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Journal Article
Nature, ISSN 0028-0836, 05/2016, Volume 534, Issue 7605, pp. 129 - 132
The epidermal growth factor receptor (EGFR)-directed tyrosine kinase inhibitors (TKIs) gefitinib, erlotinib and afatinib are approved treatments for non-small... 
CELL LUNG-CANCER | EGFR KINASE | GROWTH-FACTOR RECEPTOR | TARGETED THERAPIES | GEFITINIB | ACTIVATION | MECHANISM | MULTIDISCIPLINARY SCIENCES | MUTATIONS | AZD9291 | Lung Neoplasms - drug therapy | Receptor, Epidermal Growth Factor - genetics | Drug Resistance, Multiple - drug effects | Protein Conformation - drug effects | Lung Neoplasms - pathology | Receptor, Epidermal Growth Factor - metabolism | Antineoplastic Agents - pharmacology | Benzeneacetamides - pharmacology | Mutant Proteins - antagonists & inhibitors | Disease Models, Animal | Allosteric Regulation - drug effects | Carcinoma, Non-Small-Cell Lung - pathology | Drug Resistance, Multiple - genetics | Lung Neoplasms - enzymology | Allosteric Site - drug effects | Mutant Proteins - genetics | Cetuximab - pharmacology | Mutant Proteins - metabolism | Receptor, Epidermal Growth Factor - chemistry | Drug Synergism | Drug Resistance, Neoplasm - genetics | Animals | Mutant Proteins - chemistry | Cell Line, Tumor | Receptor, Epidermal Growth Factor - antagonists & inhibitors | Cell Proliferation - drug effects | Mice | Protein Kinase Inhibitors - pharmacology | Thiazoles - pharmacology | Carcinoma, Non-Small-Cell Lung - drug therapy | Carcinoma, Non-Small-Cell Lung - enzymology | Protein Multimerization - drug effects | Drug Resistance, Neoplasm - drug effects | Studies | Phosphorylation | Nuclear magnetic resonance--NMR | Epidermal growth factor | Mutation | Kinases | Enzyme kinetics | Tumors | Index Medicus
Journal Article
Cancer Research, ISSN 0008-5472, 10/2013, Volume 73, Issue 19, pp. 6024 - 6035
HER2/HER3 dimerization resulting from overexpression of HER2 or neuregulin (NRG1) in cancer leads to HER3-mediated oncogenic activation of phosphoinositide... 
CELLS | EXTRACELLULAR REGION | THERAPY | ERBB3 | ONCOLOGY | CRYSTAL-STRUCTURE | TYROSINE KINASE | METASTATIC BREAST-CANCER | LIGAND | FACTOR RECEPTOR | TRASTUZUMAB RESISTANCE | Receptor, ErbB-3 - metabolism | Immunoprecipitation | Humans | Protein Conformation - drug effects | Receptor, ErbB-2 - metabolism | Immunoblotting | Receptor, ErbB-3 - chemistry | Breast Neoplasms - metabolism | Receptor, Epidermal Growth Factor - metabolism | Receptor, ErbB-3 - immunology | Antibodies, Monoclonal, Humanized - pharmacology | Female | Receptor, ErbB-2 - antagonists & inhibitors | Receptor, ErbB-2 - immunology | Phosphorylation - drug effects | Tumor Cells, Cultured | Proto-Oncogene Proteins c-akt - metabolism | Signal Transduction | Receptor, ErbB-3 - antagonists & inhibitors | Survival Rate | Mice, SCID | Xenograft Model Antitumor Assays | Animals | Breast Neoplasms - pathology | Mice, Nude | Neuregulin-1 - metabolism | Receptor, Epidermal Growth Factor - antagonists & inhibitors | Breast Neoplasms - mortality | Mice, Inbred NOD | Cell Proliferation - drug effects | Mice | Mice, Inbred BALB C | Protein Multimerization - drug effects | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | Index Medicus | BASIC BIOLOGICAL SCIENCES | 60 APPLIED LIFE SCIENCES | PI-3 kinase | NRG | ligand-independent | Antibody | neuregulin | SCCHN | EGFR | resistance | feedback | HER | PIK3CA | cancer | HER2 | HER3 | ligand-dependent
Journal Article
Journal Article
NATURE, ISSN 0028-0836, 01/2011, Volume 469, Issue 7329, pp. 175 - 180
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 08/2014, Volume 34, Issue 34, pp. 11416 - 11425
Journal Article
Journal Article
Cancer Cell, ISSN 1535-6108, 2010, Volume 17, Issue 6, pp. 535 - 546
Castration-recurrent prostate cancer (CRPC) is suspected to depend on androgen receptor (AR). The AF-1 region in the amino-terminal domain (NTD) of AR contains... 
CELLCYCLE | CROSS-TALK | SIGNAL-TRANSDUCTION PATHWAYS | STEROID-BINDING | ONCOLOGY | INDEPENDENT TRANSCRIPTIONAL ACTIVATION | NUCLEAR RECEPTORS | CREB-BINDING-PROTEIN | FACTORS INDUCE | BISPHENOL-A | PROLIFERATION | EXPRESSION | CELL BIOLOGY | Protein Binding - genetics | Apoptosis - drug effects | Humans | Protein Conformation - drug effects | Transcriptional Activation - drug effects | Male | Neoplasm Recurrence, Local - pathology | Antineoplastic Agents, Hormonal - adverse effects | CREB-Binding Protein - metabolism | Prostate - pathology | Protein Binding - drug effects | Serine Endopeptidases - genetics | Prostate - drug effects | Prostate-Specific Antigen - metabolism | Benzhydryl Compounds - therapeutic use | Prostatic Neoplasms - drug therapy | Chlorohydrins - therapeutic use | Prostate-Specific Antigen - genetics | Prostate - anatomy & histology | DNA - metabolism | Prostate-Specific Antigen - blood | Androgens - pharmacology | Cell Line, Tumor | Ligands | Mice, Inbred NOD | Mice | Protein Multimerization - drug effects | Androgen Receptor Antagonists | Gene Expression - drug effects | Receptors, Androgen - metabolism | Neoplasm Recurrence, Local - drug therapy | Benzhydryl Compounds - adverse effects | Castration | Antineoplastic Agents, Hormonal - therapeutic use | Molecular Structure | Response Elements - genetics | Chlorohydrins - pharmacology | Chlorohydrins - adverse effects | Prostatic Neoplasms - pathology | Antineoplastic Agents, Hormonal - pharmacology | Prostatic Neoplasms - surgery | Protein Interaction Domains and Motifs - drug effects | Receptors, Steroid - drug effects | Mice, SCID | DNA - genetics | Xenograft Model Antitumor Assays | Animals | Benzhydryl Compounds - pharmacology | Cell Proliferation - drug effects | Chemical oceanography | Prostate cancer | Index Medicus
Journal Article
Nature, ISSN 0028-0836, 04/2016, Volume 532, Issue 7599, pp. 334 - 339
The serotonin transporter (SERT) terminates serotonergic signalling through the sodium-and chloride-dependent reuptake of neurotransmitter into presynaptic... 
HIGH-AFFINITY RECOGNITION | NEUROTRANSMITTER TRANSPORTERS | NOREPINEPHRINE TRANSPORTERS | N-LINKED GLYCOSYLATION | ALLOSTERIC BINDING | BACTERIAL HOMOLOG | MULTIDISCIPLINARY SCIENCES | BINDING-SITE | SELECTIVE RECOGNITION | MEMBRANE-PROTEINS | DOPAMINE TRANSPORTER | Citalopram - pharmacology | Humans | Protein Conformation - drug effects | Crystallography, X-Ray | Dopamine Plasma Membrane Transport Proteins - chemistry | Structure-Activity Relationship | Antidepressive Agents - metabolism | Citalopram - metabolism | Serotonin Plasma Membrane Transport Proteins - chemistry | Extracellular Space - metabolism | Antidepressive Agents - chemistry | Protein Binding - drug effects | Drug Design | Antidepressive Agents - pharmacology | Protein Stability | Allosteric Regulation - drug effects | Ions - chemistry | Serotonin Plasma Membrane Transport Proteins - immunology | Allosteric Site - drug effects | Models, Molecular | Ions - metabolism | Paroxetine - metabolism | Serotonin Plasma Membrane Transport Proteins - metabolism | Citalopram - chemistry | Intracellular Space - metabolism | Serotonin - metabolism | Ligands | Immunoglobulin Fab Fragments - immunology | Paroxetine - pharmacology | Paroxetine - chemistry | Drug metabolism | Paroxetine | Physiological research | Research | Serotonin | Binding sites (Biochemistry) | X rays | Mutation | Antidepressants | Binding sites | Index Medicus
Journal Article