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Nature, ISSN 0028-0836, 07/2016, Volume 535, Issue 7610, pp. 148 - 152
The non-receptor protein tyrosine phosphatase SHP2, encoded by PTPN11, has an important role in signal transduction downstream of growth factor receptor... 
TARGET | POTENT | PTPN11 | PROTOONCOGENE | MULTIDISCIPLINARY SCIENCES | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - metabolism | Humans | Extracellular Signal-Regulated MAP Kinases - metabolism | Oncogene Protein p21(ras) - metabolism | Pyrimidines - chemistry | Piperidines - pharmacology | Inhibitory Concentration 50 | Female | Allosteric Regulation - drug effects | Piperidines - chemistry | Reproducibility of Results | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - antagonists & inhibitors | Models, Molecular | Neoplasms - enzymology | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - chemistry | Pyrimidines - pharmacology | Receptor Protein-Tyrosine Kinases - metabolism | Neoplasms - drug therapy | Xenograft Model Antitumor Assays | Animals | MAP Kinase Signaling System - drug effects | Mice, Nude | Piperidines - therapeutic use | Pyrimidines - therapeutic use | Protein Stability - drug effects | Cell Line, Tumor | Cell Proliferation - drug effects | Mice | Protein Kinase Inhibitors - pharmacology | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - genetics | Neoplasms - pathology | Protein Structure, Tertiary - drug effects | Phosphatases | Observations | Health aspects | Phosphotransferases | Protein-protein interactions | Signal transduction | Cell growth | Peptides | Kinases | Phosphatase | Drug dosages | Cancer | Index Medicus | BASIC BIOLOGICAL SCIENCES
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 09/2016, Volume 59, Issue 17, pp. 7773 - 7782
Journal Article
BioMetals, ISSN 0966-0844, 12/2011, Volume 24, Issue 6, pp. 993 - 1004
A series of copper complexes with multi-benzimidazole derivatives, including mono- and di-nuclear, were synthesized and characterized by Fourier transform IR... 
Life Sciences | Biochemistry, general | Protein tyrosine phosphatases | Microbiology | Fluorescence | Plant Physiology | Copper complex | Inhibition | Pharmacology/Toxicology | Medicine/Public Health, general | Cell Biology | CANCER-CELLS | HOMEOSTASIS | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | CATALYTIC DOMAIN | DISOLVATE | APOPTOSIS INDUCERS | STRATEGIES | LIGANDS | PURIFICATION | PROTEASOME INHIBITORS | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - metabolism | Humans | Protein Tyrosine Phosphatases - metabolism | Structure-Activity Relationship | Benzimidazoles - chemistry | Enzyme Inhibitors - chemical synthesis | Protein Tyrosine Phosphatase, Non-Receptor Type 6 - chemistry | Protein Tyrosine Phosphatases - antagonists & inhibitors | Protein Tyrosine Phosphatases - chemistry | Protein Tyrosine Phosphatases - genetics | Protein Tyrosine Phosphatases, Non-Receptor - chemistry | Copper - chemistry | Enzyme Inhibitors - chemistry | Protein Tyrosine Phosphatases, Non-Receptor - genetics | Copper - metabolism | Molecular Structure | Protein Tyrosine Phosphatase, Non-Receptor Type 1 - genetics | Protein Tyrosine Phosphatase, Non-Receptor Type 1 - chemistry | Protein Tyrosine Phosphatase, Non-Receptor Type 2 - chemistry | Enzyme Inhibitors - metabolism | Benzimidazoles - chemical synthesis | Protein Tyrosine Phosphatase, Non-Receptor Type 1 - antagonists & inhibitors | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - antagonists & inhibitors | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - chemistry | Protein Tyrosine Phosphatase, Non-Receptor Type 2 - genetics | Protein Tyrosine Phosphatase, Non-Receptor Type 6 - genetics | Protein Tyrosine Phosphatase, Non-Receptor Type 2 - metabolism | Protein Tyrosine Phosphatase, Non-Receptor Type 1 - metabolism | Protein Tyrosine Phosphatase, Non-Receptor Type 6 - metabolism | Spectrum Analysis - methods | Benzimidazoles - metabolism | Protein Tyrosine Phosphatases, Non-Receptor - metabolism | Protein Tyrosine Phosphatase, Non-Receptor Type 2 - antagonists & inhibitors | Protein Tyrosine Phosphatase, Non-Receptor Type 6 - antagonists & inhibitors | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - genetics | Protein Tyrosine Phosphatases, Non-Receptor - antagonists & inhibitors | Tyrosine | Phosphatases | Ionization | Analysis | Phenols | T cells | Mass spectrometry | Proteins | Enzymes | Cellular biology | Copper | Index Medicus
Journal Article
Nature Medicine, ISSN 1078-8956, 05/2018, Volume 24, Issue 4, pp. 512 - 517
Most anaplastic lymphoma kinase (ALK)-rearranged non-small-cell lung tumors initially respond to small-molecule ALK inhibitors, but drug resistance often... 
MEDICINE, RESEARCH & EXPERIMENTAL | ACTIVATION | SHPTP2 | BIOCHEMISTRY & MOLECULAR BIOLOGY | CRIZOTINIB RESISTANCE | PROTEIN-TYROSINE-PHOSPHATASE | CHEMOTHERAPY | CELL BIOLOGY | Carcinoma, Non-Small-Cell Lung - pathology | Lung Neoplasms - genetics | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - metabolism | Sulfones - therapeutic use | Lung Neoplasms - enzymology | Carcinoma, Non-Small-Cell Lung - genetics | Humans | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - antagonists & inhibitors | Lung Neoplasms - pathology | Extracellular Signal-Regulated MAP Kinases - metabolism | Pyrimidines - pharmacology | Sulfones - pharmacology | Animals | Mice, Nude | Pyrimidines - therapeutic use | Cell Line, Tumor | Anaplastic Lymphoma Kinase - metabolism | Female | Protein Kinase Inhibitors - pharmacology | Carcinoma, Non-Small-Cell Lung - enzymology | Gene Rearrangement - genetics | Anaplastic Lymphoma Kinase - antagonists & inhibitors | Drug Resistance, Neoplasm - drug effects | RNA, Small Interfering - metabolism | Medical research | Receptors | Protein tyrosine kinase | Physiological aspects | Medicine, Experimental | Development and progression | Research | Drug resistance | Lung cancer, Non-small cell | Drug therapy | Health aspects | Insulin | Tyrosine | Lung cancer | Extracellular signal-regulated kinase | Activation | Kinases | Lymphoma | Sensitivity | Inhibitors | Mutation | Inhibition | Protein-tyrosine kinase | Tumors | Cancer | Protein-tyrosine-phosphatase | Index Medicus
Journal Article
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 12/2017, Volume 60, Issue 24, pp. 10205 - 10219
SHP2, a cytoplasmic protein-tyrosine phosphatase encoded by the PTPN11 gene, is involved in multiple cell signaling processes including Ras/MAPK and Hippo/YAP... 
RAS ACTIVATION | DOMAIN | CHEMISTRY, MEDICINAL | SOLID TUMORS | CRYSTAL-STRUCTURE | EPIDERMAL-GROWTH-FACTOR | PTPN11 | MUTATIONS | PROTOONCOGENE | PROTEIN-TYROSINE-PHOSPHATASE | DISCOVERY | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - metabolism | Humans | Crystallography, X-Ray | Thiazoles - administration & dosage | Phosphoproteins - antagonists & inhibitors | Structure-Activity Relationship | Antineoplastic Agents - administration & dosage | Thiazoles - pharmacokinetics | Adaptor Proteins, Signal Transducing - antagonists & inhibitors | Enzyme Inhibitors - chemistry | Inhibitory Concentration 50 | Female | Piperidines - pharmacokinetics | Antineoplastic Agents - pharmacokinetics | Antineoplastic Agents - pharmacology | Naphthalenes - pharmacokinetics | Binding Sites | Allosteric Regulation - drug effects | Naphthalenes - chemistry | Piperidines - administration & dosage | Piperidines - chemistry | Administration, Oral | Enzyme Inhibitors - pharmacology | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - antagonists & inhibitors | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - chemistry | Antineoplastic Agents - chemistry | Xenograft Model Antitumor Assays | Animals | MAP Kinase Signaling System - drug effects | Mice, Nude | Naphthalenes - administration & dosage | Thiazoles - chemistry | Cell Proliferation - drug effects | Mice, Inbred BALB C | Mutation | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - genetics | Drug Screening Assays, Antitumor | Index Medicus
Journal Article
Journal Article
Journal Article
Journal of Vascular Research, ISSN 1018-1172, 02/2008, Volume 45, Issue 2, pp. 153 - 163
Endothelial cell survival is indispensable to maintain endothelial integrity and initiate new vessel formation. We investigated the role of SHP-2 in... 
Research Paper | Angiogenesis | FGF-2 | PI3-K | SHP-2 | Tyrosine phosphatase | Endothelial cells | RECRUITMENT | endothelial cells | ACTIVATION | PHYSIOLOGY | GENE DELIVERY | angiogenesis | PHOSPHATIDYLINOSITOL 3-KINASE | MAGNETOFECTION | CELL-CYCLE PROGRESSION | SIGNAL-TRANSDUCTION | tyrosine phosphatase | RAS/RAF/MEK/ERK PATHWAY | EPIDERMAL-GROWTH-FACTOR | ENDOTHELIAL-CELLS | PERIPHERAL VASCULAR DISEASE | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - metabolism | Neovascularization, Physiologic - drug effects | Phosphorylation | Apoptosis - drug effects | Humans | Oligonucleotides, Antisense - metabolism | Phosphatidylinositol 3-Kinases - metabolism | Transfection | Time Factors | Fibroblast Growth Factor 2 - metabolism | Proto-Oncogene Proteins c-akt - metabolism | Chorioallantoic Membrane - blood supply | Cell Survival - drug effects | Tissue Culture Techniques | Cells, Cultured | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - antagonists & inhibitors | Angiogenesis Inhibitors - pharmacology | Chick Embryo | Animals | Mitogen-Activated Protein Kinase 3 - metabolism | Signal Transduction - drug effects | Cell Proliferation - drug effects | Mice | Protein Kinase Inhibitors - pharmacology | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - genetics | Endothelial Cells - enzymology | Endothelial Cells - drug effects | Mitogen-Activated Protein Kinase 1 - metabolism | Index Medicus
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 9/2013, Volume 110, Issue 37, pp. 14924 - 14929
The dysregulated ty rosi ne kinase BCR-ABL causes chronic myelogenous leukemia in humans and forms a large multiprotein complex that includes the Src-homology... 
Proteins | Phosphorylation | Phosphatases | HEK293 cells | Leukemia | Cell lines | Libraries | Chronic myeloid leukemia | Scaffolds | Crystal structure | Engineered proteins | Tyrosine phosphatase | Interaction proteomics | Protein interaction inhibitor | CELLS | ACTIVATION | MULTIDISCIPLINARY SCIENCES | engineered proteins | BINDING-PROTEINS | CHRONIC MYELOID-LEUKEMIA | tyrosine phosphatase | ROLES | MYELOGENOUS LEUKEMIA | protein interaction inhibitor | FACTOR RECEPTOR-BETA | GROWTH-FACTOR | interaction proteomics | PROTEIN-TYROSINE-PHOSPHATASE | PHOSPHOTYROSINE PHOSPHATASE | Fusion Proteins, bcr-abl - chemistry | Amino Acid Sequence | Peptides - chemistry | Signal Transduction | Humans | Enzyme Inhibitors - pharmacology | Peptides - genetics | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - antagonists & inhibitors | Models, Molecular | Crystallography, X-Ray | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - chemistry | Peptide Library | Peptides - pharmacology | src Homology Domains | Fusion Proteins, bcr-abl - genetics | Cell Transformation, Neoplastic | Enzyme Inhibitors - chemistry | Fusion Proteins, bcr-abl - antagonists & inhibitors | HEK293 Cells | K562 Cells | Protein Binding | Protein Interaction Domains and Motifs | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - genetics | Adaptor Proteins, Signal Transducing - metabolism | Tyrosine | Physiological aspects | Homology (Biology) | Research | Health aspects | Phosphotransferases | RNA-protein interactions | Peptides | Binding sites | Cancer | Index Medicus | Biological Sciences
Journal Article
NATURE MEDICINE, ISSN 1078-8956, 07/2018, Volume 24, Issue 7, pp. 968 - 968
Journal Article