Articles

Search Articles

Advanced search
Help

Catalogue

Articles

Databases

X
Search Filters
Format Format
Format Format
X
Sort by Item Count (A-Z)
Filter by Count
Journal Article (73358) 73358
Publication (8862) 8862
Book Review (1349) 1349
Book Chapter (908) 908
Book / eBook (593) 593
Newsletter (410) 410
Newspaper Article (355) 355
Conference Proceeding (181) 181
Dissertation (39) 39
Magazine Article (36) 36
Data Set (14) 14
Reference (10) 10
Trade Publication Article (9) 9
Transcript (6) 6
Web Resource (3) 3
Paper (2) 2
Presentation (2) 2
Government Document (1) 1
Streaming Video (1) 1
more...
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
index medicus (42826) 42826
animals (34652) 34652
humans (33289) 33289
proteins (20168) 20168
mice (13983) 13983
biochemistry & molecular biology (13421) 13421
neurosciences (11167) 11167
male (10559) 10559
cell biology (9563) 9563
analysis (9345) 9345
apoptosis (8740) 8740
oxidative stress (8736) 8736
alzheimer's disease (8620) 8620
female (8471) 8471
gene expression (7885) 7885
research (7880) 7880
rats (7772) 7772
physiological aspects (7720) 7720
cancer (7059) 7059
expression (6960) 6960
article (6951) 6951
pharmacology & pharmacy (6797) 6797
alzheimers-disease (6277) 6277
protein (6265) 6265
research article (5833) 5833
medicine (5663) 5663
oncology (5564) 5564
multidisciplinary sciences (5475) 5475
enzymes (5289) 5289
health aspects (5281) 5281
toxicity (5114) 5114
cells, cultured (4916) 4916
brain (4888) 4888
signal transduction (4858) 4858
in-vitro (4710) 4710
metabolism (4684) 4684
rodents (4589) 4589
biology (4519) 4519
genetic aspects (4484) 4484
mutation (4344) 4344
toxicology (4295) 4295
science (4293) 4293
cells (4269) 4269
disease models, animal (4182) 4182
cell line, tumor (4145) 4145
life sciences (4130) 4130
peptides (4103) 4103
genes (4088) 4088
neurons (4023) 4023
kinases (3955) 3955
in-vivo (3865) 3865
biotechnology & applied microbiology (3823) 3823
inflammation (3794) 3794
biochemistry (3682) 3682
immunology (3620) 3620
gene-expression (3581) 3581
activation (3578) 3578
neurology (3576) 3576
protein binding (3525) 3525
cell line (3450) 3450
phosphorylation (3419) 3419
review (3413) 3413
neurodegeneration (3390) 3390
neurodegenerative diseases (3346) 3346
mice, inbred c57bl (3312) 3312
microbiology (3291) 3291
molecular sequence data (3284) 3284
apoptosis - drug effects (3234) 3234
medicine, research & experimental (3227) 3227
amino acid sequence (3201) 3201
amyloid precursor protein (3157) 3157
care and treatment (3154) 3154
studies (3033) 3033
disease (2904) 2904
dose-response relationship, drug (2848) 2848
proteomics (2818) 2818
alzheimer disease - metabolism (2798) 2798
stem cells (2798) 2798
pathology (2771) 2771
lipids (2758) 2758
inhibition (2750) 2750
physiology (2711) 2711
biomedicine (2657) 2657
neurons - metabolism (2655) 2655
amyloid beta-peptides - metabolism (2643) 2643
biotechnology (2630) 2630
mice, transgenic (2595) 2595
biophysics (2585) 2585
cytotoxicity (2570) 2570
cell survival - drug effects (2567) 2567
biochemistry, general (2565) 2565
alzheimers disease (2514) 2514
antioxidants (2467) 2467
rats, sprague-dawley (2453) 2453
mitochondria (2447) 2447
molecular biology (2447) 2447
transgenic mice (2438) 2438
cell death (2436) 2436
medical research (2409) 2409
signal transduction - drug effects (2363) 2363
more...
Library Location Library Location
Library Location Library Location
X
Sort by Item Count (A-Z)
Filter by Count
Gerstein Science - Stacks (399) 399
UofT at Mississauga - Stacks (56) 56
Collection Dvlpm't (Acquisitions) - Vendor file (40) 40
UTL at Downsview - May be requested (29) 29
UofT at Scarborough - Stacks (22) 22
Chemistry (A D Allen) - Stacks (18) 18
Collection Dvlpm't (Acquisitions) - Closed Orders (18) 18
Online Resources - Online (18) 18
Engineering & Comp. Sci. - Stacks (14) 14
Earth Sciences (Noranda) - Stacks (12) 12
St. Michael's College (John M. Kelly) - 2nd Floor (5) 5
UofT at Scarborough - Withdrawn (4) 4
Gerstein Science - Circulation Desk (3) 3
Physics - Stacks (3) 3
Gerstein Science - Reference (2) 2
UofT at Mississauga - Missing (2) 2
UofT at Mississauga - Reference (2) 2
Baycrest Hospital - Stacks (1) 1
Chemistry (A D Allen) - May be requested in 6-10 wks (1) 1
Collection Dvlpm't (Acquisitions) - Cancelled Order (1) 1
Dentistry (Harry R Abbott) - May be requested in 6-10 wks (1) 1
Engineering & Comp. Sci. - Reference (1) 1
Gerstein Science - Missing (1) 1
Gerstein Science - Theses (1) 1
Media Commons - Microtexts (1) 1
Royal Ontario Museum - Stacks (1) 1
Sunnybrook Health Sciences Centre - Sunnybrook Stacks (1) 1
Trinity College (John W Graham) - Stacks (1) 1
UofT Schools - Stacks (1) 1
more...
Language Language
Language Language
X
Sort by Item Count (A-Z)
Filter by Count
English (75219) 75219
Spanish (38) 38
German (32) 32
Japanese (23) 23
French (20) 20
Chinese (17) 17
Portuguese (12) 12
Russian (11) 11
Polish (4) 4
Czech (3) 3
Korean (3) 3
Arabic (2) 2
Hungarian (2) 2
Bulgarian (1) 1
Dutch (1) 1
Italian (1) 1
Slovak (1) 1
Swedish (1) 1
more...
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


1. Full Text Days to criterion as an indicator of toxicity associated with human Alzheimer amyloid‐β oligomers
by Gandy, Sam and Simon, Adam J and Steele, John W and Lublin, Alex L and Lah, James J and Walker, Lary C and Levey, Allan I and Krafft, Grant A and Levy, Efrat and Checler, Frédéric and Glabe, Charles and Bilker, Warren B and Abel, Ted and Schmeidler, James and Ehrlich, Michelle E
Annals of Neurology, ISSN 0364-5134, 08/2010, Volume 68, Issue 2, pp. 220 - 230
Objective Recent evidence suggests that high molecular weight soluble oligomeric Aβ (oAβ) assemblies (also known as Aβ‐derived diffusible ligands, or ADDLs)... 
NATURAL OLIGOMERS | MEMORY | MOUSE MODEL | DISEASE | A-BETA | HEREDITARY CEREBRAL-HEMORRHAGE | DEFICITS | NEUROSCIENCES | PEPTIDE | CLINICAL NEUROLOGY | IMPAIR SYNAPTIC PLASTICITY | TRANSGENIC MICE | Alzheimer Disease - etiology | Peptide Fragments - toxicity | Amyloid beta-Protein Precursor - chemistry | Humans | Protein Processing, Post-Translational - genetics | Male | Alzheimer Disease - pathology | Amyloid beta-Peptides - genetics | Behavior, Animal - drug effects | Female | Peptide Fragments - genetics | Brain Chemistry - genetics | Disease Models, Animal | Maze Learning - physiology | Amyloid beta-Peptides - toxicity | Mice, Inbred C57BL | Behavior, Animal - physiology | Mice, Transgenic | Maze Learning - drug effects | Amyloid beta-Protein Precursor - toxicity | Peptide Fragments - chemistry | Amyloid beta-Protein Precursor - genetics | Animals | Mice | Amyloid beta-Peptides - chemistry | Alzheimer Disease - genetics | Spatial Recognition | Amyloid Precursor Protein | Amyloid | Alzheimer’s Disease | Days-to-Criterion
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
2. Full Text The amyloid precursor protein intracellular domain (AICD) as modulator of gene expression, apoptosis, and cytoskeletal dynamics—Relevance for Alzheimer's disease
by Müller, Thorsten and Meyer, Helmut E and Egensperger, Rupert and Marcus, Katrin
Progress in Neurobiology, ISSN 0301-0082, 2008, Volume 85, Issue 4, pp. 393 - 406
Since the discovery of the amyloid precursor protein (APP) in 1987, extensive research has been conducted analyzing the APP-derived β-amyloid (Aβ) which is... 
Amyloid precursor protein (APP) intracellular domain (AICD) | Transcription | Alzheimer's disease | Cytoskeletal dynamics | FE65 | Apoptosis | intracellular domain (AICD) | cytoskeletal dynamics | RECEPTOR-RELATED PROTEIN | transcription | MESSENGER-RNA ISOFORMS | apoptosis | KINESIN LIGHT-CHAIN | amyloid precursor protein (APP) | NEUROSCIENCES | C-TERMINAL FRAGMENT | GLYCOGEN-SYNTHASE KINASE-3-BETA | APP FAMILY-MEMBERS | FE65 ADAPTER PROTEIN | JNK-INTERACTING PROTEIN-1 | PHOSPHOTYROSINE-BINDING DOMAIN | GAMMA-SECRETASE ACTIVITY | Alzheimer Disease - physiopathology | Apoptosis - drug effects | Humans | Gene Expression Regulation - physiology | Amyloid beta-Protein Precursor - toxicity | Gene Expression Regulation - drug effects | Animals | Models, Biological | Alzheimer Disease - metabolism | Amyloid beta-Protein Precursor - metabolism | Cytoskeleton - physiology | Apoptosis - physiology | Alzheimer Disease - genetics | Genetic research | Gene expression | Analysis | Amyloid beta-protein | Index Medicus
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
3. Full Text The Myelin and Lymphocyte Protein MAL Is Required for Binding and Activity of Clostridium perfringens ε-Toxin
by Rumah, Kareem Rashid and Ma, Yinghua and Linden, Jennifer R and Oo, Myat Lin and Anrather, Josef and Schaeren-Wiemers, Nicole and Alonso, Miguel A and Fischetti, Vincent A and McClain, Mark S and Vartanian, Timothy
PLoS Pathogens, ISSN 1553-7366, 05/2015, Volume 11, Issue 5, p. e1004896
Clostridium perfringens epsilon-toxin (ETX) is a potent pore-forming toxin responsible for a central nervous system (CNS) disease in ruminant animals with... 
NERVOUS-SYSTEM | MDCK CELLS | MICROBIOLOGY | PLASMA-MEMBRANE | INTESTINAL INFECTIONS | DARBY CANINE KIDNEY | VIROLOGY | PORE-FORMING TOXIN | APICAL SORTING MACHINERY | RAFT-ASSOCIATED PROTEIN | HUMAN T-LYMPHOCYTES | PARASITOLOGY | INFLUENZA-VIRUS HEMAGGLUTININ | Injections, Intravenous | Cricetulus | Myelin and Lymphocyte-Associated Proteolipid Proteins - metabolism | Humans | Bacterial Toxins - toxicity | Recombinant Fusion Proteins - metabolism | Tissue Distribution | Protein Precursors - toxicity | Bacterial Toxins - genetics | Clostridium perfringens - metabolism | Protein Interaction Domains and Motifs | Cell Death - drug effects | Binding Sites | Clostridium perfringens - pathogenicity | Recombinant Fusion Proteins - administration & dosage | CHO Cells | Recombinant Proteins - metabolism | Protein Precursors - genetics | Protein Precursors - administration & dosage | Mice, Inbred C57BL | Rats | Recombinant Proteins - chemistry | Recombinant Fusion Proteins - toxicity | Recombinant Fusion Proteins - chemistry | Recombinant Proteins - administration & dosage | Mice, Knockout | Protein Precursors - metabolism | Toxicokinetics | Bacterial Toxins - metabolism | Animals | Myelin and Lymphocyte-Associated Proteolipid Proteins - chemistry | Recombinant Proteins - toxicity | Ligands | Mutagenesis, Insertional | Myelin and Lymphocyte-Associated Proteolipid Proteins - genetics
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
4. Full Text BAM8-22 peptide produces itch and nociceptive sensations in humans independent of histamine release
by Sikand, Parul and Dong, Xinzhong and LaMotte, Robert H
Journal of Neuroscience, ISSN 0270-6474, 05/2011, Volume 31, Issue 20, pp. 7563 - 7567
Chronic itch accompanying many dermatological, neurological, and systemic diseases is unresponsive to antihistamines. Our knowledge of endogenous chemicals... 
PATHWAYS | MAGNITUDE | FLARE | INJECTIONS | SUBSTANCE-P | RECEPTORS | NEUROSCIENCES | PROTEASE | FAMILY | Enkephalins - toxicity | Sensation - physiology | Peptide Fragments - toxicity | Humans | Middle Aged | Histamine Release - physiology | Male | Pain - chemically induced | Pruritus - physiopathology | Young Adult | Sensation - drug effects | Animals | Cattle | Pain - physiopathology | Protein Precursors - toxicity | Adult | Female | Pruritus - chemically induced | Histamine Release - drug effects | Brief Communications
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
5. Lipids in amyloid-β processing, aggregation, and toxicity
by Morgado, Isabel and Garvey, Megan
Advances in Experimental Medicine and Biology, ISSN 0065-2598, 2015, Volume 855, pp. 67 - 94
Aggregation of amyloid-beta (A beta) peptide is the major event underlying neuronal damage in Alzheimer's disease (AD). Specific lipids and their homeostasis... 
Protofibrils and fibrils | Cellular membranes and lipid rafts | Alzheimer’s disease | Apolipoprotein E | Peptide oligomers | Amyloid-β peptide | Gangliosides | Amyloid precursor protein | Cholesterol | Peptide oligomers, protofibrils and fibrils | MEDICINE, RESEARCH & EXPERIMENTAL | GM1 GANGLIOSIDE | ALZHEIMERS-DISEASE | CONFORMATIONAL TRANSITION | APOLIPOPROTEIN-E ISOFORMS | LOW-DENSITY-LIPOPROTEIN | TRANSMEMBRANE DOMAIN | PRECURSOR-PROTEIN APP | MEMBRANE INTERACTIONS | Amyloid-beta peptide | BIOLOGY | ION CHANNELS | Alzheimer's disease | GAMMA-SECRETASE | Amino Acid Sequence | Lipids - chemistry | Amyloid beta-Protein Precursor - chemistry | Humans | Alzheimer Disease - metabolism | Amyloid beta-Protein Precursor - metabolism | Molecular Sequence Data | Apolipoproteins E - metabolism | Lipids - toxicity | Amyloid beta-Protein Precursor - toxicity
Journal Article
Details down arrow
6. Full Text Dual mode of action of Bt proteins: Protoxin efficacy against resistant insects
by Tabashnik, Bruce E and Zhang, Min and Fabrick, Jeffrey A and Wu, Yidong and Gao, Meijing and Huang, Fangneng and Wei, Jizhen and Zhang, Jie and Yelich, Alexander and Unnithan, Gopalan C and Bravo, Alejandra and Soberón, Mario and Carrière, Yves and Li, Xianchun
Scientific Reports, ISSN 2045-2322, 10/2015, Volume 5, Issue 1, pp. 15107 - 15107
Transgenic crops that produce Bacillus thuringiensis (Bt) proteins for pest control are grown extensively, but insect adaptation can reduce their... 
SUGARCANE BORER | HELICOVERPA-ZEA BODDIE | CRY1AC TOXIN | OSTRINIA-NUBILALIS | EUROPEAN CORN-BORER | PEST RESISTANCE | MULTIDISCIPLINARY SCIENCES | SUSCEPTIBLE STRAINS | BACILLUS-THURINGIENSIS TOXINS | FIELD-EVOLVED RESISTANCE | COTTON BOLLWORM | Intestines - drug effects | Bacillus thuringiensis - chemistry | Protein Precursors - chemistry | Hemolysin Proteins - genetics | Lepidoptera - physiology | Bacterial Proteins - chemistry | Intestines - metabolism | Hemolysin Proteins - chemistry | Lepidoptera - metabolism | Bacterial Proteins - toxicity | Bacillus thuringiensis - pathogenicity | Larva - drug effects | Endotoxins - chemistry | Plants, Genetically Modified | Protein Precursors - toxicity | Hemolysin Proteins - toxicity | Lepidoptera - drug effects | Intestines - physiology | Transgenes | Bacillus thuringiensis - physiology | Insect Proteins - metabolism | Protein Structure, Tertiary | Gene Expression | Protein Precursors - genetics | Crops, Agricultural - parasitology | Protein Structure, Secondary | Endotoxins - genetics | Larva - metabolism | Bacterial Proteins - genetics | Models, Molecular | Insect Proteins - antagonists & inhibitors | Animals | Insect Proteins - chemistry | Protein Binding | Crops, Agricultural - genetics | Larva - physiology | Endotoxins - toxicity | Proteins | Insects | Toxicity | Crops | Cry1Ac toxin | Pest control | Pests | Protoxins | Index Medicus
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
7. Full Text Amyloid β protein toxicity mediated by the formation of amyloid‐β protein precursor complexes
by Lu, Daniel C and Shaked, Gideon M and Masliah, Eliezer and Bredesen, Dale E and Koo, Edward H
Annals of Neurology, ISSN 0364-5134, 12/2003, Volume 54, Issue 6, pp. 781 - 789
The amyloid‐β protein precursor, a type 1 transmembrane protein, gives rise to the amyloid β‐protein, a neurotoxic peptide postulated to be involved in the... 
NEURONAL APOPTOSIS | CYTOPLASMIC DOMAIN | ALZHEIMERS-DISEASE | TERMINAL FRAGMENTS | ANTIBODY | CASPASE CLEAVAGE | NEUROTOXICITY | SUFFICIENT | NEUROSCIENCES | OLIGOMERS | CLINICAL NEUROLOGY | DEGENERATION | Amyloid beta-Peptides - toxicity | Humans | Brain - enzymology | Amyloid beta-Protein Precursor - toxicity | Amyloid beta-Protein Precursor - genetics | Animals | Caspases - metabolism | Cell Death - genetics | Amyloid beta-Peptides - genetics | Amyloid beta-Peptides - metabolism | Amyloid beta-Protein Precursor - metabolism | Brain - pathology | Cell Line, Tumor | Mice
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
8. Full Text Cognitive and Physical Activity Differently Modulate Disease Progression in the Amyloid Precursor Protein (APP)-23 Model of Alzheimer's Disease
by Wolf, Susanne A and Kronenberg, Golo and Lehmann, Kathrin and Blankenship, Aaron and Overall, Rupert and Staufenbiel, Matthias and Kempermann, Gerd
Biological Psychiatry, ISSN 0006-3223, 12/2006, Volume 60, Issue 12, pp. 1314 - 1323
Background: In aging mice, activity maintains hippocampal plasticity and adult hippocampal neurogenesis at a level corresponding to a younger age. Here we... 
mouse | neurotrophin | enriched environment | stem cell | water maze | Adult neurogenesis | adult neurogenesis | APP23 TRANSGENIC MICE | TERM ENVIRONMENTAL ENRICHMENT | PSYCHIATRY | NEUROTROPHIC FACTOR | FACTOR MESSENGER-RNA | VOLUNTARY EXERCISE | ADULT HIPPOCAMPAL NEUROGENESIS | SUBVENTRICULAR ZONE | NEUROSCIENCES | DENTATE GYRUS | CARDIOVASCULAR FITNESS | GROWTH-FACTOR-I | Brain-Derived Neurotrophic Factor - genetics | Motor Activity - physiology | Vascular Endothelial Growth Factor A - biosynthesis | Nerve Growth Factor - biosynthesis | Cell Count | Neurotrophin 3 - genetics | Vascular Endothelial Growth Factor A - genetics | Cerebral Cortex - metabolism | Alzheimer Disease - pathology | RNA, Messenger - biosynthesis | Cognition - physiology | Female | Brain-Derived Neurotrophic Factor - biosynthesis | Alzheimer Disease - chemically induced | Alzheimer Disease - psychology | Insulin-Like Growth Factor I - biosynthesis | Maze Learning - physiology | RNA, Messenger - genetics | Fibroblast Growth Factor 2 - biosynthesis | Mice, Transgenic | Nerve Growth Factor - genetics | Reverse Transcriptase Polymerase Chain Reaction | Amyloid beta-Protein Precursor - toxicity | Disease Progression | Hippocampus - metabolism | Neurotrophin 3 - biosynthesis | Animals | Brain - pathology | Environment | Mice | Proteins | Physical fitness | Alzheimer's disease | Analysis
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
9. Full Text Induction of tau pathology by intracerebral infusion of amyloid-β-containing brain extract and by amyloid-β deposition in APP x tau transgenic mice
by Bolmont, Tristan and Clavaguera, Florence and Meyer-Luehmann, Melanie and Herzig, Martin C and Radde, Rebecca and Staufenbiel, Matthias and Lewis, Jada and Hutton, Mike and Tolnay, Markus and Jucker, Mathias
American Journal of Pathology, ISSN 0002-9440, 2007, Volume 171, Issue 6, pp. 2012 - 2020
Alzheimer's disease presents morphologically with senile plaques, primarily made of extracellular amyloid-beta (A beta) deposits, and neurofibrillary lesions,... 
NEUROFIBRILLARY TANGLES | PROTEIN | FIBRILS | ALZHEIMERS-DISEASE | MOUSE MODEL | A-BETA | EXOGENOUS INDUCTION | LEADS | NEURODEGENERATION | PATHOLOGY | Tauopathies - genetics | Amyloid beta-Peptides - toxicity | Cell Extracts - administration & dosage | Cell Extracts - toxicity | Tauopathies - pathology | Mice, Transgenic | Amyloid beta-Protein Precursor - toxicity | Alzheimer Disease - pathology | Tauopathies - metabolism | Animals | tau Proteins - genetics | Alzheimer Disease - metabolism | Amyloid beta-Peptides - metabolism | Amyloid beta-Protein Precursor - metabolism | Female | Amyloid beta-Protein Precursor - administration & dosage | Brain Chemistry | Mice | Amyloid beta-Peptides - administration & dosage | Alzheimer Disease - genetics
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
10. Full Text Aromatic small molecules remodel toxic soluble oligomers of amyloid β through three independent pathways
by Ladiwala, Ali Reza A and Dordick, Jonathan S and Tessier, Peter M
Journal of Biological Chemistry, ISSN 0021-9258, 02/2011, Volume 286, Issue 5, pp. 3209 - 3218
In protein conformational disorders ranging from Alzheimer to Parkinson disease, proteins of unrelated sequence misfold into a similar array of aggregated... 
FIBRIL FORMATION | METHYLENE-BLUE | IN-VITRO | PROTEIN OLIGOMERS | ALZHEIMERS-DISEASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | A-BETA | TANNIC-ACID | SHEET STRUCTURES | ALPHA-SYNUCLEIN | AGGREGATION | Cell Survival - drug effects | Molecular Weight | Amyloid beta-Protein Precursor - chemistry | Cells, Cultured | Solubility | Rats | Structure-Activity Relationship | Amyloid - chemistry | Amyloid beta-Protein Precursor - toxicity | Adrenal Medulla - cytology | Animals | Protein Conformation | Amyloid beta-Protein Precursor - antagonists & inhibitors | Index Medicus | Protein Structure and Folding | Protein Misfolding | Protein Self-assembly | Protein Aggregation | Amyloid | Peptide Conformation | Protein Folding
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
11. Full Text Phospho-dependent ubiquitination and degradation of PAR-1 regulates synaptic morphology and tau-mediated Aβ toxicity in Drosophila
by Lee, Seongsoo and Wang, Ji-Wu and Yu, Wendou and Lu, Bingwei
Nature Communications, ISSN 2041-1723, 2012, Volume 3, Issue 1, pp. 1312 - 1312
The conserved kinases PAR-1/MARK are critically involved in processes such as asymmetric cell division, cell polarity and neuronal differentiation. Their... 
DENDRITIC SPINES | DESTRUCTION | POLARITY | PHOSPHORYLATION | SYNAPSES | ALZHEIMERS-DISEASE | AMYLOID-BETA | MULTIDISCIPLINARY SCIENCES | F-BOX | NEUROMUSCULAR-JUNCTION | PROTEIN-KINASES | Protein Kinases - metabolism | Phosphorylation | Protein Kinases - genetics | Retina - metabolism | Retina - growth & development | Humans | Caenorhabditis elegans Proteins - metabolism | tau Proteins - metabolism | Male | Drosophila Proteins - metabolism | Drosophila melanogaster - genetics | Drosophila melanogaster - metabolism | Ubiquitination | Synapses - metabolism | tau Proteins - genetics | Proteolysis | Retina - enzymology | Amyloid beta-Protein Precursor - metabolism | HEK293 Cells | Cell Cycle Proteins - genetics | Female | Protein-Serine-Threonine Kinases - metabolism | Disease Models, Animal | Cell Cycle Proteins - metabolism | Protein-Serine-Threonine Kinases - genetics | Ubiquitin-Protein Ligases - metabolism | Synapses - enzymology | Amyloid beta-Protein Precursor - toxicity | Animals | Alzheimer Disease - metabolism | Drosophila melanogaster - enzymology | Drosophila melanogaster - growth & development | Drosophila Proteins - genetics | Alzheimer Disease - genetics | Ubiquitin-Protein Ligases - genetics | Caenorhabditis elegans Proteins - genetics | Index Medicus
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
12. Full Text Loss of tau elicits axonal degeneration in a mouse model of Alzheimer's disease
by Dawson, H.N and Cantillana, V and Jansen, M and Wang, H and Vitek, M.P and Wilcock, D.M and Lynch, J.R and Laskowitz, D.T
Neuroscience, ISSN 0306-4522, 2010, Volume 169, Issue 1, pp. 516 - 531
Abstract A central issue in the pathogenesis of tauopathy is the question of how tau protein dysfunction leads to neurodegeneration. We have previously... 
Neurology | APP | Tau | axonal degeneration | spheroids | head injury | immunization | Immunization | Head injury | Axonal degeneration | Spheroids | HEAD-INJURY | FRONTOTEMPORAL DEMENTIA | AMYLOID PRECURSOR PROTEIN | NEUROSCIENCES | TRAUMATIC BRAIN-INJURY | STEREOLOGICAL ESTIMATION | A-BETA-PEPTIDE | CENTRAL-NERVOUS-SYSTEM | PROGRESSIVE SUPRANUCLEAR PALSY | TRANSGENIC MICE | CORTICOBASAL DEGENERATION | Humans | Ataxia - etiology | Brain Injuries - metabolism | Amyloid beta-Protein Precursor - immunology | Alzheimer Disease - pathology | Neuropil - ultrastructure | tau Proteins - genetics | Neurites - ultrastructure | tau Proteins - physiology | Disease Models, Animal | Mice, Inbred C57BL | Mice, Transgenic | Recombinant Fusion Proteins - toxicity | Brain Injuries - genetics | Microscopy, Electron | Amyloid beta-Protein Precursor - toxicity | Nerve Degeneration - pathology | Mice, Knockout | tau Proteins - deficiency | Amyloid beta-Protein Precursor - genetics | Animals | Axons - pathology | Alzheimer Disease - metabolism | Recombinant Fusion Proteins - genetics | Mice | Plaque, Amyloid - ultrastructure | Alzheimer Disease - genetics | Brain Injuries - pathology
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights