marco and Palumbo, Antonio and Larocca, Alessandra and Gay, Francesca
Expert opinion on investigational drugs, ISSN 1354-3784, 06/2017, Volume 26, Issue 6, pp. 699 - 711
PIM-Kinase inhibitor | proteasome inhibitor | CDK inhibitor | AKT inhibitor | Multiple myeloma | single-agent | alkylator | kinesin-spindle protein inhibitor | MEK inhibitor | monoclonal antibody | BCL-2 inhibitor | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Drugs, Investigational - pharmacology | Proteasome Inhibitors - pharmacology | Antibodies, Monoclonal - pharmacology | Humans | Proteasome Inhibitors - administration & dosage | Drugs, Investigational - therapeutic use | Antibodies, Monoclonal - therapeutic use | Antineoplastic Agents - therapeutic use | Antineoplastic Agents - administration & dosage | Proteasome Inhibitors - therapeutic use | Multiple Myeloma - drug therapy | Multiple Myeloma - pathology | Animals | Antibodies, Monoclonal - administration & dosage | Drug Design | Drugs, Investigational - administration & dosage | Antineoplastic Agents - pharmacology | Index Medicus
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