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Nature Immunology, ISSN 1529-2908, 05/2012, Volume 13, Issue 5, pp. 439 - 447
Lymphocyte activation must be tightly regulated to ensure sufficient immunity to pathogens and prevent autoimmunity. Protein tyrosine phosphatases (PTPs) serve... 
SIGNAL-TRANSDUCTION | IMMUNE CELLS | T-CELL-RECEPTOR | PTPN22 ALLELIC VARIANT | IMMUNOLOGY | IMMATURE B-CELLS | SRC-FAMILY KINASES | ANTIGEN RECEPTOR | NEGATIVE REGULATORY TYROSINE | CUTTING EDGE | PHOSPHOTYROSINE PHOSPHATASE | Antigens, CD - immunology | Protein Tyrosine Phosphatase, Non-Receptor Type 6 - immunology | Protein Tyrosine Phosphatase, Non-Receptor Type 2 - immunology | Humans | Autoimmunity - genetics | NK Cell Lectin-Like Receptor Subfamily K - immunology | Protein Tyrosine Phosphatases - metabolism | Leukocyte Common Antigens - immunology | Signal Transduction - immunology | Protein Tyrosine Phosphatases - genetics | Protein Tyrosine Phosphatase, Non-Receptor Type 22 - immunology | Signaling Lymphocytic Activation Molecule Family Member 1 | Autoimmunity - immunology | Receptors, Antigen, T-Cell - immunology | Lymphocyte Activation | Protein Tyrosine Phosphatase, Non-Receptor Type 22 - genetics | Receptor-Like Protein Tyrosine Phosphatases, Class 3 - immunology | Protein Tyrosine Phosphatase, Non-Receptor Type 2 - genetics | Receptors, Cell Surface - immunology | Receptors, Antigen, B-Cell - immunology | Animals | Lymphocytes - enzymology | Mice | Protein Tyrosine Phosphatase, Non-Receptor Type 6 - deficiency | Protein Tyrosine Phosphatase, Non-Receptor Type 12 - immunology | Tyrosine | Autoimmunity | Phosphatases | Immune response | Lymphocytes | Physiological aspects | Research | Properties
Journal Article
Immunity, ISSN 1074-7613, 07/2013, Volume 39, Issue 1, pp. 111 - 122
Immune cells sense microbial products through Toll-like receptors (TLR), which trigger host defense responses including type 1 interferons (IFNs) secretion. A... 
TUMOR-NECROSIS-FACTOR | ACTIVATION | I INTERFERONS | CHORIOMENINGITIS VIRUS | PROTEIN-TYROSINE PHOSPHATASES | HOST-DEFENSE | MURINE LUPUS | INFLAMMATORY ARTHRITIS | IMMUNOLOGY | NF-KAPPA-B | T-CELLS | Lymphocytic choriomeningitis virus - immunology | Colitis - genetics | Humans | Autoimmunity - genetics | Immunoblotting | Arthritis - genetics | Interferon Type I - immunology | Lymphocytic Choriomeningitis - immunology | Host-Pathogen Interactions - immunology | Protein Tyrosine Phosphatase, Non-Receptor Type 22 - immunology | Autoimmunity - immunology | Myeloid Cells - immunology | TNF Receptor-Associated Factor 3 - genetics | Colitis - chemically induced | HEK293 Cells | Arthritis - immunology | Interferon Type I - metabolism | Lymphocytic choriomeningitis virus - physiology | Toll-Like Receptors - metabolism | Colitis - immunology | Lymphocytic Choriomeningitis - genetics | Cell Line | Lymphocytic Choriomeningitis - virology | Mice, Inbred C57BL | Protein Tyrosine Phosphatase, Non-Receptor Type 22 - genetics | Protein Tyrosine Phosphatase, Non-Receptor Type 22 - metabolism | Toll-Like Receptors - immunology | Cells, Cultured | Immunity - immunology | Mice, Transgenic | TNF Receptor-Associated Factor 3 - metabolism | Ubiquitination - immunology | Reverse Transcriptase Polymerase Chain Reaction | Mice, Knockout | Animals | Dextran Sulfate - immunology | TNF Receptor-Associated Factor 3 - immunology | Toll-Like Receptors - genetics | Interferon Type I - genetics | Myeloid Cells - metabolism | Mice | Immunity - genetics | Ubiquitin | Autoimmunity | Interferon | Biological response modifiers
Journal Article
Annual Review of Immunology, ISSN 0732-0582, 2009, Volume 27, Issue 1, pp. 363 - 391
Extraordinary technical advances in the field of human genetics over the post few years have catalyzed an explosion of new information about the genetics of... 
Genome-wide association (GWA) study | NF-κB | Interferon | Autoantigen | Autophagy | SYSTEMIC-LUPUS-ERYTHEMATOSUS | autophagy | JUVENILE IDIOPATHIC ARTHRITIS | genome-wide association (GWA) study | SINGLE-NUCLEOTIDE POLYMORPHISM | IMMUNOLOGY | interferon | LYMPHOID TYROSINE PHOSPHATASE | MULTIPLE-SCLEROSIS SUSCEPTIBILITY | COPY-NUMBER-VARIATION | NF-kappa B | INFLAMMATORY-BOWEL-DISEASE | TYPE-1 DIABETES LOCUS | autoantigen | NF-KAPPA-B | GENOME-WIDE ASSOCIATION | Receptors, Pattern Recognition - immunology | Humans | NF-kappa B - immunology | Autoimmunity - genetics | Autoimmune Diseases - genetics | Signal Transduction - immunology | Protein Tyrosine Phosphatase, Non-Receptor Type 22 - immunology | Autoimmunity - immunology | Adaptor Proteins, Signal Transducing - immunology | Transcription Factors - immunology | Cytokines - genetics | Cytokines - immunology | Receptors, Tumor Necrosis Factor - genetics | Genetic Predisposition to Disease | Membrane Proteins - genetics | Gene Frequency | Protein Tyrosine Phosphatase, Non-Receptor Type 22 - genetics | Autoimmune Diseases - immunology | Membrane Proteins - immunology | Signal Transduction - genetics | Transcription Factors - genetics | Animals | NF-kappa B - genetics | Adaptor Proteins, Signal Transducing - genetics | Receptors, Pattern Recognition - genetics | Genome, Human | Receptors, Tumor Necrosis Factor - immunology | Autoimmunity | Genetic aspects | Biological response modifiers | Autoimmune diseases | Immunological research
Journal Article
Journal of Autoimmunity, ISSN 0896-8411, 2009, Volume 32, Issue 3, pp. 231 - 239
Journal Article
Science Signaling, ISSN 1945-0877, 11/2012, Volume 5, Issue 252, pp. ra87 - ra87
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 10/2017, Volume 12, Issue 10, p. e0186625
The PTPN22(R620W) single nucleotide polymorphism increases the risk of developing multiple autoimmune diseases including type 1 diabetes, rheumatoid arthritis... 
IMMUNITY | COMPLEX | INTERFERON | MANNOSE RECEPTOR | PHOSPHORYLATION | MULTIDISCIPLINARY SCIENCES | MACROPINOCYTOSIS | DEGRADATION | ENDOCYTOSIS | AUTOIMMUNE-DISEASE | VARIANT | Ovalbumin - immunology | Coculture Techniques | Dendritic Cells - immunology | Antigens, Bacterial - immunology | Listeria monocytogenes - immunology | Protein Tyrosine Phosphatase, Non-Receptor Type 22 - immunology | Antigen Presentation | Ovalbumin - chemistry | Endocytosis - immunology | Fluorescent Dyes - chemistry | Gene Expression | Antigens, Bacterial - chemistry | Signal Transduction | Lymphocyte Activation | Mice, Inbred C57BL | Protein Tyrosine Phosphatase, Non-Receptor Type 22 - genetics | Mice, Knockout | Immunological Synapses | Animals | Listeria monocytogenes - chemistry | T-Lymphocytes - cytology | Staining and Labeling | Pinocytosis - immunology | T-Lymphocytes - immunology | Dendritic Cells - cytology | Mice | Polymorphism, Single Nucleotide | Phosphatases | Research | Dendritic cells | T cells | Genetic polymorphisms | Cell proliferation | Pediatrics | Phosphorylation | Antigen processing | Lymphocytes T | Biology | Arthritis | Infections | Single-nucleotide polymorphism | Kinases | Phosphatase | Degradation | Proteins | Signal transduction | Cell activation | Endocytosis | Immunology | Publishing | Pathways | Rodents | Bone marrow | Life sciences | Tyrosine | Spleen | Antigen presentation | Antigens | Immune response | Granulocyte-macrophage colony-stimulating factor | Diabetes mellitus | Rheumatology | Health risks | Inflammation | T cell receptors | Pattern recognition | Medicine | Signaling | Antigen-presenting cells | Rheumatoid arthritis | Autoimmune diseases | Protein-tyrosine-phosphatase | Cancer | Polymorphism
Journal Article
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2012, Volume 131, Issue 4, pp. 1130 - 1135.e1
Background The 1858T allele of protein tyrosine phosphatase nonreceptor type 22 ( PTPN22 ; R620W) exhibits one of the strongest and most consistent... 
Allergy and Immunology | autoimmunity | Primary antibody deficiency | selective IgA deficiency | common variable immunodeficiency | IgG subclass deficiency | specific antibody deficiency | protein tyrosine phosphatase nonreceptor type 22 | RHEUMATOID-ARTHRITIS | MOTH-EATEN MICE | SYSTEMIC-LUPUS-ERYTHEMATOSUS | SINGLE-NUCLEOTIDE POLYMORPHISM | IGA DEFICIENCY | IMMUNOLOGY | C1858T POLYMORPHISM | MEMORY B-CELLS | ALLERGY | DISEASE | MUTATIONS | Genetic Predisposition to Disease | Gene Frequency | Humans | Middle Aged | Protein Tyrosine Phosphatase, Non-Receptor Type 22 - genetics | Risk Factors | Autoimmunity - genetics | Immunophenotyping | Male | Genotyping Techniques | Case-Control Studies | B-Lymphocytes - immunology | Protein Tyrosine Phosphatase, Non-Receptor Type 22 - immunology | Alleles | Immunologic Deficiency Syndromes - genetics | Adult | Female | Polymorphism, Single Nucleotide | B-Lymphocytes - pathology | Australia | Immunologic Deficiency Syndromes - immunology | B-Lymphocytes - metabolism | Amino Acid Substitution | Viral antibodies | Tyrosine | Autoimmunity | Phosphatases | Fluorescein | Antibodies | Phenols | T cells | Psoriasis | Pathogenesis | Thyroid diseases | Infections | Arthritis | Phosphatase | Proteins | Genotype & phenotype | Vitiligo | Genetic testing | Autoimmune diseases | Deoxyribonucleic acid--DNA | Immune system
Journal Article