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Cell reports (Cambridge), ISSN 2211-1247, 2016, Volume 16, Issue 10, pp. 2576 - 2592
The mechanisms underlying Zika virus (ZIKV)-related microcephaly and other neurodevelopment defects remain poorly understood. Here, we describe the derivation... 
NEURAL PROGENITORS | LONG-TERM | HUMAN BRAIN | ADAPTER | CENTRAL-NERVOUS-SYSTEM | INFECTION | MICE | BINDING KINASE 1 | ORGANOIDS | INNATE IMMUNITY | CELL BIOLOGY | Neocortex - pathology | Neurons - pathology | Transcription, Genetic - drug effects | Brain - embryology | Neuroglia - ultrastructure | Neuroglia - pathology | Humans | Brain - virology | Centrosome - drug effects | Gene Expression Profiling | Microcephaly - virology | Neural Stem Cells - ultrastructure | Zika Virus Infection - virology | Neural Stem Cells - immunology | Neuroepithelial Cells - immunology | Neuroprotective Agents - pharmacology | Spinal Cord - pathology | Microcephaly - pathology | Neuroepithelial Cells - virology | Nucleosides - pharmacology | Fetus - virology | Cell Death - drug effects | Phosphorylation - drug effects | Neurons - drug effects | Protein-Serine-Threonine Kinases - metabolism | Zika Virus - pathogenicity | Proto-Oncogene Proteins - metabolism | Zika Virus - ultrastructure | Neurons - virology | Virus Replication - drug effects | Neuroepithelial Cells - ultrastructure | Immunity, Innate - drug effects | Zika Virus Infection - pathology | Neural Stem Cells - virology | Zika Virus - physiology | Zika Virus - drug effects | Mitochondria - metabolism | Mitochondria - drug effects | Receptor Protein-Tyrosine Kinases - metabolism | Neural Stem Cells - enzymology | Centrosome - metabolism | Mitosis - drug effects | Brain - pathology | Protein Kinase Inhibitors - pharmacology | Neuroglia - virology | Neuroepithelial Cells - drug effects | Neurons/pathology | Zika Virus/pathogenicity | Mitochondria/metabolism | Virus Replication/drug effects | Microcephaly/pathology | Neurons/drug effects | Protein-Serine-Threonine Kinases/metabolism | Neural Stem Cells/immunology | Neuroglia/ultrastructure | Neuroepithelial Cells/drug effects | Neuroepithelial Cells/virology | Life Sciences | Brain/pathology | Zika Virus/drug effects | Brain/embryology | Mitochondria/drug effects | Fetus/virology | Neocortex/pathology | Neuroglia/pathology | Cell Death/drug effects | Mitosis/drug effects | Transcription, Genetic/drug effects | Nucleosides/pharmacology | Neural Stem Cells/enzymology | Neural Stem Cells/ultrastructure | Neuroepithelial Cells/ultrastructure | Receptor Protein-Tyrosine Kinases/metabolism | Microcephaly/virology | Proto-Oncogene Proteins/metabolism | Neuroprotective Agents/pharmacology | Zika Virus/ultrastructure | Neuroepithelial Cells/immunology | Brain/virology | Immunity, Innate/drug effects | Spinal Cord/pathology | Zika Virus/physiology | Neuroglia/virology | Microbiology and Parasitology | Zika Virus Infection/pathology | Neurons/virology | Zika Virus Infection/virology | Neural Stem Cells/virology | Centrosome/drug effects | Protein Kinase Inhibitors/pharmacology | Centrosome/metabolism | Phosphorylation/drug effects
Journal Article
The Plant cell, ISSN 1532-298X, 2013, Volume 25, Issue 8, pp. 2907 - 2924
The INDUCER OF CBF EXPRESSION (ICE)—C-REPEAT BINDING FACTOR/DRE BINDING FACTOR1 (CBF/DREB1) transcriptional pathway plays a critical role in modulating cold stress responses in Arabidopsis thaliana... 
Proteins | Altitude tolerance | Transcription factors | RESEARCH ARTICLES | Genes | Acclimatization | Gene expression regulation | Plants | Freezing | Plant cells | Seedlings | DEFENSE | BIOCHEMISTRY & MOLECULAR BIOLOGY | COLD-ACCLIMATION | LOW-TEMPERATURE | ANTHOCYANIN ACCUMULATION | PLANT SCIENCES | CELL BIOLOGY | REDUCES CHILLING INJURY | METHYL JASMONATE | GENE | MALE-STERILE | ABSCISIC-ACID | PROTEINS | Transcription, Genetic - drug effects | Arabidopsis - physiology | Adaptation, Physiological - drug effects | Structure-Activity Relationship | Arabidopsis Proteins - drug effects | Arabidopsis Proteins - metabolism | Basic Helix-Loop-Helix Transcription Factors - metabolism | Adaptation, Physiological - genetics | Stress, Physiological - drug effects | Repressor Proteins - metabolism | Protein Structure, Tertiary | Arabidopsis Proteins - genetics | Arabidopsis - drug effects | Stress, Physiological - genetics | Signal Transduction - genetics | Cyclopentanes - pharmacology | Mutation - genetics | Arabidopsis - genetics | Transcription Factors - metabolism | Up-Regulation - drug effects | Oxylipins - metabolism | Two-Hybrid System Techniques | Gene Expression Regulation, Plant - drug effects | Phenotype | Signal Transduction - drug effects | Genes, Plant - genetics | Models, Biological | Oxylipins - pharmacology | Protein Binding | Cyclopentanes - metabolism | Trans-Activators - metabolism | Arabidopsis thaliana | Physiological aspects | Instrument industry | Chemical properties
Journal Article
Human Molecular Genetics, ISSN 0964-6906, 2014, Volume 23, Issue 17, pp. 4491 - 4509
.... Moreover, it disrupts local helix formation in the presence of SDS, decreases binding to lipid vesicles C-terminal to the site of mutation and severely inhibits helical folding in the presence of acidic vesicles... 
WILD-TYPE | INCLUSION FORMATION | OXIDATIVE STRESS | HUMAN PLASMA | BIOCHEMISTRY & MOLECULAR BIOLOGY | GENETICS & HEREDITY | RAT-BRAIN NEURONS | MONOCLONAL-ANTIBODY | SOLUTION NMR-SPECTROSCOPY | PULSED ESR MEASUREMENTS | TRANSGENIC MICE | PHOSPHOLIPID-BINDING | Neurons - pathology | Humans | alpha-Synuclein - ultrastructure | Saccharomyces cerevisiae - drug effects | Protein Transport - drug effects | Brain - metabolism | Saccharomyces cerevisiae - metabolism | Cell Nucleus - metabolism | Protein Binding - drug effects | Sodium Dodecyl Sulfate - pharmacology | Cell Membrane - metabolism | Neurons - metabolism | alpha-Synuclein - genetics | Phosphorylation - drug effects | Buffers | Inclusion Bodies - metabolism | Neurons - drug effects | Protein Aggregation, Pathological - genetics | Cell Membrane - drug effects | Neuroblastoma - pathology | Protein Aggregates - drug effects | Cell Line | Parkinson Disease - pathology | Protein Structure, Secondary | Subcellular Fractions - drug effects | Cells, Cultured | Inclusion Bodies - drug effects | Mitochondria - metabolism | alpha-Synuclein - secretion | Mitochondria - drug effects | Parkinson Disease - genetics | Mutation - genetics | Subcellular Fractions - metabolism | alpha-Synuclein - chemistry | Brain - drug effects | Unilamellar Liposomes - metabolism | Nuclear Envelope - metabolism | Nuclear Envelope - drug effects | Cell Differentiation - drug effects | Brain - pathology | Cell Nucleus - drug effects | Index Medicus
Journal Article
The New phytologist, ISSN 0028-646X, 2016, Volume 210, Issue 1, pp. 208 - 226
In tomato ( ), high pigment mutations ( and ) were mapped to genes encoding UV-damaged DNA binding protein 1 (DDB1... 
Full papers | tomato (Solanum lycopersicum) | high pigment | de‐etiolated‐1 (DET1) | UV‐damaged DNA binding protein 1 (DDB1) | Cullin4 (CUL4) | plastid biogenesis | fruit quality | MBD | Tomato (Solanum lycopersicum) | High pigment | De-etiolated-1 (DET1) | Plastid biogenesis | Fruit quality | UV-damaged DNA binding protein 1 (DDB1) | MUTANT | DET1 | COMPLEX | UBIQUITIN LIGASE | DOWN-REGULATION | FRUIT-DEVELOPMENT | FAMILY | PLANT SCIENCES | de-etiolated-1 (DET1) | GENE | TRANSCRIPTION FACTOR | EXPRESSION | Transcription, Genetic - drug effects | Transcription, Genetic - radiation effects | Plant Development - drug effects | Methyl CpG Binding Domain | Plant Development - genetics | DNA-Binding Proteins - metabolism | Saccharomyces cerevisiae - metabolism | Plant Development - radiation effects | Pigmentation - radiation effects | Ubiquitination - drug effects | Pigmentation - genetics | Plant Proteins - chemistry | Light | Plants, Genetically Modified | Protein Binding - drug effects | Protein Binding - radiation effects | Lycopersicon esculentum - genetics | Plastids - metabolism | Plant Proteins - metabolism | Protein Stability - radiation effects | Fruit - genetics | Protein Multimerization - radiation effects | Lycopersicon esculentum - drug effects | Amino Acid Sequence | Lycopersicon esculentum - metabolism | Gene Expression Regulation, Plant - radiation effects | Pigmentation - drug effects | Genetic Pleiotropy | Lycopersicon esculentum - radiation effects | Subcellular Fractions - metabolism | Leupeptins - pharmacology | Gene Expression Regulation, Plant - drug effects | Phenotype | Protein Stability - drug effects | CpG Islands - genetics | Ubiquitination - radiation effects | Protein Multimerization - drug effects | Proteins | Physiological aspects | Tomatoes | Analysis | DNA | Protein binding
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 2014, Volume 111, Issue 16, pp. 6046 - 6051
.... Here, we demonstrate that IFN-inducible guanylate binding protein (Gbp) proteins stimulate caspase-11... 
Pathogens | Cell death | Bacteria | Infections | Legionella | Macrophages | Immunity | Cytosol | Vacuoles | Gram negative bacteria | Interferon | Nos2 | Immunity-related GTPases | LEGIONELLA-PNEUMOPHILA INFECTION | IMMUNITY | FLAGELLIN | cell death | RECOGNITION | MACROPHAGES | MULTIDISCIPLINARY SCIENCES | MECHANISMS | interferon | NONCANONICAL INFLAMMASOME ACTIVATION | immunity-related GTPases | VACUOLE | HOST-DEFENSE | TOXOPLASMA-GONDII | Membrane Glycoproteins - metabolism | Apoptosis - drug effects | NADPH Oxidases - metabolism | Cytoplasm - metabolism | Legionella pneumophila - growth & development | Caspases - metabolism | Legionnaires' Disease - microbiology | Salmonella typhimurium - drug effects | Macrophages - microbiology | Salmonella typhimurium - physiology | Mice, Inbred C57BL | Legionella pneumophila - drug effects | Enzyme Activation - drug effects | Mutation - genetics | NADPH Oxidase 2 | Macrophages - metabolism | Animals | Legionnaires' Disease - pathology | Lipopolysaccharides - pharmacology | Legionella pneumophila - physiology | Macrophages - drug effects | Mice | Macrophage Activation - drug effects | Cytoplasm - drug effects | Interferon-gamma - pharmacology | GTP-Binding Proteins - metabolism | Nitric Oxide Synthase Type II - metabolism | Physiological aspects | Protein research | Research | Binding proteins | Apoptosis | Biological Sciences
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 07/2012, Volume 32, Issue 28, pp. 9677 - 9689
Passive immunization against beta-amyloid (A beta) has become an increasingly desirable strategy as a therapeutic treatment for Alzheimer's disease (AD).... 
APP TRANSGENIC MICE | NATURAL OLIGOMERS | HUMAN IGG1 | ALZHEIMERS-DISEASE | PROTEIN-KINASE | LONG-TERM POTENTIATION | SYNAPTIC PLASTICITY | NEUROSCIENCES | PASSIVE-IMMUNIZATION | SECRETED OLIGOMERS | P38 MAP KINASE | Microglia - metabolism | Humans | Middle Aged | Male | Green Fluorescent Proteins - genetics | Neuroprotective Agents - metabolism | Alzheimer Disease - pathology | Neuroprotective Agents - pharmacology | Time Factors | Protein Binding - drug effects | Amyloid beta-Peptides - metabolism | Statistics, Nonparametric | Aged, 80 and over | Neurons - metabolism | p38 Mitogen-Activated Protein Kinases - metabolism | Alzheimer Disease - immunology | Receptors, Chemokine - genetics | Plaque, Amyloid - immunology | Disease Models, Animal | Animals, Newborn | Rats | Mice, Transgenic | Mutation - genetics | Rats, Sprague-Dawley | Microscopy, Confocal | Plaque, Amyloid - metabolism | Mice | CX3C Chemokine Receptor 1 | Alzheimer Disease - blood | Immunoglobulin G - metabolism | Tumor Necrosis Factor-alpha - metabolism | Dose-Response Relationship, Immunologic | Cerebral Cortex - cytology | Dose-Response Relationship, Drug | Immunoglobulin G - pharmacology | Female | Neurons - drug effects | Peptide Fragments - metabolism | Double-Blind Method | Enzyme-Linked Immunosorbent Assay | Microglia - drug effects | Plaque, Amyloid - pathology | Gene Expression Regulation - genetics | Gene Expression Regulation - immunology | Alzheimer Disease - therapy | Cells, Cultured | Presenilin-1 - genetics | Hippocampus - cytology | Gene Expression Regulation - drug effects | Amyloid beta-Protein Precursor - genetics | Animals | Amyloid beta-Peptides - immunology | Aged
Journal Article
Nature medicine, ISSN 1078-8956, 2017, Volume 23, Issue 9, pp. 1055 - 1062
.... The gene encoding the E3 ubiquitin ligase substrate-binding adaptor speckle-type POZ protein (SPOP... 
SELECTIVE-INHIBITION | TARGET | MEDICINE, RESEARCH & EXPERIMENTAL | ANDROGEN RECEPTOR | STEM-CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | ACUTE MYELOID-LEUKEMIA | ENHANCERS | CELL BIOLOGY | RNA-SEQ | BROMODOMAIN INHIBITION | MUTATIONS | BRD4 | Prostatic Neoplasms - metabolism | Immunoprecipitation | TOR Serine-Threonine Kinases - metabolism | Humans | Drug Resistance, Neoplasm | Male | Gene Expression Profiling | Molecular Targeted Therapy | Mechanistic Target of Rapamycin Complex 1 | Transcription Factors - drug effects | Multiprotein Complexes - metabolism | Prostatic Neoplasms - genetics | Proteasome Endopeptidase Complex - drug effects | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Nuclear Proteins - drug effects | Nuclear Proteins - genetics | Proto-Oncogene Proteins c-akt - metabolism | TOR Serine-Threonine Kinases - drug effects | Multiprotein Complexes - drug effects | Prostatic Neoplasms - drug therapy | Protein-Serine-Threonine Kinases - metabolism | Repressor Proteins - metabolism | RNA-Binding Proteins - antagonists & inhibitors | Triazoles - therapeutic use | Cell Survival | Repressor Proteins - genetics | Nuclear Proteins - metabolism | Transcription Factors - antagonists & inhibitors | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Azepines - therapeutic use | RNA-Binding Proteins - drug effects | Azepines - pharmacology | Transcription Factors - metabolism | Triazoles - pharmacology | Nuclear Proteins - antagonists & inhibitors | Protein-Serine-Threonine Kinases - drug effects | Cell Line, Tumor | Cell Proliferation - drug effects | Mutation | RNA-Binding Proteins - metabolism | rac1 GTP-Binding Protein - metabolism | Proto-Oncogene Proteins c-akt - drug effects | rac1 GTP-Binding Protein - genetics | Gene mutations | Physiological aspects | Genetic aspects | Research | Drug resistance | Drug therapy | Prostate cancer | Ubiquitin | Inhibitor drugs | Stabilization | AKT protein | Activation | Biosynthesis | Degradation | Proteins | Ubiquitination | Transcription activation | Ubiquitin-protein ligase | Binding | Rac1 protein | Tumor cell lines | Gene expression | Cholesterol | Mutants | Inhibitors | Proteasomes | Biomarkers | Bet protein | Prostate | Cancer | Guanosinetriphosphatase
Journal Article
Journal of Immunology, ISSN 0022-1767, 07/2015, Volume 195, Issue 2, pp. 661 - 671
CD47, a self recognition marker expressed on tissue cells, interacts with immunoreceptor SIRP alpha expressed on the surface of macrophages to initiate... 
SIGNAL | IN-VITRO | PHAGOCYTOSIS | INHIBITION | CALRETICULIN | THERAPEUTIC TARGET | REGULATORY PROTEIN-ALPHA | RED-BLOOD-CELLS | NEUTROPHIL TRANSMIGRATION | IMMUNOLOGY | EXPRESSION | Spleen - immunology | Apoptosis - drug effects | Apoptosis - radiation effects | Membrane Microdomains - radiation effects | Epithelial Cells - drug effects | Humans | Protein Transport - drug effects | Spleen - drug effects | beta-Cyclodextrins - pharmacology | CD47 Antigen - immunology | Phagocytosis - radiation effects | Ultraviolet Rays | Leukocytes, Mononuclear - immunology | Leukocytes, Mononuclear - radiation effects | Macrophages - radiation effects | Receptors, Immunologic - immunology | Epithelial Cells - cytology | Binding Sites | Macrophages - immunology | CD47 Antigen - genetics | Epithelial Cells - radiation effects | Phagocytosis - drug effects | Leukocytes, Mononuclear - drug effects | Signal Transduction | Mice, Inbred C57BL | CD47 Antigen - chemistry | Gene Expression Regulation | Spleen - cytology | Macrophages - cytology | Animals | Fibroblasts - radiation effects | Membrane Microdomains - drug effects | Protein Transport - radiation effects | Epithelial Cells - immunology | Fibroblasts - drug effects | Cell Line, Tumor | Protein Binding | Fibroblasts - immunology | Leukocytes, Mononuclear - cytology | Macrophages - drug effects | Spleen - radiation effects | Antigens, Differentiation - genetics | Fibroblasts - cytology | Mice | Primary Cell Culture | Receptors, Immunologic - genetics | Antigens, Differentiation - immunology
Journal Article
American Journal of Physiology - Endocrinology and Metabolism, ISSN 0193-1849, 2016, Volume 311, Issue 5, pp. E836 - E849
...; its dysregulation may provoke apoptosis and lead to muscle atrophy. We investigated the acute effects of alcohol ingestion on autophagic cell signaling responses to a bout of concurrent... 
Alcohol | Exercise | Autophagy | Protein | Apoptosis | alcohol | ACTIVATION | PHYSIOLOGY | autophagy | MITOCHONDRIAL BIOGENESIS | INCREASES | exercise | apoptosis | HUMAN SKELETAL-MUSCLE | MTOR | CELL-DEATH | DIRECT PHOSPHORYLATION | P53 | MESSENGER-RNA | RESISTANCE EXERCISE | protein | ENDOCRINOLOGY & METABOLISM | Molecular Chaperones - metabolism | Apoptosis - drug effects | Humans | Male | Autophagy - physiology | Alcohol Drinking | Carrier Proteins - drug effects | Autophagy - drug effects | Electron Transport Complex IV - metabolism | Transcription Factors - drug effects | Central Nervous System Depressants - pharmacology | Mitochondrial Proteins - drug effects | Young Adult | Organelle Biogenesis | Mitochondrial Proteins - metabolism | Dietary Proteins - pharmacology | Nuclear Respiratory Factor 1 - metabolism | Mitochondrial Proton-Translocating ATPases - drug effects | Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha - drug effects | Voltage-Dependent Anion Channel 1 - drug effects | Mitochondrial Degradation - physiology | Mitochondrial Proton-Translocating ATPases - metabolism | Cross-Over Studies | Signal Transduction - drug effects | Mitochondrial Degradation - drug effects | Adolescent | Electron Transport Complex IV - drug effects | Membrane Proteins - drug effects | Exercise - physiology | RNA-Binding Proteins - metabolism | Protein Kinases - metabolism | Muscle Fibers, Skeletal - drug effects | Healthy Volunteers | DNA-Binding Proteins - metabolism | Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha - metabolism | Adult | Molecular Chaperones - drug effects | Membrane Proteins - metabolism | DNA Fragmentation - drug effects | Muscle Fibers, Skeletal - physiology | Proto-Oncogene Proteins - metabolism | Protein Kinases - drug effects | Proto-Oncogene Proteins - drug effects | Dietary Carbohydrates - pharmacology | DNA-Binding Proteins - drug effects | Tumor Suppressor Protein p53 - metabolism | Voltage-Dependent Anion Channel 1 - metabolism | Tumor Suppressor Protein p53 - drug effects | Nuclear Respiratory Factor 1 - drug effects | RNA-Binding Proteins - drug effects | Transcription Factors - metabolism | Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - drug effects | Ethanol - pharmacology | Carrier Proteins - metabolism | Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - metabolism | Apoptosis - physiology | Autophagy (Cytology) | Cell research | Alcoholic beverages | Physiological aspects | Cellular signal transduction | Research
Journal Article
Cancer cell, ISSN 1535-6108, 2010, Volume 17, Issue 6, pp. 535 - 546
Castration-recurrent prostate cancer (CRPC) is suspected to depend on androgen receptor (AR). The AF-1 region in the amino-terminal domain (NTD) of AR contains... 
CELLCYCLE | CROSS-TALK | SIGNAL-TRANSDUCTION PATHWAYS | STEROID-BINDING | ONCOLOGY | INDEPENDENT TRANSCRIPTIONAL ACTIVATION | NUCLEAR RECEPTORS | CREB-BINDING-PROTEIN | FACTORS INDUCE | BISPHENOL-A | PROLIFERATION | EXPRESSION | CELL BIOLOGY | Protein Binding - genetics | Apoptosis - drug effects | Humans | Protein Conformation - drug effects | Transcriptional Activation - drug effects | Male | Neoplasm Recurrence, Local - pathology | Antineoplastic Agents, Hormonal - adverse effects | CREB-Binding Protein - metabolism | Prostate - pathology | Protein Binding - drug effects | Serine Endopeptidases - genetics | Prostate - drug effects | Prostate-Specific Antigen - metabolism | Benzhydryl Compounds - therapeutic use | Prostatic Neoplasms - drug therapy | Chlorohydrins - therapeutic use | Prostate-Specific Antigen - genetics | Prostate - anatomy & histology | DNA - metabolism | Prostate-Specific Antigen - blood | Androgens - pharmacology | Cell Line, Tumor | Ligands | Mice, Inbred NOD | Mice | Protein Multimerization - drug effects | Androgen Receptor Antagonists | Gene Expression - drug effects | Receptors, Androgen - metabolism | Neoplasm Recurrence, Local - drug therapy | Benzhydryl Compounds - adverse effects | Castration | Antineoplastic Agents, Hormonal - therapeutic use | Molecular Structure | Response Elements - genetics | Chlorohydrins - pharmacology | Chlorohydrins - adverse effects | Prostatic Neoplasms - pathology | Antineoplastic Agents, Hormonal - pharmacology | Prostatic Neoplasms - surgery | Protein Interaction Domains and Motifs - drug effects | Receptors, Steroid - drug effects | Mice, SCID | DNA - genetics | Xenograft Model Antitumor Assays | Animals | Benzhydryl Compounds - pharmacology | Cell Proliferation - drug effects | Chemical oceanography | Prostate cancer | Index Medicus
Journal Article