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2010, 2nd ed., Methods in molecular biology, ISBN 9781607617945, Volume 661., xiv, 529
Book
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 12/1998, Volume 253, Issue 2, pp. 532 - 543
Journal Article
Journal Article
Toxicology and Applied Pharmacology, ISSN 0041-008X, 08/2017, Volume 329, pp. 112 - 120
In this study, we found that catechins found in green tea (EGCG, EGC, and EC) differentially interfere with the IL-1β signaling pathway which regulates the... 
EGC | Catechins | Inflammation | Green tea | Rheumatoid arthritis | EGCG | CELLS | ACTIVATION | CYCLOOXYGENASE-2 | RAT | PHARMACOLOGY & PHARMACY | POLYPHENOL | TOXICOLOGY | EPIGALLOCATECHIN-3-GALLATE | EXTRACT | Interleukin-1beta - pharmacology | Phosphorylation | Humans | Synovial Membrane - immunology | NF-kappa B - metabolism | Synovial Membrane - drug effects | MAP Kinase Kinase Kinases - chemistry | Arthritis, Rheumatoid - metabolism | Arthritis, Rheumatoid - drug therapy | Anti-Inflammatory Agents - isolation & purification | p38 Mitogen-Activated Protein Kinases - metabolism | Antirheumatic Agents - pharmacology | Interleukin-8 - metabolism | Phytotherapy | Catechin - pharmacology | MAP Kinase Kinase Kinases - antagonists & inhibitors | Interleukin-6 - metabolism | Fibroblasts - metabolism | Catalytic Domain | Cyclooxygenase 2 Inhibitors - pharmacology | Anti-Inflammatory Agents - pharmacology | Matrix Metalloproteinase 2 - metabolism | Cells, Cultured | Cyclooxygenase 2 Inhibitors - isolation & purification | MAP Kinase Kinase Kinases - metabolism | Protein Kinase Inhibitors - isolation & purification | Synovial Membrane - metabolism | Anti-Inflammatory Agents - chemistry | Signal Transduction - drug effects | Antirheumatic Agents - isolation & purification | Proto-Oncogene Proteins c-jun - metabolism | Fibroblasts - drug effects | p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors | Catechin - isolation & purification | Protein Binding | Fibroblasts - immunology | Catechin - analogs & derivatives | Molecular Docking Simulation | Protein Kinase Inhibitors - pharmacology | Antirheumatic Agents - chemistry | Arthritis, Rheumatoid - immunology | Catechin - chemistry | Plants, Medicinal | Tea - chemistry | Index Medicus | PHOSPHORUS 38 | RHEUMATIC DISEASES | INHIBITION | SIGNALS | BEVERAGES | 60 APPLIED LIFE SCIENCES | FIBROBLASTS
Journal Article
Nature Cell Biology, ISSN 1465-7392, 12/2003, Volume 5, Issue 12, pp. 1104 - 1110
Journal Article
PLoS ONE, ISSN 1932-6203, 03/2017, Volume 12, Issue 3, p. e0173074
Scope Olive-tree polyphenols have demonstrated potential for the management of obesity-related pathologies. We aimed to explore the capacity of Olive-tree... 
QUERCETIN | ACTIVATED PROTEIN-KINASE | OIL | SIGNALING PATHWAY | PEEL EXTRACT | MULTIDISCIPLINARY SCIENCES | ALTERNATE BEARING | DIFFERENTIATION | PLANT-DERIVED POLYPHENOLS | ADIPOGENESIS | IDENTIFICATION | Plant Extracts - chemistry | AMP-Activated Protein Kinases - metabolism | Protein Subunits - analysis | AMP-Activated Protein Kinases - analysis | Polyphenols - pharmacology | Adipocytes - cytology | Adipocytes - drug effects | Chromatography, High Pressure Liquid | Protein Subunits - metabolism | Polyphenols - metabolism | Chromatography, Reverse-Phase | Plant Extracts - analysis | Triglycerides - analysis | Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | Binding Sites | Plant Leaves - chemistry | Protein Structure, Tertiary | Polyphenols - isolation & purification | 3T3-L1 Cells | AMP-Activated Protein Kinases - chemistry | Triglycerides - metabolism | Gene Expression Regulation - drug effects | Animals | Plant Leaves - metabolism | Adipocytes - metabolism | Polyphenols - chemistry | Olea - metabolism | Mice | Molecular Docking Simulation | Microscopy, Fluorescence | Olea - chemistry | Olive | Obesity | Care and treatment | Analysis | Medicine, Botanic | Polyphenols | Physiological aspects | Medicine, Herbal | Research | Protein kinases | Health aspects | Phosphorylation | Cinnamic acid | Lignans | Homeostasis | Adipocytes | Fruit trees | Kinases | AMP-activated protein kinase | Accumulation | Modulators | Molecular docking | Proteins | Leaves | Energy | Food | Functional foods & nutraceuticals | Analytical chemistry | Fractionation | Immunomodulation | Research & development--R&D | Bioassays | Triglycerides | Liquid chromatography | Metabolism | High-performance liquid chromatography | Phenolic compounds | Chromatography | Flavonoids | Microscopy | Ionization | Phenols | Phenylpropanoids | Intracellular | Immunofluorescence | High performance liquid chromatography | Research & development | R&D
Journal Article
Molecular Cell, ISSN 1097-2765, 07/2004, Volume 15, Issue 1, pp. 141 - 152
Journal Article
NATURE COMMUNICATIONS, ISSN 2041-1723, 04/2019, Volume 10, Issue 1, pp. 1676 - 13
p27(Kip1) is an intrinsically disordered protein (IDP) that inhibits cyclin-dependent kinase (Cdk)/cyclin complexes (e.g., Cdk2/cyclin A), causing cell cycle... 
SITE | INTRINSICALLY DISORDERED PROTEIN | PHOSPHORYLATION | LANDSCAPE | STABILITY | MULTIDISCIPLINARY SCIENCES | STRUCTURAL DISORDER | COMPLEXES | FRET | BINDING | P27(KIP1) | Phosphorylation - physiology | Crystallography, X-Ray | Threonine - metabolism | Recombinant Proteins - isolation & purification | Cyclin-Dependent Kinase Inhibitor p27 - metabolism | Proteolysis | src-Family Kinases - metabolism | Recombinant Proteins - metabolism | Cyclin-Dependent Kinase 2 - metabolism | Mutagenesis, Site-Directed | Cyclin A - metabolism | Cyclin A - isolation & purification | Recombinant Proteins - genetics | Cyclin-Dependent Kinase 2 - isolation & purification | Molecular Dynamics Simulation | Protein Processing, Post-Translational - physiology | Cell Division - physiology | src-Family Kinases - isolation & purification | Tyrosine - metabolism | Signal Transduction - physiology | Cyclin-Dependent Kinase Inhibitor p27 - isolation & purification | Fusion Proteins, bcr-abl - metabolism | Cyclin-Dependent Kinase Inhibitor p27 - genetics | Protein Binding - physiology | Protein Structure, Tertiary - physiology | Tyrosine | BCR protein | Phosphorylation | Threonine | Cyclin-dependent kinases | Cell division | Abl protein | Kinases | Proteins | Cyclin-dependent kinase 2 | Signaling | Cyclin A | Dynamic stability | Cell cycle | Cyclin-dependent kinase inhibitor p27 | Fusion protein
Journal Article
Journal Article
The EMBO Journal, ISSN 0261-4189, 08/1998, Volume 17, Issue 15, pp. 4426 - 4441
We have identified a novel mitogen‐ and stress‐activated protein kinase (MSK1) that contains two protein kinase domains in a single polypeptide. MSK1 is... 
MSK1 | p38 MAP kinase | MAP kinase | CREB | signal transduction | Signal transduction | BIOCHEMISTRY & MOLECULAR BIOLOGY | GLYCOGEN-SYNTHASE KINASE-3 | CELLULAR STRESSES | IDENTIFICATION | PHOSPHORYLATION SITES | CELL BIOLOGY | INSULIN | SAP KINASES | SUBSTRATE-SPECIFICITY | PATHWAY | SEQUENCE | S6 KINASE | Tetradecanoylphorbol Acetate - pharmacology | Epidermal Growth Factor - physiology | Ribosomal Protein S6 Kinases - metabolism | Humans | Molecular Sequence Data | PC12 Cells | Kidney | Ribosomal Protein S6 Kinases - immunology | Ultraviolet Rays | Base Sequence | Ribosomal Protein S6 Kinases - chemistry | p38 Mitogen-Activated Protein Kinases | Protein-Serine-Threonine Kinases - metabolism | DNA-Binding Proteins | Calcium-Calmodulin-Dependent Protein Kinases - physiology | Mitogen-Activated Protein Kinases | Amino Acid Sequence | Cell Line | Transcription Factors - radiation effects | Calcium-Calmodulin-Dependent Protein Kinases - genetics | Protein-Serine-Threonine Kinases - physiology | Protein-Serine-Threonine Kinases - genetics | Protein-Serine-Threonine Kinases - isolation & purification | Intracellular Signaling Peptides and Proteins | Rats | Enzyme Activation - drug effects | Enzyme Activation - radiation effects | Precipitin Tests | Cyclic AMP Response Element-Binding Protein - radiation effects | Transcription Factors - metabolism | Calcium-Calmodulin-Dependent Protein Kinases - isolation & purification | Phosphorylation - radiation effects | Animals | Activating Transcription Factor 1 | Cyclic AMP Response Element-Binding Protein - metabolism | Tumor Necrosis Factor-alpha - physiology | Signal Transduction - physiology | Mice | HeLa Cells | Mitogen-Activated Protein Kinase 1 | Calcium-Calmodulin-Dependent Protein Kinases - metabolism | Ribosomal Protein S6 Kinases, 90-kDa
Journal Article
PLoS ONE, ISSN 1932-6203, 06/2013, Volume 8, Issue 6, p. e66796
Human protein kinases (HPKs) have profound effects on cellular responses. To better understand the role of HPKs and the signaling networks that influence... 
A VIRUS | SIGNAL-TRANSDUCTION | ANTIVIRAL THERAPY | AVIAN INFLUENZA | PROTEIN-KINASE | MULTIDISCIPLINARY SCIENCES | IN-VIVO | CELL-CYCLE ARREST | NF-KAPPA-B | RESISTANT INFLUENZA | RESPIRATORY SYNCYTIAL VIRUS | Protein Kinases - metabolism | Up-Regulation | Protein Kinases - genetics | Influenza, Human - pathology | MicroRNAs - antagonists & inhibitors | Virus Replication - genetics | Humans | Influenza A virus - genetics | Influenza, Human - enzymology | Protein Kinases - chemistry | MicroRNAs - metabolism | RNA Interference | NIMA-Related Kinases - antagonists & inhibitors | Base Sequence | Madin Darby Canine Kidney Cells | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Viral Core Proteins - metabolism | Influenza, Human - virology | MicroRNAs - agonists | RNA, Ribosomal, 18S - metabolism | MAP Kinase Kinase Kinase 1 - antagonists & inhibitors | Protein-Serine-Threonine Kinases - metabolism | MAP Kinase Kinase Kinase 1 - metabolism | A549 Cells | Influenza A virus - physiology | RNA, Ribosomal, 18S - genetics | Protein-Serine-Threonine Kinases - genetics | Influenza A virus - isolation & purification | Phenotype | Sequence Alignment | Animals | Influenza, Human - genetics | Dogs | NIMA-Related Kinases - metabolism | NIMA-Related Kinases - genetics | MAP Kinase Kinase Kinase 1 - genetics | RNA-Binding Proteins - metabolism | Influenza viruses | MicroRNA | Health aspects | Protein kinases | Influenza | Genes | Pandemics | Transcription | Genomics | Viruses | Infections | Antagonists | Kinases | Genetic screening | Proteins | Signal transduction | Cell cycle | miRNA | siRNA | Gene expression | Ribonucleic acid--RNA | Studies | Signaling | Infectious diseases | Swine flu | MicroRNAs | Proteomics | Replication | Viral infections | Apoptosis | RNA | Ribonucleic acid
Journal Article