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1. Full Text Structural basis of Nav1.7 inhibition by an isoform-selective small-molecule antagonist
by Ahuja, Shivani and Mukund, Susmith and Deng, Lunbin and Khakh, Kuldip and Chang, Elaine and Ho, Hoangdung and Shriver, Stephanie and Young, Clint and Lin, Sophia and Johnson, J.P and Wu, Ping and Li, Jun and Coons, Mary and Tam, Christine and Brillantes, Bobby and Sampang, Honorio and Mortara, Kyle and Bowman, Krista K and Clark, Kevin R and Estevez, Alberto and Xie, Zhiwei and Verschoof, Henry and Grimwood, Michael and Dehnhardt, Christoph and Andrez, Jean-Christophe and Focken, Thilo and Sutherlin, Daniel P and Safina, Brian S and Starovasnik, Melissa A and Ortwine, Daniel F and Franke, Yvonne and Cohen, Charles J and Hackos, David H and Koth, Christopher M and Payandeh, Jian
Science (American Association for the Advancement of Science), ISSN 0036-8075, 12/2015, Volume 350, Issue 6267, pp. aac5464 - aac5464
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Protein Structure, Tertiary | Amino Acid Sequence | Protein Structure, Secondary | Sulfonamides - chemistry | Humans | Models, Molecular | Molecular Sequence Data | Crystallography, X-Ray | Sodium Channel Blockers - pharmacology | Sulfonamides - pharmacology | Cell Membrane - chemistry | NAV1.7 Voltage-Gated Sodium Channel - chemistry | Pain Perception - drug effects | DNA Mutational Analysis | Protein Isoforms - chemistry | Thiadiazoles - chemistry | Protein Engineering | NAV1.7 Voltage-Gated Sodium Channel - genetics | Sodium Channel Blockers - chemistry | Crystallization - methods | Protein Isoforms - antagonists & inhibitors | Thiadiazoles - pharmacology | Pharmacology | Biophysics | Molecular biology | Crystal structure | Index Medicus | Design engineering | Electric potential | Inhibitors | Pain | Sodium | Bacteria | Perception | Channels
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2. Full Text P53 isoforms regulate astrocyte-mediated neuroprotection and neurodegeneration
by Turnquist, C and Horikawa, I and Foran, E and Major, E.O and Vojtesek, B and Lane, D.P and Lu, X and Harris, B.T and Harris, C.C
Cell death and differentiation, ISSN 1350-9047, 09/2016, Volume 23, Issue 9, pp. 1515 - 1528
Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Alternative Splicing | Tumor Suppressor Protein p53 - antagonists & inhibitors | Coculture Techniques | Humans | Neurons - cytology | Serine-Arginine Splicing Factors - metabolism | Serine-Arginine Splicing Factors - genetics | Autophagy - drug effects | Tumor Suppressor Protein p53 - genetics | Alzheimer Disease - pathology | Brain - metabolism | Protein Isoforms - metabolism | RNA Interference | Cellular Senescence | Neurons - metabolism | Interleukin-6 - metabolism | Sequestosome-1 Protein - metabolism | Astrocytes - cytology | Astrocytes - drug effects | Interleukin-6 - genetics | Sequestosome-1 Protein - antagonists & inhibitors | Cells, Cultured | Neuroprotection - physiology | Tumor Suppressor Protein p53 - metabolism | Genetic Vectors - metabolism | Genetic Vectors - genetics | Serine-Arginine Splicing Factors - antagonists & inhibitors | Leupeptins - pharmacology | Sequestosome-1 Protein - genetics | Amyotrophic Lateral Sclerosis - pathology | Alzheimer Disease - metabolism | Amyotrophic Lateral Sclerosis - metabolism | Brain - pathology | Protein Isoforms - antagonists & inhibitors | Astrocytes - metabolism | Protein Isoforms - genetics | RNA, Small Interfering - metabolism | Index Medicus | Original Paper
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3. Full Text BCL-2 family isoforms in apoptosis and cancer
by Warren, Chloe F. A and Wong-Brown, Michelle W and Bowden, Nikola A
Cell death & disease, ISSN 2041-4889, 03/2019, Volume 10, Issue 3, pp. 177 - 177
Life Sciences & Biomedicine | Science & Technology | Cell Biology | Neoplasms - metabolism | Amino Acid Sequence | Mitochondrial Membrane Transport Proteins - metabolism | Apoptosis - drug effects | Humans | Myeloid Cell Leukemia Sequence 1 Protein - metabolism | bcl-X Protein - genetics | Apoptosis - genetics | Myeloid Cell Leukemia Sequence 1 Protein - genetics | Neoplasms - drug therapy | Membrane Proteins | Proto-Oncogene Proteins c-bcl-2 - metabolism | Animals | Apoptosis Regulatory Proteins | Protein Isoforms - metabolism | Biomimetics | bcl-X Protein - antagonists & inhibitors | Proto-Oncogene Proteins c-bcl-2 - antagonists & inhibitors | bcl-X Protein - metabolism | Proto-Oncogene Proteins c-bcl-2 - genetics | Proteins | Cell survival | Lymphocytes B | Splicing | Bcl-2 protein | Cell death | Isoforms | Homology | Apoptosis | B-cell lymphoma | Cancer | Index Medicus
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4. Full Text Structures of a pan‐specific antagonist antibody complexed to different isoforms of TGFβ reveal structural plasticity of antibody–antigen interactions
by Moulin, Aaron and Mathieu, Magali and Lawrence, Catherine and Bigelow, Russell and Levine, Mark and Hamel, Christine and Marquette, Jean‐Piere and Parc, Josiane and Loux, Christophe and Ferrari, Paul and Capdevila, Cecile and Dumas, Jacques and Dumas, Bruno and Rak, Alexey and Bird, Julie and Qiu, Huawei and Pan, Clark Q and Edmunds, Tim and Wei, Ronnie R
Protein science, ISSN 0961-8368, 12/2014, Volume 23, Issue 12, pp. 1698 - 1707
antibody | receptor | transforming growth factor beta | X‐ray crystallography | fibrosis | pan‐specific inhibitor | protein complex | ligand | X-ray crystallography | pan-specific inhibitor | Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Transforming Growth Factor beta - immunology | Humans | Models, Molecular | Crystallography, X-Ray | Transforming Growth Factor beta - chemistry | Antibodies, Neutralizing - immunology | Antibody Specificity - immunology | Protein Isoforms - chemistry | Antibodies, Neutralizing - chemistry | Immunoglobulin Fab Fragments - chemistry | Protein Conformation | Immunoglobulin Fab Fragments - immunology | Protein Isoforms - immunology | Antigen-Antibody Reactions - immunology | Antibodies, Monoclonal - chemistry | Antibodies, Monoclonal - immunology | Single-Chain Antibodies - chemistry | Single-Chain Antibodies - immunology | Antibodies | Antigens | Fab | Isoforms | Crystal structure | Index Medicus
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5. Full Text Regulation of Vascular Endothelial Growth Factor (VEGF) splicing from pro-angiogenic to anti-angiogenic isoforms: A novel therapeutic strategy for angiogenesis
by Nowak, Dawid G and Amin, Elianna Mohamed and Rennel, Emma S and Hoareau-Aveilla, Coralie and Gammons, Melissa and Damodoran, Gopinath and Hagiwara, Masatoshi and Harper, Steven J and Woolard, Jeanette and Ladomery, Michael R and Bates, David O
The Journal of biological chemistry, ISSN 0021-9258, 02/2010, Volume 285, Issue 8, pp. 5532 - 5540
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Vascular Endothelial Growth Factor A - biosynthesis | Alternative Splicing | Humans | Insulin-Like Growth Factor I - genetics | Retinal Neovascularization - metabolism | RNA-Binding Proteins | Vascular Endothelial Growth Factor A - genetics | RNA, Messenger - biosynthesis | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Retinal Neovascularization - genetics | Nuclear Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | Disease Models, Animal | Angiogenesis Inhibitors - genetics | RNA, Messenger - genetics | Enzyme Inhibitors - pharmacology | Protein-Serine-Threonine Kinases - genetics | Nuclear Proteins - metabolism | Retinal Neovascularization - therapy | Animals | Angiogenesis Inhibitors - biosynthesis | Protein Isoforms - biosynthesis | Nuclear Proteins - antagonists & inhibitors | Serine-Arginine Splicing Factors | Mice | Cell Line, Transformed | Insulin-Like Growth Factor I - metabolism | Protein Isoforms - genetics | Index Medicus | Angiogenesis | RNA | Growth Factors | Splicing | ASF | VEGF | SF2 | SRPK1
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6. Full Text Differential Activation of Mitogenic Signaling Pathways in Aortic Smooth Muscle Cells Deficient in Superoxide Dismutase Isoforms
by Madamanchi, Nageswara R and Moon, Sung-Kwon and Hakim, Zeenat S and Clark, Shantres and Mehrizi, Ali and Patterson, Cam and Runge, Marschall S
Arteriosclerosis, thrombosis, and vascular biology, ISSN 1079-5642, 05/2005, Volume 25, Issue 5, pp. 950 - 956
SMC | SOD | Thrombin | Cell signaling | ROS | Peripheral Vascular Disease | Life Sciences & Biomedicine | Hematology | Cardiovascular System & Cardiology | Science & Technology | Fundamental and applied biological sciences. Psychology | Cardiology. Vascular system | Blood vessels and receptors | Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous | Atherosclerosis (general aspects, experimental research) | Biological and medical sciences | Medical sciences | Vertebrates: cardiovascular system | Blood and lymphatic vessels | MAP Kinase Signaling System - physiology | Superoxide Dismutase - genetics | Reactive Oxygen Species - metabolism | Protein-Tyrosine Kinases - metabolism | Extracellular Signal-Regulated MAP Kinases - antagonists & inhibitors | Extracellular Signal-Regulated MAP Kinases - metabolism | Janus Kinase 2 | Mice, Mutant Strains | p38 Mitogen-Activated Protein Kinases - metabolism | Aorta - enzymology | STAT3 Transcription Factor - metabolism | Superoxide Dismutase - metabolism | Proto-Oncogene Proteins - metabolism | Proto-Oncogene Proteins - antagonists & inhibitors | Atherosclerosis - pathology | Mice, Inbred C57BL | Cells, Cultured | Enzyme Inhibitors - pharmacology | Atherosclerosis - metabolism | Cell Division - drug effects | Aorta - pathology | Cell Compartmentation - physiology | Cell Division - physiology | Gene Expression Regulation, Enzymologic | Muscle, Smooth, Vascular - pathology | Animals | MAP Kinase Signaling System - drug effects | p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors | Mice | Superoxide Dismutase-1 | Muscle, Smooth, Vascular - enzymology | Hypertrophy | Protein-Tyrosine Kinases - antagonists & inhibitors | Index Medicus
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7. Full Text Inhibition of RAF Isoforms and Active Dimers by LY3009120 Leads to Anti-tumor Activities in RAS or BRAF Mutant Cancers
by Peng, Sheng-Bin and Henry, James R and Kaufman, Michael D and Lu, Wei-Ping and Smith, Bryan D and Vogeti, Subha and Rutkoski, Thomas J and Wise, Scott and Chun, Lawrence and Zhang, Youyan and Van Horn, Robert D and Yin, Tinggui and Zhang, Xiaoyi and Yadav, Vipin and Chen, Shih-Hsun and Gong, Xueqian and Ma, Xiwen and Webster, Yue and Buchanan, Sean and Mochalkin, Igor and Huber, Lysiane and Kays, Lisa and Donoho, Gregory P and Walgren, Jennie and McCann, Denis and Patel, Phenil and Conti, Ilaria and Plowman, Gregory D and Starling, James J and Flynn, Daniel L
Cancer cell, ISSN 1535-6108, 09/2015, Volume 28, Issue 3, pp. 384 - 398
ras Proteins - genetics | Proto-Oncogene Proteins c-raf - genetics | Humans | Signal Transduction - genetics | Pyrimidines - pharmacology | Mutation - genetics | Neoplasms - drug therapy | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Phosphorylation - genetics | MAP Kinase Signaling System - drug effects | MAP Kinase Signaling System - genetics | Mutation - drug effects | Neoplasms - genetics | Signal Transduction - drug effects | Proto-Oncogene Proteins B-raf - genetics | Cell Line, Tumor | Mitogen-Activated Protein Kinases - genetics | Antineoplastic Agents - pharmacology | Phenylurea Compounds - pharmacology | Protein Kinase Inhibitors - pharmacology | Phosphorylation - drug effects | Dimerization | Protein Isoforms - antagonists & inhibitors | Protein Isoforms - genetics | Cancer | Index Medicus
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8. Full Text Sulfocoumarins (1,2-Benzoxathiine-2,2-dioxides): A Class of Potent and Isoform-Selective Inhibitors of Tumor-Associated Carbonic Anhydrases
by Tars, Kaspars and Vullo, Daniela and Kazaks, Andris and Leitans, Janis and Lends, Alons and Grandane, Aiga and Zalubovskis, Raivis and Scozzafava, Andrea and Supuran, Claudiu T
Journal of medicinal chemistry, ISSN 0022-2623, 01/2013, Volume 56, Issue 1, pp. 293 - 300
Carbonic Anhydrase Inhibitors - chemistry | Triazoles - chemistry | Antineoplastic Agents - chemical synthesis | Humans | Coumarins - chemistry | Crystallography, X-Ray | Isoenzymes - chemistry | Structure-Activity Relationship | Carbonic Anhydrases - chemistry | Antigens, Neoplasm - chemistry | Carbonic Anhydrase II - antagonists & inhibitors | Triazoles - chemical synthesis | Molecular Structure | Carbonic Anhydrase IX | Catalytic Domain | Click Chemistry | Carbonic Anhydrase Inhibitors - chemical synthesis | Carbonic Anhydrase I - chemistry | Antineoplastic Agents - chemistry | Hydrolysis | Carbonic Anhydrase I - antagonists & inhibitors | Coumarins - chemical synthesis | Protein Binding | Isoenzymes - antagonists & inhibitors | Carbonic Anhydrase II - chemistry | Index Medicus
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9. Full Text Characterization of Recombinant Long-Chain Rat Acyl-CoA Synthetase Isoforms 3 and 6:  Identification of a Novel Variant of Isoform 6
by Van Horn, Cynthia G and Caviglia, Jorge M and Li, Lei O and Wang, Shuli and Granger, Deborah A and Coleman, Rosalind A
Biochemistry (Easton), ISSN 0006-2960, 02/2005, Volume 44, Issue 5, pp. 1635 - 1642
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Amino Acid Sequence | Recombinant Proteins - antagonists & inhibitors | Alternative Splicing | Coenzyme A Ligases - genetics | Isoenzymes - genetics | Triazenes - chemistry | Brain - enzymology | Coenzyme A Ligases - antagonists & inhibitors | Molecular Sequence Data | Octoxynol - chemistry | Rats | Recombinant Proteins - chemistry | Isoenzymes - chemistry | Recombinant Proteins - genetics | Fatty Acids, Unsaturated - metabolism | Hot Temperature | Thiazolidinediones - chemistry | Brain - metabolism | Animals | Coenzyme A Ligases - chemistry | Fatty Acids, Unsaturated - chemistry | Enzyme Inhibitors - chemistry | Kinetics | Isoenzymes - antagonists & inhibitors | Rats as laboratory animals | Research | Chemical properties | Ligases | Fatty acids | Analysis | Index Medicus
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