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1. Full Text Residual LCMV antigen in transiently CD4+ T cell‐depleted mice induces high levels of virus‐specific antibodies but only limited B‐cell memory
by Schweier, Oliver and Aichele, Ulrike and Marx, Anna‐Friederike and Straub, Tobias and Verbeek, J. Sjef and Pinschewer, Daniel D and Pircher, Hanspeter
European Journal of Immunology, ISSN 0014-2980, 04/2019, Volume 49, Issue 4, pp. 626 - 637
Infection of C57BL/6 mice with lymphocytic choriomeningitis virus (LCMV) strain Armstrong (Arm) induces an acute infection with rapid virus clearance by CD8 +... 
memory B cells | CD4 | antibodies | LCMV | T cell depletion | residual antigen | COMPLEMENT | PERSISTENCE | MONOCLONAL-ANTIBODY | INDUCTION | IMMUNOLOGY | memory B cells | LYMPHOCYTIC CHORIOMENINGITIS VIRUS | RESPONSES | PROTECTIVE IMMUNITY | FOLLICULAR DENDRITIC CELLS | INFECTION | CD4(+) T cell depletion | RECEPTORS | Memory (Computers) | Immunoglobulin G | Mice | B cells | T cells | Health aspects | Viral antigens | Complement receptors | Antigens | Memory cells | Immunological memory | CD8 antigen | Antibodies | Viruses | Priming | Infections | Lymphocytes T | CD4 antigen | Computer memory | Receptors | Depletion | Lymphocytes B | Lymphocytes
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2. Full Text Long-lived epithelial immunity by tissue-resident memory T (TRM) cells in the absence of persisting local antigen presentation
by Laura K. Mackay and Angus T. Stock and Joel Z. Ma and Claerwen M. Jones and Stephen J. Kent and Scott N. Mueller and William R. Heath and Francis R. Carbone and Thomas Gebhardt
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 5/2012, Volume 109, Issue 18, pp. 7037 - 7042
Although circulating memory T cells provide enhanced protection against pathogen challenge, they often fail to do so if infection is localized to peripheral or... 
T lymphocytes | Antigens | Pathogens | Simplexvirus | Memory | Viruses | Infections | Inflammation | Immunity | Ganglia | MIGRATION | EFFECTOR | HERPES-SIMPLEX-VIRUS | PROTECTIVE IMMUNITY | IMMUNOLOGICAL MEMORY | NONLYMPHOID TISSUE | MULTIDISCIPLINARY SCIENCES | COPY NUMBER | NORMAL SKIN | RESIDUAL ANTIGEN | VIRAL-INFECTION | T-Lymphocyte Subsets - immunology | Lymphocyte Activation | Mice, Inbred C57BL | Mice, Transgenic | Adoptive Transfer | Epithelium - virology | Herpes Simplex - immunology | Skin Diseases, Viral - immunology | Epithelium - immunology | Animals | Herpes Genitalis - prevention & control | Antigen Presentation | Time Factors | Skin Diseases, Viral - prevention & control | Female | Herpes Simplex - prevention & control | Immunologic Memory | Mice | CD8-Positive T-Lymphocytes - immunology | Herpes Genitalis - immunology | Skin - virology | Skin - immunology | Physiological aspects | Immunology | Research | T cells | Health aspects | Biological Sciences
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3. Full Text CD8+ T cells prevent antigen-induced antibody-dependent enhancement of dengue disease in mice
by Zellweger, Raphaël M and Eddy, William E and Tang, William W and Miller, Robyn and Shresta, Sujan
Journal of Immunology, ISSN 0022-1767, 10/2014, Volume 193, Issue 8, pp. 4117 - 4124
Dengue virus (DENV) causes pathologies ranging from the febrile illness dengue fever to the potentially lethal severe dengue disease. A major risk factor for... 
PATHOGENESIS | RESPONSES | VIRUS-INFECTION | RISK-FACTOR | HEMORRHAGIC-FEVER | PROTECTIVE ROLE | MOUSE MODEL | IN-VIVO | MEDIATED NEUTRALIZATION | IMMUNOLOGY | FLAVIVIRUS INFECTION | Adjuvants, Immunologic | CD8-Positive T-Lymphocytes - transplantation | Mice, Transgenic | Adoptive Transfer | Antibody-Dependent Enhancement - immunology | Viral Load - immunology | Dengue - prevention & control | Antigens, Viral - immunology | Animals | Dengue Virus - immunology | Immunoglobulin G - immunology | Immunization, Passive | Antibodies, Viral - immunology | Mice | CD8-Positive T-Lymphocytes - immunology | Dengue - immunology
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4. Full Text Memory CD8 + T cell differentiation: initial antigen encounter triggers a developmental program in naïve cells
by Kaech, Susan M and Ahmed, Rafi
Nature Immunology, ISSN 1529-2908, 05/2001, Volume 2, Issue 5, pp. 415 - 422
The rules that govern memory T cell differentiation are not well understood. This study shows that after antigenic stimulation naive CD8(+)T cells become... 
RESPONSES | PROTECTIVE IMMUNITY | BYSTANDER ACTIVATION | IN-VIVO | EFFECTOR FUNCTION | BACTERIAL-INFECTION | IMMUNOLOGY | VIRAL PERSISTENCE | LYMPHOCYTIC CHORIOMENINGITIS VIRUS | EXPRESSION | CUTTING EDGE | CD8-Positive T-Lymphocytes - cytology | Lymphocyte Activation | Mice, Transgenic | Adoptive Transfer | Models, Immunological | Animals | H-2 Antigens - genetics | Interleukin-2 - immunology | Cell Division | Thy-1 Antigens - genetics | Immunologic Memory | Cell Differentiation | Mice | CD8-Positive T-Lymphocytes - immunology
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5. Full Text Development and application of a Bacillus anthracis protective antigen domain-1 in-house ELISA for the detection of anti-protective antigen antibodies in cattle in Zambia
by Simbotwe, Manyando and Fujikura, Daisuke and Ohnuma, Miyuki and Omori, Ryosuke and Omori, Ryosuke and Furuta, Yoshikazu and Furuta, Yoshikazu and Muuka, Geoffrey Munkombwe and Muuka, Geoffrey Munkombwe and Hang’ombe, Bernard Mudenda and Hang'ombe, Bernard Mudenda and Higashi, Hideaki and Higashi, Hideaki
PLoS ONE, ISSN 1932-6203, 10/2018, Volume 13, Issue 10, p. e0205986
In Zambia, anthrax outbreaks among cattle are reported on nearly an annual basis. Presently, there is a lack of serological assays and information to develop... 
Antigens | Bacillus anthracis | Care and treatment | Control | Usage | Anthrax | Cattle | Genetic aspects | Research | Enzyme-linked immunosorbent assay | Veterinary colleges | Vaccination | Antibodies | Outbreaks | Infections | Assaying | Veterinary medicine | Epidemiology | Coefficient of variation | Protective coatings | Public health | Recombinant | Immunoglobulins | Seroconversion | Zoonoses | Dilution | Protective antigen | Surveillance | Titration | Livestock | Farming
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6. Full Text Endolysosomal‐Escape Nanovaccines through Adjuvant‐Induced Tumor Antigen Assembly for Enhanced Effector CD8+ T Cell Activation
by Qiu, Liping and Valente, Michael and Dolen, Yusuf and Jäger, Eliezer and Beest, Martin ter and Zheng, Liyan and Figdor, Carl G and Verdoes, Martijn
Small, ISSN 1613-6810, 04/2018, Volume 14, Issue 15, pp. e1703539 - n/a
The activation of tumor‐specific effector immune cells is key for successful immunotherapy and vaccination is a powerful strategy to induce such adaptive... 
antigen/adjuvant codelivery | endolysosomal escape | cancer nanovaccines | T cell activation | cross‐presentation | cross-presentation | PHYSICS, CONDENSED MATTER | PHYSICS, APPLIED | adjuvant codelivery | DENDRITIC CELLS | DRUG-DELIVERY | MATERIALS SCIENCE, MULTIDISCIPLINARY | CHEMISTRY, PHYSICAL | NANOSCIENCE & NANOTECHNOLOGY | antigen | CANCER-IMMUNOTHERAPY | MELANOMA PATIENTS | CHEMISTRY, MULTIDISCIPLINARY | NANOPARTICLES | RESPONSES | GENERATION | ANTITUMOR IMMUNITY | VACCINES | Antigens | Dendritic cells | T cells | Analysis | Immunotherapy | Tumors | Lymphocytes | Biocompatibility | Strategy | T cell receptors | Activation | Vaccines | Protective coatings | Assembly | Anticancer properties | Immune system
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7. Full Text Memory CD8+ T cells exhibit increased antigen threshold requirements for recall proliferation
by Mehlhop-Williams, Erin R and Bevan, Michael J
Journal of Experimental Medicine, ISSN 0022-1007, 02/2014, Volume 211, Issue 2, pp. 345 - 356
A hallmark of immunological memory is the ability of previously primed T cells to undergo rapid recall responses upon antigen reencounter. Classic work has... 
MEDICINE, RESEARCH & EXPERIMENTAL | RESPONSES | PROTECTIVE IMMUNITY | SIGNALING PATHWAYS | ENHANCED EXPRESSION | CYTOKINE PRODUCTION | DENDRITIC CELLS | IN-VIVO | SELF-ANTIGENS | IMMUNOLOGY | NAIVE | LYMPHOCYTE-ACTIVATION | CD8-Positive T-Lymphocytes - cytology | Cell Proliferation | Ovalbumin - immunology | Receptors, Antigen, T-Cell - metabolism | Lymphocyte Activation | Dendritic Cells - immunology | Mice, Inbred C57BL | Mice, Transgenic | Animals | Ovalbumin - administration & dosage | Antigen Presentation | Immunologic Memory | Mice | CD8-Positive T-Lymphocytes - immunology
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8. Full Text A unique serine-rich repeat protein (Srr-2) and novel surface antigen ({varepsilon}) associated with a virulent lineage of serotype III Streptococcus agalactiae
by Seifert, Kyle N and Adderson, Elisabeth E and Whiting, April A and Bohnsack, John F and Crowley, Paula J and Brady, L. Jeannine
Microbiology, ISSN 1350-0872, 04/2006, Volume 152, Issue 4, pp. 1029 - 1040
1 Department of Biology, James Madison University, Harrisonburg, VA 22807, USA 2 Department of Infectious Diseases, St Jude Children's Research Hospital,... 
PATTERN TYPE III-3 | PROTECTIVE IMMUNITY | GENOME SEQUENCE | ALPHA-C-PROTEIN | FIMBRIAE-ASSOCIATED ADHESIN | SURFACE-PROTEINS | GROUP-B STREPTOCOCCUS | ACID-BINDING ADHESIN | MICROBIOLOGY | ACCESSORY SEC LOCUS | INVASIVE NEONATAL DISEASE | Virulence Factors - genetics | Streptococcus agalactiae - pathogenicity | DNA Fingerprinting | Humans | Molecular Sequence Data | Streptococcus agalactiae - classification | Bacterial Proteins - analysis | Antigens, Bacterial - genetics | Membrane Proteins - analysis | Streptococcus agalactiae - genetics | Membrane Transport Proteins - genetics | Staphylococcus - genetics | Streptococcus agalactiae - chemistry | Disease Models, Animal | Streptococcal Infections - microbiology | Membrane Proteins - genetics | Bacterial Proteins - genetics | Sequence Analysis, DNA | SEC Translocation Channels | Sequence Homology, Amino Acid | Animals | DNA, Bacterial - genetics | Polymorphism, Restriction Fragment Length | Survival Analysis | Antigens, Bacterial - analysis | Virulence Factors - analysis | Adenosine Triphosphatases - genetics | Mice | Streptococcus agalactiae | Bacterial proteins | Research
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9. Full Text Co-administration of α-GalCer analog and TLR4 agonist induces robust CD8+ T-cell responses to PyCS protein and WT-1 antigen and activates memory-like effector NKT cells
by Coelho-dos-Reis, Jordana G and Huang, Jing and Tsao, Tiffany and Pereira, Felipe V and Funakoshi, Ryota and Nakajima, Hiroko and Sugiyama, Haruo and Tsuji, Moriya
Clinical Immunology, ISSN 1521-6616, 2015, Volume 168, pp. 6 - 15
Abstract In the present study, the combined adjuvant effect of 7DW8-5, a potent α-GalCer-analog, and MPLA, a TLR4 agonist, on the induction of vaccine-induced... 
Allergy and Immunology | Cancer vaccine | NKT cells | Malaria vaccine | Memory-like effector NKT cells | WT-1 | Adjuvant | CD1d | TLR4 | Circumsporozoite protein | Glycolipid | GENE WT1 PRODUCT | DENDRITIC CELLS | IMMUNOLOGY | CANCER | TUMOR-IMMUNITY | PROTECTIVE IMMUNITY | IMMUNE-RESPONSES | IN-VIVO | TOLL-LIKE RECEPTORS | MICE | HLA-A2 Antigen - genetics | Humans | Lipid A - analogs & derivatives | Interferon-gamma - metabolism | Galactosylceramides - administration & dosage | Galactosylceramides - pharmacology | Protective Agents - pharmacology | WT1 Proteins - immunology | CD8-Positive T-Lymphocytes - metabolism | Killer Cells, Natural - immunology | Toll-Like Receptor 4 - agonists | Protozoan Proteins - chemistry | Epitopes, T-Lymphocyte - immunology | WT1 Proteins - genetics | Immunologic Memory - immunology | Amino Acid Sequence | Lipid A - administration & dosage | Plasmodium yoelii - physiology | HLA-A2 Antigen - immunology | Immunization - methods | Malaria - immunology | Mice, Inbred C57BL | Peptides - immunology | Mice, Transgenic | Plasmodium yoelii - immunology | Toll-Like Receptor 4 - metabolism | Drug Synergism | Malaria - prevention & control | Models, Immunological | Animals | CD8-Positive T-Lymphocytes - drug effects | Interferon-gamma - immunology | Lipid A - pharmacology | Malaria - parasitology | Cell Line, Tumor | Killer Cells, Natural - drug effects | Mice, Inbred BALB C | Killer Cells, Natural - metabolism | Protective Agents - administration & dosage | CD8-Positive T-Lymphocytes - immunology | Protozoan Proteins - immunology
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10. Full Text Self-recognition of CD1 by γ/δ T cells: Implications for innate immunity
by Spada, Franca M and Grant, Ethan P and Peters, Peter J and Sugita, Masahiko and Melián, Augustín and Leslie, David S and Lee, Hoi K and Van Donselaar, Elly and Hanson, Dennis A and Krensky, Alan M and Majdic, Otto and Porcelli, Steven A and Morita, Craig T and Brenner, Michael B
Journal of Experimental Medicine, ISSN 0022-1007, 03/2000, Volume 191, Issue 6, pp. 937 - 948
The specificity of immunoglobulins and alpha/beta T cell receptors (TCRs) provides a framework for the molecular basis of antigen recognition. Yet, evolution... 
T lymphocytes | CD1 | Cytolysis | Granulysin | T cell antigen receptors γ/δ | MYCOBACTERIUM-TUBERCULOSIS | LISTERIA-MONOCYTOGENES | MEDICINE, RESEARCH & EXPERIMENTAL | ACTIVATION | NONPEPTIDE ANTIGENS | IMMUNOLOGY | ANTIGEN-PRESENTING MOLECULES | T cell antigen receptors gamma/delta | cytolysis | RECEPTOR-GAMMA-DELTA | PROTECTIVE ROLE | IN-VIVO | granulysin | MONOCLONAL-ANTIBODIES | LYMPHOCYTES-T | T-Lymphocyte Subsets - immunology | Cytotoxicity Tests, Immunologic | T-Lymphocyte Subsets - cytology | Anti-Infective Agents - metabolism | Humans | Molecular Sequence Data | Receptors, Antigen, T-Cell, gamma-delta - genetics | Th1 Cells - immunology | Gene Rearrangement, delta-Chain T-Cell Antigen Receptor | Th1 Cells - metabolism | Membrane Glycoproteins - physiology | Base Sequence | Pore Forming Cytotoxic Proteins | fas Receptor - physiology | Perforin | Amino Acid Sequence | Cell Line | Antigen-Presenting Cells - metabolism | Antigens, CD1 - biosynthesis | Receptors, Antigen, T-Cell, gamma-delta - metabolism | Lymphocyte Activation | Immunity, Innate | Antigen-Presenting Cells - immunology | Gene Rearrangement, gamma-Chain T-Cell Antigen Receptor | Cell Differentiation - immunology | Receptors, Antigen, T-Cell, gamma-delta - physiology | T-Lymphocyte Subsets - metabolism | Antigens, CD1 - metabolism | T-Lymphocyte Subsets - microbiology | Antigens, Differentiation, T-Lymphocyte - biosynthesis | Cytotoxicity, Immunologic | T cell antigen receptors γ | Original
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11. Full Text Antigen-dependent competition shapes the local repertoire of tissue-resident memory CD8+ T cells
by Muschaweckh, Andreas and Buchholz, Veit R and Fellenzer, Anne and Hessel, Christian and König, Paul-Albert and Tao, Sha and Tao, Ronny and Heikenwälder, Mathias and Busch, Dirk H and Korn, Thomas and Kastenmüller, Wolfgang and Drexler, Ingo and Gasteiger, Georg
Journal of Experimental Medicine, ISSN 0022-1007, 2016, Volume 213, Issue 13, pp. 3075 - 3086
Tissue-resident memory CD8(+) T cells (T-RM) constitute a major component of the immune-surveillance system in nonlymphoid organs. Local, noncognate factors... 
MIGRATION | MEDICINE, RESEARCH & EXPERIMENTAL | PROTECTIVE IMMUNITY | CYTOKINES | NONLYMPHOID TISSUE | STRATEGY | HERPES | RM CELLS | INFECTION | IMMUNOLOGY | EXIT | CD8-Positive T-Lymphocytes - pathology | Vaccinia - pathology | Antigens, Viral - genetics | Mice, Transgenic | Signal Transduction - genetics | Vaccinia virus - genetics | Vaccinia - genetics | Vaccinia virus - immunology | Antigens, Viral - immunology | Signal Transduction - immunology | Animals | Vaccinia - immunology | Receptors, Antigen, T-Cell - immunology | Mice | Receptors, Antigen, T-Cell - genetics | CD8-Positive T-Lymphocytes - immunology | 312 | 319
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12. Full Text The Chemokine Receptor CX3CR1 Defines Three Antigen-Experienced CD8 T Cell Subsets with Distinct Roles in Immune Surveillance and Homeostasis
by Gerlach, Carmen and Moseman, E. Ashley and Loughhead, Scott M and Alvarez, David and Zwijnenburg, Anthonie J and Waanders, Lisette and Garg, Rohit and de la Torre, Juan C and von Andrian, Ulrich H
Immunity, ISSN 1074-7613, 12/2016, Volume 45, Issue 6, pp. 1270 - 1284
Infections induce pathogen-specific T cell differentiation into diverse effectors (Teff) that give rise to memory (Tmem) subsets. The cell-fate decisions and... 
EFFECTOR | PROTECTIVE IMMUNITY | MIGRATORY PROPERTIES | RESIDENT MEMORY | LYMPH-NODES | IMMUNOSURVEILLANCE | PERIPHERAL-TISSUES | SKIN | IMMUNOLOGY | EXPRESSION | LYMPHOCYTES | T-Lymphocyte Subsets - immunology | Animals | Flow Cytometry | Cell Separation | Mice, Inbred C57BL | Homeostasis - immunology | Mice | Receptors, Chemokine - immunology | CD8-Positive T-Lymphocytes - immunology | CX3C Chemokine Receptor 1 | Immunologic Surveillance - immunology | Immunologic Memory - immunology | Virus diseases | Antigens | Microbiology | T cells | Cell differentiation | Pathogens | Medical research | Lymphocytes | Cytotoxicity | T cell receptors | Infections | Experiments | Viral infections
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13. Full Text Phenotypic heterogeneity of antigen-specific CD4 T cells under different conditions of antigen persistence and antigen load
by Harari, Alexandre and Vallelian, Florence and Pantaleo, Giuseppe
European Journal of Immunology, ISSN 0014-2980, 12/2004, Volume 34, Issue 12, pp. 3525 - 3533
The factors responsible for the phenotypic heterogeneity of memory CD4 T cells are unclear. In the present study, we have identified a third population of... 
Heterogeneity | Memory CD4 T cells | Phenotype | memory CD4 T cells | phenotype | VIRUS | SUBSETS | ANTIRETROVIRAL THERAPY | IMMUNOLOGY | heterogeneity |