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Nature (London), ISSN 1476-4687, 2016, Volume 530, Issue 7589, pp. 233 - 236
The proteasome is a multi-component protease complex responsible for regulating key processes such as the cell cycle and antigen presentation(1). Compounds... 
VISUALIZATION | FALCIPARUM MALARIA | MECHANISM | SPECIFICITY | ARTEMISININ RESISTANCE | MULTIDISCIPLINARY SCIENCES | VALIDATION | ELECTRON-MICROSCOPY | IDENTIFICATION | PARASITE | HUMAN 20S PROTEASOME | Plasmodium falciparum - enzymology | Plasmodium - enzymology | Plasmodium chabaudi - enzymology | Species Specificity | Humans | Proteasome Inhibitors - chemistry | Plasmodium - drug effects | Plasmodium falciparum - drug effects | Protein Subunits - metabolism | Dose-Response Relationship, Drug | Artemisinins - pharmacology | Plasmodium chabaudi - physiology | Drug Design | Plasmodium - growth & development | Female | Drug Resistance | Antimalarials - adverse effects | Catalytic Domain | Proteasome Inhibitors - pharmacology | Models, Molecular | Proteasome Endopeptidase Complex - chemistry | Proteasome Inhibitors - toxicity | Proteasome Inhibitors - adverse effects | Antimalarials - pharmacology | Cryoelectron Microscopy | Drug Synergism | Animals | Substrate Specificity - drug effects | Proteasome Endopeptidase Complex - ultrastructure | Antimalarials - chemistry | Plasmodium chabaudi - drug effects | Mice | Mice, Inbred BALB C | Protein Subunits - antagonists & inhibitors | Protein Subunits - chemistry | Antimalarials - toxicity | Enzyme Activation | Plasmodium falciparum - growth & development | Proteasome Endopeptidase Complex - metabolism | Ubiquitin-proteasome system | Plasmodium | Health aspects | Proteins | Malaria | Protease inhibitors | Proteases | Erythrocytes | Ligands | Parasites | Drug dosages
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 2010, Volume 107, Issue 43, pp. 18599 - 18604
Most antigenic peptides presented by MHC class I molecules result from the degradation of intracellular proteins by the proteasome. In lymphoid tissues and... 
T lymphocytes | Antigens | Dendritic cells | HEK293 cells | Liver | Melanoma | Cell lines | Antibodies | Cellular immunity | Tumors | MAGE | Antigenic peptide | Tumor antigen | Immunoproteasome | Antigen processing | immunoproteasome | DENDRITIC CELLS | MULTIDISCIPLINARY SCIENCES | CYTOLYTIC T-LYMPHOCYTES | antigenic peptide | SUBUNIT COMPOSITION | CLEAVAGE | 20S PROTEASOME | tumor antigen | ANGSTROM RESOLUTION | GENERATION | antigen processing | STANDARD PROTEASOME | TUMOR-ASSOCIATED ANTIGEN | Recombinant Proteins - metabolism | Amino Acid Sequence | Antigens, Neoplasm - genetics | Protein Subunits | Humans | Molecular Sequence Data | Proteasome Endopeptidase Complex - chemistry | Recombinant Proteins - genetics | Neoplasm Proteins - metabolism | Mice, Knockout | Histocompatibility Antigens Class I - metabolism | Proteasome Endopeptidase Complex - genetics | Sequence Homology, Amino Acid | Animals | Antigen Presentation | Recombinant Proteins - immunology | Antigens, Neoplasm - metabolism | Cell Line, Tumor | Mice | Proteasome Endopeptidase Complex - metabolism | Neoplasm Proteins - genetics | Proteasome Endopeptidase Complex - classification | Research | Ubiquitin-proteasome system | Properties | Tumor antigens | Methods | Immunological research | CD8 antigen | Tumor cells | proteasomes | Lymphocytes T | Lymphoid tissue | Small intestine | Kidney | Major histocompatibility complex | Antigen (tumor-associated) | Histocompatibility antigen HLA | Colon | Catalytic subunits | Biological Sciences
Journal Article
Current pharmaceutical design, ISSN 1381-6128, 2013, Volume 19, Issue 22, pp. 4140 - 4151
Journal Article
Nature (London), ISSN 0028-0836, 2013, Volume 497, Issue 7450, pp. 512 - 516
The proteasomal ATPase ring, comprising Rpt1-Rpt6, associates with the heptameric alpha-ring of the proteasome core particle (CP) in the mature proteasome,... 
REGULATORY PARTICLE | CORE | STRUCTURAL BASIS | PATHWAY | MULTIDISCIPLINARY SCIENCES | YEAST 26S PROTEASOME | GATE | S PROTEASOME | 20S PROTEASOMES | ATPASES | SUBUNIT | Physiological aspects | Ubiquitin-proteasome system | Brewer's yeast | Adenosine triphosphatase | Peptides | Enzymes | Yeast | proteasome | chaperone | single particle cryoEM | ATPase
Journal Article