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Drug Discovery Today, ISSN 1359-6446, 01/2016, Volume 21, Issue 1, pp. 5 - 10
Journal Article
Annals of the Rheumatic Diseases, ISSN 0003-4967, 05/2016, Volume 75, Issue 5, pp. 831 - 841
ObjectivesTofacitinib is an oral Janus kinase inhibitor for the treatment of rheumatoid arthritis (RA). To further assess the potential role of Janus kinase... 
JAK INHIBITOR | MODIFYING ANTIRHEUMATIC DRUGS | Rheumatoid Arthritis | INADEQUATE RESPONSE | Inflammation | RHEUMATOLOGY | PSORIATIC-ARTHRITIS | LONG-TERM EXTENSION | BACKGROUND METHOTREXATE | FACTOR THERAPY | DMARDs (synthetic) | Treatment | DOUBLE-BLIND | NECROSIS-FACTOR INHIBITORS | SKIN-CANCER | Antirheumatic Agents - administration & dosage | Humans | Middle Aged | Male | Protein Kinase Inhibitors - adverse effects | Incidence | Dose-Response Relationship, Drug | Janus Kinase 3 - antagonists & inhibitors | Young Adult | Clinical Trials, Phase III as Topic | Multicenter Studies as Topic | Neoplasms - chemically induced | Arthritis, Rheumatoid - drug therapy | Pyrroles - administration & dosage | Antirheumatic Agents - adverse effects | Pyrroles - adverse effects | Adult | Female | Pyrroles - therapeutic use | Antirheumatic Agents - therapeutic use | Piperidines - administration & dosage | Administration, Oral | Pyrimidines - administration & dosage | Randomized Controlled Trials as Topic | Protein Kinase Inhibitors - administration & dosage | Piperidines - therapeutic use | Protein Kinase Inhibitors - therapeutic use | Pyrimidines - therapeutic use | Piperidines - adverse effects | Adolescent | Pyrimidines - adverse effects | Aged | Neoplasms - epidemiology | Clinical Trials, Phase II as Topic | Clinical trials | Care and treatment | Usage | Dosage and administration | Tofacitinib | Rheumatoid arthritis | Index Medicus | Clinical and Epidemiological Research | 1506
Journal Article
Journal Article
Analytical and Bioanalytical Chemistry, ISSN 1618-2642, 10/2012, Volume 404, Issue 6-7, pp. 2083 - 2086
Here, we describe the application of the core-shell separation technology in the field of protein kinase inhibitor analysis with the HPLC-diode-array detector... 
Proteins | Separation | Flow rate | Inhibitors | Mathematical analysis | Standard deviation | Kinases | Joints
Journal Article
Bioinformatics, ISSN 1367-4803, 01/2019, Volume 35, Issue 2, pp. 235 - 242
Abstract Motivation Kinases play a significant role in diverse disease signaling pathways and understanding kinase inhibitor selectivity, the tendency of drugs... 
PROFILES | PROTEIN | EFFICACY | TYROSINE KINASE | BIOCHEMICAL RESEARCH METHODS | INTERACTION MAP | SIMILARITY ANALYSIS | PREDICTION | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | IMATINIB | MATHEMATICAL & COMPUTATIONAL BIOLOGY | FUNCTIONAL CLASSIFICATION | MOLECULAR-MECHANISMS | Index Medicus
Journal Article
Cell Stem Cell, ISSN 1934-5909, 06/2013, Volume 12, Issue 6, pp. 713 - 726
Amyotrophic lateral sclerosis (ALS) is a rapidly progressing neurodegenerative disease, characterized by motor neuron (MN) death, for which there are no truly... 
SURVIVAL | MATRIX METALLOPROTEINASES | PROTEIN-KINASE | TDP-43 | MOUSE MODEL | DEATH | AMYOTROPHIC-LATERAL-SCLEROSIS | FRONTOTEMPORAL LOBAR DEGENERATION | C-JUN | DISEASE PROGRESSION | CELL & TISSUE ENGINEERING | CELL BIOLOGY | Superoxide Dismutase - genetics | Embryonic Stem Cells - cytology | Humans | Intracellular Signaling Peptides and Proteins - metabolism | Structure-Activity Relationship | Amyotrophic Lateral Sclerosis - drug therapy | Protein Kinase Inhibitors - chemistry | Protein Kinase Inhibitors - analysis | Motor Neurons - cytology | Cholestenones - chemistry | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Indoles - pharmacology | Amyotrophic Lateral Sclerosis - enzymology | Induced Pluripotent Stem Cells - cytology | Motor Neurons - drug effects | Protein-Serine-Threonine Kinases - metabolism | Superoxide Dismutase - metabolism | Cell Survival - drug effects | Glycogen Synthase Kinase 3 - antagonists & inhibitors | Intracellular Signaling Peptides and Proteins - antagonists & inhibitors | Cells, Cultured | Mice, Transgenic | Benzazepines - pharmacology | Motor Neurons - enzymology | Glycogen Synthase Kinase 3 - metabolism | Amyotrophic Lateral Sclerosis - pathology | Animals | Cell Differentiation - drug effects | Cholestenones - pharmacology | Mice | Protein Kinase Inhibitors - pharmacology | Mutation | Superoxide Dismutase-1 | Benzazepines - chemistry | Indoles - chemistry | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 07/2018, Volume 13, Issue 7, pp. e0201321 - e0201321
Chemogenomic approaches involving highly annotated compound sets and cell based high throughput screening are emerging as a means to identify novel drug... 
GENETIC SCREEN | POTENT | VIRUS ENTRY REQUIRES | HOST FACTORS | PROTEIN-KINASE | MARIBAVIR | MULTIDISCIPLINARY SCIENCES | WEST-NILE-VIRUS | MUTATIONS | HIV-1 REPLICATION | STRUCTURE-BASED DESIGN | Cell Line | RNA, Small Interfering - genetics | Virus Replication - drug effects | Antiviral Agents - pharmacology | Humans | Intracellular Signaling Peptides and Proteins - antagonists & inhibitors | RNA, Small Interfering - pharmacology | Protein-Serine-Threonine Kinases - genetics | Drug Discovery - methods | Cytomegalovirus Infections - genetics | Machine Learning | Cytomegalovirus Infections - drug therapy | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Cytomegalovirus Infections - virology | Protein Kinase Inhibitors - pharmacology | Cytomegalovirus - physiology | Intracellular Signaling Peptides and Proteins - genetics | Cytomegalovirus - drug effects | Viral proteins | Antiviral agents | Machine learning | Phosphorylation | Target recognition | Toxicity | Genomics | High-throughput screening | Cytotoxicity | Viruses | Infections | Kinases | Drug resistance | Proteins | Consortia | Learning | Lead | Inhibition | Cytomegalovirus | Immunoglobulins | IE2 protein | Cloning | siRNA | Lead compounds | Gene expression | Medical screening | Learning algorithms | Screening | Inhibitors | Pharmacy | Replication | Artificial intelligence | Cancer | Index Medicus
Journal Article
Molecular Cancer Therapeutics, ISSN 1535-7163, 09/2008, Volume 7, Issue 9, pp. 2955 - 2966
Journal Article