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Biochemical Journal, ISSN 0264-6021, 09/2011, Volume 438, Issue 2, pp. 369 - 378
Obesity is associated with induction of the ER (endoplasmic reticulum)-stress response signalling and insulin resistance. PTP1B (protein tyrosine phosphatase... 
Obesity | Insulin resistance | Endoplasmic reticulum (ER) stress | Metabolic syndrome | Protein tyrosine phosphatase 1B (PTP1B) | OXIDATIVE STRESS | ER STRESS | BIOCHEMISTRY & MOLECULAR BIOLOGY | protein tyrosine phosphatase 1B (PTP1B) | endoplasmic reticulum (ER) stress | INSULIN SENSITIVITY | metabolic syndrome | SIGNAL-TRANSDUCTION | GLUCOSE-HOMEOSTASIS | LEPTIN ACTION | IN-VIVO | GENE-EXPRESSION | BINDING PROTEIN-1 | insulin resistance | HEPATIC STEATOSIS | obesity | Organ Specificity - drug effects | Class Ia Phosphatidylinositol 3-Kinase - metabolism | Liver - pathology | Liver - enzymology | Humans | Protein Transport - drug effects | RNA, Messenger - metabolism | X-Box Binding Protein 1 | Gene Knockdown Techniques | DNA-Binding Proteins - metabolism | Endoplasmic Reticulum - pathology | Organ Specificity - genetics | Cell Nucleus - metabolism | Liver - drug effects | Endoplasmic Reticulum - drug effects | Gene Deletion | Eukaryotic Initiation Factor-2 - metabolism | Protein Tyrosine Phosphatase, Non-Receptor Type 1 - genetics | Stress, Physiological - drug effects | Homeostasis - drug effects | Protein-Serine-Threonine Kinases - metabolism | Endoribonucleases - metabolism | RNA, Messenger - genetics | Protein Tyrosine Phosphatase, Non-Receptor Type 1 - deficiency | Regulatory Factor X Transcription Factors | Hep G2 Cells | Obesity - pathology | Transcription Factors - metabolism | Activating Transcription Factor 6 - metabolism | Protein Tyrosine Phosphatase, Non-Receptor Type 1 - metabolism | Animals | Signal Transduction - drug effects | Tunicamycin - pharmacology | Lipid Metabolism - drug effects | Glucose - metabolism | Thapsigargin - pharmacology | Mice | Obesity - enzymology | Cell Nucleus - drug effects | Index Medicus | ER stress | PTP1B
Journal Article
Nature Chemical Biology, ISSN 1552-4450, 2014, Volume 10, Issue 7, pp. 558 - 566
PTP1B, a validated therapeutic target for diabetes and obesity, has a critical positive role in HER2 signaling in breast tumorigenesis. Efforts to develop... 
LAPATINIB | OVEREXPRESSION | TYROSINE-PHOSPHATASE 1B | BIOCHEMISTRY & MOLECULAR BIOLOGY | ACQUIRED-RESISTANCE | BINDING-SITE | MECHANISMS | INDUCTION | HUMAN BREAST-CANCER | CONTRIBUTES | TUMORS | Receptor, ErbB-2 - genetics | Humans | Gene Expression Regulation, Neoplastic | Receptor, ErbB-2 - metabolism | Molecular Targeted Therapy | Mammary Neoplasms, Experimental - genetics | Breast Neoplasms - enzymology | Protein Binding - drug effects | Mammary Neoplasms, Experimental - pathology | Female | Antineoplastic Agents - pharmacology | Protein Tyrosine Phosphatase, Non-Receptor Type 1 - genetics | Mammary Neoplasms, Experimental - enzymology | Spermine - analogs & derivatives | Mammary Neoplasms, Experimental - drug therapy | Allosteric Regulation - drug effects | Protein Structure, Tertiary | Catalytic Domain | Protein Structure, Secondary | Signal Transduction | Allosteric Site - drug effects | Protein Tyrosine Phosphatase, Non-Receptor Type 1 - antagonists & inhibitors | Spermine - chemistry | Models, Molecular | Antineoplastic Agents - chemistry | Breast Neoplasms - drug therapy | Protein Tyrosine Phosphatase, Non-Receptor Type 1 - metabolism | Animals | Breast Neoplasms - genetics | Spermine - pharmacology | Breast Neoplasms - pathology | Cholestanes - chemistry | Cholestanes - pharmacology | Mice | Kinetics | Breast cancer | Tumorigenesis | Diabetes | Drug therapy | Index Medicus | Cholestanes | Allosteric Regulation | Breast Neoplasms | Life Sciences | Biomolecules | Biochemistry, Molecular Biology | Antineoplastic Agents | Spermine | Protein Tyrosine Phosphatase, Non-Receptor Type 1 | Mammary Neoplasms, Experimental | Allosteric Site | Protein Binding | Receptor, ErbB-2
Journal Article
Journal Article
Nature Cell Biology, ISSN 1465-7392, 03/2010, Volume 12, Issue 3, pp. 267 - 272
Journal Article
American Journal of Respiratory Cell and Molecular Biology, ISSN 1044-1549, 11/2013, Volume 49, Issue 5, pp. 721 - 730
Protein phosphatase-2A (PP2A) is a primary serine-threonine phosphatase that modulates inflammatory responses in asthma and chronic obstructive pulmonary... 
Phosphorylation | Inflammation | Oxidation | Kinase | PROTEIN PHOSPHATASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | oxidation | INNATE IMMUNE | CERAMIDE | CELL BIOLOGY | kinase | OBSTRUCTIVE PULMONARY-DISEASE | inflammation | RESPIRATORY SYSTEM | EMPHYSEMA | CIGARETTE-SMOKE | MICE | phosphorylation | EXPRESSION | LUNG INFLAMMATION | Smoking - adverse effects | Oxidative Stress | Humans | Pneumonia - pathology | Pneumonia - prevention & control | Pulmonary Disease, Chronic Obstructive - pathology | Pulmonary Alveoli - enzymology | Case-Control Studies | Gene Knockdown Techniques | Respiratory Mucosa - pathology | Transfection | RNA Interference | Mice, Inbred CBA | Protein Tyrosine Phosphatase, Non-Receptor Type 1 - genetics | Glutathione Peroxidase - deficiency | Pneumonia - genetics | Cell Line | Glutathione Peroxidase - metabolism | Pneumonia - etiology | Pulmonary Alveoli - pathology | Oxidation-Reduction | Signal Transduction | Pneumonia - enzymology | Mice, Inbred C57BL | Respiratory Mucosa - enzymology | Pulmonary Emphysema - pathology | Glutathione Peroxidase - genetics | Mice, Knockout | Pulmonary Disease, Chronic Obstructive - enzymology | Protein Tyrosine Phosphatase, Non-Receptor Type 1 - metabolism | Animals | Protein Phosphatase 2 - metabolism | Protein Binding | Mice | Enzyme Activation | Pulmonary Emphysema - enzymology | Index Medicus
Journal Article
Clinical Science, ISSN 0143-5221, 10/2017, Volume 131, Issue 20, pp. 2489 - 2501
Cardiovascular disease (CVD) is the most prevalent cause of mortality among patients with type 1 or type 2 diabetes, due to accelerated atherosclerosis. Recent... 
MEDICINE, RESEARCH & EXPERIMENTAL | OBESITY | PTP1B | HIGH-FAT DIET | INFLAMMATION | ENDOTHELIAL-CELLS | HEART-FAILURE | MACROPHAGE | GENE DELETION | KNOCKOUT MICE | INSULIN SENSITIVITY | AMP-Activated Protein Kinases - metabolism | Phosphorylation | Atherosclerosis - genetics | Cholesterol - blood | Homeostasis | Male | Enzyme Inhibitors - administration & dosage | Atherosclerosis - enzymology | Time Factors | Diet, High-Fat | Receptors, LDL - deficiency | Aortic Diseases - prevention & control | Aortic Diseases - enzymology | Chemokine CCL2 - metabolism | Proto-Oncogene Proteins c-akt - metabolism | Aorta - enzymology | Spermine - analogs & derivatives | Aortic Diseases - pathology | Disease Models, Animal | Receptors, LDL - genetics | Atherosclerosis - pathology | Genetic Predisposition to Disease | Drug Administration Schedule | Spermine - administration & dosage | Aorta - drug effects | Protein Tyrosine Phosphatase, Non-Receptor Type 1 - antagonists & inhibitors | Biomarkers - blood | Plaque, Atherosclerotic | Mice, Knockout | Aorta - pathology | Blood Glucose - drug effects | Aortic Diseases - genetics | Phenotype | Protein Tyrosine Phosphatase, Non-Receptor Type 1 - metabolism | Animals | Signal Transduction - drug effects | Weight Loss | Triglycerides - blood | Cholestanes - administration & dosage | Blood Glucose - metabolism | Atherosclerosis - prevention & control | Index Medicus
Journal Article
Circulation Research, ISSN 0009-7330, 05/2008, Volume 102, Issue 10, pp. 1182 - 1191
Journal Article
Journal of the American Chemical Society, ISSN 0002-7863, 10/2018, Volume 140, Issue 41, pp. 13253 - 13259
Journal Article
Journal Article