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Nature Immunology, ISSN 1529-2908, 05/2012, Volume 13, Issue 5, pp. 439 - 447
Lymphocyte activation must be tightly regulated to ensure sufficient immunity to pathogens and prevent autoimmunity. Protein tyrosine phosphatases (PTPs) serve... 
SIGNAL-TRANSDUCTION | IMMUNE CELLS | T-CELL-RECEPTOR | PTPN22 ALLELIC VARIANT | IMMUNOLOGY | IMMATURE B-CELLS | SRC-FAMILY KINASES | ANTIGEN RECEPTOR | NEGATIVE REGULATORY TYROSINE | CUTTING EDGE | PHOSPHOTYROSINE PHOSPHATASE | Antigens, CD - immunology | Protein Tyrosine Phosphatase, Non-Receptor Type 6 - immunology | Protein Tyrosine Phosphatase, Non-Receptor Type 2 - immunology | Humans | Autoimmunity - genetics | NK Cell Lectin-Like Receptor Subfamily K - immunology | Protein Tyrosine Phosphatases - metabolism | Leukocyte Common Antigens - immunology | Signal Transduction - immunology | Protein Tyrosine Phosphatases - genetics | Protein Tyrosine Phosphatase, Non-Receptor Type 22 - immunology | Signaling Lymphocytic Activation Molecule Family Member 1 | Autoimmunity - immunology | Receptors, Antigen, T-Cell - immunology | Lymphocyte Activation | Protein Tyrosine Phosphatase, Non-Receptor Type 22 - genetics | Receptor-Like Protein Tyrosine Phosphatases, Class 3 - immunology | Protein Tyrosine Phosphatase, Non-Receptor Type 2 - genetics | Receptors, Cell Surface - immunology | Receptors, Antigen, B-Cell - immunology | Animals | Lymphocytes - enzymology | Mice | Protein Tyrosine Phosphatase, Non-Receptor Type 6 - deficiency | Protein Tyrosine Phosphatase, Non-Receptor Type 12 - immunology | Tyrosine | Autoimmunity | Phosphatases | Immune response | Lymphocytes | Physiological aspects | Research | Properties
Journal Article
Nature, ISSN 0028-0836, 07/2017, Volume 547, Issue 7664, pp. 413 - 418
Immunotherapy with PD-1 checkpoint blockade is effective in only a minority of patients with cancer, suggesting that additional treatment strategies are... 
MELANOMA | T-CELL IMMUNITY | GENE | MULTIDISCIPLINARY SCIENCES | ACUTE LYMPHOBLASTIC-LEUKEMIA | CD94/NKG2A | BLOCKADE | EXPRESSION | PD-1 | HLA-E | Tumor Escape - drug effects | Immunotherapy - methods | Loss of Function Mutation | Tumor Escape - genetics | Genomics | Humans | NF-kappa B - metabolism | Interferons - immunology | Melanoma, Experimental - immunology | T-Lymphocytes - drug effects | Tumor Escape - immunology | Melanoma, Experimental - therapy | Melanoma, Experimental - pathology | Antigen Presentation - genetics | Protein Tyrosine Phosphatase, Non-Receptor Type 2 - deficiency | Protein Tyrosine Phosphatase, Non-Receptor Type 2 - genetics | Antigen Presentation - immunology | Unfolded Protein Response | CRISPR-Cas Systems - genetics | Gene Editing | Xenograft Model Antitumor Assays | Protein Tyrosine Phosphatase, Non-Receptor Type 2 - metabolism | Animals | Melanoma, Experimental - genetics | T-Lymphocytes - immunology | Mice | Care and treatment | Analysis | Immunotherapy | Diagnosis | Genetic screening | Methods | Cancer | Animal models | PD-1 protein | Genes | Genomes | Synergism | Proteins | Signal transduction | Clonal deletion | Lymphocytes | Protein folding | Tyrosine | Antigen presentation | NF-κB protein | CRISPR | Melanoma | Medical screening | Patients | Screening | Signaling | Immune checkpoint | PD-L1 protein | Interferon | Genetic testing | Tumors | Protein-tyrosine-phosphatase | PTPN2 protein
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 05/2017, Volume 486, Issue 3, pp. 759 - 766
Multiple sclerosis (MS) is an immune-mediated demyelinating disease of the central nervous system, and its pathogenesis remains largely unclear. Much attention... 
Multiple sclerosis | IL-1β | miR-448 | Th17 | PTPN2 | BIOPHYSICS | INFLAMMATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | NEUROFILAMENT LIGHT | IL-1 beta | CYTOKINE | DIFFERENTIATION | CANCER | Multiple Sclerosis - diagnosis | CD8-Positive T-Lymphocytes - pathology | Luciferases - metabolism | Protein Tyrosine Phosphatase, Non-Receptor Type 2 - immunology | Humans | Interleukin-17 - immunology | NF-kappa B - immunology | Interleukin-1beta - genetics | Case-Control Studies | Luciferases - genetics | Cell Differentiation | B-Lymphocytes - pathology | Genes, Reporter | Nuclear Receptor Subfamily 1, Group F, Member 3 - genetics | Neutrophils - pathology | Th17 Cells - pathology | Severity of Illness Index | Nuclear Receptor Subfamily 1, Group F, Member 3 - immunology | Signal Transduction | Gene Expression Regulation | Neutrophils - immunology | Interleukin-17 - genetics | Interleukin-1beta - immunology | Multiple Sclerosis - genetics | Protein Tyrosine Phosphatase, Non-Receptor Type 2 - genetics | MicroRNAs - immunology | Remission Induction | B-Lymphocytes - immunology | NF-kappa B - genetics | Multiple Sclerosis - immunology | Multiple Sclerosis - pathology | Th17 Cells - immunology | MicroRNAs - genetics | Primary Cell Culture | CD8-Positive T-Lymphocytes - immunology | Tyrosine | Medical colleges | Phosphatases | MicroRNA | Interleukins | Phenols | T cells
Journal Article
Journal Article
Cell Metabolism, ISSN 1550-4131, 11/2011, Volume 14, Issue 5, pp. 684 - 699
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 12/2008, Volume 359, Issue 26, pp. 2767 - 2777
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 12/2011, Volume 121, Issue 12, pp. 4758 - 4774
Journal Article
PLoS ONE, ISSN 1932-6203, 06/2013, Volume 8, Issue 6, p. e66456
Journal Article
Nature Genetics, ISSN 1061-4036, 06/2010, Volume 42, Issue 6, pp. 530 - 535
Journal Article