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Journal of Biological Chemistry, ISSN 0021-9258, 08/2011, Volume 286, Issue 34, pp. 29681 - 29690
12-O-tetradecanoylphorbol-13-acetate (TPA) has been shown to induce transcriptional activation of human manganese superoxide dismutase (MnSOD) mRNA in human... 
SIGNAL-TRANSDUCTION | CANCER-CELLS | FORKHEAD TRANSCRIPTION FACTOR | TUMOR-NECROSIS-FACTOR | OXIDATIVE STRESS | BIOCHEMISTRY & MOLECULAR BIOLOGY | GENE-EXPRESSION | PROMOTER REVEAL | PHORBOL ESTER | NF-KAPPA-B | FACTOR-ALPHA | Phosphorylation - physiology | Gene Expression Regulation, Enzymologic - drug effects | Oxidants - pharmacology | Superoxide Dismutase - genetics | Superoxide Dismutase - biosynthesis | Tetradecanoylphorbol Acetate - pharmacology | Protein Kinase C-alpha - metabolism | Humans | Phosphoprotein Phosphatases - metabolism | Protein Kinase C-alpha - genetics | NADPH Oxidases - metabolism | Oxidants - metabolism | Gene Expression Regulation, Enzymologic - physiology | Proto-Oncogene Proteins c-akt - genetics | Tumor Suppressor Protein p53 - genetics | Gene Knockdown Techniques | Carcinogens - pharmacology | Forkhead Transcription Factors - metabolism | NADPH Oxidases - genetics | Phosphorylation - drug effects | Proto-Oncogene Proteins c-akt - metabolism | Hydrogen Peroxide - pharmacology | Tumor Suppressor Protein p53 - metabolism | Forkhead Transcription Factors - genetics | Hydrogen Peroxide - metabolism | Cyclic AMP Response Element-Binding Protein - genetics | Tumor Necrosis Factor-alpha - pharmacology | Phosphoprotein Phosphatases - genetics | Cyclic AMP Response Element-Binding Protein - metabolism | Cell Line, Tumor | Forkhead Box Protein O3 | Index Medicus | Foxo | CREB | Signal Transduction | Superoxide Dismutase (SOD) | TPA | Protein Kinase C (PKC) | Akt | Akt PKB
Journal Article
Hepatology, ISSN 0270-9139, 04/2014, Volume 59, Issue 4, pp. 1543 - 1554
This study examines the role of protein kinase C (PKC) and AMP‐activated kinase (AMPK) in acetaminophen (APAP) hepatotoxicity. Treatment of primary mouse... 
OXIDATIVE STRESS | ACTIVATION | INHIBITION | RAT HEPATOCYTES | PHORBOL 12-MYRISTATE 13-ACETATE | AUTOPHAGY | GASTROENTEROLOGY & HEPATOLOGY | ISOENZYMES | INDUCED LIVER-INJURY | EXTENDED FAMILY | CELL-DEATH | Acetaminophen - adverse effects | Mitochondria, Liver - metabolism | Maleimides - pharmacology | Hepatocytes - pathology | Male | Hepatocytes - metabolism | Necrosis - pathology | AMP-Activated Protein Kinases - drug effects | Indoles - pharmacology | Chemical and Drug Induced Liver Injury - pathology | Hepatocytes - drug effects | Disease Models, Animal | JNK Mitogen-Activated Protein Kinases - drug effects | JNK Mitogen-Activated Protein Kinases - antagonists & inhibitors | Protein Kinase C - physiology | AMP-Activated Protein Kinases - antagonists & inhibitors | Mice, Inbred C57BL | Protein Kinase C - drug effects | Cells, Cultured | Necrosis - metabolism | Protein Kinase C - antagonists & inhibitors | Chemical and Drug Induced Liver Injury - physiopathology | Mitochondria, Liver - drug effects | AMP-Activated Protein Kinases - physiology | Animals | Chemical and Drug Induced Liver Injury - metabolism | JNK Mitogen-Activated Protein Kinases - physiology | Signal Transduction - physiology | Mice | Protein Kinase Inhibitors - pharmacology | In Vitro Techniques | Cytotoxicity | Mitochondria | Kinases | Autophagy | Liver | Hepatology | Index Medicus
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 03/2013, Volume 288, Issue 12, pp. 8299 - 8312
Neurotrophins, such as brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3), are believed to be genuine molecular mediators of neuronal growth... 
GEMFIBROZIL | PHENYLACETATE | BDNF | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSCRIPTION | PHASE-I | EXPRESSION | BRAIN | MULTIPLE | LIPID-LOWERING DRUG | FAMILY | Memory - drug effects | Brain-Derived Neurotrophic Factor - genetics | Brain-Derived Neurotrophic Factor - secretion | Phosphorylation | Humans | Male | Neurotrophin 3 - genetics | Receptors, Nerve Growth Factor - metabolism | Glial Fibrillary Acidic Protein - metabolism | Cell Shape | Phenylbutyrates - administration & dosage | Phenylbutyrates - pharmacology | Brain-Derived Neurotrophic Factor - metabolism | Neurons - metabolism | Neurons - drug effects | Alzheimer Disease - psychology | Neurotrophin 3 - secretion | Astrocytes - drug effects | Administration, Oral | Mice, Inbred C57BL | Cells, Cultured | Alzheimer Disease - drug therapy | Mice, Transgenic | Hippocampus - pathology | Receptors, Nerve Growth Factor - genetics | Up-Regulation - drug effects | Astrocytes - physiology | Animals | Neurotrophin 3 - metabolism | Formates - pharmacology | Alzheimer Disease - metabolism | Cyclic AMP Response Element-Binding Protein - metabolism | Mice | Protein Processing, Post-Translational | Primary Cell Culture | Astrocytes - metabolism | Protein Kinase C | Index Medicus | Brain-derived Neurotrophic Factor (BDNF) | CREB | Neurotrophins | Synaptic Plasticity | Protein Kinase C (PKC) | Neurobiology
Journal Article
Diabetes, ISSN 0012-1797, 06/2019, Volume 68, Issue Supplement 1, p. 1787
PKCs are serine/threonine kinases sub-divided into three categories, namely, conventional, novel and atypical. Depending upon the isoform some have been... 
Protein kinase C | Threonine | Neurodegenerative diseases | Serine | Cognitive ability | AKT protein | Adipocytes | Glucose | Kinases | Insulin | Skeletal muscle | 1-Phosphatidylinositol 3-kinase | Signal transduction | Plasticity (synaptic) | Hepatocytes | Acetic acid | Phorbol 12-myristate 13-acetate
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 07/2010, Volume 285, Issue 30, pp. 23410 - 23419
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 06/2012, Volume 287, Issue 24, pp. 20088 - 20099
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 06/2012, Volume 287, Issue 23, pp. 19177 - 19187
Glutamate transporter-1 (GLT-1) is the main glutamate transporter in the central nervous system, and its concentration severely decreases in neurodegenerative... 
PHORBOL-ESTER | WW DOMAINS | NEDD4-2 | EPITHELIAL NA+ CHANNEL | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL-SURFACE EXPRESSION | DEPENDENT ENDOCYTOSIS | DEGRADATION | DOPAMINE TRANSPORTER | DIFFERENTIAL REGULATION | SODIUM-CHANNEL | Glutamate Plasma Membrane Transport Proteins - metabolism | Phosphorylation - physiology | Protein Kinase C - genetics | Tetradecanoylphorbol Acetate - pharmacology | Humans | Cercopithecus aethiops | Endosomal Sorting Complexes Required for Transport - genetics | Glutamate Plasma Membrane Transport Proteins - genetics | Protein Transport - physiology | Protein Transport - drug effects | Carcinogens - pharmacology | Ubiquitination - drug effects | Protein Kinase C - metabolism | Nedd4 Ubiquitin Protein Ligases | Phosphorylation - drug effects | Ubiquitination - physiology | Endocytosis - drug effects | Xenopus laevis | Endosomal Sorting Complexes Required for Transport - metabolism | Ubiquitin-Protein Ligases - metabolism | Xenopus Proteins | Down-Regulation - drug effects | Enzyme Activation - drug effects | Endocytosis - physiology | Down-Regulation - physiology | Animals | Dogs | Ubiquitin-Protein Ligases - genetics | COS Cells | Enzyme Activation - physiology | Index Medicus | Glutamate Transporter | Endocytosis | Phosphorylation | Ubiquitination | Membrane Biology | Ubiquitin Ligase | Amino Acid Transport
Journal Article
Journal of Immunology, ISSN 0022-1767, 06/2006, Volume 176, Issue 12, pp. 7502 - 7510
Journal Article
Molecular and Cellular Proteomics, ISSN 1535-9476, 03/2017, Volume 16, Issue 3, pp. 346 - 367
Journal Article