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1. Full Text Potent inhibition of protein tyrosine phosphatases by copper complexes with multi-benzimidazole derivatives
by Li, Ying and Lu, Liping and Zhu, Miaoli and Wang, Qingming and Yuan, Caixia and Xing, Shu and Fu, Xueqi and Mei, Yuhua
Biometals, ISSN 0966-0844, 12/2011, Volume 24, Issue 6, pp. 993 - 1004
Life Sciences | Biochemistry, general | Protein tyrosine phosphatases | Microbiology | Fluorescence | Plant Physiology | Copper complex | Inhibition | Pharmacology/Toxicology | Medicine/Public Health, general | Cell Biology | Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - metabolism | Humans | Protein Tyrosine Phosphatases - metabolism | Structure-Activity Relationship | Benzimidazoles - chemistry | Enzyme Inhibitors - chemical synthesis | Protein Tyrosine Phosphatase, Non-Receptor Type 6 - chemistry | Protein Tyrosine Phosphatases - antagonists & inhibitors | Protein Tyrosine Phosphatases - chemistry | Protein Tyrosine Phosphatases - genetics | Protein Tyrosine Phosphatases, Non-Receptor - chemistry | Copper - chemistry | Enzyme Inhibitors - chemistry | Protein Tyrosine Phosphatases, Non-Receptor - genetics | Copper - metabolism | Molecular Structure | Protein Tyrosine Phosphatase, Non-Receptor Type 1 - genetics | Protein Tyrosine Phosphatase, Non-Receptor Type 1 - chemistry | Protein Tyrosine Phosphatase, Non-Receptor Type 2 - chemistry | Enzyme Inhibitors - metabolism | Benzimidazoles - chemical synthesis | Protein Tyrosine Phosphatase, Non-Receptor Type 1 - antagonists & inhibitors | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - antagonists & inhibitors | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - chemistry | Protein Tyrosine Phosphatase, Non-Receptor Type 2 - genetics | Protein Tyrosine Phosphatase, Non-Receptor Type 6 - genetics | Protein Tyrosine Phosphatase, Non-Receptor Type 2 - metabolism | Protein Tyrosine Phosphatase, Non-Receptor Type 1 - metabolism | Protein Tyrosine Phosphatase, Non-Receptor Type 6 - metabolism | Spectrum Analysis - methods | Benzimidazoles - metabolism | Protein Tyrosine Phosphatases, Non-Receptor - metabolism | Protein Tyrosine Phosphatase, Non-Receptor Type 2 - antagonists & inhibitors | Protein Tyrosine Phosphatase, Non-Receptor Type 6 - antagonists & inhibitors | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - genetics | Protein Tyrosine Phosphatases, Non-Receptor - antagonists & inhibitors | Tyrosine | Phosphatases | Ionization | Analysis | Phenols | T cells | Mass spectrometry | Proteins | Enzymes | Cellular biology | Copper | Spectroscopy | Inhibitors | Derivatives | Index Medicus
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2. Full Text Protein tyrosine phosphatases in lymphocyte activation and autoimmunity
by Rhee, Inmoo and Veillette, André
Nature immunology, ISSN 1529-2908, 05/2012, Volume 13, Issue 5, pp. 439 - 447
Life Sciences & Biomedicine | Immunology | Science & Technology | Antigens, CD - immunology | Protein Tyrosine Phosphatase, Non-Receptor Type 6 - immunology | Protein Tyrosine Phosphatase, Non-Receptor Type 2 - immunology | Humans | Autoimmunity - genetics | NK Cell Lectin-Like Receptor Subfamily K - immunology | Protein Tyrosine Phosphatases - metabolism | Leukocyte Common Antigens - immunology | Signal Transduction - immunology | Protein Tyrosine Phosphatases - genetics | Protein Tyrosine Phosphatase, Non-Receptor Type 22 - immunology | Signaling Lymphocytic Activation Molecule Family Member 1 | Autoimmunity - immunology | Receptors, Antigen, T-Cell - immunology | Lymphocyte Activation | Protein Tyrosine Phosphatase, Non-Receptor Type 22 - genetics | Receptor-Like Protein Tyrosine Phosphatases, Class 3 - immunology | Protein Tyrosine Phosphatase, Non-Receptor Type 2 - genetics | Receptors, Cell Surface - immunology | Receptors, Antigen, B-Cell - immunology | Animals | Lymphocytes - enzymology | Mice | Protein Tyrosine Phosphatase, Non-Receptor Type 6 - deficiency | Protein Tyrosine Phosphatase, Non-Receptor Type 12 - immunology | Tyrosine | Autoimmunity | Phosphatases | Immune response | Lymphocytes | Physiological aspects | Research | Properties | Index Medicus
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3. Full Text Dinuclear copper complexes of organic claw: Potent inhibition of protein tyrosine phosphatases
by Ma, Ling and Lu, Liping and Zhu, Miaoli and Wang, Qingming and Gao, Fei and Yuan, Caixia and Wu, Yanbo and Xing, Shu and Fu, Xueqi and Mei, Yuhua and Gao, Xiaoli
Journal of inorganic biochemistry, ISSN 0162-0134, 2011, Volume 105, Issue 9, pp. 1138 - 1147
PTPs | Inhibitor | Selectivity | Dinuclear copper complexes | Biochemistry & Molecular Biology | Physical Sciences | Chemistry, Inorganic & Nuclear | Chemistry | Life Sciences & Biomedicine | Science & Technology | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - metabolism | Escherichia coli | Humans | Substrate Specificity | Crystallography, X-Ray | Enzyme Inhibitors - chemical synthesis | Spectrometry, Mass, Electrospray Ionization | Transformation, Bacterial | X-Ray Diffraction | Protein Tyrosine Phosphatases, Non-Receptor - genetics | Acids, Heterocyclic - chemical synthesis | Cloning, Molecular | Copper - metabolism | Protein Tyrosine Phosphatase, Non-Receptor Type 1 - genetics | Acids, Heterocyclic - pharmacology | Recombinant Proteins - metabolism | Recombinant Proteins - antagonists & inhibitors | Enzyme Inhibitors - pharmacology | Protein Tyrosine Phosphatase, Non-Receptor Type 1 - antagonists & inhibitors | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - antagonists & inhibitors | Models, Molecular | Recombinant Proteins - genetics | Chelating Agents - pharmacology | Protein Tyrosine Phosphatase, Non-Receptor Type 2 - genetics | Potentiometry | Protein Tyrosine Phosphatase, Non-Receptor Type 6 - genetics | Protein Tyrosine Phosphatase, Non-Receptor Type 2 - metabolism | Protein Tyrosine Phosphatase, Non-Receptor Type 1 - metabolism | Protein Tyrosine Phosphatase, Non-Receptor Type 6 - metabolism | Signal Transduction - drug effects | Protein Tyrosine Phosphatases, Non-Receptor - metabolism | Protein Tyrosine Phosphatase, Non-Receptor Type 2 - antagonists & inhibitors | Protein Tyrosine Phosphatase, Non-Receptor Type 6 - antagonists & inhibitors | Ligands | Signal Transduction - physiology | Kinetics | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - genetics | Chelating Agents - chemical synthesis | Protein Tyrosine Phosphatases, Non-Receptor - antagonists & inhibitors | Tyrosine | Phenols | Phosphatases | Analysis | Index Medicus
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4. Full Text Mutant KRAS-driven cancers depend on PTPN11/SHP2 phosphatase
by Ruess, Dietrich A and Heynen, Guus J and Ciecielski, Katrin J and Ai, Jiaoyu and Berninger, Alexandra and Kabacaoglu, Derya and Görgülü, Kivanc and Dantes, Zahra and Wörmann, Sonja M and Diakopoulos, Kalliope N and Karpathaki, Angeliki F and Kowalska, Marlena and Kaya-Aksoy, Ezgi and Song, Liang and Van Der Laan, Eveline A. Zeeuw and López-Alberca, María P and Nazaré, Marc and Reichert, Maximilian and Saur, Dieter and Erkan, Mert M and Hopt, Ulrich T and Sainz, Bruno and Birchmeier, Walter and Schmid, Roland M and Lesina, Marina and Algül, Hana
Nature medicine, ISSN 1078-8956, 07/2018, Volume 24, Issue 7, pp. 954 - 960
Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Cell Biology | Research & Experimental Medicine | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - metabolism | Pancreatic Neoplasms - metabolism | Proto-Oncogene Proteins p21(ras) - genetics | Humans | Lung Neoplasms - metabolism | Pancreatic Neoplasms - pathology | Mitogen-Activated Protein Kinase Kinases - antagonists & inhibitors | Lung Neoplasms - pathology | Mutation - genetics | Carcinogenesis - metabolism | Disease Progression | Carcinogenesis - pathology | Mitogen-Activated Protein Kinase Kinases - metabolism | Animals | Protein Kinase Inhibitors - therapeutic use | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - deficiency | Cell Line, Tumor | Mice | Protein Kinase Inhibitors - pharmacology | Tyrosine | Care and treatment | Cellular signal transduction | Genetic aspects | Research | Gene expression | Cancer | Adenocarcinoma | Animal models | Xenotransplantation | Lung cancer | Phosphatase | Carcinogenesis | K-Ras protein | Proteins | Signal transduction | Carcinogens | Allosteric properties | Clonal deletion | Organoids | Dependence | Xenografts | Protein-tyrosine kinase receptors | Inhibition | Pancreas | Protein-tyrosine kinase | MAP kinase | Tumor cell lines | Signaling | Tumors | Protein-tyrosine-phosphatase | Index Medicus
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5. Full Text Protein tyrosine phosphatases – from housekeeping enzymes to master regulators of signal transduction
by Tonks, Nicholas K
The FEBS journal, ISSN 1742-464X, 01/2013, Volume 280, Issue 2, pp. 346 - 378
kinase | tyrosine phosphatase | cancer | drug discovery | signal transduction | diabetes | Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Pregnancy | Catalytic Domain | Phosphorylation | Protein Tyrosine Phosphatase, Non-Receptor Type 1 - metabolism | Signal Transduction | Humans | Models, Molecular | Crystallography, X-Ray | Female | Placenta - enzymology | Protein Tyrosine Phosphatase, Non-Receptor Type 1 - genetics | Protein Tyrosine Phosphatase, Non-Receptor Type 1 - chemistry | Tyrosine | Enzymes | Phosphatases | Home economics | Physiological aspects | Phenols | Hypoglycemic agents | Proteins | Signal transduction | Biochemistry | Index Medicus
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