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Human molecular genetics, ISSN 0964-6906, 12/2014, Volume 23, Issue 25, pp. 6732 - 6745
Journal Article
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 06/2018, Volume 13, Issue 6, p. e0198266
Protein L-isoaspartyl methyltransferase (PIMT/PCMT1), a product of the pcmt1 gene, catalyzes repair of abnormal L-isoaspartyl linkages in age-damaged proteins.... 
DIRECT LINEAR PLOT | REPAIR | MULTIDISCIPLINARY SCIENCES | CONSEQUENCES | MICE | DEFICIENCY | BRAINS | Genetics, Population | Temperature | Gene Frequency | Humans | Catalytic Domain - genetics | Nerve Degeneration - genetics | Nerve Degeneration - pathology | Aging - pathology | Protein D-Aspartate-L-Isoaspartate Methyltransferase - metabolism | Aging - genetics | DNA Mutational Analysis | Protein Aggregates - genetics | Protein D-Aspartate-L-Isoaspartate Methyltransferase - genetics | Aged | Polymorphism, Single Nucleotide | Catalysis | Enzyme Stability - genetics | Enzyme Activation - genetics | Protein D-Aspartate-L-Isoaspartate Methyltransferase - chemistry | Child | Protein Aggregation, Pathological - genetics | Aging - metabolism | Research | Single nucleotide polymorphisms | Thermal analysis | Methyltransferases | Genetic variation | Brain | Laboratories | Epilepsy | Methyltransferase | Central nervous system | Amino acids | Biochemistry | Agglomeration | Catalytic activity | Single-nucleotide polymorphism | Kinases | Thermal stability | Proteins | Enzymatic activity | E coli | Melt temperature | Aging | Fluorimetry | Age | Protein-L-isoaspartate(D-aspartate) O-methyltransferase | Binding | Protein L | Methionine | Substrates | Neurological diseases | Algorithms | Plasmids | Mutation | Molecular biology | Methods
Journal Article
Journal of Neuroscience Research, ISSN 0360-4012, 08/2017, Volume 95, Issue 8, pp. 1647 - 1665
Glycoprotein nonmetastatic melanoma protein B (GPNMB) aggregates are observed in the spinal cord of amyotrophic lateral sclerosis (ALS) patients, but the... 
Transactive response DNA binding protein 43kDa (TDP‐43) | Glycoprotein nonmetastatic melanoma protein B (GPNMB) | Amyotrophic lateral sclerosis (ALS) | Sporadic ALS patient | mouse motor neuron cells (NSC34) | Transactive response DNA binding protein 43kDa (TDP-43) | HUMAN TDP-43 | ALS | MELANOMA PROTEIN-B | AMYOTROPHIC-LATERAL-SCLEROSIS | NEUROSCIENCES | SKELETAL-MUSCLE | IN-VITRO | NEUROPROTECTIVE FACTOR | PRESYMPTOMATIC TRANSGENIC MICE | SOD1 GENE | EARLY DECREASE | Membrane Glycoproteins - metabolism | Microtubule-Associated Proteins - metabolism | Humans | Male | Glial Fibrillary Acidic Protein - metabolism | DNA-Binding Proteins - metabolism | MAP Kinase Signaling System - genetics | Cell Death - genetics | Protein Aggregates - genetics | Spinal Cord - pathology | Female | Proto-Oncogene Proteins c-akt - metabolism | Motor Neurons - physiology | Gene Expression Regulation - genetics | Cells, Cultured | Signal Transduction - genetics | DNA-Binding Proteins - genetics | Mutation - genetics | Motor Neurons - metabolism | Amyotrophic Lateral Sclerosis - pathology | Animals | MAP Kinase Signaling System - drug effects | Signal Transduction - physiology | Aged | Mice | Neurofilament Proteins - metabolism | Medical research | Nervous system diseases | Neurons | Cell death | Melanoma | Medicine, Experimental | Amyotrophic lateral sclerosis | Biochemistry | Protein binding | Spinal cord | Calcium | AKT protein | Motor task performance | Neuronal-glial interactions | Proteins | Transfection | Rodents | Microtubule-associated protein 2 | Localization | Deoxyribonucleic acid--DNA | Recombinant | Binding | Stresses | Neurodegenerative diseases | Glial fibrillary acidic protein | Mortality | Glycoprotein | Extracellular signal-regulated kinase | Protein B | Neurofilament H | Patients | Stress | Microglia | Neurological diseases | Aggregates | Plasmids | Mutation | Apoptosis
Journal Article
Journal Article