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Science, ISSN 0036-8075, 9/2010, Volume 329, Issue 5996, pp. 1175 - 1180
Recent reports of increased tolerance to artemisinin derivatives—the most recently adopted class of antimalarials— have prompted a need for new treatments. The... 
Malaria | Artemisinins | RESEARCH ARTICLES | Genomics | Adenosine triphosphatases | Antimalarials | Parasites | Inhibitory concentration 50 | Drug resistance | Dosage | Genetic mutation | VIVAX | MULTIDISCIPLINARY SCIENCES | PARASITE PLASMODIUM-FALCIPARUM | ERADICATION | CALCIUM-PUMP | DRUG-RESISTANCE | SARCOPLASMIC-RETICULUM | ANTIMALARIALS | IDENTIFICATION | CHLOROQUINE | ARTEMISININ | Parasitic Sensitivity Tests | Humans | Male | Plasmodium falciparum - drug effects | Indoles - administration & dosage | Plasmodium falciparum - genetics | Protein Synthesis Inhibitors - pharmacology | Mutant Proteins - antagonists & inhibitors | Antimalarials - pharmacokinetics | Adenosine Triphosphatases - metabolism | Models, Molecular | Rats | Spiro Compounds - pharmacokinetics | Adenosine Triphosphatases - antagonists & inhibitors | Antimalarials - administration & dosage | Malaria - parasitology | Adenosine Triphosphatases - genetics | Mice | Mutation | Erythrocytes - parasitology | Plasmodium berghei - drug effects | Plasmodium vivax - growth & development | Protein Synthesis Inhibitors - chemistry | Rats, Wistar | Spiro Compounds - administration & dosage | Genes, Protozoan | Protozoan Proteins - genetics | Protein Synthesis Inhibitors - administration & dosage | Protozoan Proteins - metabolism | Female | Indoles - pharmacology | Protozoan Proteins - chemistry | Drug Resistance | Spiro Compounds - chemistry | Cell Line | Plasmodium vivax - drug effects | Mutant Proteins - metabolism | Drug Discovery | Protozoan Proteins - biosynthesis | Antimalarials - pharmacology | Protein Synthesis Inhibitors - pharmacokinetics | Animals | Mutant Proteins - chemistry | Antimalarials - chemistry | Adenosine Triphosphatases - chemistry | Indoles - pharmacokinetics | Malaria - drug therapy | Plasmodium falciparum - growth & development | Indoles - chemistry | Spiro Compounds - pharmacology | Research | Pharmacology | Inhibitor drugs | Drug therapy | Protein synthesis | Drugs | Mutations | Nanomaterials | Encoding | Cations | Nanostructure | Ablation | Index Medicus
Journal Article
Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 10/2016, Volume 60, Issue 10, pp. 6271 - 6280
Journal Article
The American Journal of Cardiology, ISSN 0002-9149, 2004, Volume 94, Issue 9, pp. 1140 - 1146
Three-hydroxy-3-methylglutaryl coenzyme-A reductase inhibitors (statins) are first-line treatments for hypercholesterolemia. Although exceedingly well... 
CLARITHROMYCIN | INDUCED RHABDOMYOLYSIS | LOVASTATIN | CARDIAC & CARDIOVASCULAR SYSTEMS | CONCOMITANT USE | ERYTHROMYCIN | FATAL RHABDOMYOLYSIS | ITRACONAZOLE | ROSUVASTATIN | DRUG-INTERACTION | CYCLOSPORINE | Hydroxymethylglutaryl-CoA Reductase Inhibitors - administration & dosage | Pyrroles - pharmacokinetics | Cytochrome P-450 Enzyme Inhibitors | Cytochrome P-450 Enzyme System - administration & dosage | Area Under Curve | Heptanoic Acids - pharmacokinetics | Humans | Middle Aged | Mibefradil - pharmacokinetics | Male | Protein Synthesis Inhibitors - administration & dosage | Verapamil - administration & dosage | Dose-Response Relationship, Drug | Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacokinetics | Antiprotozoal Agents - pharmacokinetics | Drug Interactions | Itraconazole - pharmacokinetics | Pyrroles - administration & dosage | Clarithromycin - pharmacokinetics | Mibefradil - administration & dosage | Clarithromycin - administration & dosage | Heptanoic Acids - administration & dosage | Adult | Female | Itraconazole - administration & dosage | Drug Therapy, Combination | Double-Blind Method | Simvastatin - administration & dosage | Verapamil - pharmacokinetics | Biomarkers - blood | Simvastatin - pharmacokinetics | Protein Synthesis Inhibitors - pharmacokinetics | Atorvastatin Calcium | Anticholesteremic Agents - pharmacokinetics | Pravastatin - administration & dosage | Anticholesteremic Agents - administration & dosage | Adolescent | Antiprotozoal Agents - administration & dosage | Calcium Channel Blockers - administration & dosage | Creatine Kinase - drug effects | Calcium Channel Blockers - pharmacokinetics | Pravastatin - pharmacokinetics | Index Medicus | Abridged Index Medicus
Journal Article
Toxicology Letters, ISSN 0378-4274, 09/2016, Volume 258, pp. 11 - 19
The plant-derived toxins ricin and abrin, operate by site-specific depurination of ribosomes, which in turn leads to protein synthesis arrest. The clinical... 
Abrin | Ricin | Depurination | 28SrRNA | Lung | ACTIVATED PROTEIN-KINASE | RNA | MACROPHAGES | SHIGA TOXIN | DEOXYNIVALENOL | HUMAN POLYMORPHONUCLEAR LEUKOCYTES | CHAIN | TOXICOLOGY | RIBOSOME-INACTIVATING PROTEINS | RIBOTOXIC STRESS-RESPONSE | Poisoning - metabolism | Protein Synthesis Inhibitors - chemistry | Respiratory Mucosa - drug effects | Poisoning - physiopathology | Pneumonia - prevention & control | RNA, Ribosomal, 28S - metabolism | Respiratory Insufficiency - etiology | Ribosomes - metabolism | Cytotoxins - administration & dosage | Ricinus - enzymology | Abrin - administration & dosage | Cytotoxins - toxicity | Abrin - isolation & purification | Protein Synthesis Inhibitors - administration & dosage | Respiratory Mucosa - pathology | Ribosomes - enzymology | Abrus - enzymology | Antitoxins - therapeutic use | Flow Cytometry | Respiratory Insufficiency - prevention & control | Abrin - toxicity | Cytotoxins - metabolism | Female | Lung - metabolism | Ricin - antagonists & inhibitors | Cytotoxins - antagonists & inhibitors | Lung - pathology | Pneumonia - etiology | Protein Synthesis Inhibitors - toxicity | Purines - metabolism | Poisoning - drug therapy | Lethal Dose 50 | Poisoning - pathology | Protein Synthesis Inhibitors - metabolism | Ricin - administration & dosage | Administration, Intranasal | Ricin - toxicity | Abrin - metabolism | Animals | Ricin - metabolism | Lung - drug effects | Ribosomes - drug effects | Mice | Respiratory Mucosa - metabolism | DNA, Complementary - metabolism | Lectins | Enzymes | Protein biosynthesis | Analysis | Index Medicus | Lungs | Catalysts | Catalytic activity | Exposure | Toxins | Intoxication | Damage
Journal Article
American Journal of Hematology, ISSN 0361-8609, 05/2013, Volume 88, Issue 5, pp. 350 - 354
Omacetaxine mepesuccinate (omacetaxine) is a first‐in‐class cephalotaxine with a unique mode of action, independent of BCR‐ABL, that has shown promising... 
CHRONIC MYELOGENOUS LEUKEMIA | CELLS | APOPTOSIS | THERAPY | BCR-ABL | IMATINIB | DOWN-REGULATION | HOMOHARRINGTONINE | HEMATOLOGY | FAILURE | NILOTINIB | Drug Resistance, Multiple | Humans | Leukemia, Myeloid, Chronic-Phase - pathology | Middle Aged | Harringtonines - adverse effects | Drug Resistance, Neoplasm | Male | Antineoplastic Agents - therapeutic use | Protein Kinase Inhibitors - adverse effects | Harringtonines - therapeutic use | Protein Synthesis Inhibitors - administration & dosage | Hematopoiesis - drug effects | Maintenance Chemotherapy - adverse effects | Young Adult | Antineoplastic Agents, Phytogenic - administration & dosage | Antineoplastic Agents - adverse effects | Injections, Subcutaneous | Harringtonines - administration & dosage | Adult | Bone Marrow Cells - drug effects | Female | Antineoplastic Agents, Phytogenic - therapeutic use | Antineoplastic Agents, Phytogenic - adverse effects | Leukemia, Myeloid, Chronic-Phase - blood | Leukemia, Myeloid, Chronic-Phase - drug therapy | Bone Marrow Cells - pathology | Induction Chemotherapy - adverse effects | Protein Kinase Inhibitors - therapeutic use | Survival Analysis | Aged | Drug Monitoring | Protein Synthesis Inhibitors - adverse effects | Protein Synthesis Inhibitors - therapeutic use | Protein-Tyrosine Kinases - antagonists & inhibitors | Tyrosine | Phenols | Research | Chronic myeloid leukemia | Oncology, Experimental | Cancer | Index Medicus
Journal Article
Neuropsychopharmacology, ISSN 0893-133X, 06/2013, Volume 38, Issue 7, pp. 1308 - 1321
Antagonism of group I metabotropic glutamate receptors (mGluR1 and mGluR5) reduces behavioral effects of drugs of abuse, including cocaine. However, the... 
conditioned place preference (CPP) | protein synthesis | long-term depression (LTD) | DHPG | group I mGluRs | PSYCHIATRY | CUE-INDUCED REINSTATEMENT | BEHAVIORAL SENSITIZATION | SYNAPTIC PLASTICITY | NEUROSCIENCES | VENTRAL TEGMENTAL AREA | TRANSLATIONAL CONTROL | RAPAMYCIN SIGNALING PATHWAY | LONG-TERM DEPRESSION | MOUSE MODEL | FRAGILE-X-SYNDROME | MIDBRAIN DOPAMINE NEURONS | PHARMACOLOGY & PHARMACY | Glycine - analogs & derivatives | TOR Serine-Threonine Kinases - metabolism | Receptors, Metabotropic Glutamate - physiology | Male | Receptors, Metabotropic Glutamate - metabolism | Extracellular Signal-Regulated MAP Kinases - metabolism | Long-Term Synaptic Depression - drug effects | Ventral Tegmental Area - physiology | Quinolines - administration & dosage | Protein Synthesis Inhibitors - administration & dosage | Quinolines - pharmacology | Receptor, Cannabinoid, CB1 - physiology | Resorcinols - pharmacology | Drug Interactions | Synapses - metabolism | Nerve Tissue Proteins - biosynthesis | Dopaminergic Neurons - drug effects | Dopaminergic Neurons - physiology | Protein Synthesis Inhibitors - pharmacology | Cocaine - antagonists & inhibitors | Cycloheximide - administration & dosage | Long-Term Synaptic Depression - physiology | Synapses - drug effects | Nerve Tissue Proteins - physiology | Ventral Tegmental Area - drug effects | Microinjections | Conditioning (Psychology) - drug effects | Conditioning (Psychology) - physiology | Inhibitory Postsynaptic Potentials - physiology | Rats | Peptide Chain Elongation, Translational - drug effects | Nerve Tissue Proteins - drug effects | Cycloheximide - pharmacology | Cocaine - pharmacology | Animals | Glycine - pharmacology | Signal Transduction - drug effects | Signal Transduction - physiology | Receptors, Metabotropic Glutamate - agonists | Inhibitory Postsynaptic Potentials - drug effects | Receptors, Metabotropic Glutamate - antagonists & inhibitors | Index Medicus | Behavioral Science | Addiction & Substance Abuse | cocaine conditioned place preference | long-term depression | Neuropharmacology | Glutamate | Group I mGluRs | Original
Journal Article
Human Molecular Genetics, ISSN 0964-6906, 09/2012, Volume 21, Issue 18, pp. 4007 - 4020
Molecules that induce ribosomal read-through of nonsense mutations in mRNA and allow production of a full-length functional protein hold great therapeutic... 
FIREFLY LUCIFERASE | PTC124 | BIOCHEMISTRY & MOLECULAR BIOLOGY | GENETICS & HEREDITY | NONSENSE MUTATIONS | GENE-THERAPY | MICE | CYSTIC-FIBROSIS | STOP MUTATIONS | SUPPRESSION | PREMATURE TERMINATION CODONS | MOLECULAR-BASIS | Oxadiazoles - administration & dosage | Transcription, Genetic - drug effects | Thiazolidines - pharmacokinetics | Furans - pharmacology | Male | Muscle, Skeletal - metabolism | Reading Frames | Gentamicins - administration & dosage | Muscle Fibers, Skeletal - drug effects | Muscle Fibers, Skeletal - metabolism | Protein Synthesis Inhibitors - administration & dosage | Schiff Bases - pharmacology | Dose-Response Relationship, Drug | Furans - pharmacokinetics | Gentamicins - pharmacology | Muscular Dystrophy, Duchenne - physiopathology | Oxadiazoles - pharmacology | Muscle, Skeletal - drug effects | Mice, Inbred mdx | Protein Synthesis Inhibitors - pharmacology | Drug Evaluation, Preclinical | Oxadiazoles - pharmacokinetics | Thiazolidines - pharmacology | Dystrophin - metabolism | Disease Models, Animal | Phenols - pharmacology | Muscular Dystrophy, Duchenne - drug therapy | Mice, Inbred C57BL | Injections, Intraperitoneal | Codon, Nonsense | Injections, Intramuscular | Schiff Bases - administration & dosage | Animals | Dystrophin - genetics | Muscle, Skeletal - physiopathology | Phenols - administration & dosage | Mice | Muscle Strength - drug effects | Muscular Dystrophy, Duchenne - metabolism | Thiazolidines - administration & dosage | Furans - administration & dosage | Index Medicus
Journal Article