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2010, 1. Aufl., ISBN 0470411961, xxii, 486
This book gives pharmaceutical scientists an up-to-date resource on protein aggregation and its consequences, and available methods to control or slow down the... 
Development | Pharmacology | Drug Discovery | MEDICAL | Protein drugs | Aggregation (Chemistry)
Book
Proceedings of the National Academy of Sciences - PNAS, ISSN 0027-8424, 11/2010, Volume 107, Issue 46, pp. 19808 - 19813
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 03/2006, Volume 103, Issue 13, pp. 4918 - 4923
Journal Article
PloS one, ISSN 1932-6203, 04/2013, Volume 8, Issue 4, pp. e61418 - e61418
Gaucher's disease (GD) is characterized by loss of lysosomal glucocerebrosidase (GC) activity. Mutations in the gene encoding GC destabilize the protein's native folding leading to ER-associated degradation... 
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Glucosylceramidase - genetics | Gene Silencing - drug effects | Calcium - metabolism | Humans | Cytosol - drug effects | Endoplasmic Reticulum - metabolism | Protein Transport - drug effects | Gaucher Disease - pathology | Proto-Oncogene Proteins c-bcl-2 - metabolism | Lysosomes - metabolism | Protein Folding - drug effects | Endoplasmic Reticulum - drug effects | Cytoprotection - drug effects | Cell Death - drug effects | Endoplasmic Reticulum-Associated Degradation - drug effects | Homeostasis - drug effects | Fibroblasts - metabolism | Gaucher Disease - enzymology | Lysosomes - drug effects | Unfolded Protein Response - drug effects | Heat-Shock Proteins - metabolism | Mutant Proteins - metabolism | Glucosylceramidase - metabolism | Fibroblasts - pathology | Mutation - genetics | Up-Regulation - drug effects | Fibroblasts - drug effects | Dihydropyridines - pharmacology | Cytosol - metabolism | Enzymes | Genetic aspects | Apoptosis | Disease | Homeostasis | Ryanodine receptors | Remodeling | Guanylate cyclase | Retention | Modulators | Degradation | Proteins | Receptors | Protein folding | Calcium channels (L-type) | Fibroblasts | Bone marrow | Membrane trafficking | Glucosylceramidase | Mutation | Inhibition | Endoplasmic reticulum | Cytoplasm | Folding | Calcium homeostasis | Index Medicus
Journal Article
Current medicinal chemistry, ISSN 0929-8673, 01/2019, Volume 26, Issue 42, pp. 7537 - 7554
...) structures of proteins, thus providing basic knowledge for rational drug design. Understanding the folding mechanism of proteins is valuable for predicting their 3D structures and for designing proteins with new functions and medicinal applications... 
Pharmacology & Pharmacy | Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Chemistry, Medicinal | Science & Technology | Amino Acid Sequence | Phosphorylation | Temperature | Proteins - metabolism | Protein Conformation | Glycosylation | Protein Processing, Post-Translational | Acetylation | Protein Folding | Sequences | Enthalpy | Entropy | Perturbation | Drug development | Paradoxes | Environmental effects | Free energy | Proteins | Protein folding | Environment | Protein structure | Folding
Journal Article