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Developmental Cell, ISSN 1534-5807, 04/2017, Volume 41, Issue 1, pp. 47 - 58.e4
Journal Article
Nature Medicine, ISSN 1078-8956, 08/2013, Volume 19, Issue 8, pp. 1054 - 1060
Increased hepatic lipid content is an early correlate of insulin resistance and can be caused by nutrient-induced activation of mammalian target of rapamycin... 
MAMMALIAN TARGET | MEDICINE, RESEARCH & EXPERIMENTAL | COMPLEX | PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL BIOLOGY | PATHWAY | TRANSCRIPTION FACTOR FOXO1 | INSULIN-RESISTANCE | LIPOGENESIS | PPAR-GAMMA | MICE | ADIPOSE-TISSUE | TOR Serine-Threonine Kinases - metabolism | Fatty Liver - pathology | Receptors, Notch - metabolism | Humans | Body Weight - drug effects | Male | Mechanistic Target of Rapamycin Complex 1 | Multiprotein Complexes - metabolism | Receptors, Notch - antagonists & inhibitors | Lipogenesis - genetics | Liver - drug effects | Diet, High-Fat | HEK293 Cells | Lipid Metabolism - genetics | Proto-Oncogene Proteins c-akt - metabolism | Immunoglobulin J Recombination Signal Sequence-Binding Protein - metabolism | Insulin - pharmacology | Fatty Liver - metabolism | Liver - metabolism | Mice, Inbred C57BL | Insulin Resistance | Enzyme Activation - drug effects | Blotting, Western | Triglycerides - metabolism | Gene Expression Regulation - drug effects | Animals | Signal Transduction - drug effects | Lipogenesis - drug effects | Protein Stability - drug effects | Lipid Metabolism - drug effects | Cell Line, Tumor | Mice | Obesity | Complications and side effects | Physiological aspects | Insulin resistance | Development and progression | Cellular signal transduction | Genetic aspects | Research | Lipids | Liver diseases | Metabolic syndrome | Index Medicus
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 09/2012, Volume 18, Issue 17, pp. 4682 - 4690
Journal Article
Development (Cambridge), ISSN 0950-1991, 05/2016, Volume 143, Issue 10, pp. 1674 - 1687
Journal Article
Biomaterials, ISSN 0142-9612, 2014, Volume 35, Issue 14, pp. 4333 - 4344
Journal Article
Journal Article
Nature, ISSN 0028-0836, 07/2016, Volume 535, Issue 7610, pp. 148 - 152
The non-receptor protein tyrosine phosphatase SHP2, encoded by PTPN11, has an important role in signal transduction downstream of growth factor receptor... 
TARGET | POTENT | PTPN11 | PROTOONCOGENE | MULTIDISCIPLINARY SCIENCES | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - metabolism | Humans | Extracellular Signal-Regulated MAP Kinases - metabolism | Oncogene Protein p21(ras) - metabolism | Pyrimidines - chemistry | Piperidines - pharmacology | Inhibitory Concentration 50 | Female | Allosteric Regulation - drug effects | Piperidines - chemistry | Reproducibility of Results | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - antagonists & inhibitors | Models, Molecular | Neoplasms - enzymology | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - chemistry | Pyrimidines - pharmacology | Receptor Protein-Tyrosine Kinases - metabolism | Neoplasms - drug therapy | Xenograft Model Antitumor Assays | Animals | MAP Kinase Signaling System - drug effects | Mice, Nude | Piperidines - therapeutic use | Pyrimidines - therapeutic use | Protein Stability - drug effects | Cell Line, Tumor | Cell Proliferation - drug effects | Mice | Protein Kinase Inhibitors - pharmacology | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - genetics | Neoplasms - pathology | Protein Structure, Tertiary - drug effects | Phosphatases | Observations | Health aspects | Phosphotransferases | Protein-protein interactions | Signal transduction | Cell growth | Peptides | Kinases | Phosphatase | Drug dosages | Cancer | Index Medicus | BASIC BIOLOGICAL SCIENCES
Journal Article