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Journal of Clinical Immunology, ISSN 0271-9142, 6/2011, Volume 31, Issue 3, pp. 472 - 478
Leptin, one of the adipokines, functions as a hormone and a cytokine. In this investigation, we show for the first time that leptin, in a... 
Medical Microbiology | Biomedicine | Immunology | Internal Medicine | Infectious Diseases | activation markers | cytokines | B cells | PROTEIN-KINASE | TRANSDUCER | RECEPTOR | PROLIFERATION | IMMUNOLOGY | BLOOD MONONUCLEAR-CELLS | DEFICIENCY | PI3K/AKT | IMMUNE-RESPONSES | T-CELLS | Autoimmunity | Interleukin-6 - analysis | Janus Kinase 2 - biosynthesis | Mitogen-Activated Protein Kinase 3 - analysis | Humans | p38 Mitogen-Activated Protein Kinases - biosynthesis | p38 Mitogen-Activated Protein Kinases - analysis | Dose-Response Relationship, Drug | Signal Transduction - immunology | Inflammation - metabolism | Mitogen-Activated Protein Kinases - analysis | Mitogen-Activated Protein Kinase 3 - biosynthesis | Mitogen-Activated Protein Kinase 6 - analysis | Leptin - pharmacology | Phosphorylation - drug effects | Interleukin-10 - analysis | B-Lymphocytes - metabolism | Janus Kinase 2 - analysis | Enzyme-Linked Immunosorbent Assay | Lymphocyte Activation | Cells, Cultured | Mitogen-Activated Protein Kinases - biosynthesis | Receptors, Leptin - immunology | STAT3 Transcription Factor - analysis | Inflammation - immunology | Tumor Necrosis Factor-alpha - analysis | STAT3 Transcription Factor - biosynthesis | B-Lymphocytes - drug effects | B-Lymphocytes - immunology | Mitogen-Activated Protein Kinase 6 - biosynthesis | Interleukin-6 - biosynthesis | Interleukin-10 - biosynthesis | Receptors, Leptin - metabolism | Tumor Necrosis Factor-alpha - biosynthesis
Journal Article
Nature, ISSN 0028-0836, 2014, Volume 508, Issue 1, pp. 118 - 122
Treatment of BRAF(V600E) mutant melanoma by small molecule drugs that target the BRAF or MEK kinases can be effective, but resistance develops invariably(1,2).... 
GROWTH-FACTOR RECEPTOR | BRAF INHIBITOR | RAF INHIBITION | CELLS | MULTIDISCIPLINARY SCIENCES | IMPROVED SURVIVAL | DIFFERENTIATION | C-JUN | CANCER | EXPRESSION | EGFR | Receptor, Epidermal Growth Factor - genetics | Humans | Receptor Protein-Tyrosine Kinases - biosynthesis | Cellular Senescence - drug effects | Melanoma - enzymology | Antineoplastic Agents - administration & dosage | Receptor, Platelet-Derived Growth Factor beta - genetics | Indoles - administration & dosage | Mitogen-Activated Protein Kinase Kinases - metabolism | Receptor, Epidermal Growth Factor - metabolism | Flow Cytometry | Melanoma - genetics | Female | Indoles - pharmacology | Antineoplastic Agents - pharmacology | Gene Expression Regulation, Neoplastic - drug effects | SOXE Transcription Factors - deficiency | Proto-Oncogene Proteins B-raf - metabolism | Receptor, Platelet-Derived Growth Factor beta - metabolism | Receptor, Epidermal Growth Factor - biosynthesis | Gene Library | Mitogen-Activated Protein Kinase Kinases - antagonists & inhibitors | Melanoma - pathology | Receptor Protein-Tyrosine Kinases - metabolism | Sulfonamides - pharmacology | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Protein Kinase Inhibitors - administration & dosage | Transforming Growth Factor beta - pharmacology | Drug Resistance, Neoplasm - genetics | Animals | Receptor Protein-Tyrosine Kinases - genetics | Signal Transduction - drug effects | Proto-Oncogene Proteins B-raf - genetics | Melanoma - drug therapy | Cell Proliferation - drug effects | Mice | Protein Kinase Inhibitors - pharmacology | RNA, Small Interfering | Transforming Growth Factor beta - metabolism | Receptor, Platelet-Derived Growth Factor beta - biosynthesis | Sulfonamides - administration & dosage | Drug Resistance, Neoplasm - drug effects | SOXE Transcription Factors - genetics | Proteins | Biopsy | Rodents | Genes | Melanoma | Mutation | Kinases | Drug resistance | Patients | Tumors | Index Medicus
Journal Article
Cancer Research, ISSN 0008-5472, 04/2006, Volume 66, Issue 7, pp. 3903 - 3911
Journal Article
Progress in Neuropsychopharmacology & Biological Psychiatry, ISSN 0278-5846, 08/2011, Volume 35, Issue 7, pp. 1774 - 1779
Recent studies demonstrate that rapid antidepressant response to ketamine is mediated by activation of the mammalian target of rapamycin (mTOR) signaling... 
Prefrontal cortex | Translation initiation pathway | Major depressive disorder | Postmortem | PHOSPHORYLATION | INITIATION | PSYCHIATRY | RECEPTOR | SYNAPTIC PLASTICITY | PROTEIN-SYNTHESIS | NEUROSCIENCES | CLINICAL NEUROLOGY | KETAMINE | PHARMACOLOGY & PHARMACY | EUKARYOTIC TRANSLATION | Ribosomal Protein S6 Kinases, 70-kDa - analysis | TOR Serine-Threonine Kinases - metabolism | Depressive Disorder, Major - metabolism | Humans | Middle Aged | Prefrontal Cortex - physiopathology | Male | Depressive Disorder, Major - immunology | Prefrontal Cortex - pathology | Ribosomal Protein S6 Kinases - immunology | Ribosomal Protein S6 Kinases, 70-kDa - biosynthesis | Signal Transduction - immunology | TOR Serine-Threonine Kinases - genetics | Autopsy | Eukaryotic Initiation Factors - immunology | Aged, 80 and over | Ribosomal Protein S6 Kinases - analysis | Adult | Female | Eukaryotic Initiation Factors - genetics | Prefrontal Cortex - immunology | Ribosomal Protein S6 Kinases, 70-kDa - genetics | Signal Transduction - genetics | Eukaryotic Initiation Factors - biosynthesis | Ribosomal Protein S6 Kinases, 70-kDa - immunology | TOR Serine-Threonine Kinases - immunology | TOR Serine-Threonine Kinases - analysis | Depressive Disorder, Major - genetics | Family | Aged | Eukaryotic Initiation Factors - analysis | Ribosomal Protein S6 Kinases - biosynthesis | Ribosomal Protein S6 Kinases - genetics | Proteins | Methyl aspartate | Glutamate | Antidepressants | major depressive disorder | prefrontal cortex; translation initiation pathway | postmortem
Journal Article
Journal of Clinical Oncology, ISSN 0732-183X, 2018, Volume 36, Issue 9, pp. 911 - 919
Journal Article
Blood, ISSN 0006-4971, 06/2011, Volume 117, Issue 23, pp. 6287 - 6296
B-cell receptor (BCR) signaling is aberrantly activated in chronic lymphocytic leukemia (CLL). Bruton tyrosine kinase (BTK) is essential to BCR signaling and... 
B-CELLS | SURVIVAL | APOPTOSIS | ACTIVATION | FLUDARABINE PLUS CYCLOPHOSPHAMIDE | RITUXIMAB | LYMPHOMA | PROLIFERATION | INHIBITOR | HEMATOLOGY | EXPRESSION | T-Lymphocytes - enzymology | Apoptosis - drug effects | Humans | Tumor Necrosis Factor-alpha - genetics | Cell Survival - genetics | Apoptosis - genetics | Male | NF-kappa B - metabolism | Neoplasm Proteins - antagonists & inhibitors | Receptors, Antigen, B-Cell - metabolism | Mitogen-Activated Protein Kinase 1 - genetics | Neoplasm Proteins - genetics | Interleukin-6 - metabolism | Cell Survival - drug effects | Drug Screening Assays, Antitumor - methods | Interleukin-6 - genetics | Mitogen-Activated Protein Kinase 3 - genetics | Gene Expression Regulation, Leukemic - drug effects | Pyrimidines - pharmacology | Leukemia, Lymphocytic, Chronic, B-Cell - enzymology | B-Cell Activating Factor - metabolism | CD40 Ligand - genetics | Mitogen-Activated Protein Kinase 3 - metabolism | Gene Expression Regulation, Enzymologic - genetics | Cell Line, Tumor | Receptors, Antigen, B-Cell - genetics | Mice | Leukemia, Lymphocytic, Chronic, B-Cell - drug therapy | Mitogen-Activated Protein Kinase 1 - metabolism | Protein-Tyrosine Kinases - antagonists & inhibitors | Tumor Necrosis Factor-alpha - metabolism | Gene Expression Regulation, Enzymologic - drug effects | Phosphatidylinositol 3-Kinases - metabolism | Gene Expression Regulation, Leukemic - genetics | Protein-Tyrosine Kinases - genetics | CD40 Ligand - metabolism | MAP Kinase Signaling System - genetics | Female | Interleukin-4 - genetics | Protein-Tyrosine Kinases - biosynthesis | Pyrazoles - pharmacology | B-Lymphocytes - enzymology | Neoplasm Proteins - biosynthesis | Interleukin-4 - metabolism | Phosphatidylinositol 3-Kinases - genetics | Animals | MAP Kinase Signaling System - drug effects | NF-kappa B - genetics | B-Cell Activating Factor - genetics | Cell Proliferation - drug effects | Lymphoid Neoplasia
Journal Article
Journal of Experimental Botany, ISSN 0022-0957, 02/2018, Volume 69, Issue 5, pp. 1109 - 1123
An ABA-responsive SnRK2-type kinase, AaAPK1, is involved in positively regulating artemisinin biosynthesis in Artemisia annua through phosphorylation of... 
kinase | Artemisia annua | transgene | bZIP1 | phosphorylation | artemisinin biosynthesis | ABA | SEED-GERMINATION | BOTRYTIS-CINEREA | AP2/ERF TRANSCRIPTION FACTOR | SNRK2 PROTEIN-KINASES | PLANT SCIENCES | GENE | PATHWAY | ANNUA L | ARABIDOPSIS | EXPRESSION | Research Papers
Journal Article
PLOS Genetics, ISSN 1553-7390, 06/2017, Volume 13, Issue 6, p. e1006832
Plants actively perceive and respond to perturbations in their cell walls which arise during growth, biotic and abiotic stresses. However, few components... 
ORGANIZATION | CORTICAL MICROTUBULES | FERONIA | MUTANT | PROTEIN | BIOSYNTHESIS | GENES | GENETICS & HEREDITY | RESISTANCE | HELICAL GROWTH | CELLULOSE SYNTHASE COMPLEXES | Arabidopsis Proteins - genetics | Protein Kinases - genetics | Arabidopsis - drug effects | Stress, Physiological - genetics | Cell Wall - genetics | Plant Roots - genetics | Plant Diseases - microbiology | Sodium Chloride - toxicity | Plant Roots - drug effects | Arabidopsis - genetics | Cellulose - biosynthesis | Oxylipins - metabolism | Gene Expression Regulation, Plant - drug effects | Cell Wall - drug effects | Lignin - biosynthesis | Arabidopsis Proteins - biosynthesis | Cyclopentanes - metabolism | Plant Diseases - genetics | Stress, Physiological - drug effects | Protein Kinases - biosynthesis | Disease Resistance - genetics | Fusarium - pathogenicity | Receptors, Cell Surface - genetics | Arabidopsis thaliana | Physiological aspects | Genetic aspects | Gene expression | Observations | Phosphotransferases | Plant cell walls | Lignin | Research parks | Laboratories | Genomics | Cellulose | Biosynthesis | Plants (organisms) | Leucine | Kinases | Cell adhesion & migration | Fungi | Fusarium | Life sciences | Charitable foundations | Jasmonic acid | Plates | Stresses | Cues | Pathogens | Fusarium oxysporum | Cell walls | Abiotic stress | Grants | Acid production | College campuses | Immunological tolerance | Alleles | Molecular biology | Detection | Integrity
Journal Article
Genetics, ISSN 0016-6731, 10/2016, Volume 204, Issue 2, pp. 807 - 819
The CKS1B gene located on chromosome 1q21 is frequently amplified in breast, lung, and liver cancers. CKS1B codes for a conserved regulatory subunit of... 
Cyclin-dependent kinase | CKS1 | Polo-like kinase | Synthetic dosage lethal | FISSION YEAST | BUDDING YEAST | CRYSTAL-STRUCTURE | synthetic dosage lethal | SACCHAROMYCES-CEREVISIAE | HEPATOCELLULAR-CARCINOMA | CYCLE CONTROL | polo-like kinase | GENETICS & HEREDITY | REGULATORY PROTEIN CKS1 | cyclin-dependent kinase | MORPHOGENESIS CHECKPOINT | SCHIZOSACCHAROMYCES-POMBE | Neoplasms - metabolism | Synthetic Lethal Mutations - genetics | Conserved Sequence - genetics | Saccharomyces cerevisiae - genetics | Humans | Gene Expression Regulation, Neoplastic | CDC2-CDC28 Kinases - biosynthesis | Saccharomyces cerevisiae Proteins - biosynthesis | Mitosis - genetics | Proto-Oncogene Proteins - biosynthesis | Saccharomyces cerevisiae - metabolism | Protein-Tyrosine Kinases - genetics | Neoplasms - genetics | Nuclear Proteins - biosynthesis | Cell Cycle Proteins - genetics | Nuclear Proteins - genetics | Protein-Tyrosine Kinases - biosynthesis | Gene Expression Regulation, Fungal | Protein-Serine-Threonine Kinases - genetics | CDC28 Protein Kinase, S cerevisiae - genetics | Proto-Oncogene Proteins - genetics | Cell Cycle Proteins - biosynthesis | Saccharomyces cerevisiae Proteins - genetics | CDC28 Protein Kinase, S cerevisiae - biosynthesis | Protein Interaction Mapping | Protein-Serine-Threonine Kinases - biosynthesis | Adaptor Proteins, Signal Transducing - genetics | Cell Line, Tumor | Adaptor Proteins, Signal Transducing - biosynthesis | CDC2-CDC28 Kinases - genetics | Lethal mutation | Yeast | Research | Chromosomes | Cancer cells | Medical research | Phosphorylation | Cyclin-dependent kinases | Singers | Genomes | Kinases | Academic libraries | Studies | AACR | Gene amplification | Cell cycle | Mutation | Cancer | Apoptosis | Crystal structure | Investigations
Journal Article
Nature Reviews Cancer, ISSN 1474-175X, 2013, Volume 13, Issue 10, pp. 685 - 700
The burgeoning field of anaplastic lymphoma kinase (ALK) in cancer encompasses many cancer types, from very rare cancers to the more prevalent non-small-cell... 
ANAPLASTIC LYMPHOMA KINASE | MOLECULAR CHARACTERIZATION | LUNG-CANCER |