X
Search Filters
Format Format
Format Format
X
Sort by Item Count (A-Z)
Filter by Count
Journal Article (321382) 321382
Book Review (45857) 45857
Publication (41710) 41710
Newsletter (4449) 4449
Book Chapter (2632) 2632
Newspaper Article (1580) 1580
Book / eBook (1026) 1026
Conference Proceeding (777) 777
Dissertation (192) 192
Reference (104) 104
Magazine Article (59) 59
Data Set (40) 40
Transcript (16) 16
Web Resource (16) 16
Government Document (12) 12
Paper (11) 11
Trade Publication Article (9) 9
Patent (3) 3
Presentation (2) 2
Streaming Audio (1) 1
Streaming Video (1) 1
more...
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
index medicus (279808) 279808
humans (163468) 163468
animals (156787) 156787
biochemistry & molecular biology (132201) 132201
cell biology (83554) 83554
proteins (78366) 78366
mice (68002) 68002
phosphorylation (60626) 60626
signal transduction (51101) 51101
apoptosis (45994) 45994
male (41585) 41585
expression (40888) 40888
cancer (39700) 39700
research (38160) 38160
gene expression (37657) 37657
rats (37333) 37333
activation (36418) 36418
kinases (36341) 36341
female (34468) 34468
cell line, tumor (32650) 32650
article (32205) 32205
analysis (32050) 32050
biochemistry (30685) 30685
oncology (30649) 30649
cell line (30216) 30216
research article (29698) 29698
physiological aspects (29410) 29410
cells, cultured (28964) 28964
protein binding (28072) 28072
biophysics (26981) 26981
molecular sequence data (26536) 26536
cells (26158) 26158
multidisciplinary sciences (25324) 25324
amino acid sequence (24738) 24738
protein (23732) 23732
medicine (23213) 23213
biology (22951) 22951
mutation (22038) 22038
genetic aspects (21703) 21703
gene-expression (20161) 20161
pharmacology & pharmacy (19294) 19294
life sciences (19093) 19093
oxidative stress (18979) 18979
science (18784) 18784
neurosciences (18097) 18097
enzymes (18081) 18081
inhibition (18023) 18023
signal transduction - drug effects (17939) 17939
rodents (17635) 17635
health aspects (17365) 17365
enzyme inhibitors - pharmacology (17301) 17301
molecular biology (17211) 17211
cell cycle (16994) 16994
genes (16980) 16980
physiology (16734) 16734
binding sites (16495) 16495
apoptosis - drug effects (16319) 16319
genetics & heredity (16188) 16188
inflammation (15288) 15288
cell proliferation (15160) 15160
protein kinases (14926) 14926
blotting, western (14845) 14845
in-vitro (14747) 14747
biochemistry, general (14440) 14440
in-vivo (14332) 14332
identification (13740) 13740
growth (13381) 13381
binding (13308) 13308
models, molecular (13084) 13084
kinetics (12777) 12777
metabolism (12777) 12777
base sequence (12769) 12769
nf-kappa-b (12455) 12455
dose-response relationship, drug (12442) 12442
tumors (12357) 12357
transfection (12344) 12344
enzyme activation (12277) 12277
gene expression regulation (12276) 12276
immunology (12234) 12234
chemistry, medicinal (12215) 12215
gene (12182) 12182
models, biological (12081) 12081
mice, inbred c57bl (11804) 11804
rna, messenger - metabolism (11446) 11446
rna (11217) 11217
cell proliferation - drug effects (11215) 11215
transcription (11175) 11175
pathway (11056) 11056
protein-serine-threonine kinases - metabolism (11026) 11026
protein structure, tertiary (11024) 11024
antineoplastic agents - pharmacology (11002) 11002
genetics (10852) 10852
protein kinase inhibitors - pharmacology (10762) 10762
dna (10687) 10687
transcription factors (10685) 10685
kinase (10570) 10570
time factors (10559) 10559
ligands (10453) 10453
rats, sprague-dawley (10375) 10375
signal transduction - physiology (10323) 10323
more...
Library Location Library Location
Library Location Library Location
X
Sort by Item Count (A-Z)
Filter by Count
Gerstein Science - Stacks (621) 621
UofT at Mississauga - Stacks (103) 103
Collection Dvlpm't (Acquisitions) - Vendor file (55) 55
UTL at Downsview - May be requested (48) 48
UofT at Scarborough - Stacks (42) 42
Online Resources - Online (37) 37
Collection Dvlpm't (Acquisitions) - Closed Orders (36) 36
Chemistry (A D Allen) - Stacks (34) 34
Engineering & Comp. Sci. - Stacks (20) 20
Earth Sciences (Noranda) - Stacks (18) 18
UofT at Scarborough - Withdrawn (6) 6
St. Michael's College (John M. Kelly) - 2nd Floor (5) 5
Trinity College (John W Graham) - Stacks (5) 5
Gerstein Science - Circulation Desk (4) 4
Royal Ontario Museum - Stacks (3) 3
UofT at Mississauga - Reference (3) 3
Physics - Stacks (2) 2
Sunnybrook Health Sciences Centre - Sunnybrook Stacks (2) 2
UofT at Mississauga - Missing (2) 2
Victoria University E.J. Pratt - Oversize (2) 2
Chemistry (A D Allen) - May be requested in 6-10 wks (1) 1
Collection Dvlpm't (Acquisitions) - Cancelled Order (1) 1
Earth Sciences (Noranda) - Circulation Desk (1) 1
Earth Sciences (Noranda) - Oversize (1) 1
Engineering & Comp. Sci. - Reference (1) 1
Gerstein Science - Missing (1) 1
Gerstein Science - Not Returned (1) 1
Gerstein Science - Reference (1) 1
Gerstein Science - Reserve desk (1) 1
Law (Bora Laskin) - Stacks (1) 1
Physics - Course Reserves (1) 1
St. Michael's Hospital - Stacks (1) 1
Trinity College (John W Graham) - Oversize (1) 1
UofT at Mississauga - Circulation Desk (1) 1
UofT at Scarborough - May be requested in 6-10 wks (1) 1
Victoria University E.J. Pratt - Circulation Desk (1) 1
more...
Language Language
Language Language
X
Sort by Item Count (A-Z)
Filter by Count
English (328939) 328939
Chinese (154) 154
Japanese (114) 114
German (94) 94
Spanish (65) 65
French (55) 55
Russian (40) 40
Korean (18) 18
Polish (17) 17
Czech (13) 13
Hungarian (12) 12
Portuguese (6) 6
Ukrainian (6) 6
Italian (5) 5
Dutch (4) 4
Arabic (3) 3
Turkish (3) 3
Slovak (2) 2
Swedish (2) 2
Afrikaans (1) 1
more...
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


Nature chemical biology, ISSN 1552-4450, 12/2014, Volume 10, Issue 12, pp. 1066 - 1072
Chemical probes that form a covalent bond with a protein target often show enhanced selectivity, potency and utility for biological studies. Despite these... 
RHEUMATOID-ARTHRITIS | DESIGN | LIGANDS | BIOCHEMISTRY & MOLECULAR BIOLOGY | REACTIVITY | KINASE INHIBITORS | GENERATION | OPTIMIZATION | ELECTROPHILES | PREDICTION | TOOL | Small Molecule Libraries - pharmacology | Humans | Bacterial Proteins - chemistry | Molecular Probes - pharmacology | Janus Kinase 3 - antagonists & inhibitors | Protein Kinase Inhibitors - chemistry | beta-Lactamases - genetics | Janus Kinase 3 - chemistry | Ribosomal Protein S6 Kinases, 90-kDa - antagonists & inhibitors | Cysteine - metabolism | Bacterial Proteins - antagonists & inhibitors | Bacterial Proteins - genetics | Recombinant Proteins - chemistry | Recombinant Proteins - genetics | Cysteine - chemistry | beta-Lactamase Inhibitors - pharmacology | Ribosomal Protein S6 Kinases, 90-kDa - chemistry | Serine - chemistry | Drug Discovery | Serine - metabolism | Gram-Negative Bacteria - enzymology | Gram-Negative Bacteria - drug effects | Small Molecule Libraries - chemistry | beta-Lactamases - chemistry | Molecular Probes - chemistry | Animals | Ribosomal Protein S6 Kinases, 90-kDa - genetics | Gram-Negative Bacteria - growth & development | Janus Kinase 3 - genetics | Hydrophobic and Hydrophilic Interactions | Protein Binding | Ligands | Molecular Docking Simulation | Protein Kinase Inhibitors - pharmacology | COS Cells | beta-Lactamase Inhibitors - chemistry | Proteins | Chemical bonds | Biochemistry | Crystal structure | Index Medicus | boronic acid | covalent virtual screening | JAK3 kinase | covalent fragments | covalent inhibition | beta-lactamase | RSK2 kinase | cyanoacrylamide | reversible covalent | covalent electrophile | MSK1 kinase
Journal Article
Cancer Discovery, ISSN 2159-8274, 2014, Volume 4, Issue 9, pp. 1046 - 1061
First-generation EGFR tyrosine kinase inhibitors (EGFR TKI) provide significant clinical benefit in patients with advanced EGFR-mutant (EGFRm(+)) non-small... 
GENE-MUTATIONS | GROWTH-FACTOR RECEPTOR | 1ST-LINE TREATMENT | GEFITINIB | ONCOLOGY | T790M MUTATIONS | PHASE-III | ACQUIRED-RESISTANCE | TYROSINE KINASE INHIBITOR | OPEN-LABEL | ERLOTINIB | Lung Neoplasms - drug therapy | Receptor, Epidermal Growth Factor - genetics | Phosphorylation | Humans | Middle Aged | Molecular Conformation | Lung Neoplasms - pathology | Male | Antineoplastic Agents - therapeutic use | Protein Kinase Inhibitors - chemistry | Female | Antineoplastic Agents - pharmacology | Acrylamides - pharmacology | Disease Models, Animal | Lung Neoplasms - genetics | Aniline Compounds - pharmacology | Models, Molecular | Treatment Outcome | Antineoplastic Agents - chemistry | Receptor, Epidermal Growth Factor - chemistry | Acrylamides - chemistry | Xenograft Model Antitumor Assays | Drug Resistance, Neoplasm - genetics | Animals | Signal Transduction - drug effects | Tumor Burden - drug effects | Genes, erbB-2 | Protein Kinase Inhibitors - therapeutic use | Cell Line, Tumor | Protein Binding | Receptor, Epidermal Growth Factor - antagonists & inhibitors | Acrylamides - therapeutic use | Cell Proliferation - drug effects | Protein Kinase Inhibitors - pharmacology | Aniline Compounds - chemistry | Aniline Compounds - therapeutic use | Mutation | Index Medicus | EGFR tyrosine kinase inhibitor | EGFR mutant lung cancer | AZD9291
Journal Article
SCIENCE TRANSLATIONAL MEDICINE, ISSN 1946-6234, 03/2015, Volume 7, Issue 279, pp. 279ra41 - 279ra41
Journal Article
Nature Chemical Biology, ISSN 1552-4450, 10/2016, Volume 12, Issue 10, pp. 876 - 884
Journal Article