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JOURNAL OF MEDICINAL CHEMISTRY, ISSN 0022-2623, 07/2013, Volume 56, Issue 14, pp. 5675 - 5690
Journal Article
Nature Chemical Biology, ISSN 1552-4450, 07/2015, Volume 11, Issue 7, pp. 525 - 531
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Nature Chemical Biology, ISSN 1552-4450, 2014, Volume 10, Issue 4, pp. 305 - 312
Journal Article
Nature chemical biology, ISSN 1552-4450, 12/2014, Volume 10, Issue 12, pp. 1013 - 1019
Vps34 is a phosphoinositide 3-kinase (PI3K) class III isoform that has attracted major attention over the recent years because of its role in autophagy. Herein... 
KINASE VPS34 | LIPID KINASE | PHOSPHATIDYLINOSITOL 3-PHOSPHATE | T-CELL HOMEOSTASIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | DISEASE | MECHANISMS | OPTIMIZATION | MAMMALIAN-CELLS | MTOR | REVEALS | Kidney - pathology | Antineoplastic Agents - chemical synthesis | Humans | Kidney - enzymology | Sirolimus - chemical synthesis | Autophagy - drug effects | Endosomes - metabolism | TOR Serine-Threonine Kinases - antagonists & inhibitors | Lysosomes - metabolism | TOR Serine-Threonine Kinases - genetics | Adenosine Triphosphate - metabolism | Endosomes - drug effects | Class III Phosphatidylinositol 3-Kinases - chemistry | Pyrimidinones - pharmacology | Antineoplastic Agents - pharmacology | Autophagy - genetics | Pyrimidinones - chemical synthesis | Everolimus | Lysosomes - drug effects | Protein Kinase Inhibitors - chemical synthesis | Catalytic Domain | Gene Expression | Sirolimus - analogs & derivatives | Signal Transduction | Pyridines - chemical synthesis | Recombinant Proteins - chemistry | Recombinant Proteins - genetics | Sirolimus - pharmacology | Drug Synergism | TOR Serine-Threonine Kinases - chemistry | Class III Phosphatidylinositol 3-Kinases - genetics | Cell Line, Tumor | Cell Proliferation - drug effects | Class III Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Molecular Docking Simulation | Protein Kinase Inhibitors - pharmacology | Pyridines - pharmacology | Kinetics | Adenosine Triphosphate - chemistry | Proteins | Lipids | Kinases | Autophagy | Binding sites | Adenosine triphosphatase
Journal Article
Nature Chemical Biology, ISSN 1552-4450, 10/2016, Volume 12, Issue 10, pp. 876 - 884
Journal Article
Journal Article
ChemMedChem, ISSN 1860-7179, 04/2017, Volume 12, Issue 7, pp. 487 - 501
Sulfoximines have gained considerable recognition as an important structural motif in drug discovery of late. In particular, the clinical kinase inhibitors for... 
kinase inhibitors | pharmacophores | sulfoximines | drug design | medicinal chemistry | PHOSPHODIESTERASE-5 INHIBITORS | CHEMISTRY, MEDICINAL | ASYMMETRIC-SYNTHESIS | DIELS-ALDER REACTIONS | DEPENDENT KINASE INHIBITOR | BREAST-CANCER | POTENT INHIBITOR | STRUCTURAL BASIS | CDK4/6 INHIBITOR | PHARMACOLOGY & PHARMACY | ERECTILE DYSFUNCTION | Estradiol - analogs & derivatives | Sulfoxides - chemical synthesis | Cyclin-Dependent Kinases - metabolism | Ataxia Telangiectasia Mutated Proteins - metabolism | Imatinib Mesylate - chemical synthesis | Pyrazoles - chemical synthesis | Pyridines - chemistry | Imatinib Mesylate - metabolism | Piperazines - metabolism | Piperazines - chemistry | Aminopyridines - metabolism | Fulvestrant | Aminopyridines - chemistry | Protein Kinase Inhibitors - chemistry | Pyrazoles - chemistry | Vardenafil Dihydrochloride - chemistry | Drug Design | Ataxia Telangiectasia Mutated Proteins - antagonists & inhibitors | Cyclin-Dependent Kinases - antagonists & inhibitors | Purines - chemical synthesis | Estradiol - metabolism | Protein Kinase Inhibitors - chemical synthesis | Piperidines - chemistry | Piperidines - metabolism | Purines - metabolism | Pyridines - chemical synthesis | Pyrazoles - metabolism | Piperidines - chemical synthesis | Imatinib Mesylate - chemistry | Vardenafil Dihydrochloride - metabolism | Aminopyridines - chemical synthesis | Sulfoxides - chemistry | Estradiol - chemistry | Purines - chemistry | Pyridines - metabolism | Vardenafil Dihydrochloride - chemical synthesis | Sulfoxides - metabolism | Piperazines - chemical synthesis | Estradiol - chemical synthesis | Protein Kinase Inhibitors - metabolism | Drug discovery | Chemical properties | Pharmaceutical industry | Full Paper | Full Papers
Journal Article
Journal Article
Nature Chemical Biology, ISSN 1552-4450, 09/2009, Volume 5, Issue 9, pp. 647 - 654
Journal Article