X
Search Filters
Format Format
Format Format
X
Sort by Item Count (A-Z)
Filter by Count
Journal Article (111815) 111815
Book Chapter (639) 639
Newspaper Article (393) 393
Newsletter (77) 77
Magazine Article (72) 72
Book / eBook (51) 51
Conference Proceeding (34) 34
Reference (12) 12
Trade Publication Article (10) 10
Dissertation (9) 9
Book Review (5) 5
Transcript (2) 2
Government Document (1) 1
Publication (1) 1
Web Resource (1) 1
more...
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
humans (52844) 52844
animals (43862) 43862
proteins (39388) 39388
cell biology (20788) 20788
biochemistry & molecular biology (20596) 20596
gene expression (20218) 20218
multidisciplinary sciences (19071) 19071
mice (18906) 18906
signal transduction (17243) 17243
research (17216) 17216
kinases (15916) 15916
male (15711) 15711
expression (15575) 15575
research article (15452) 15452
cancer (15432) 15432
apoptosis (15083) 15083
female (14267) 14267
medicine (14210) 14210
phosphorylation (14048) 14048
analysis (13170) 13170
science (12425) 12425
biology (12177) 12177
oncology (11611) 11611
activation (11548) 11548
genetic aspects (11468) 11468
physiological aspects (10889) 10889
mutation (10725) 10725
genes (10670) 10670
neurosciences (10038) 10038
protein (9831) 9831
rats (9277) 9277
cell line, tumor (9271) 9271
health aspects (8714) 8714
protein binding (8588) 8588
inflammation (8324) 8324
genomes (7958) 7958
rodents (7827) 7827
gene-expression (7707) 7707
cells, cultured (7639) 7639
biochemistry (7530) 7530
binding sites (7418) 7418
cells (6972) 6972
signal transduction - drug effects (6865) 6865
genetics (6812) 6812
life sciences (6797) 6797
tumors (6640) 6640
enzymes (6579) 6579
studies (6550) 6550
genetics & heredity (6453) 6453
immunology (6434) 6434
cell line (6331) 6331
identification (6331) 6331
oxidative stress (6305) 6305
physiology (6216) 6216
models, molecular (6142) 6142
metabolism (6117) 6117
ligands (5993) 5993
inhibition (5933) 5933
amino acid sequence (5931) 5931
binding (5928) 5928
microbiology (5911) 5911
cell cycle (5888) 5888
genomics (5871) 5871
transcription (5788) 5788
deoxyribonucleic acid--dna (5728) 5728
map kinase (5632) 5632
cell proliferation (5602) 5602
molecular sequence data (5497) 5497
transcription factors (5441) 5441
pharmacology & pharmacy (5415) 5415
cytokines (5199) 5199
molecular biology (4953) 4953
review (4899) 4899
in-vitro (4787) 4787
care and treatment (4712) 4712
proteomics (4669) 4669
biotechnology & applied microbiology (4585) 4585
gene (4564) 4564
apoptosis - drug effects (4546) 4546
signaling (4544) 4544
growth (4531) 4531
biophysics (4519) 4519
brain (4498) 4498
medical research (4461) 4461
medicine, research & experimental (4457) 4457
disease (4373) 4373
middle aged (4370) 4370
adult (4349) 4349
metastasis (4335) 4335
peptides (4334) 4334
breast cancer (4211) 4211
biotechnology (4204) 4204
stem cells (4204) 4204
biology and life sciences (4196) 4196
chemistry (4159) 4159
development and progression (4151) 4151
in-vivo (4151) 4151
nf-kappa-b (4117) 4117
mice, inbred c57bl (4102) 4102
gene expression profiling (4015) 4015
more...
Library Location Library Location
Library Location Library Location
X
Sort by Item Count (A-Z)
Filter by Count
Gerstein Science - Stacks (14) 14
UofT at Mississauga - Stacks (5) 5
Collection Dvlpm't (Acquisitions) - Vendor file (4) 4
St. Michael's College (John M. Kelly) - 2nd Floor (3) 3
Sunnybrook Health Sciences Centre - Sunnybrook Stacks (3) 3
Victoria University E.J. Pratt - Oversize (3) 3
Earth Sciences (Noranda) - Circulation Desk (2) 2
Earth Sciences (Noranda) - Oversize (2) 2
Earth Sciences (Noranda) - Stacks (2) 2
Gerstein Science - Circulation Desk (2) 2
Gerstein Science - Reserve desk (2) 2
Trinity College (John W Graham) - Stacks (2) 2
UofT at Mississauga - Circulation Desk (2) 2
Victoria University E.J. Pratt - Circulation Desk (2) 2
Online Resources - Online (1) 1
Physics - Course Reserves (1) 1
Robarts - Stacks (1) 1
St. Michael's Hospital - Stacks (1) 1
UofT at Scarborough - Stacks (1) 1
more...
Language Language
Language Language
X
Sort by Item Count (A-Z)
Filter by Count
English (113111) 113111
Japanese (151) 151
German (91) 91
Norwegian (45) 45
Portuguese (37) 37
Dutch (26) 26
Chinese (22) 22
French (12) 12
Russian (8) 8
Italian (5) 5
Czech (3) 3
Polish (3) 3
Croatian (2) 2
Spanish (2) 2
Arabic (1) 1
Slovak (1) 1
more...
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


Molecular cell, ISSN 1097-2765, 2016, Volume 63, Issue 3, pp. 514 - 525
An emerging therapeutic strategy for cancer is to induce selective lethality in a tumor by exploiting interactions between its driving mutations and specific drug targets... 
COMBINED INHIBITION | FISSION YEAST | REPAIR | TUMOR MUTATIONS | STRATEGY | BIOCHEMISTRY & MOLECULAR BIOLOGY | GENETIC INTERACTION MAP | DNA-DAMAGE | SACCHAROMYCES-CEREVISIAE | DRUGGABLE GENOME | CHK1 INHIBITION | CELL BIOLOGY | Protein Interaction Maps - drug effects | RecQ Helicases - metabolism | Saccharomyces cerevisiae - genetics | Humans | RecQ Helicases - genetics | Saccharomyces cerevisiae - drug effects | Antineoplastic Agents - therapeutic use | Synthetic Lethal Mutations | Gene Regulatory Networks - drug effects | Molecular Targeted Therapy | Dose-Response Relationship, Drug | Saccharomyces cerevisiae - metabolism | Gene Expression Regulation, Fungal - drug effects | Transfection | RNA Interference | Time Factors | Uterine Cervical Neoplasms - metabolism | Cell Cycle Proteins - genetics | Female | Gene Expression Regulation, Neoplastic - drug effects | Genes, Tumor Suppressor | Uterine Cervical Neoplasms - mortality | Cell Survival - drug effects | Genetic Predisposition to Disease | Cell Cycle Proteins - metabolism | Kaplan-Meier Estimate | Uterine Cervical Neoplasms - drug therapy | Saccharomyces cerevisiae Proteins - genetics | Uterine Cervical Neoplasms - genetics | Phenotype | Signal Transduction - drug effects | Saccharomyces cerevisiae Proteins - metabolism | Biomarkers, Tumor - genetics | Cell Proliferation - drug effects | HeLa Cells | Mutation | Precision Medicine - methods | Antimitotic agents | Care and treatment | Analysis | Drug therapy, Combination | Antineoplastic agents | Health aspects | Phosphotransferases | Cancer
Journal Article
Journal Article
Journal Article
Journal Article
Journal Article
PloS one, ISSN 1932-6203, 07/2017, Volume 12, Issue 7, p. e0180616
Background Acquired drug resistance to the chemotherapeutic drug irinotecan (the active metabolite of which is... 
LIVER METASTASES | PROTEIN-INTERACTION NETWORKS | DIFFERENTIAL EXPRESSION | BINDING PEPTIDE | MULTIDISCIPLINARY SCIENCES | ADJUVANT TREATMENT | TUMOR-CELLS | OVARIAN-CANCER | CLINICAL-PRACTICE | MOLECULAR-BASIS | THYMIDYLATE-SYNTHASE | Protein Interaction Maps - drug effects | Colorectal Neoplasms - genetics | Genes, Neoplasm | HCT116 Cells | Humans | Kaplan-Meier Estimate | Gene Expression Profiling | Signal Transduction - genetics | Down-Regulation - drug effects | Up-Regulation - drug effects | Drug Resistance, Neoplasm - genetics | MAP Kinase Signaling System - drug effects | MAP Kinase Signaling System - genetics | Protein Interaction Maps - genetics | Signal Transduction - drug effects | Gene Expression Regulation, Neoplastic - drug effects | Camptothecin - pharmacology | Gene Ontology | Camptothecin - analogs & derivatives | Drug Resistance, Neoplasm - drug effects | Colorectal cancer | Cellular signal transduction | Genetic aspects | Research | Biological markers | Drug therapy | Drug resistance | Correlation | Fibroblast growth factor receptor 9 | Colorectal carcinoma | Genes | Metastasis | Kinases | Autophagy | Cancer therapies | Proteins | Disease resistance | Databases | Pathways | Surgery | Deoxyribonucleic acid--DNA | Fibroblast growth factor 2 | Bone morphogenetic protein 6 | Medical research | MAP kinase | RNA polymerase | Gene expression | Patients | Survival | Medicine | Irinotecan | Chemotherapy | Hospitals | Brain-derived neurotrophic factor | Medical prognosis | Biomarkers | Transduction | Clinical medicine | Gene mapping | Protein interaction | Binding sites | Tumors | Cancer | Apoptosis | Deoxyribonucleic acid | DNA
Journal Article
Nature communications, ISSN 2041-1723, 2017, Volume 8, Issue 1, p. 14356
.... Integration of cancer genes into networks offers opportunities to reveal protein-protein interactions (PPIs... 
CELL LUNG-CANCER | BREAST-CANCER | SWI/SNF COMPLEX | INHIBITION | INTEGRATION | DATABASE | LANDSCAPE | SCALE MAP | MULTIDISCIPLINARY SCIENCES | KINASE | LKB1 | Lung Neoplasms - drug therapy | Protein Interaction Domains and Motifs - physiology | Cyclin-Dependent Kinase 4 - genetics | Genomics | Humans | Lung Neoplasms - metabolism | Gene Regulatory Networks - drug effects | Molecular Targeted Therapy | Neoplasm Proteins - metabolism | Oncogenes - physiology | Genes, Tumor Suppressor - drug effects | Protein Interaction Domains and Motifs - genetics | Databases, Protein | Tumor Suppressor Proteins - genetics | Gene Expression Regulation, Neoplastic - drug effects | Protein Stability | Neoplasm Proteins - genetics | Nuclear Proteins - genetics | Gene Expression Regulation, Neoplastic - genetics | Protein-Serine-Threonine Kinases - metabolism | Lung Neoplasms - genetics | Cell Survival - drug effects | Oncogenes - genetics | Histone-Lysine N-Methyltransferase - genetics | Tumor Suppressor Proteins - metabolism | Gene Regulatory Networks - genetics | Protein Interaction Domains and Motifs - drug effects | Protein-Serine-Threonine Kinases - genetics | Nuclear Proteins - metabolism | Signal Transduction - genetics | Transcription Factors - genetics | Cyclin-Dependent Kinase 4 - metabolism | Protein Interaction Mapping | Transcription Factors - metabolism | Histone-Lysine N-Methyltransferase - metabolism | Signal Transduction - drug effects | Genes, myc - genetics | Cell Line, Tumor | Oncogenes - drug effects | Protein Kinase Inhibitors - pharmacology | Cell Cycle Proteins
Journal Article
The Journal of neuroscience, ISSN 1529-2401, 2006, Volume 26, Issue 37, pp. 9439 - 9447
...)-PI3K interaction within the same population of neurons or whether E-2 activation of extracellular signal-regulated kinase 1/2 (ERK1/2... 
Estrogen receptor | Estrogen signaling | PI3K | Therapeutic development | Akt | Estrogen therapy | MAPK | Alzheimer's disease | estrogen therapy | MEDIATED NEUROPROTECTION | estrogen receptor | AktD | MEDROXYPROGESTERONE ACETATE | estrogen signaling | POTENTIAL INITIATION MECHANISM | PHOSPHOINOSITIDE 3-KINASE | HIPPOCAMPAL-NEURONS | NEUROSCIENCES | therapeutic development | CALCIUM-CHANNELS | SEXUAL-DIFFERENTIATION | ENDOTHELIAL-CELLS | CENTRAL-NERVOUS-SYSTEM | GROWTH-FACTOR-I | Estrogen Replacement Therapy | Protein Subunits - drug effects | MAP Kinase Signaling System - physiology | Receptors, Estrogen - metabolism | Estrogens - pharmacology | Extracellular Signal-Regulated MAP Kinases - drug effects | Phosphatidylinositol 3-Kinases - metabolism | Extracellular Signal-Regulated MAP Kinases - metabolism | Neuroprotective Agents - metabolism | Protein Subunits - metabolism | Neuroprotective Agents - pharmacology | Alzheimer Disease - prevention & control | Phosphatidylinositol 3-Kinases - drug effects | Cerebral Cortex - drug effects | Phosphorylation - drug effects | Estrogens - metabolism | Neurons - drug effects | Oncogene Protein v-akt - metabolism | Estradiol - pharmacology | Estradiol - metabolism | Alzheimer Disease - physiopathology | Cerebral Cortex - enzymology | Receptors, Estrogen - agonists | Oncogene Protein v-akt - drug effects | Cells, Cultured | Rats | Enzyme Activation - drug effects | Rats, Sprague-Dawley | Animals | MAP Kinase Signaling System - drug effects | Neurons - enzymology | Enzyme Activation - physiology
Journal Article
Journal Article
Journal Article
PloS one, ISSN 1932-6203, 03/2014, Volume 9, Issue 3, p. e92917
.... Here, we construct a light-gated protein-protein interaction system to regulate the activation pattern of the Raf/MEK/ERK signaling pathway... 
PHEOCHROMOCYTOMA CELLS | SIGNALING PATHWAYS | ACTIVATED PROTEIN-KINASE | MAP KINASE | MULTIDISCIPLINARY SCIENCES | NEURONAL DIFFERENTIATION | MAMMALIAN-CELLS | PLASMA-MEMBRANE | NUCLEAR TRANSLOCATION | NERVE GROWTH-FACTOR | LIVING CELLS | NIH 3T3 Cells | Protein Transport - drug effects | Extracellular Signal-Regulated MAP Kinases - metabolism | raf Kinases - metabolism | PC12 Cells | Light | Cell Membrane - metabolism | Cell Membrane - drug effects | Neurites - drug effects | Cell Membrane - radiation effects | Cryptochromes - metabolism | Cell Differentiation - radiation effects | Protein Structure, Tertiary | MAP Kinase Signaling System - radiation effects | Proto-Oncogene Proteins c-raf | Nerve Growth Factor - pharmacology | Rats | MAP Kinase Kinase Kinases - metabolism | Neurites - metabolism | Enzyme Activation - drug effects | Enzyme Activation - radiation effects | Animals | MAP Kinase Signaling System - drug effects | Cell Differentiation - drug effects | Protein Transport - radiation effects | Cryptochromes - chemistry | Mice | Kinetics | Dose-Response Relationship, Radiation | Neurites - radiation effects | Nerve growth factor | Cellular signal transduction | Epidermal growth factor | Protein-protein interactions | Phosphorylation | Raf protein | Stimulation | Activation | Kinases | Proteins | Signal transduction | Cell growth | Cell cycle | Localization | Growth factors | Axonogenesis | Extracellular signal-regulated kinase | Gene expression | Studies | Signaling | Cell lines | Pheochromocytoma cells | Transduction | Genetic engineering | Protein interaction
Journal Article