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1. Full Text Regulation of the chikungunya-virus-induced innate inflammatory response by protein tyrosine phosphatase non-receptor 6 in muscle cells
by Thanapati, Subrat and Sudeep, A B and Kulkarni, Shruti P and Tripathy, Anuradha S
Archives of Virology, ISSN 0304-8608, 1/2018, Volume 163, Issue 1, pp. 243 - 248
Chikungunya virus (CHIKV)-induced myositis is an emerging affliction with high incidence globally. Given the essential regulatory role of protein tyrosine... 
Medical Microbiology | Rhabdomyosarcoma cell line | Biomedicine | Chikungunya | Infectious Diseases | PTPN6 | Virology | EVOLUTION | VIROLOGY | INFECTION | MYOSITIS | MANIFESTATIONS | Tumor Necrosis Factor-alpha - metabolism | Up-Regulation | Humans | Tumor Necrosis Factor-alpha - genetics | Gene Expression Regulation | Rhabdomyosarcoma | Immunity, Innate | Muscle, Skeletal - cytology | Protein Tyrosine Phosphatase, Non-Receptor Type 6 - genetics | Inflammation - metabolism | Animals | Protein Tyrosine Phosphatase, Non-Receptor Type 6 - metabolism | Chikungunya virus | Cell Line, Tumor | Inflammation - genetics | Tyrosine | Phenols | Hepatitis | Phosphatases | Gene expression | Genes | Immune response | Myositis | Immunoblotting | siRNA | Inflammation | Tumor necrosis factor-α | Phosphatase | Protein-tyrosine-phosphatase
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2. Full Text THEMIS enhances TCR signaling and enables positive selection by selective inhibition of the phosphatase SHP-1
by Choi, Seeyoung and Warzecha, Claude and Zvezdova, Ekaterina and Lee, Jan and Argenty, Jérémy and Lesourne, Renaud and Aravind, L and Love, Paul E
Nature Immunology, ISSN 1529-2908, 03/2017, Volume 18, Issue 4, pp. 433 - 441
THEMIS, a T cell-specific protein with high expression in CD4(+)CD8(+) thymocytes, has a crucial role in positive selection and T cell development. THEMIS... 
LIGAND DISCRIMINATION | SURVIVAL | THYMOCYTE DEVELOPMENT | ACTIVATION | STIMULATION | REDOX REGULATION | T-CELL-RECEPTOR | PROTEIN-TYROSINE PHOSPHATASES | NEGATIVE SELECTION | GENERATION | IMMUNOLOGY | Reactive Oxygen Species - metabolism | Thymocytes - metabolism | Humans | Intracellular Signaling Peptides and Proteins - metabolism | Protein Tyrosine Phosphatase, Non-Receptor Type 6 - chemistry | Cell Differentiation - genetics | T-Lymphocytes - metabolism | Gene Deletion | Protein Interaction Domains and Motifs | Intracellular Signaling Peptides and Proteins - genetics | Cell Line | Oxidation-Reduction | Receptors, Antigen, T-Cell - metabolism | Signal Transduction | Protein Tyrosine Phosphatase, Non-Receptor Type 6 - genetics | Clonal Selection, Antigen-Mediated - immunology | Mice, Knockout | Thymocytes - immunology | Cell Differentiation - immunology | Animals | Protein Tyrosine Phosphatase, Non-Receptor Type 6 - metabolism | T-Lymphocytes - cytology | Protein Tyrosine Phosphatase, Non-Receptor Type 6 - antagonists & inhibitors | Protein Binding | T-Lymphocytes - immunology | Thymocytes - cytology | Mice | Cellular proteins | Cellular signal transduction | Genetic aspects | Properties | T cells
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3. Full Text A THEMIS:SHP1 complex promotes T‐cell survival
by Paster, Wolfgang and Bruger, Annika M and Katsch, Kristin and Grégoire, Claude and Roncagalli, Romain and Fu, Guo and Gascoigne, Nicholas RJ and Nika, Konstantina and Cohnen, Andre and Feller, Stephan M and Simister, Philip C and Molder, Kelly C and Cordoba, Shaun‐Paul and Dushek, Omer and Malissen, Bernard and Acuto, Oreste
The EMBO Journal, ISSN 0261-4189, 02/2015, Volume 34, Issue 3, pp. 393 - 409
THEMIS is critical for conventional T‐cell development, but its precise molecular function remains elusive. Here, we show that THEMIS constitutively associates... 
SHP1 | THEMIS | apoptosis | TCR | negative feedback | ACTIVATION | TCR SIGNALING THRESHOLDS | PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | PROTEIN-TYROSINE PHOSPHATASES | RECEPTOR | SHP-1 | THYMOCYTE POSITIVE SELECTION | CELL BIOLOGY | GENE | PROTEOMICS FACILITIES PIPELINE | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - metabolism | Humans | Cell Survival - genetics | Multiprotein Complexes - genetics | Intracellular Signaling Peptides and Proteins - metabolism | Cell Differentiation - genetics | Multiprotein Complexes - metabolism | CD3 Complex - genetics | T-Lymphocytes - metabolism | GRB2 Adaptor Protein - genetics | Intracellular Signaling Peptides and Proteins - genetics | Receptors, Antigen, T-Cell - metabolism | Signal Transduction | Jurkat Cells | Lymphocyte Specific Protein Tyrosine Kinase p56(lck) - metabolism | CD3 Complex - metabolism | Protein Tyrosine Phosphatase, Non-Receptor Type 6 - genetics | Mice, Knockout | src Homology Domains | Proteins - genetics | Animals | Proteins - metabolism | Protein Tyrosine Phosphatase, Non-Receptor Type 6 - metabolism | T-Lymphocytes - cytology | Mice | Receptors, Antigen, T-Cell - genetics | Lymphocyte Specific Protein Tyrosine Kinase p56(lck) - genetics | Mutation | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - genetics | GRB2 Adaptor Protein - metabolism | Ligands | Phosphorylation | T cell receptors | Phosphatase | Immune system
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4. Full Text Capillarisin inhibits constitutive and inducible STAT3 activation through induction of SHP-1 and SHP-2 tyrosine phosphatases
by Lee, Jong Hyun and Chiang, Shu Yuan and Nam, Dongwoo and Chung, Won-Seok and Lee, Junhee and Na, Young-Soon and Sethi, Gautam and Ahn, Kwang Seok
Cancer Letters, ISSN 0304-3835, 2013, Volume 345, Issue 1, pp. 140 - 148
Abstract Signal transducers and activators of transcription (STAT)-3 is a latent cytosolic transcription factor that has been closely associated with survival,... 
Hematology, Oncology and Palliative Medicine | Capillarisin | PTP | STAT3 | Multiple myeloma | Apoptosis | ARTEMISIA-CAPILLARIS | INDUCED APOPTOSIS | TRANSCRIPTION | KAPPA-B | MULTIPLE-MYELOMA CELLS | IN-VITRO | ONCOLOGY | CHEN-HAO-TANG | SIGNAL TRANSDUCERS | EXPRESSION | ALDOSE REDUCTASE | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - metabolism | Apoptosis - drug effects | Humans | Multiple Myeloma - metabolism | Protein Tyrosine Phosphatase, Non-Receptor Type 6 - biosynthesis | Protein Tyrosine Phosphatase, Non-Receptor Type 6 - genetics | Multiple Myeloma - drug therapy | Multiple Myeloma - pathology | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - biosynthesis | Protein Tyrosine Phosphatase, Non-Receptor Type 6 - metabolism | Signal Transduction - drug effects | Cell Line, Tumor | Enzyme Induction - drug effects | Cell Proliferation - drug effects | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - genetics | Chromones - pharmacology | Multiple Myeloma - genetics | STAT3 Transcription Factor - metabolism | Tyrosine | Phenols | Phosphatases | Vascular endothelial growth factor | Phosphorylation | Membranes | Free radicals | Genes | Kinases | Phosphatase | Proteins | Studies | Angiogenesis | Rodents | Tumorigenesis | Deoxyribonucleic acid--DNA | Cancer | Milk
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5. Full Text RIP1-driven autoinflammation targets IL-1α independently of inflammasomes and RIP3
by Lukens, John R and Vogel, Peter and Johnson, Gordon R and Kelliher, Michelle A and Iwakura, Yoichiro and Lamkanfi, Mohamed and Kanneganti, Thirumala-Devi
Nature, ISSN 0028-0836, 2013, Volume 498, Issue 7453, pp. 224 - 227
The protein-tyrosine phosphatase SHP-1 has critical roles in immune signalling, but how mutations in SHP-1 cause inflammatory disease in humans remains poorly... 
ACTIVATION | STERILE INFLAMMATION | GENE | AUTOIMMUNITY | MULTIDISCIPLINARY SCIENCES | MOTH-EATEN | DISEASE | MICE | IDENTIFICATION | CELL | PHOSPHATASES | Receptor-Interacting Protein Serine-Threonine Kinases - metabolism | Inflammation - pathology | Inflammasomes - metabolism | Dermatitis - immunology | Humans | Interleukin-1alpha - metabolism | Male | NF-kappa B - metabolism | Wound Healing | Inflammation - metabolism | Interleukin-1beta - metabolism | Gene Deletion | Cell Death | Female | Interleukin-1alpha - genetics | Disease Models, Animal | Signal Transduction | Wounds and Injuries - pathology | Extremities - pathology | Inflammation - immunology | Interleukin-1alpha - secretion | Wounds and Injuries - immunology | Protein Tyrosine Phosphatase, Non-Receptor Type 6 - genetics | Dermatitis - pathology | Animals | Protein Tyrosine Phosphatase, Non-Receptor Type 6 - metabolism | Interleukin-1alpha - deficiency | Mice | Protein Tyrosine Phosphatase, Non-Receptor Type 6 - deficiency | Dermatitis - metabolism | NOD-like receptor | cell death | inflammation | inflammasome | Ptpn6 | SHP-1 | interleukin | RIP3 | RIP1 | caspase
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6. Full Text Maintenance of murine platelet homeostasis by the kinase Csk and phosphatase CD148
by Mori, Jun and Nagy, Zoltan and Di Nunzio, Giada and Smith, Christopher W and Geer, Mitchell J and Al Ghaithi, Rashid and van Geffen, Johanna P and Heising, Silke and Boothman, Luke and Tullemans, Bibian M E and Correia, Joao N and Tee, Louise and Kuijpers, Marijke J E and Harrison, Paul and Heemskerk, Johan W M and Jarvis, Gavin E and Tarakhovsky, Alexander and Weiss, Arthur and Mazharian, Alexandra and Senis, Yotis A
Blood, ISSN 0006-4971, 03/2018, Volume 131, Issue 10, p. 1122
Src family kinases (SFKs) coordinate the initiating and propagating activation signals in platelets, but it remains unclear how they are regulated. Here, we... 
Blood Platelets - pathology | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - metabolism | Homeostasis | Platelet Membrane Glycoproteins - genetics | Receptor-Like Protein Tyrosine Phosphatases, Class 3 - genetics | Protein Tyrosine Phosphatase, Non-Receptor Type 6 - genetics | Amino Acid Motifs | Mice, Knockout | Thrombosis - metabolism | Animals | Protein Tyrosine Phosphatase, Non-Receptor Type 6 - metabolism | Blood Platelets - metabolism | Receptor-Like Protein Tyrosine Phosphatases, Class 3 - metabolism | Platelet Membrane Glycoproteins - metabolism | src-Family Kinases - metabolism | Thrombosis - genetics | Mice | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - genetics | src-Family Kinases - genetics
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7. Full Text Signalling thresholds and negative B-cell selection in acute lymphoblastic leukaemia
by Chen, Zhengshan and Shojaee, Seyedmehdi and Buchner, Maike and Geng, Huimin and Lee, Jae Woong and Klemm, Lars and Titz, Björn and Graeber, Thomas G and Park, Eugene and Tan, Ying Xim and Satterthwaite, Anne and Paietta, Elisabeth and Hunger, Stephen P and Willman, Cheryl L and Melnick, Ari and Loh, Mignon L and Jung, Jae U and Coligan, John E and Bolland, Silvia and Mak, Tak W and Limnander, Andre and Jumaa, Hassan and Reth, Michael and Weiss, Arthur and Lowell, Clifford A and Müschen, Markus
Nature, ISSN 0028-0836, 05/2015, Volume 521, Issue 7552, pp. 357 - 361
B cells are selected for an intermediate level of B-cell antigen receptor (BCR) signalling strength: attenuation below minimum(for example, non-functional... 
MOTIFS | RECEPTOR | ACTIVATION | MULTIDISCIPLINARY SCIENCES | IN-VIVO | DELETION | Protein-Tyrosine Kinases - metabolism | Receptors, Antigen, B-Cell - deficiency | Humans | Precursor Cells, B-Lymphoid - metabolism | Inositol Polyphosphate 5-Phosphatases | Intracellular Signaling Peptides and Proteins - metabolism | Precursor Cells, B-Lymphoid - drug effects | Receptors, Antigen, B-Cell - metabolism | Antigens, CD - metabolism | Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy | Precursor Cell Lymphoblastic Leukemia-Lymphoma - metabolism | Precursor Cells, B-Lymphoid - pathology | Platelet Endothelial Cell Adhesion Molecule-1 - metabolism | Gene Deletion | Female | B-Lymphocytes - pathology | Cell Death - drug effects | Precursor Cell Lymphoblastic Leukemia-Lymphoma - pathology | Syk Kinase | B-Lymphocytes - metabolism | Disease Models, Animal | Phosphoric Monoester Hydrolases - antagonists & inhibitors | Enzyme Activation - drug effects | Mice, SCID | Protein Tyrosine Phosphatase, Non-Receptor Type 6 - genetics | Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics | Xenograft Model Antitumor Assays | B-Lymphocytes - drug effects | Fusion Proteins, bcr-abl - genetics | Tyrosine - metabolism | Animals | Protein Tyrosine Phosphatase, Non-Receptor Type 6 - metabolism | Signal Transduction - drug effects | Cell Transformation, Neoplastic | Intracellular Signaling Peptides and Proteins - agonists | Cell Line, Tumor | Mice, Inbred NOD | Receptors, Antigen, B-Cell - genetics | Mice | Amino Acid Motifs - genetics | Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases | Phosphoric Monoester Hydrolases - metabolism | Receptors, Immunologic - genetics | Protein Tyrosine Phosphatase, Non-Receptor Type 6 - deficiency | Receptors, Immunologic - metabolism | Drug Resistance, Neoplasm - drug effects | Physiological aspects | Acute lymphocytic leukemia | B cells | Signal transduction | Rodents | Leukemia | Mutation | Drug resistance | Kinases | Cells
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8. Full Text Crocin Suppresses Constitutively Active STAT3 Through Induction of Protein Tyrosine Phosphatase SHP‐1
by Kim, Buyun and Lee, Ki Yong and Park, Byoungduck
Journal of Cellular Biochemistry, ISSN 0730-2312, 10/2017, Volume 118, Issue 10, pp. 3290 - 3298
ABSTRACT The aim of the present study is to investigate the effect of a natural compound crocin, one of the active components of saffron, on human multiple... 
APOPTOSIS | SHP‐1 | CROCIN | STAT3 | SHP-1 | MULTIPLE-MYELOMA | TARGET | BIOCHEMISTRY & MOLECULAR BIOLOGY | PROLIFERATION | CANCER | CELL BIOLOGY | INFLAMMATION | ACTIVATION PATHWAY | EXPRESSION | CARCINOMA | SIGNAL TRANSDUCER | Apoptosis - drug effects | Humans | Apoptosis - genetics | G1 Phase - drug effects | Multiple Myeloma - metabolism | Neoplasm Proteins - metabolism | Protein Tyrosine Phosphatase, Non-Receptor Type 6 - genetics | Carotenoids - pharmacology | Enzyme Induction - genetics | Multiple Myeloma - drug therapy | Multiple Myeloma - pathology | Protein Tyrosine Phosphatase, Non-Receptor Type 6 - metabolism | Enzyme Induction - drug effects | G1 Phase - genetics | HeLa Cells | Neoplasm Proteins - genetics | Multiple Myeloma - genetics | STAT3 Transcription Factor - genetics | STAT3 Transcription Factor - metabolism | Tyrosine | Phenols | Phosphatases | Gene expression | Vascular endothelial growth factor | Multiple myeloma | Cell proliferation | Bax protein | Bcl-2 protein | SHP-1 protein | Activation | Cyclin D1 | Kinases | Phosphatase | Nuclei | Prevention | Proteins | Angiogenesis | Signal transduction | Janus kinase 2 | Cell cycle | Janus kinase | Saffron | Inhibition | G1 phase | Translocation | Pervanadate | Stat3 protein | Src protein | CXCR4 protein | Inhibitors | Protein phosphatase | Protein-tyrosine-phosphatase | Apoptosis
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9. Full Text Protein Tyrosine Phosphatases, TC-PTP, SHP1, and SHP2, Cooperate in Rapid Dephosphorylation of Stat3 in Keratinocytes Following UVB Irradiation
by Kim, Dae Joon and Tremblay, Michel L and DiGiovanni, John
PLoS ONE, ISSN 1932-6203, 2010, Volume 5, Issue 4, p. e10290
Stat3 is initially dephosphorylated in murine keratinocytes in response to UVB irradiation. Treatment with Na3VO4 desensitized keratinocytes to UVB-induced... 
GROWTH-FACTOR RECEPTOR | ACTIVATION | TRANSCRIPTION 3 | PROMOTION STAGES | EPITHELIAL CARCINOGENESIS | SUBSTRATE | BIOLOGY | SKIN CARCINOGENESIS | PROLIFERATION | SIGNAL TRANSDUCER | NEGATIVE REGULATOR | Protein Tyrosine Phosphatase, Non-Receptor Type 2 - radiation effects | Apoptosis - radiation effects | Keratinocytes - radiation effects | RNA, Small Interfering - pharmacology | Cells, Cultured | Protein Tyrosine Phosphatase, Non-Receptor Type 2 - physiology | STAT3 Transcription Factor - radiation effects | Protein Tyrosine Phosphatase, Non-Receptor Type 6 - physiology | Protein Tyrosine Phosphatase, Non-Receptor Type 2 - genetics | Protein Tyrosine Phosphatase, Non-Receptor Type 6 - radiation effects | Protein Tyrosine Phosphatase, Non-Receptor Type 6 - genetics | Protein Tyrosine Phosphatases, Non-Receptor - physiology | Ultraviolet Rays - adverse effects | Protein Tyrosine Phosphatases, Non-Receptor - radiation effects | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - radiation effects | Phosphorylation - radiation effects | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - physiology | Animals | Keratinocytes - metabolism | Protein Tyrosine Phosphatases, Non-Receptor - genetics | Mice | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - genetics | STAT3 Transcription Factor - metabolism | Tyrosine | Phenols | Skin | Phosphatases | Apoptosis | Pediatrics | Phosphorylation | Transcription factors | SHP-1 protein | c-Myc protein | Genomes | Myc protein | Dephosphorylation | Cyclin D1 | Phosphatase | Experiments | Carcinogenesis | Proteins | Signal transduction | Carcinogens | Toxicology | Cell growth | Epidermal growth factor | Rodents | Cell cycle | Translocation | Desensitization | U.V. radiation | RNA-mediated interference | Stat3 protein | Keratinocytes | Epidermis | siRNA | Nuclear transport | Studies | Irradiation | Diabetes | Endoplasmic reticulum | Cytoplasm | Protein-tyrosine-phosphatase | Tumors | Cancer
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10. Full Text Alteration in the Gene Encoding Protein Tyrosine Phosphatase Nonreceptor Type 6 ( PTPN6/SHP1 ) May Contribute to Neutrophilic Dermatoses
by Nesterovitch, Andrew B and Gyorfy, Zsuzsa and Hoffman, Mark D and Moore, Ellen C and Elbuluk, Nada and Tryniszewska, Beata and Rauch, Tibor A and Simon, Melinda and Kang, Sewon and Fisher, Gary J and Mikecz, Katalin and Tharp, Michael D and Glant, Tibor T
American Journal of Pathology, The, ISSN 0002-9440, 2011, Volume 178, Issue 4, pp. 1434 - 1441
We have found a B2 repeat insertion in the gene encoding protein tyrosine phosphatase nonreceptor type 6 (PTPN6) in a mouse that developed a skin disorder with... 
Pathology | HEMATOPOIETIC-CELLS | MOTH-EATEN MICE | MYELOGENOUS-LEUKEMIA | DISEASE | PYODERMA-GANGRENOSUM | SWEETS-SYNDROME | MUTATIONS | PATHOLOGY | SHP-1 EXPRESSION | T-CELLS | AUTOINFLAMMATORY SYNDROMES | Alternative Splicing | Cytokines - metabolism | Skin Diseases - genetics | Exons | Humans | Middle Aged | Molecular Sequence Data | Male | Protein Tyrosine Phosphatase, Non-Receptor Type 6 - physiology | Reverse Transcriptase Polymerase Chain Reaction | Protein Tyrosine Phosphatase, Non-Receptor Type 6 - genetics | Base Sequence | Gene Deletion | Adult | Female | Heterozygote | Aged | Mutation | Neutrophils - metabolism | Phosphoric Monoester Hydrolases - chemistry | Short Communication
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11. Full Text B Cell-Specific Deletion of Protein-Tyrosine Phosphatase Shp1 Promotes B-1a Cell Development and Causes Systemic Autoimmunity
by Pao, Lily I and Lam, Kong-Peng and Henderson, Joel M and Kutok, Jeffery L and Alimzhanov, Marat and Nitschke, Lars and Thomas, Matthew L and Neel, Benjamin G and Rajewsky, Klaus
Immunity, ISSN 1074-7613, 2007, Volume 27, Issue 1, pp. 35 - 48
Spontaneous loss-of-function mutations in the protein-tyrosine phosphatase Shp1 cause the motheaten phenotype, characterized by widespread inflammation and... 
MOLIMMUNO | MICE REVEAL | RESPONSES | GENE | VIABLE MOTH-EATEN | BONE-MARROW CELLS | RECEPTOR | IMMUNOLOGY | IDENTIFICATION | THRESHOLDS | CD22 | LYMPHOCYTES | Autoimmune Diseases - enzymology | Mice, Inbred C57BL | Cells, Cultured | Glomerulonephritis - genetics | B-Lymphocyte Subsets - cytology | Glomerulonephritis - immunology | B-Lymphocyte Subsets - enzymology | Protein Tyrosine Phosphatase, Non-Receptor Type 6 - genetics | Autoimmune Diseases - genetics | Cell Differentiation - genetics | Cell Differentiation - immunology | Animals | Mice, Mutant Strains | Gene Deletion | Glomerulonephritis - pathology | B-Lymphocyte Subsets - immunology | Mice | Antigen-Antibody Complex - metabolism | Glomerulonephritis - enzymology | Autoimmune Diseases - pathology | Protein Tyrosine Phosphatase, Non-Receptor Type 6 - deficiency | Autoimmunity | Esterases | Proteins | Genotype & phenotype | Rodents | Cloning | Bone marrow | Software | Mutation | Kinases | Deoxyribonucleic acid--DNA
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12. Full Text Potent inhibition of protein tyrosine phosphatases by copper complexes with multi-benzimidazole derivatives
by Li, Ying and Lu, Liping and Zhu, Miaoli and Wang, Qingming and Yuan, Caixia and Xing, Shu and Fu, Xueqi and Mei, Yuhua
BioMetals, ISSN 0966-0844, 12/2011, Volume 24, Issue 6, pp. 993 - 1004
A series of copper complexes with multi-benzimidazole derivatives, including mono- and di-nuclear, were synthesized and characterized by Fourier transform IR... 
Life Sciences | Biochemistry, general | Protein tyrosine phosphatases | Microbiology | Fluorescence | Plant Physiology | Copper complex | Inhibition | Pharmacology/Toxicology | Medicine/Public Health, general | Cell Biology | CANCER-CELLS | HOMEOSTASIS | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | CATALYTIC DOMAIN | DISOLVATE | APOPTOSIS INDUCERS | STRATEGIES | LIGANDS | PURIFICATION | PROTEASOME INHIBITORS | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - metabolism | Humans | Protein Tyrosine Phosphatases - metabolism | Structure-Activity Relationship | Benzimidazoles - chemistry | Enzyme Inhibitors - chemical synthesis | Protein Tyrosine Phosphatase, Non-Receptor Type 6 - chemistry | Protein Tyrosine Phosphatases - antagonists & inhibitors | Protein Tyrosine Phosphatases - chemistry | Protein Tyrosine Phosphatases - genetics | Protein Tyrosine Phosphatases, Non-Receptor - chemistry | Copper - chemistry | Enzyme Inhibitors - chemistry | Protein Tyrosine Phosphatases, Non-Receptor - genetics | Copper - metabolism | Molecular Structure | Protein Tyrosine Phosphatase, Non-Receptor Type 1 - genetics | Protein Tyrosine Phosphatase, Non-Receptor Type 1 - chemistry | Protein Tyrosine Phosphatase, Non-Receptor Type 2 - chemistry | Enzyme Inhibitors - metabolism | Benzimidazoles - chemical synthesis | Protein Tyrosine Phosphatase, Non-Receptor Type 1 - antagonists & inhibitors | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - antagonists & inhibitors | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - chemistry | Protein Tyrosine Phosphatase, Non-Receptor Type 2 - genetics | Protein Tyrosine Phosphatase, Non-Receptor Type 6 - genetics | Protein Tyrosine Phosphatase, Non-Receptor Type 2 - metabolism | Protein Tyrosine Phosphatase, Non-Receptor Type 1 - metabolism | Protein Tyrosine Phosphatase, Non-Receptor Type 6 - metabolism | Spectrum Analysis - methods | Benzimidazoles - metabolism | Protein Tyrosine Phosphatases, Non-Receptor - metabolism | Protein Tyrosine Phosphatase, Non-Receptor Type 2 - antagonists & inhibitors | Protein Tyrosine Phosphatase, Non-Receptor Type 6 - antagonists & inhibitors | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - genetics | Protein Tyrosine Phosphatases, Non-Receptor - antagonists & inhibitors | Tyrosine | Phosphatases | Ionization | Analysis | Phenols | T cells | Mass spectrometry | Proteins | Enzymes | Cellular biology | Copper
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