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Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 11/2016, Volume 36, Issue 11, pp. 2143 - 2151
APC (activated protein C), derived from the plasma protease zymogen, is antithrombotic and anti-inflammatory. In preclinical injury models, recombinant APC... 
neurogenesis | endothelial cells | anticoagulant | neurons | stroke | FOCAL ISCHEMIC-STROKE | TISSUE-PLASMINOGEN ACTIVATOR | REDUCED ANTICOAGULANT ACTIVITY | HIPPOCAMPAL-NEURONS | RECEPTOR 1 | ENDOTHELIAL-CELLS | COAGULATION-FACTOR VA | PERIPHERAL VASCULAR DISEASE | MICE | HEMATOLOGY | GLUTAMATE EXCITOTOXICITY | BRAIN | Neuroprotective Agents - therapeutic use | Recombinant Proteins - therapeutic use | Endothelial Protein C Receptor | Neurons - pathology | Reperfusion Injury - etiology | Receptor, PAR-1 - metabolism | Humans | Brain Ischemia - metabolism | Recombinant Proteins - adverse effects | Antigens, CD - metabolism | Brain - metabolism | Stroke - pathology | Intracranial Thrombosis - drug therapy | Neurogenesis - drug effects | Neurons - metabolism | Neuroprotective Agents - adverse effects | Neurons - drug effects | Reperfusion Injury - metabolism | Hemostasis - drug effects | Intracranial Thrombosis - pathology | Reperfusion Injury - pathology | Endothelial Cells - metabolism | Receptors, Cell Surface - agonists | Receptors, Cell Surface - metabolism | Stroke - drug therapy | Intracranial Thrombosis - metabolism | Brain - drug effects | Stroke - metabolism | Animals | Reperfusion Injury - prevention & control | Signal Transduction - drug effects | Brain Ischemia - drug therapy | Brain Ischemia - pathology | Brain - pathology | Endothelial Cells - pathology | Thrombolytic Therapy - adverse effects | Protein C - adverse effects | Protein C - therapeutic use | Endothelial Cells - drug effects | Receptor Cross-Talk - drug effects
Journal Article
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 03/2001, Volume 344, Issue 10, pp. 699 - 709
Journal Article
Archives of Disease in Childhood - Fetal and Neonatal Edition, ISSN 1359-2998, 11/2017, Volume 102, Issue 6, pp. F497 - F503
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 08/2004, Volume 351, Issue 9, pp. 884 - 892
Journal Article
American Journal of Respiratory and Critical Care Medicine, ISSN 1073-449X, 09/2007, Volume 176, Issue 5, pp. 483 - 490
Journal Article
Critical Care Medicine, ISSN 0090-3493, 06/2010, Volume 38 Suppl, Identification and Prevention of Common Adverse Drug Events in the Intensive Care Unit, Issue 6, pp. S198 - S218
Disorders of coagulation are common adverse drug events encountered in critically ill patients and present a serious concern for intensive care unit (ICU)... 
Critical illness | Thrombolytic | Prophylaxis | Reversal | Anticoagulation | Heparin | Low-molecular-weight heparin | Adverse drug event | Bleeding | Clotting | bleeding | clotting | critical illness | LOW-DOSE HEPARIN | anticoagulation | thrombolytic | ACUTE INTRACEREBRAL HEMORRHAGE | prophylaxis | ACTIVATED FACTOR-VII | heparin | EPSILON-AMINOCAPROIC ACID | reversal | INTERMITTENT PNEUMATIC COMPRESSION | DEEP VENOUS THROMBOSIS | ACUTE PULMONARY-EMBOLISM | MOLECULAR-WEIGHT HEPARIN | RECOMBINANT-FACTOR-VIIA | adverse drug event | low-molecular-weight heparin | CRITICALLY-ILL PATIENTS | CRITICAL CARE MEDICINE | Critical Care - methods | Blood Coagulation Disorders - chemically induced | Anti-Infective Agents - adverse effects | Humans | Thrombin - antagonists & inhibitors | Polysaccharides - adverse effects | Erythropoietin - adverse effects | Drug-Related Side Effects and Adverse Reactions - etiology | Antifibrinolytic Agents - adverse effects | Factor VIIa - adverse effects | Recombinant Proteins - adverse effects | Anticoagulants - adverse effects | Blood Coagulation Disorders - therapy | Deamino Arginine Vasopressin - adverse effects | Hemostatics - adverse effects | Fibrinolytic Agents - adverse effects | Vitamin K - antagonists & inhibitors | Blood Coagulation Factors - adverse effects | Colloids - adverse effects | Thromboembolism - drug therapy | Estrogens, Conjugated (USP) - adverse effects | Drug-Related Side Effects and Adverse Reactions - therapy | Protein C - adverse effects
Journal Article