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PloS one, ISSN 1932-6203, 2010, Volume 5, Issue 4, p. e10290
.... Treatment with Na3VO4 desensitized keratinocytes to UVB-induced apoptosis with the recovery of phosphorylated Stat3 protein levels, implying that a protein tyrosine phosphatase (PTP... 
GROWTH-FACTOR RECEPTOR | ACTIVATION | TRANSCRIPTION 3 | PROMOTION STAGES | EPITHELIAL CARCINOGENESIS | SUBSTRATE | BIOLOGY | SKIN CARCINOGENESIS | PROLIFERATION | SIGNAL TRANSDUCER | NEGATIVE REGULATOR | Protein Tyrosine Phosphatase, Non-Receptor Type 2 - radiation effects | Apoptosis - radiation effects | Keratinocytes - radiation effects | RNA, Small Interfering - pharmacology | Cells, Cultured | Protein Tyrosine Phosphatase, Non-Receptor Type 2 - physiology | STAT3 Transcription Factor - radiation effects | Protein Tyrosine Phosphatase, Non-Receptor Type 6 - physiology | Protein Tyrosine Phosphatase, Non-Receptor Type 2 - genetics | Protein Tyrosine Phosphatase, Non-Receptor Type 6 - radiation effects | Protein Tyrosine Phosphatase, Non-Receptor Type 6 - genetics | Protein Tyrosine Phosphatases, Non-Receptor - physiology | Ultraviolet Rays - adverse effects | Protein Tyrosine Phosphatases, Non-Receptor - radiation effects | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - radiation effects | Phosphorylation - radiation effects | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - physiology | Animals | Keratinocytes - metabolism | Protein Tyrosine Phosphatases, Non-Receptor - genetics | Mice | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - genetics | STAT3 Transcription Factor - metabolism | Tyrosine | Phenols | Skin | Phosphatases | Apoptosis | Pediatrics | Phosphorylation | Transcription factors | SHP-1 protein | c-Myc protein | Genomes | Myc protein | Dephosphorylation | Cyclin D1 | Phosphatase | Experiments | Carcinogenesis | Proteins | Signal transduction | Carcinogens | Toxicology | Cell growth | Epidermal growth factor | Rodents | Cell cycle | Translocation | Desensitization | U.V. radiation | RNA-mediated interference | Stat3 protein | Keratinocytes | Epidermis | siRNA | Nuclear transport | Studies | Irradiation | Diabetes | Endoplasmic reticulum | Cytoplasm | Protein-tyrosine-phosphatase | Tumors | Cancer
Journal Article
Nature (London), ISSN 1476-4687, 2016, Volume 535, Issue 7610, pp. 148 - 152
The non-receptor protein tyrosine phosphatase SHP2, encoded by PTPN11, has an important role in signal transduction downstream of growth factor receptor signalling and was the first reported oncogenic... 
TARGET | POTENT | PTPN11 | PROTOONCOGENE | MULTIDISCIPLINARY SCIENCES | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - metabolism | Humans | Extracellular Signal-Regulated MAP Kinases - metabolism | Oncogene Protein p21(ras) - metabolism | Pyrimidines - chemistry | Piperidines - pharmacology | Inhibitory Concentration 50 | Female | Allosteric Regulation - drug effects | Piperidines - chemistry | Reproducibility of Results | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - antagonists & inhibitors | Models, Molecular | Neoplasms - enzymology | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - chemistry | Pyrimidines - pharmacology | Receptor Protein-Tyrosine Kinases - metabolism | Neoplasms - drug therapy | Xenograft Model Antitumor Assays | Animals | MAP Kinase Signaling System - drug effects | Mice, Nude | Piperidines - therapeutic use | Pyrimidines - therapeutic use | Protein Stability - drug effects | Cell Line, Tumor | Cell Proliferation - drug effects | Mice | Protein Kinase Inhibitors - pharmacology | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - genetics | Neoplasms - pathology | Protein Structure, Tertiary - drug effects | Phosphatases | Observations | Health aspects | Phosphotransferases | Protein-protein interactions | Signal transduction | Cell growth | Peptides | Kinases | Phosphatase | Drug dosages | Cancer | BASIC BIOLOGICAL SCIENCES
Journal Article
Journal Article
Cancer Letters, ISSN 0304-3835, 2013, Volume 345, Issue 1, pp. 140 - 148
Journal Article
Journal Article
BioMetals, ISSN 0966-0844, 12/2011, Volume 24, Issue 6, pp. 993 - 1004
.... Their inhibitory effects against human protein tyrosine phosphatase 1B (PTP1B), T-cell protein tyrosine phosphatase (TCPTP... 
Life Sciences | Biochemistry, general | Protein tyrosine phosphatases | Microbiology | Fluorescence | Plant Physiology | Copper complex | Inhibition | Pharmacology/Toxicology | Medicine/Public Health, general | Cell Biology | CANCER-CELLS | HOMEOSTASIS | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | CATALYTIC DOMAIN | DISOLVATE | APOPTOSIS INDUCERS | STRATEGIES | LIGANDS | PURIFICATION | PROTEASOME INHIBITORS | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - metabolism | Humans | Protein Tyrosine Phosphatases - metabolism | Structure-Activity Relationship | Benzimidazoles - chemistry | Enzyme Inhibitors - chemical synthesis | Protein Tyrosine Phosphatase, Non-Receptor Type 6 - chemistry | Protein Tyrosine Phosphatases - antagonists & inhibitors | Protein Tyrosine Phosphatases - chemistry | Protein Tyrosine Phosphatases - genetics | Protein Tyrosine Phosphatases, Non-Receptor - chemistry | Copper - chemistry | Enzyme Inhibitors - chemistry | Protein Tyrosine Phosphatases, Non-Receptor - genetics | Copper - metabolism | Molecular Structure | Protein Tyrosine Phosphatase, Non-Receptor Type 1 - genetics | Protein Tyrosine Phosphatase, Non-Receptor Type 1 - chemistry | Protein Tyrosine Phosphatase, Non-Receptor Type 2 - chemistry | Enzyme Inhibitors - metabolism | Benzimidazoles - chemical synthesis | Protein Tyrosine Phosphatase, Non-Receptor Type 1 - antagonists & inhibitors | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - antagonists & inhibitors | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - chemistry | Protein Tyrosine Phosphatase, Non-Receptor Type 2 - genetics | Protein Tyrosine Phosphatase, Non-Receptor Type 6 - genetics | Protein Tyrosine Phosphatase, Non-Receptor Type 2 - metabolism | Protein Tyrosine Phosphatase, Non-Receptor Type 1 - metabolism | Protein Tyrosine Phosphatase, Non-Receptor Type 6 - metabolism | Spectrum Analysis - methods | Benzimidazoles - metabolism | Protein Tyrosine Phosphatases, Non-Receptor - metabolism | Protein Tyrosine Phosphatase, Non-Receptor Type 2 - antagonists & inhibitors | Protein Tyrosine Phosphatase, Non-Receptor Type 6 - antagonists & inhibitors | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - genetics | Protein Tyrosine Phosphatases, Non-Receptor - antagonists & inhibitors | Tyrosine | Phosphatases | Ionization | Analysis | Phenols | T cells | Mass spectrometry | Proteins | Enzymes | Cellular biology | Copper | Spectroscopy | Inhibitors | Derivatives
Journal Article
Nature communications, ISSN 2041-1723, 2019, Volume 10, Issue 1, pp. 1444 - 1444
Journal Article
Cell reports (Cambridge), ISSN 2211-1247, 09/2015, Volume 12, Issue 12, pp. 1978 - 1985
.... We found that suppression of protein tyrosine phosphatase non-receptor type 11 (PTPN11) confers sensitivity to BRAF inhibitors in colon cancer... 
Humans | RNA, Small Interfering/genetics | Gene Expression Regulation, Neoplastic | Proto-Oncogene Proteins B-raf/genetics | Genomic Library | MAP Kinase Signaling System | Indoles/pharmacology | ras Proteins/genetics | Antineoplastic Agents/pharmacology | Melanoma/drug therapy | Transduction, Genetic | Drug Resistance, Neoplasm/drug effects | Xenograft Model Antitumor Assays | ErbB Receptors/genetics | Vemurafenib | Protein Tyrosine Phosphatase, Non-Receptor Type 11/antagonists & inhibitors | Animals | Sulfonamides/pharmacology | Cell Line, Tumor | Mice, Inbred NOD | High-Throughput Nucleotide Sequencing | Mice | Genetic Vectors | Colonic Neoplasms/drug therapy | Lentivirus/genetics | COLON-CANCER | SHP2 PTPN11 | LUNG-CANCER | MEK INHIBITION | BRAF(V600E) INHIBITION | GROWTH | PROTEIN-TYROSINE PHOSPHATASES | RAF INHIBITORS | MUTATIONS | NOONAN-SYNDROME | CELL BIOLOGY | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - metabolism | RNA, Small Interfering - genetics | Receptor, Epidermal Growth Factor - genetics | ras Proteins - genetics | Colonic Neoplasms - genetics | Colonic Neoplasms - drug therapy | ras Proteins - metabolism | Colonic Neoplasms - metabolism | Receptor, Epidermal Growth Factor - metabolism | Melanoma - genetics | Indoles - pharmacology | Lentivirus - genetics | Antineoplastic Agents - pharmacology | Proto-Oncogene Proteins B-raf - metabolism | Melanoma - metabolism | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - antagonists & inhibitors | Melanoma - pathology | Sulfonamides - pharmacology | Drug Resistance, Neoplasm - genetics | Proto-Oncogene Proteins B-raf - genetics | Colonic Neoplasms - pathology | Melanoma - drug therapy | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - genetics | Drug Resistance, Neoplasm - drug effects | RNA, Small Interfering - metabolism
Journal Article
The FEBS journal, ISSN 1742-464X, 11/2014, Volume 281, Issue 21, pp. 4852 - 4865
Journal Article
Journal Article