X
Search Filters
Format Format
Format Format
X
Sort by Item Count (A-Z)
Filter by Count
Journal Article (664624) 664624
Book Review (98193) 98193
Publication (78231) 78231
Newsletter (18982) 18982
Newspaper Article (9402) 9402
Book Chapter (5438) 5438
Conference Proceeding (1975) 1975
Book / eBook (1160) 1160
Dissertation (802) 802
Government Document (189) 189
Magazine Article (164) 164
Reference (159) 159
Trade Publication Article (115) 115
Web Resource (112) 112
Data Set (67) 67
Transcript (56) 56
Paper (24) 24
Streaming Video (15) 15
Presentation (6) 6
Patent (3) 3
Report (3) 3
Journal / eJournal (1) 1
Streaming Audio (1) 1
more...
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
index medicus (555788) 555788
humans (336368) 336368
animals (314119) 314119
proteins (152298) 152298
mice (137677) 137677
biochemistry & molecular biology (131888) 131888
cell biology (128634) 128634
male (112564) 112564
phosphorylation (109950) 109950
signal transduction (98435) 98435
apoptosis (95592) 95592
female (95231) 95231
oncology (91002) 91002
expression (87660) 87660
cancer (85748) 85748
research (85032) 85032
rats (79747) 79747
kinases (79356) 79356
gene expression (76541) 76541
activation (70963) 70963
cells, cultured (64329) 64329
cell line, tumor (64102) 64102
analysis (63736) 63736
article (57297) 57297
physiological aspects (57111) 57111
cells (51487) 51487
cell line (51352) 51352
neurosciences (47893) 47893
genetic aspects (47630) 47630
research article (46869) 46869
multidisciplinary sciences (45800) 45800
mutation (45629) 45629
pharmacology & pharmacy (44195) 44195
protein (42663) 42663
gene-expression (41360) 41360
health aspects (40508) 40508
signal transduction - drug effects (40377) 40377
protein binding (39666) 39666
rodents (39505) 39505
medicine (38075) 38075
biology (37419) 37419
physiology (36514) 36514
cell cycle (35772) 35772
enzyme inhibitors - pharmacology (35087) 35087
protein kinases (34856) 34856
genes (34566) 34566
inhibition (34539) 34539
immunology (34411) 34411
molecular sequence data (34398) 34398
inflammation (34277) 34277
oxidative stress (34123) 34123
apoptosis - drug effects (33922) 33922
middle aged (33656) 33656
cell proliferation (33200) 33200
tumors (31768) 31768
blotting, western (31142) 31142
biochemistry (30639) 30639
science (30177) 30177
amino acid sequence (29861) 29861
in-vitro (29810) 29810
adult (29405) 29405
enzymes (28832) 28832
in-vivo (28821) 28821
growth (28259) 28259
biophysics (27993) 27993
mice, inbred c57bl (27729) 27729
care and treatment (27464) 27464
rats, sprague-dawley (26611) 26611
medicine, research & experimental (26507) 26507
dose-response relationship, drug (26411) 26411
aged (26187) 26187
endocrinology & metabolism (25604) 25604
life sciences (25187) 25187
signal transduction - physiology (25026) 25026
nf-kappa-b (24983) 24983
immunohistochemistry (24972) 24972
genetics & heredity (24802) 24802
time factors (24225) 24225
rna, messenger - metabolism (23962) 23962
metastasis (23919) 23919
transfection (23889) 23889
abridged index medicus (23867) 23867
studies (23768) 23768
gene (23530) 23530
proliferation (23430) 23430
cell proliferation - drug effects (23284) 23284
development and progression (22783) 22783
pathway (22570) 22570
molecular biology (22280) 22280
disease models, animal (22251) 22251
protein kinase inhibitors - pharmacology (22236) 22236
antineoplastic agents - pharmacology (22170) 22170
gene expression regulation (22161) 22161
metabolism (22024) 22024
differentiation (21562) 21562
identification (21553) 21553
transcription factors (21420) 21420
binding sites (21119) 21119
binding (21039) 21039
enzyme activation (20954) 20954
more...
Library Location Library Location
Library Location Library Location
X
Sort by Item Count (A-Z)
Filter by Count
Gerstein Science - Stacks (672) 672
UofT at Mississauga - Stacks (104) 104
Online Resources - Online (102) 102
Collection Dvlpm't (Acquisitions) - Vendor file (64) 64
UTL at Downsview - May be requested (54) 54
UofT at Scarborough - Stacks (42) 42
Collection Dvlpm't (Acquisitions) - Closed Orders (37) 37
Chemistry (A D Allen) - Stacks (34) 34
Engineering & Comp. Sci. - Stacks (20) 20
Earth Sciences (Noranda) - Stacks (18) 18
UofT at Scarborough - Withdrawn (7) 7
Trinity College (John W Graham) - Stacks (5) 5
Gerstein Science - Circulation Desk (4) 4
St. Michael's College (John M. Kelly) - 2nd Floor (4) 4
Royal Ontario Museum - Stacks (3) 3
UofT at Mississauga - Reference (3) 3
Physics - Stacks (2) 2
Sunnybrook Health Sciences Centre - Sunnybrook Stacks (2) 2
UofT at Mississauga - Missing (2) 2
Chemistry (A D Allen) - May be requested in 6-10 wks (1) 1
Collection Dvlpm't (Acquisitions) - Cancelled Order (1) 1
Earth Sciences (Noranda) - Circulation Desk (1) 1
Earth Sciences (Noranda) - Oversize (1) 1
Engineering & Comp. Sci. - Reference (1) 1
Gerstein Science - Missing (1) 1
Gerstein Science - Not Returned (1) 1
Gerstein Science - Reference (1) 1
Gerstein Science - Reserve desk (1) 1
Gerstein Science - Theses (1) 1
Law (Bora Laskin) - Stacks (1) 1
Media Commons - Microtexts (1) 1
Trinity College (John W Graham) - Oversize (1) 1
UofT at Mississauga - Circulation Desk (1) 1
UofT at Scarborough - May be requested in 6-10 wks (1) 1
Victoria University E.J. Pratt - Circulation Desk (1) 1
Victoria University E.J. Pratt - Oversize (1) 1
more...
Language Language
Language Language
X
Sort by Item Count (A-Z)
Filter by Count
English (692864) 692864
Chinese (1845) 1845
Japanese (867) 867
French (629) 629
German (452) 452
Russian (370) 370
Spanish (212) 212
Korean (125) 125
Polish (79) 79
Hungarian (60) 60
Czech (56) 56
Portuguese (49) 49
Italian (28) 28
Dutch (25) 25
Ukrainian (24) 24
Turkish (19) 19
Swedish (18) 18
Danish (17) 17
Finnish (8) 8
Norwegian (8) 8
Croatian (7) 7
Arabic (5) 5
Romanian (4) 4
Hebrew (3) 3
Serbian (3) 3
Afrikaans (1) 1
Bulgarian (1) 1
Malay (1) 1
Persian (1) 1
Slovak (1) 1
Slovenian (1) 1
more...
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


2012, Methods in molecular biology, ISBN 1617793361, Volume 795., xi, 256
Book
2012, 1. Aufl., Current topics in microbiology and immunology, ISBN 3642282954, Volume 355., x, 234
Cancer drug development is currently undergoing a profound shift. Drugs targeting fundamental cellular processes such DNA-replication and microtubule function,... 
Chemotherapy | Antineoplastic Protocols | Cancer | Clinical & internal medicine | Protein kinases | Inhibitors
Book
2012, Methods in molecular biology, ISBN 9781617793370, Volume 795.
Web Resource
2009, 1. Aufl., Wiley Series in Drug Discovery and Development, ISBN 0470278293, Volume 10, xv, 510
A comprehensive resource on case studies of marketed kinase drugs and promising drug trialsSince the discovery of protein kinase activity in 1954, the field of... 
Protein Kinase Inhibitors | Inhibitors | drug therapy | pharmacology | metabolism | Antineoplastic agents | Protein kinases | Drug Discovery | Neoplasms | Therapeutic use | Protein kinases–Inhibitors–Therapeutic use | Medical | Pharmacology
Book
2016, Resistance to Targeted Anti-Cancer Therapeutics, ISBN 9783319460901, Volume 10
Web Resource
2012, Current topics in microbiology and immunology, ISBN 3642282954, Volume 355
Web Resource
Biochemical Journal, ISSN 0264-6021, 12/2007, Volume 408, Issue 3, pp. 297 - 315
The specificities of 65 compounds reported to be relatively specific inhibitors of protein kinases have been profiled against a panel of 70-80 protein kinases.... 
Drug discovery | Kinase profiling | Protein kinase | Anti-cancer drugs | Inhibitor specificity | RHO-ASSOCIATED KINASE | TUMOR PROGRESSION | FAMILY-MEMBERS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL-PROLIFERATION | protein kinase | P38 MAP KINASE | CYCLIN-DEPENDENT KINASES | RECEPTOR TYROSINE KINASES | drug discovery | kinase profiling | SB 203580 | anti-cancer drugs | ISOFORMS IN-VITRO | P90 RSK | inhibitor specificity | Amino Acid Sequence | Cell Line | Phosphorylation | Recombinant Proteins - antagonists & inhibitors | Animals | Mitogen-Activated Protein Kinases - antagonists & inhibitors | Humans | Drug Design | Protein Kinase Inhibitors - pharmacology | Enzyme Activation | Mitogen-Activated Protein Kinases - metabolism | Spodoptera | Index Medicus | Yes1, Yamaguchi sarcoma viral oncogene homologue 1 | CSK, C-terminal Src kinase | Lck, lymphocyte cell-specific protein-tyrosine kinase | EGF, epidermal growth factor | FGF-R, fibroblast-growth-factor receptor | PAK, p21-activated protein kinase | PDK, 3-phosphoinositide-dependent protein kinase | PI3K, phosphatidylinositol (phosphoinositide) 3-kinase | NEK, NIMA (never in mitosis in Aspergillus nidulans)-related kinase | RSK, p90 ribosomal S6 kinase | HEK-293 cells, human embryonic kidney-293 cells | VEGF, vascular endothelial growth factor (vasoendothelial growth factor) | EF2K, elongation-factor-2 kinase | CK, casein kinase | PTEN, phosphatase and tensin homologue deleted on chromosome 10 | ERK, extracellular-signal-regulated kinase | ATM, ataxia telangiectasia mutated | SRPK, serine-arginine protein kinase | IL-1, interleukin 1 | MNK, MAPK-integrating protein kinase | ROCK, Rho-dependent protein kinase | CaMKK, CaMK kinase | GST, glutathione transferase | MKK1, MAPK kinase-1 (also called MEK1, MAPK or ERK kinase 1) | GAK, cyclin G-associated kinase | FMK, fluoromethylketone | MST, mammalian homologue Ste20-like kinase | PKA, cAMP-dependent protein kinase | FKBP, FK506-binding protein | PPAR, peroxisome-proliferator-activated receptor | IKK, inhibitory κB kinase | PH, pleckstrin homology | MBP, myelin basic protein | AICAR, aminoimidazole-4-carboxamide-1-β-D-ribofuranoside | MAPKAP-K, MAPK-activated protein kinase | Sf21, Spodoptera frugiperda (fall armyworm) 21 | MARK, microtubule-affinity-regulating kinase | PIM, provirus integration site for Moloney murine leukaemia virus | LPS, lipopolysaccharide | MSK, mitogen- and stress-activated protein kinase | MAPK, mitogen-activated protein kinase | MELK, maternal embryonic leucine-zipper kinase | His6, hexahistidine | CAK, cyclin-dependent kinase-activating kinase | Eph-A2, Ephrin A2 receptor | PLK, polo-like kinase | ATF2, activating transcription factor 2 | PKD, protein kinase D | Src, sarcoma kinase | AMPK, AMP-activated protein kinase | MMS, methyl methanesulfonate | CHK, checkpoint kinase | JNK, c-Jun N-terminal kinase | TORC1, mTOR (mammalian target of rapamycin)–raptor (regulatory associated protein of mTOR) complex | BRSK, brain-specific kinase | RIP2, receptor-interacting protein 2 | IGF-1, insulin-like growth factor-1 | S6K1, S6 kinase 1 | DYRK, dual-specificity tyrosine-phosphorylated and -regulated kinase | HIPK, homeodomain-interacting protein kinase | ZMP, aminoimidazole-4-carboxamide-1-β-D-ribofuranoside monophosphate | PRAK, p38-regulated activated kinase | PKC, protein kinase C | Src-I1, Src inhibitor 1 | TANK, TRAF (tumour-necrosis-factor-receptor-associated factor)-family-member-associated nuclear factor κB activator | NFAT, nuclear factor for activated T-cells | PHK, phosphorylase kinase | GSK3, glycogen synthase kinase 3 | PKB, protein kinase B (also called Akt) | CaMK, calmodulin-dependent kinase | CDK, cyclin-dependent protein kinase | NDRG, N-myc downstream-regulated gene | SmMLCK, smooth-muscle myosin light-chain kinase | TBK1, TANK-binding kinase 1 | PRK, protein kinase C-related kinase | SGK, serum- and glucocorticoid-induced kinase
Journal Article
Molecules, ISSN 1420-3049, 2018, Volume 23, Issue 7, p. 1818
Journal Article
Drug Discovery Today, ISSN 1359-6446, 01/2016, Volume 21, Issue 1, pp. 5 - 10
Journal Article
Nature, ISSN 0028-0836, 12/2009, Volume 462, Issue 7276, pp. 1070 - 1074
Journal Article
Molecular Cell, ISSN 1097-2765, 05/2015, Volume 58, Issue 4, pp. 708 - 708.e1
Selective small-molecule inhibitors of protein kinases can serve as powerful tools to elucidate biological function. Efforts to develop potential drug... 
UPDATE | SELECTIVITY | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL BIOLOGY | Protein Kinases - metabolism | Small Molecule Libraries - pharmacology | Animals | Signal Transduction - drug effects | Biocatalysis - drug effects | Humans | Protein Kinase Inhibitors - pharmacology | Phosphorylation - drug effects | Index Medicus
Journal Article
Nature Chemical Biology, ISSN 1552-4450, 07/2015, Volume 11, Issue 7, pp. 525 - 531
Journal Article
Molecular Cell, ISSN 1097-2765, 05/2015, Volume 58, Issue 4, pp. 710 - 710.e1
Selective small-molecule inhibitors of protein kinases can serve as powerful tools to elucidate biological function. Efforts to develop potential drug... 
UPDATE | SELECTIVITY | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL BIOLOGY | Protein Kinases - metabolism | Small Molecule Libraries - pharmacology | Animals | Signal Transduction - drug effects | Biocatalysis - drug effects | Humans | Protein Kinase Inhibitors - pharmacology | Phosphorylation - drug effects | Index Medicus
Journal Article