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Nature, ISSN 0028-0836, 06/2015, Volume 522, Issue 7557, pp. 450 - 454
.... Its regulation by coactivator subunits, phosphorylation, the mitotic checkpoint complex and interphase early mitotic inhibitor 1 (Emi1... 
E3 LIGASE | ANAPHASE-PROMOTING COMPLEX | ACTIVATION | PHOSPHORYLATION | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | MITOTIC REGULATION | CONJUGATING ENZYME | CHAIN ELONGATION | REVEALS | SUBUNIT | Phosphorylation | Ubiquitin - ultrastructure | Cadherins - metabolism | Humans | Apc11 Subunit, Anaphase-Promoting Complex-Cyclosome - chemistry | Ubiquitin - metabolism | Cell Cycle Proteins - ultrastructure | Substrate Specificity | Apc10 Subunit, Anaphase-Promoting Complex-Cyclosome - ultrastructure | Structure-Activity Relationship | Anaphase-Promoting Complex-Cyclosome - ultrastructure | Protein Subunits - metabolism | Ubiquitin-Conjugating Enzymes - chemistry | Apc1 Subunit, Anaphase-Promoting Complex-Cyclosome - metabolism | Cell Cycle Proteins - chemistry | Apc3 Subunit, Anaphase-Promoting Complex-Cyclosome - chemistry | Ubiquitination | Apc8 Subunit, Anaphase-Promoting Complex-Cyclosome - metabolism | Cadherins - chemistry | Cytoskeletal Proteins - metabolism | Lysine - metabolism | Anaphase-Promoting Complex-Cyclosome - chemistry | Cadherins - ultrastructure | Apc10 Subunit, Anaphase-Promoting Complex-Cyclosome - metabolism | Catalytic Domain | F-Box Proteins - metabolism | Apc3 Subunit, Anaphase-Promoting Complex-Cyclosome - metabolism | F-Box Proteins - chemistry | Cell Cycle Proteins - metabolism | Ubiquitin - chemistry | Models, Molecular | Ubiquitin-Conjugating Enzymes - ultrastructure | Cytoskeletal Proteins - chemistry | Apc1 Subunit, Anaphase-Promoting Complex-Cyclosome - chemistry | Apc8 Subunit, Anaphase-Promoting Complex-Cyclosome - chemistry | Cryoelectron Microscopy | F-Box Proteins - ultrastructure | Ubiquitin-Conjugating Enzymes - metabolism | Protein Binding | Protein Subunits - chemistry | Apc10 Subunit, Anaphase-Promoting Complex-Cyclosome - chemistry | Anaphase-Promoting Complex-Cyclosome - metabolism | Apc11 Subunit, Anaphase-Promoting Complex-Cyclosome - metabolism | Apc1 Subunit, Anaphase-Promoting Complex-Cyclosome - ultrastructure | Apc8 Subunit, Anaphase-Promoting Complex-Cyclosome - ultrastructure | Ubiquitin | Physiological aspects | Structure | Ubiquitin-proteasome system | Ligases | Proteins | Peptides | Molecular structure | Cyclin-dependent kinases | Cell division | Kinases | Gene expression
Journal Article
Nature (London), ISSN 1476-4687, 2015, Volume 523, Issue 7562, pp. 555 - 560
Journal Article
Biochemical Pharmacology, ISSN 0006-2952, 05/2016, Volume 107, pp. 59 - 66
[Display omitted] Gαq inhibitor UBO-QIC (FR900359) is becoming an important pharmacological tool, but its selectivity against other G proteins and their subunits, especially βγ... 
UBO-QIC | Gαq inhibitor | GPCR | FR900359 | Gβγ subunits | G protein | inhibitor | GTP-Binding Protein alpha Subunits, Gi-Go - agonists | GTP-Binding Protein alpha Subunits, Gi-Go - genetics | Receptor, Muscarinic M2 - agonists | Receptor, Muscarinic M2 - genetics | Cricetulus | Humans | GTP-Binding Protein beta Subunits - antagonists & inhibitors | GTP-Binding Protein gamma Subunits - antagonists & inhibitors | Depsipeptides - pharmacology | GTP-Binding Protein alpha Subunits, Gq-G11 - chemistry | GTP-Binding Protein gamma Subunits - agonists | HEK293 Cells | Platelet Aggregation Inhibitors - pharmacology | Receptor, Muscarinic M2 - antagonists & inhibitors | GTP-Binding Protein beta Subunits - metabolism | GTP-Binding Protein alpha Subunits, Gq-G11 - metabolism | Proto-Oncogene Proteins c-akt - metabolism | Receptor, Adenosine A1 - genetics | CHO Cells | Pertussis Toxin - pharmacology | Recombinant Proteins - metabolism | GTP-Binding Protein gamma Subunits - metabolism | Receptor, Muscarinic M2 - metabolism | Enzyme Inhibitors - pharmacology | GTP-Binding Protein beta Subunits - agonists | Recombinant Proteins - chemistry | GTP-Binding Protein alpha Subunits, Gq-G11 - antagonists & inhibitors | Receptor, Adenosine A1 - chemistry | Receptor, Adenosine A1 - metabolism | Animals | MAP Kinase Signaling System - drug effects | GTP-Binding Protein alpha Subunits, Gi-Go - antagonists & inhibitors | Signal Transduction - drug effects | Models, Biological | Proto-Oncogene Proteins c-akt - agonists | GTP-Binding Protein alpha Subunits, Gi-Go - metabolism | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | Gβγsubunits
Journal Article
British journal of pharmacology, ISSN 0007-1188, 2009, Volume 147, Issue S1, pp. S46 - S55
Journal Article
Science (American Association for the Advancement of Science), ISSN 0036-8075, 11/2010, Volume 330, Issue 6008, pp. 1203 - 1209
Crystal structures of prokaryotic ribosomes have described in detail the universally conserved core of the translation mechanism. However, many facets of the... 
Proteins | Yeasts | RESEARCH ARTICLE | Messenger RNA | RNA | Prokaryotes | Ribosomes | Crystals | Eukaryotic cells | Transfer RNA | Crystal structure | E-SITE | ANGSTROM RESOLUTION | TRANSLOCATION | MESSENGER-RNA | MULTIDISCIPLINARY SCIENCES | MOVEMENT | TRANSLATION INITIATION | TRANSFER-RNA | 70S RIBOSOME | 80S RIBOSOME | SUBUNIT | Ribosomal Proteins - analysis | Ribosomal Proteins - chemistry | RNA, Fungal - analysis | Ribosome Subunits, Large, Eukaryotic - ultrastructure | Protein Biosynthesis | Ribosome Subunits, Small, Eukaryotic - chemistry | Saccharomyces cerevisiae - genetics | RNA, Messenger - analysis | Ribosomes - metabolism | Crystallography, X-Ray | Peptide Chain Initiation, Translational | Saccharomyces cerevisiae - ultrastructure | RNA, Messenger - metabolism | Ribosomal Proteins - metabolism | Saccharomyces cerevisiae - metabolism | Ribosome Subunits, Large, Eukaryotic - metabolism | Nucleic Acid Conformation | RNA, Transfer - chemistry | RNA, Transfer - metabolism | Ribosome Subunits, Large, Eukaryotic - chemistry | RNA, Fungal - chemistry | RNA, Ribosomal - chemistry | Crystallization | Ribosomes - chemistry | Models, Molecular | RNA, Ribosomal - metabolism | Ribosome Subunits, Small, Eukaryotic - ultrastructure | Saccharomyces cerevisiae - chemistry | RNA, Fungal - metabolism | Ribosomes - ultrastructure | Saccharomyces cerevisiae Proteins - metabolism | Protein Binding | Protein Conformation | RNA, Messenger - chemistry | RNA, Ribosomal - analysis | Ribosome Subunits, Small, Eukaryotic - metabolism | Saccharomyces cerevisiae Proteins - analysis | Saccharomyces cerevisiae Proteins - chemistry | Composition | Eukaryotes | Physiological aspects | Protein biosynthesis | Research | Structure | Conformation | Networks | Protein synthesis | Bacteria | Mathematical models | Ratcheting | Translations
Journal Article
Nature chemical biology, ISSN 1552-4469, 2011, Volume 7, Issue 3, pp. 182 - 188
...), a subunit of the transcription factor TFIIH, and inhibits its DNA-dependent ATPase activity, which leads to the inhibition of RNA polymerase II-mediated transcription and likely nucleotide excision repair... 
RNA-POLYMERASE-II | TRIPTERYGIUM-WILFORDII | INHIBITION | PROTEIN | INITIATION | COMMON TARGET | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSCRIPTION FACTOR IIH | TRANSLATION | CYTOTOXICITY | CHEMOTHERAPY | Humans | Drugs, Chinese Herbal - pharmacology | Biological Products - pharmacology | Transcription Factor TFIIH - chemistry | RNA Polymerase II - metabolism | Phenanthrenes - isolation & purification | Protein Subunits - metabolism | DNA-Binding Proteins - metabolism | Dose-Response Relationship, Drug | Phenanthrenes - chemistry | Epoxy Compounds - pharmacology | Antineoplastic Agents - isolation & purification | Antineoplastic Agents - pharmacology | Drugs, Chinese Herbal - isolation & purification | Diterpenes - chemistry | Epoxy Compounds - isolation & purification | Diterpenes - pharmacology | Cell Survival - drug effects | DNA Helicases - chemistry | Diterpenes - isolation & purification | Adenosine Triphosphatases - metabolism | Antineoplastic Agents - chemistry | DNA-Binding Proteins - chemistry | Biological Products - isolation & purification | DNA Helicases - metabolism | Phenanthrenes - pharmacology | Biological Products - chemistry | Drugs, Chinese Herbal - chemistry | Epoxy Compounds - chemistry | Transcription Factor TFIIH - metabolism | Protein Binding | Adenosine Triphosphatases - chemistry | RNA Polymerase II - genetics | Protein Subunits - chemistry | HeLa Cells | Chinese medicine | Eukaryotes | Biochemistry | Flowers & plants | Adenosine triphosphatase
Journal Article