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Nature, ISSN 0028-0836, 03/2010, Volume 464, Issue 7287, pp. 427 - 430
Tumours with mutant BRAF are dependent on the RAF–MEK–ERK signalling pathway for their growth. We found that ATP-competitive RAF inhibitors inhibit ERK... 
SELECTIVE INHIBITOR | ACTIVATION | MELANOMA | MECHANISM | MULTIDISCIPLINARY SCIENCES | SENSITIVITY | HETERODIMERIZATION | KINASE INHIBITOR | B-RAF | CRAF | ONCOGENIC BRAF | Neoplasms - metabolism | ras Proteins - genetics | Phosphorylation | raf Kinases - antagonists & inhibitors | Humans | Protein Multimerization | Transcriptional Activation - drug effects | ras Proteins - metabolism | Extracellular Signal-Regulated MAP Kinases - metabolism | raf Kinases - metabolism | Mitogen-Activated Protein Kinase Kinases - metabolism | Neoplasms - genetics | Adenosine Triphosphate - metabolism | Indoles - pharmacology | raf Kinases - genetics | Proto-Oncogene Proteins B-raf - metabolism | Proto-Oncogene Proteins B-raf - chemistry | Cell Line | raf Kinases - chemistry | Catalytic Domain | Neoplasms - enzymology | Enzyme Activation - drug effects | Sulfonamides - pharmacology | Neoplasms - drug therapy | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Animals | MAP Kinase Signaling System - drug effects | Models, Biological | Protein Kinase Inhibitors - therapeutic use | Proto-Oncogene Proteins B-raf - genetics | Cell Line, Tumor | Protein Binding | Mice | Protein Kinase Inhibitors - pharmacology | Protein Kinase Inhibitors - metabolism | Care and treatment | Enzyme inhibitors | Gene mutations | Cellular signal transduction | Genetic aspects | Research | Health aspects | Cancer | Proteins | Competition | Drugs | Mutation | Kinases | Tumors | Index Medicus
Journal Article
Clinical Pharmacokinetics, ISSN 0312-5963, 9/2011, Volume 50, Issue 9, pp. 551 - 603
Journal Article
Journal Article
Journal Article
Nature, ISSN 0028-0836, 02/2009, Volume 457, Issue 7230, pp. 687 - 693
Aberrant folding of proteins in the endoplasmic reticulum activates the bifunctional transmembrane kinase/ endoribonuclease Ire1. Ire1 excises an intron from... 
GROWTH-FACTOR RECEPTOR | ACTIVATION | MESSENGER-RNA | MECHANISM | ER-STRESS | MULTIDISCIPLINARY SCIENCES | KINASE | ENDOPLASMIC-RETICULUM | TRANSCRIPTION FACTOR | AUTOPHOSPHORYLATION | SOFTWARE | Membrane Glycoproteins - metabolism | Ribonucleases - chemistry | Membrane Glycoproteins - chemistry | Protein Multimerization | Crystallography, X-Ray | Ribonucleases - metabolism | Protein Kinase Inhibitors - chemistry | Membrane Glycoproteins - antagonists & inhibitors | Protein Binding - drug effects | Protein Denaturation | Protein Structure, Quaternary | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Phosphorylation - drug effects | Binding Sites | Protein-Serine-Threonine Kinases - metabolism | Protein Structure, Tertiary | Introns - genetics | Saccharomyces cerevisiae Proteins - antagonists & inhibitors | Models, Molecular | Repressor Proteins - genetics | Basic-Leucine Zipper Transcription Factors - genetics | Saccharomyces cerevisiae Proteins - genetics | Enzyme Activation - drug effects | Protein Folding | Saccharomyces cerevisiae - chemistry | Saccharomyces cerevisiae Proteins - metabolism | Saccharomyces cerevisiae - enzymology | Cytosol - metabolism | Protein Kinase Inhibitors - pharmacology | Protein-Serine-Threonine Kinases - chemistry | Protein Kinase Inhibitors - metabolism | Saccharomyces cerevisiae Proteins - chemistry | Physiological aspects | Cellular proteins | Genetic aspects | Research | Protein folding | Endoplasmic reticulum | Enzymes | Signal transduction | E coli | Acids | Data collection | RNA polymerase | Kinases | Index Medicus
Journal Article