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Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 10/2009, Volume 106, Issue 42, pp. 17841 - 17846
Journal Article
Genes and Development, ISSN 0890-9369, 05/2013, Volume 27, Issue 10, pp. 1101 - 1114
Tumorigenesis results from dysregulation of oncogenes and tumor suppressors that influence cellular proliferation, differentiation, apoptosis, and/or... 
Huwe1 | c-Myc | Mule | Ras | p21 | Miz1 | DNA-DAMAGE | KERATINOCYTE GROWTH | DEVELOPMENTAL BIOLOGY | CELL BIOLOGY | BASE EXCISION-REPAIR | HUWE1 UBIQUITIN LIGASE | NEGATIVE REGULATION | GENETICS & HEREDITY | ARF TUMOR-SUPPRESSOR | DIFFERENTIATION | MIZ-1 | HUMAN CANCER | Protein Inhibitors of Activated STAT - deficiency | Tetradecanoylphorbol Acetate - pharmacology | 9,10-Dimethyl-1,2-benzanthracene - pharmacology | Male | Protein Inhibitors of Activated STAT - metabolism | Cyclin-Dependent Kinase Inhibitor p15 - biosynthesis | Oncogene Protein p21(ras) - metabolism | Cyclin-Dependent Kinase Inhibitor p16 | Oncogene Protein p21(ras) - antagonists & inhibitors | Cyclin-Dependent Kinase Inhibitor p21 - genetics | Cell Transformation, Neoplastic - genetics | Cyclin-Dependent Kinase Inhibitor p15 - genetics | Nuclear Proteins - deficiency | Protein Inhibitors of Activated STAT - genetics | Cyclin-Dependent Kinase Inhibitor p21 - metabolism | Female | Nuclear Proteins - genetics | Protein Inhibitors of Activated STAT - antagonists & inhibitors | Skin Neoplasms - pathology | Cyclin-Dependent Kinase Inhibitor p21 - biosynthesis | Signal Transduction | Down-Regulation | Cells, Cultured | Ubiquitin-Protein Ligases - metabolism | Nuclear Proteins - metabolism | Skin Neoplasms - chemically induced | Proto-Oncogene Proteins c-myc - metabolism | Mice, Knockout | Skin Neoplasms - metabolism | Keratinocytes - pathology | Animals | Tumor Suppressor Protein p53 | Keratinocytes - drug effects | Keratinocytes - metabolism | Nuclear Proteins - antagonists & inhibitors | Proto-Oncogene Proteins c-myc - deficiency | Skin Neoplasms - genetics | Proto-Oncogene Proteins c-myc - antagonists & inhibitors | Ubiquitin-Protein Ligases - deficiency | Mice | Proto-Oncogene Proteins c-myc - genetics | Cyclin-Dependent Kinase Inhibitor p15 - metabolism | Genes, ras | Ubiquitin-Protein Ligases - genetics | Oncogene Protein p21(ras) - genetics | Carcinogenesis | Ras genes | Analysis | Research Paper
Journal Article
Nature, ISSN 0028-0836, 12/2009, Volume 462, Issue 7275, pp. 935 - 939
Journal Article
Molecular Cell, ISSN 1097-2765, 01/2015, Volume 57, Issue 1, pp. 150 - 164
We show that central components of the Fanconi anemia (FA) DNA repair pathway, the tumor suppressor proteins FANCI and FANCD2 (the ID complex), are SUMOylated... 
E3 LIGASE | REPAIR | SEGREGASE | PROTEIN | FANCD2 | PATHWAY | BIOCHEMISTRY & MOLECULAR BIOLOGY | DVC1 C1ORF124 | RNF4 | IDENTIFICATION | SUMOYLATION | CELL BIOLOGY | Hydroxyurea - pharmacology | Ataxia Telangiectasia Mutated Proteins - metabolism | Fanconi Anemia Complementation Group D2 Protein - genetics | Humans | Ubiquitin - metabolism | Protein Inhibitors of Activated STAT - metabolism | Recombinant Fusion Proteins - metabolism | Small Ubiquitin-Related Modifier Proteins - genetics | Poly-ADP-Ribose Binding Proteins | Fanconi Anemia Complementation Group Proteins - metabolism | Ubiquitination | Cysteine Endopeptidases - metabolism | HEK293 Cells | Protein Inhibitors of Activated STAT - genetics | Protein Interaction Domains and Motifs | Nuclear Proteins - genetics | Signal Transduction | Small Ubiquitin-Related Modifier Proteins - metabolism | Fanconi Anemia Complementation Group Proteins - genetics | Gene Expression Regulation | Nuclear Proteins - metabolism | Ubiquitin - genetics | Transcription Factors - genetics | Transcription Factors - metabolism | Fanconi Anemia Complementation Group D2 Protein - metabolism | Cysteine Endopeptidases - genetics | Cell Line, Tumor | Protein Binding | Recombinant Fusion Proteins - genetics | Sumoylation | DNA Damage | Ataxia Telangiectasia Mutated Proteins - genetics | Ubiquitin | Sumo | Proteases | Ligases | DNA damage | DNA | Molecular biology | Fanconi's anemia
Journal Article
Journal Article
Journal Article
by Li, R and Wei, J and Jiang, C and Liu, DM and Deng, L and Zhang, K and Wang, P
CANCER RESEARCH, ISSN 0008-5472, 09/2013, Volume 73, Issue 18, pp. 5742 - 5753
Proto-oncogene Akt plays essential roles in cell proliferation and tumorigenesis. Full activation of Akt is regulated by phosphorylation, ubiquitination, and... 
E3 LIGASE | PIAS PROTEINS | UBIQUITINATION | ACTIVATION | SUMO | ONCOLOGY | PROTEIN SUMOYLATION | KINASE | DEGRADATION | CANCER | REVEALS | RNA, Small Interfering - genetics | Phosphorylation | Adenocarcinoma - pathology | Cell Proliferation | Immunoprecipitation | Humans | Lung Neoplasms - metabolism | Lung Neoplasms - pathology | Male | Protein Inhibitors of Activated STAT - metabolism | Wound Healing | Embryo, Mammalian - metabolism | Immunoenzyme Techniques | Proto-Oncogene Proteins c-akt - genetics | Ubiquitination | Adenocarcinoma - metabolism | Protein Inhibitors of Activated STAT - genetics | Adenocarcinoma - genetics | Proto-Oncogene Proteins c-akt - metabolism | Real-Time Polymerase Chain Reaction | Protein Inhibitors of Activated STAT - antagonists & inhibitors | Fibroblasts - metabolism | Lung Neoplasms - genetics | RNA, Messenger - genetics | Cells, Cultured | Ubiquitin-Conjugating Enzymes - genetics | Mice, SCID | Reverse Transcriptase Polymerase Chain Reaction | Cell Transformation, Neoplastic - metabolism | Blotting, Western | Animals | Embryo, Mammalian - cytology | Mice, Nude | Ubiquitin-Conjugating Enzymes - metabolism | Fluorescent Antibody Technique | Sumoylation | Mice, Inbred NOD | Fibroblasts - cytology | Mice | Mice, Inbred BALB C | Ubiquitin-Conjugating Enzymes - antagonists & inhibitors | Cell Transformation, Neoplastic - pathology | Apoptosis
Journal Article
Diabetes, ISSN 0012-1797, 12/2015, Volume 64, Issue 12, pp. 4061 - 4074
Journal Article
Genome Research, ISSN 1088-9051, 10/2013, Volume 23, Issue 10, pp. 1563 - 1579
Journal Article
PLoS ONE, ISSN 1932-6203, 03/2012, Volume 7, Issue 3, p. e32777
Background: Lying downstream of a myriad of cytokine receptors, the Janus kinase (JAK) - Signal transducer and activator of transcription (STAT) pathway is... 
GENOME DUPLICATION | ADAPTIVE IMMUNITY | PIAS PROTEINS | SIGNALING PATHWAYS | JAK/STAT PATHWAY | INTERLEUKIN-2 IL-2 | SOCS PROTEINS | BIOLOGY | GENE-ACTIVATION | PROTEIN-TYROSINE-PHOSPHATASE | CYTOKINE RECEPTORS | Janus Kinases - genetics | Signal Transduction | Humans | STAT Transcription Factors - metabolism | Synteny | Suppressor of Cytokine Signaling Proteins - genetics | Janus Kinases - metabolism | Protein Inhibitors of Activated STAT - metabolism | Receptors, Cytoplasmic and Nuclear - genetics | Phylogeny | Receptors, Cytoplasmic and Nuclear - classification | Janus Kinases - classification | Protein Inhibitors of Activated STAT - classification | STAT Transcription Factors - genetics | Animals | Immune System - metabolism | Models, Biological | Protein Inhibitors of Activated STAT - genetics | STAT Transcription Factors - classification | Suppressor of Cytokine Signaling Proteins - classification | Suppressor of Cytokine Signaling Proteins - metabolism | Evolution, Molecular | Receptors, Cytoplasmic and Nuclear - metabolism | Tyrosine | Proteins | Phosphatases | Cytokines | Analysis | Genomics | Immune system | Regulators | Adaptive systems | Intercellular signalling | Phosphorylation | Transcription factors | Transcription | Genes | Biological evolution | Cytokine receptors | Genomes | Cell interactions | Kinases | Phosphatase | Immunity | Receptors | Reproduction (copying) | Rodents | Emergence | Janus kinase | Evolution | Expansion | Medical research | Upstream | Adaptive immunity | Mammals | Vertebrates | Communications systems | Hypotheses | Stem cells | Mutation | Protein-tyrosine-phosphatase | Signal transduction | Bioinformatics
Journal Article