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Nature medicine, ISSN 1546-170X, 05/2018, Volume 24, Issue 7, pp. 954 - 960
Journal Article
Biometals, ISSN 0966-0844, 12/2011, Volume 24, Issue 6, pp. 993 - 1004
.... Their inhibitory effects against human protein tyrosine phosphatase 1B (PTP1B), T-cell protein tyrosine phosphatase (TCPTP... 
Life Sciences | Biochemistry, general | Protein tyrosine phosphatases | Microbiology | Fluorescence | Plant Physiology | Copper complex | Inhibition | Pharmacology/Toxicology | Medicine/Public Health, general | Cell Biology | Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - metabolism | Humans | Protein Tyrosine Phosphatases - metabolism | Structure-Activity Relationship | Benzimidazoles - chemistry | Enzyme Inhibitors - chemical synthesis | Protein Tyrosine Phosphatase, Non-Receptor Type 6 - chemistry | Protein Tyrosine Phosphatases - antagonists & inhibitors | Protein Tyrosine Phosphatases - chemistry | Protein Tyrosine Phosphatases - genetics | Protein Tyrosine Phosphatases, Non-Receptor - chemistry | Copper - chemistry | Enzyme Inhibitors - chemistry | Protein Tyrosine Phosphatases, Non-Receptor - genetics | Copper - metabolism | Molecular Structure | Protein Tyrosine Phosphatase, Non-Receptor Type 1 - genetics | Protein Tyrosine Phosphatase, Non-Receptor Type 1 - chemistry | Protein Tyrosine Phosphatase, Non-Receptor Type 2 - chemistry | Enzyme Inhibitors - metabolism | Benzimidazoles - chemical synthesis | Protein Tyrosine Phosphatase, Non-Receptor Type 1 - antagonists & inhibitors | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - antagonists & inhibitors | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - chemistry | Protein Tyrosine Phosphatase, Non-Receptor Type 2 - genetics | Protein Tyrosine Phosphatase, Non-Receptor Type 6 - genetics | Protein Tyrosine Phosphatase, Non-Receptor Type 2 - metabolism | Protein Tyrosine Phosphatase, Non-Receptor Type 1 - metabolism | Protein Tyrosine Phosphatase, Non-Receptor Type 6 - metabolism | Spectrum Analysis - methods | Benzimidazoles - metabolism | Protein Tyrosine Phosphatases, Non-Receptor - metabolism | Protein Tyrosine Phosphatase, Non-Receptor Type 2 - antagonists & inhibitors | Protein Tyrosine Phosphatase, Non-Receptor Type 6 - antagonists & inhibitors | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - genetics | Protein Tyrosine Phosphatases, Non-Receptor - antagonists & inhibitors | Tyrosine | Phosphatases | Ionization | Analysis | Phenols | T cells | Mass spectrometry | Proteins | Enzymes | Cellular biology | Copper | Spectroscopy | Inhibitors | Derivatives | Index Medicus
Journal Article
Nature (London), ISSN 1476-4687, 06/2016, Volume 535, Issue 7610, pp. 148 - 152
The non-receptor protein tyrosine phosphatase SHP2, encoded by PTPN11, has an important role in signal transduction downstream of growth factor receptor signalling and was the first reported oncogenic... 
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - metabolism | Humans | Extracellular Signal-Regulated MAP Kinases - metabolism | Oncogene Protein p21(ras) - metabolism | Pyrimidines - chemistry | Piperidines - pharmacology | Inhibitory Concentration 50 | Female | Allosteric Regulation - drug effects | Piperidines - chemistry | Reproducibility of Results | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - antagonists & inhibitors | Models, Molecular | Neoplasms - enzymology | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - chemistry | Pyrimidines - pharmacology | Receptor Protein-Tyrosine Kinases - metabolism | Neoplasms - drug therapy | Xenograft Model Antitumor Assays | Animals | MAP Kinase Signaling System - drug effects | Mice, Nude | Piperidines - therapeutic use | Pyrimidines - therapeutic use | Protein Stability - drug effects | Cell Line, Tumor | Cell Proliferation - drug effects | Mice | Protein Kinase Inhibitors - pharmacology | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - genetics | Neoplasms - pathology | Protein Structure, Tertiary - drug effects | Phosphatases | Observations | Health aspects | Phosphotransferases | Protein-protein interactions | Signal transduction | Cell growth | Peptides | Kinases | Phosphatase | Drug dosages | Cancer | Index Medicus | BASIC BIOLOGICAL SCIENCES
Journal Article
Nature genetics, ISSN 1546-1718, 05/2016, Volume 48, Issue 7, pp. 747 - 757
...; however, the mechanisms by which genetic factors influence the development of sporadic pancreatic cancer remain largely unknown... 
Life Sciences & Biomedicine | Genetics & Heredity | Science & Technology | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - metabolism | Cell Proliferation | Pancreatic Neoplasms - metabolism | Humans | DNA Repair Enzymes - genetics | Gene Expression Regulation, Neoplastic | Extracellular Signal-Regulated MAP Kinases - metabolism | Extracellular Signal-Regulated MAP Kinases - genetics | Case-Control Studies | RNA Splicing Factors - metabolism | STAT1 Transcription Factor - metabolism | Ubiquitination | Proteolysis | DNA Repair Enzymes - metabolism | src-Family Kinases - metabolism | Nuclear Proteins - genetics | Binding Sites | Genome-Wide Association Study | Signal Transduction | Pancreatic Neoplasms - pathology | Nuclear Proteins - metabolism | Pancreatic Neoplasms - genetics | RNA, Long Noncoding - genetics | Pancreas - metabolism | RNA Splicing Factors - genetics | STAT1 Transcription Factor - genetics | Polymorphism, Single Nucleotide - genetics | MicroRNAs - genetics | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - genetics | src-Family Kinases - genetics | MicroRNA | Phosphatases | Genetic variation | Pancreatic cancer | Development and progression | Genetic aspects | Properties | Health aspects | Proteins | Studies | Confidence intervals | Research & development--R&D | Genomes | Mutation | Gene expression | Phosphatase | Cancer | Index Medicus
Journal Article
Journal Article
PloS one, ISSN 1932-6203, 04/2010, Volume 5, Issue 4, pp. e10290 - e10290
.... Treatment with Na(3)VO(4) desensitized keratinocytes to UVB-induced apoptosis with the recovery of phosphorylated Stat3 protein levels, implying that a protein tyrosine phosphatase (PTP... 
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Protein Tyrosine Phosphatase, Non-Receptor Type 2 - radiation effects | Apoptosis - radiation effects | Keratinocytes - radiation effects | RNA, Small Interfering - pharmacology | Cells, Cultured | Protein Tyrosine Phosphatase, Non-Receptor Type 2 - physiology | STAT3 Transcription Factor - radiation effects | Protein Tyrosine Phosphatase, Non-Receptor Type 6 - physiology | Protein Tyrosine Phosphatase, Non-Receptor Type 2 - genetics | Protein Tyrosine Phosphatase, Non-Receptor Type 6 - radiation effects | Protein Tyrosine Phosphatase, Non-Receptor Type 6 - genetics | Protein Tyrosine Phosphatases, Non-Receptor - physiology | Ultraviolet Rays - adverse effects | Protein Tyrosine Phosphatases, Non-Receptor - radiation effects | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - radiation effects | Phosphorylation - radiation effects | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - physiology | Animals | Keratinocytes - metabolism | Protein Tyrosine Phosphatases, Non-Receptor - genetics | Mice | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - genetics | STAT3 Transcription Factor - metabolism | Tyrosine | Phenols | Skin | Phosphatases | Apoptosis | Pediatrics | Phosphorylation | Transcription factors | SHP-1 protein | c-Myc protein | Genomes | Myc protein | Dephosphorylation | Cyclin D1 | Phosphatase | Experiments | Carcinogenesis | Proteins | Signal transduction | Carcinogens | Toxicology | Cell growth | Epidermal growth factor | Rodents | Cell cycle | Translocation | Desensitization | U.V. radiation | RNA-mediated interference | Stat3 protein | Keratinocytes | Epidermis | siRNA | Nuclear transport | Studies | Irradiation | Diabetes | Endoplasmic reticulum | Cytoplasm | Protein-tyrosine-phosphatase | Tumors | Cancer | Index Medicus
Journal Article