X
Search Filters
Format Format
Format Format
X
Sort by Item Count (A-Z)
Filter by Count
Journal Article (1982) 1982
Book Review (619) 619
Publication (374) 374
Book / eBook (49) 49
Book Chapter (15) 15
Conference Proceeding (5) 5
Dissertation (5) 5
Reference (1) 1
more...
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
index medicus (1810) 1810
animals (1295) 1295
humans (1191) 1191
mice (773) 773
signal transduction (583) 583
cell biology (447) 447
phosphorylation (443) 443
proteins (441) 441
biochemistry & molecular biology (414) 414
male (387) 387
tyrosine (366) 366
female (349) 349
mice, knockout (309) 309
phosphatases (299) 299
article (295) 295
immunology (291) 291
kinases (287) 287
activation (261) 261
protein-tyrosine-phosphatase (261) 261
physiological aspects (257) 257
research (252) 252
mutation (241) 241
mice, inbred c57bl (236) 236
cancer (233) 233
genetic aspects (231) 231
gene expression (223) 223
analysis (198) 198
expression (197) 197
oncology (191) 191
apoptosis (182) 182
rodents (182) 182
research article (181) 181
endocrinology & metabolism (172) 172
multidisciplinary sciences (168) 168
cells, cultured (164) 164
phosphatase (164) 164
medicine (162) 162
biology (147) 147
health aspects (147) 147
protein tyrosine phosphatase, non-receptor type 1 - metabolism (142) 142
abridged index medicus (137) 137
cell line (136) 136
inflammation (136) 136
signal transduction - physiology (134) 134
in-vivo (132) 132
protein tyrosine phosphatases - metabolism (131) 131
genetics & heredity (129) 129
signal transduction - drug effects (129) 129
receptor (126) 126
neurosciences (123) 123
protein tyrosine phosphatases - genetics (123) 123
gene-expression (122) 122
adult (119) 119
genes (119) 119
science (119) 119
autoimmunity (118) 118
protein tyrosine phosphatase, non-receptor type 11 - metabolism (117) 117
medicine, research & experimental (116) 116
signal-transduction (116) 116
rats (115) 115
cell line, tumor (112) 112
disease (112) 112
physiology (112) 112
phenols (111) 111
development and progression (110) 110
insulin (110) 110
cytokines (109) 109
diabetes (109) 109
pharmacology & pharmacy (109) 109
cell proliferation (108) 108
review (106) 106
biochemistry (105) 105
protein (105) 105
signaling (105) 105
cells (104) 104
disease models, animal (104) 104
protein binding (104) 104
protein tyrosine phosphatase, non-receptor type 11 (103) 103
nf-kappa-b (102) 102
protein tyrosine phosphatase, non-receptor type 11 - genetics (102) 102
t cells (102) 102
genetics (101) 101
intracellular signaling peptides and proteins (99) 99
protein-tyrosine kinases - metabolism (99) 99
metabolism (98) 98
obesity (97) 97
mice, transgenic (95) 95
phenotype (93) 93
protein kinases (93) 93
risk factors (93) 93
cellular signal transduction (91) 91
insulin resistance (90) 90
life sciences (90) 90
care and treatment (88) 88
gene expression regulation (87) 87
homeostasis (87) 87
hormones, hormone substitutes, and hormone antagonists (87) 87
protein tyrosine phosphatase, non-receptor type 1 - genetics (87) 87
models, biological (86) 86
middle aged (85) 85
more...
Library Location Library Location
Library Location Library Location
X
Sort by Item Count (A-Z)
Filter by Count
Gerstein Science - Stacks (33) 33
UofT at Mississauga - Stacks (9) 9
Collection Dvlpm't (Acquisitions) - Closed Orders (5) 5
Online Resources - Online (5) 5
Collection Dvlpm't (Acquisitions) - Vendor file (3) 3
Engineering & Comp. Sci. - Stacks (1) 1
UofT at Scarborough - Stacks (1) 1
more...
Language Language
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


Nature Medicine, ISSN 1078-8956, 07/2018, Volume 24, Issue 7, pp. 954 - 960
The ubiquitously expressed non-receptor protein tyrosine phosphatase SHP2, encoded by PTPN11, is involved in signal transduction downstream of multiple growth... 
MEDICINE, RESEARCH & EXPERIMENTAL | PANCREATIC DUCTAL ADENOCARCINOMA | TYROSINE PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL BIOLOGY | COLON-CANCER | SHP2 | INHIBITION | K-RAS | CELL LUNG-CARCINOMA | MOUSE MODEL | PROGRESSION | PHOSPHOTYROSINE PHOSPHATASE | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - metabolism | Pancreatic Neoplasms - metabolism | Proto-Oncogene Proteins p21(ras) - genetics | Humans | Lung Neoplasms - metabolism | Pancreatic Neoplasms - pathology | Mitogen-Activated Protein Kinase Kinases - antagonists & inhibitors | Lung Neoplasms - pathology | Mutation - genetics | Carcinogenesis - metabolism | Disease Progression | Carcinogenesis - pathology | Mitogen-Activated Protein Kinase Kinases - metabolism | Animals | Protein Kinase Inhibitors - therapeutic use | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - deficiency | Cell Line, Tumor | Mice | Protein Kinase Inhibitors - pharmacology | Tyrosine | Care and treatment | Cellular signal transduction | Genetic aspects | Research | Gene expression | Cancer | Adenocarcinoma | Animal models | Xenotransplantation | Lung cancer | Phosphatase | Carcinogenesis | K-Ras protein | Proteins | Signal transduction | Carcinogens | Allosteric properties | Clonal deletion | Organoids | Dependence | Xenografts | Deletion | Protein-tyrosine kinase receptors | Inhibition | Pancreas | Protein-tyrosine kinase | MAP kinase | Tumor cell lines | Signaling | Transduction | Tumors | Protein-tyrosine-phosphatase | Index Medicus
Journal Article
Cancer Cell, ISSN 1535-6108, 2011, Volume 19, Issue 5, pp. 629 - 639
The human gene , which encodes the tyrosine phosphatase Shp2, may act as a proto-oncogene because dominantly activating mutations have been detected in several... 
BREAST-CANCER | CELLS | ACTIVATION | HUMAN-DISEASE | ONCOLOGY | SHP2 TYROSINE PHOSPHATASE | INFLAMMATION | STAT3 | LIVER | MUTATIONS | DIFFERENTIATION | CELL BIOLOGY | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - metabolism | Carcinoma, Hepatocellular - chemically induced | Liver - pathology | Hepatitis - enzymology | Liver - enzymology | Carcinoma, Hepatocellular - prevention & control | Humans | Hyperplasia | Lipopolysaccharides - administration & dosage | Adenoma, Liver Cell - pathology | Liver Neoplasms - chemically induced | Male | Necrosis | Liver - drug effects | Time Factors | Tumor Suppressor Proteins - deficiency | Carcinoma, Hepatocellular - genetics | Diethylnitrosamine | Hepatitis - genetics | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - deficiency | Tumor Suppressor Proteins - genetics | STAT3 Transcription Factor - deficiency | Liver Neoplasms - pathology | Adenoma, Liver Cell - enzymology | Liver Neoplasms - enzymology | Cytokines - genetics | Interleukin-6 - administration & dosage | Adenoma, Liver Cell - genetics | STAT3 Transcription Factor - genetics | Cytokines - blood | Liver Neoplasms - prevention & control | Liver Regeneration | Tumor Suppressor Proteins - metabolism | Liver Neoplasms - genetics | Signal Transduction | Mice, Inbred C57BL | Gene Expression Regulation | Inflammation Mediators - blood | Hepatitis - pathology | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - analysis | Carcinoma, Hepatocellular - enzymology | Mice, Knockout | Animals | Carcinoma, Hepatocellular - pathology | Mice | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - genetics | Tyrosine | Liver cancer | Development and progression | Phosphatases | Leukemia | Index Medicus
Journal Article
Journal Article
Journal Article
Nature, ISSN 0028-0836, 2013, Volume 499, Issue 7459, pp. 491 - 495
The tyrosine phosphatase SHP2, encoded by PTPN11, is required for the survival, proliferation and differentiation of various cell types(1,2). Germline... 
ENCHONDROMATOSIS | RANVIER | OSTEOCLASTS | MULTIDISCIPLINARY SCIENCES | OSSIFICATION GROOVE | PERICHONDRIAL RING | CELL PROLIFERATION | RECEPTOR | OSTEOGENESIS | CHONDROGENESIS | CARTILAGE | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - metabolism | Cartilage - pathology | Hedgehog Proteins - metabolism | Monocytes - metabolism | Bone Neoplasms - pathology | Bone Neoplasms - metabolism | MAP Kinase Signaling System | Fibroblast Growth Factors - metabolism | Mitogen-Activated Protein Kinase Kinases - metabolism | Mesenchymal Stromal Cells - cytology | Cell Division | Gene Deletion | Genes, Tumor Suppressor - physiology | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - deficiency | Exostoses, Multiple Hereditary - genetics | Bone Neoplasms - genetics | Bone Neoplasms - drug therapy | Osteopetrosis - genetics | Osteopetrosis - pathology | Mitogen-Activated Protein Kinase Kinases - antagonists & inhibitors | Exostoses, Multiple Hereditary - metabolism | Mesenchymal Stromal Cells - metabolism | Mice, Transgenic | Osteopetrosis - metabolism | Chondromatosis - metabolism | Hedgehog Proteins - antagonists & inhibitors | Cartilage - metabolism | Osteoclasts - metabolism | Parathyroid Hormone-Related Protein - metabolism | Exostoses, Multiple Hereditary - pathology | Mice, Knockout | Exostoses, Multiple Hereditary - drug therapy | Gene Expression Regulation - drug effects | Cell Lineage | Cathepsin K - genetics | Macrophages - metabolism | Animals | Chondromatosis - drug therapy | Cathepsin K - metabolism | Chondromatosis - genetics | Signal Transduction - drug effects | Chondromatosis - pathology | Mice | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - genetics | Cathepsin K - deficiency | Tyrosine | Phosphatases | Physiological aspects | Cellular signal transduction | Research | Bone diseases | Health aspects | Hedgehog proteins | Flow cytometry | Pathogenesis | Rodents | Bone density | Mutation | Kinases | Gene expression | Index Medicus
Journal Article
Journal of Immunology, ISSN 0022-1767, 10/2017, Volume 199, Issue 7, pp. 2323 - 2332
Journal Article
Journal of Cellular Physiology, ISSN 0021-9541, 11/2016, Volume 231, Issue 11, pp. 2529 - 2540
Journal Article
Blood, ISSN 0006-4971, 05/2011, Volume 117, Issue 20, pp. 5350 - 5361
Journal Article
NATURE COMMUNICATIONS, ISSN 2041-1723, 03/2019, Volume 10, Issue 1, pp. 1444 - 14
Journal Article
Journal of Immunology, ISSN 0022-1767, 09/2012, Volume 189, Issue 6, pp. 3159 - 3167
Journal Article
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, ISSN 0363-6119, 12/2014, Volume 307, Issue 12, pp. R1438 - R1447
Previous studies showed that Src homology-2 tyrosine phosphatase (Shp2) is an important regulator of body weight. In this study, we examined the impact of Shp2... 
blood pressure | heart rate | ACTIVATION | PHYSIOLOGY | acute stress | CARDIOVASCULAR FUNCTION | RESISTANCE | energy balance | MICE | RECEPTORS