Articles

UofT Libraries is getting a new library services platform in January 2021.
Learn more about the change.

Search Articles

Advanced search
Help

Catalogue

Articles

Databases

X
Search Filters
Format Format
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
science & technology (6441) 6441
life sciences & biomedicine (5794) 5794
humans (4719) 4719
animals (4225) 4225
mice (2194) 2194
phosphorylation (2114) 2114
signal transduction (2067) 2067
biochemistry & molecular biology (1929) 1929
cell biology (1724) 1724
proteins (1648) 1648
male (1332) 1332
protein tyrosine phosphatases - metabolism (1317) 1317
female (1218) 1218
tyrosine (1138) 1138
kinases (1097) 1097
biological and medical sciences (1044) 1044
oncology (985) 985
intracellular signaling peptides and proteins (964) 964
protein tyrosine phosphatase, non-receptor type 6 (886) 886
protein tyrosine phosphatase, non-receptor type 11 (865) 865
phosphatases (851) 851
research (835) 835
gene expression (831) 831
cell line (800) 800
mutation (766) 766
cells, cultured (761) 761
rats (755) 755
cell line, tumor (750) 750
immunology (712) 712
research article (681) 681
medical sciences (680) 680
protein binding (676) 676
apoptosis (667) 667
cancer (665) 665
protein tyrosine phosphatases - genetics (642) 642
science & technology - other topics (628) 628
multidisciplinary sciences (622) 622
genetic aspects (619) 619
analysis (616) 616
physiological aspects (614) 614
protein tyrosine phosphatase, non-receptor type 11 - metabolism (596) 596
signal transduction - drug effects (538) 538
mice, inbred c57bl (532) 532
protein tyrosine phosphatase, non-receptor type 1 - metabolism (527) 527
fundamental and applied biological sciences. psychology (524) 524
amino acid sequence (520) 520
protein-tyrosine kinases - metabolism (514) 514
mice, knockout (511) 511
signal transduction - physiology (509) 509
molecular sequence data (507) 507
phosphatase (501) 501
protein tyrosine phosphatase, non-receptor type 6 - metabolism (501) 501
protein tyrosine phosphatase, non-receptor type 1 (497) 497
abridged index medicus (476) 476
endocrinology & metabolism (469) 469
tyrosine - metabolism (454) 454
cell proliferation (444) 444
medicine (443) 443
biology (442) 442
enzyme inhibitors - pharmacology (437) 437
adult (433) 433
genetics & heredity (432) 432
health aspects (420) 420
transfection (416) 416
neurosciences (409) 409
rodents (407) 407
binding sites (400) 400
tumors (398) 398
enzyme activation (397) 397
src-family kinases - metabolism (396) 396
pharmacology & pharmacy (394) 394
neurosciences & neurology (390) 390
science (376) 376
middle aged (372) 372
signaling (372) 372
genes (364) 364
phosphorylation - drug effects (361) 361
protein tyrosine phosphatase, non-receptor type 11 - genetics (361) 361
blotting, western (358) 358
physiology (355) 355
protein-tyrosine-phosphatase (333) 333
life sciences (325) 325
phenols (318) 318
sh2 domain-containing protein tyrosine phosphatases (318) 318
diabetes (315) 315
enzymes (314) 314
medicine, research & experimental (310) 310
research & experimental medicine (310) 310
biochemistry (308) 308
hematology (296) 296
phosphatidylinositol 3-kinases - metabolism (296) 296
src homology domains (295) 295
protein tyrosine phosphatase, non-receptor type 1 - antagonists & inhibitors (293) 293
gene expression regulation (291) 291
phosphoproteins - metabolism (288) 288
models, biological (287) 287
chemistry (284) 284
cell cycle (283) 283
inflammation (282) 282
insulin (280) 280
more...
Library Location Library Location
Language Language
Language Language
X
Sort by Item Count (A-Z)
Filter by Count
English (7323) 7323
Chinese (32) 32
Japanese (26) 26
German (5) 5
Dutch (3) 3
Portuguese (3) 3
Polish (2) 2
Norwegian (1) 1
Russian (1) 1
Spanish (1) 1
more...
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


1. Full Text Potent inhibition of protein tyrosine phosphatases by copper complexes with multi-benzimidazole derivatives
by Li, Ying and Lu, Liping and Zhu, Miaoli and Wang, Qingming and Yuan, Caixia and Xing, Shu and Fu, Xueqi and Mei, Yuhua
Biometals, ISSN 0966-0844, 12/2011, Volume 24, Issue 6, pp. 993 - 1004
Life Sciences | Biochemistry, general | Protein tyrosine phosphatases | Microbiology | Fluorescence | Plant Physiology | Copper complex | Inhibition | Pharmacology/Toxicology | Medicine/Public Health, general | Cell Biology | Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - metabolism | Humans | Protein Tyrosine Phosphatases - metabolism | Structure-Activity Relationship | Benzimidazoles - chemistry | Enzyme Inhibitors - chemical synthesis | Protein Tyrosine Phosphatase, Non-Receptor Type 6 - chemistry | Protein Tyrosine Phosphatases - antagonists & inhibitors | Protein Tyrosine Phosphatases - chemistry | Protein Tyrosine Phosphatases - genetics | Protein Tyrosine Phosphatases, Non-Receptor - chemistry | Copper - chemistry | Enzyme Inhibitors - chemistry | Protein Tyrosine Phosphatases, Non-Receptor - genetics | Copper - metabolism | Molecular Structure | Protein Tyrosine Phosphatase, Non-Receptor Type 1 - genetics | Protein Tyrosine Phosphatase, Non-Receptor Type 1 - chemistry | Protein Tyrosine Phosphatase, Non-Receptor Type 2 - chemistry | Enzyme Inhibitors - metabolism | Benzimidazoles - chemical synthesis | Protein Tyrosine Phosphatase, Non-Receptor Type 1 - antagonists & inhibitors | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - antagonists & inhibitors | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - chemistry | Protein Tyrosine Phosphatase, Non-Receptor Type 2 - genetics | Protein Tyrosine Phosphatase, Non-Receptor Type 6 - genetics | Protein Tyrosine Phosphatase, Non-Receptor Type 2 - metabolism | Protein Tyrosine Phosphatase, Non-Receptor Type 1 - metabolism | Protein Tyrosine Phosphatase, Non-Receptor Type 6 - metabolism | Spectrum Analysis - methods | Benzimidazoles - metabolism | Protein Tyrosine Phosphatases, Non-Receptor - metabolism | Protein Tyrosine Phosphatase, Non-Receptor Type 2 - antagonists & inhibitors | Protein Tyrosine Phosphatase, Non-Receptor Type 6 - antagonists & inhibitors | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - genetics | Protein Tyrosine Phosphatases, Non-Receptor - antagonists & inhibitors | Tyrosine | Phosphatases | Ionization | Analysis | Phenols | T cells | Mass spectrometry | Proteins | Enzymes | Cellular biology | Copper | Spectroscopy | Inhibitors | Derivatives | Index Medicus
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
2. Full Text Protein tyrosine phosphatases in lymphocyte activation and autoimmunity
by Rhee, Inmoo and Veillette, André
Nature immunology, ISSN 1529-2908, 05/2012, Volume 13, Issue 5, pp. 439 - 447
Life Sciences & Biomedicine | Immunology | Science & Technology | Antigens, CD - immunology | Protein Tyrosine Phosphatase, Non-Receptor Type 6 - immunology | Protein Tyrosine Phosphatase, Non-Receptor Type 2 - immunology | Humans | Autoimmunity - genetics | NK Cell Lectin-Like Receptor Subfamily K - immunology | Protein Tyrosine Phosphatases - metabolism | Leukocyte Common Antigens - immunology | Signal Transduction - immunology | Protein Tyrosine Phosphatases - genetics | Protein Tyrosine Phosphatase, Non-Receptor Type 22 - immunology | Signaling Lymphocytic Activation Molecule Family Member 1 | Autoimmunity - immunology | Receptors, Antigen, T-Cell - immunology | Lymphocyte Activation | Protein Tyrosine Phosphatase, Non-Receptor Type 22 - genetics | Receptor-Like Protein Tyrosine Phosphatases, Class 3 - immunology | Protein Tyrosine Phosphatase, Non-Receptor Type 2 - genetics | Receptors, Cell Surface - immunology | Receptors, Antigen, B-Cell - immunology | Animals | Lymphocytes - enzymology | Mice | Protein Tyrosine Phosphatase, Non-Receptor Type 6 - deficiency | Protein Tyrosine Phosphatase, Non-Receptor Type 12 - immunology | Tyrosine | Autoimmunity | Phosphatases | Immune response | Lymphocytes | Physiological aspects | Research | Properties | Index Medicus
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
3. Full Text Dinuclear copper complexes of organic claw: Potent inhibition of protein tyrosine phosphatases
by Ma, Ling and Lu, Liping and Zhu, Miaoli and Wang, Qingming and Gao, Fei and Yuan, Caixia and Wu, Yanbo and Xing, Shu and Fu, Xueqi and Mei, Yuhua and Gao, Xiaoli
Journal of inorganic biochemistry, ISSN 0162-0134, 2011, Volume 105, Issue 9, pp. 1138 - 1147
PTPs | Inhibitor | Selectivity | Dinuclear copper complexes | Biochemistry & Molecular Biology | Physical Sciences | Chemistry, Inorganic & Nuclear | Chemistry | Life Sciences & Biomedicine | Science & Technology | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - metabolism | Escherichia coli | Humans | Substrate Specificity | Crystallography, X-Ray | Enzyme Inhibitors - chemical synthesis | Spectrometry, Mass, Electrospray Ionization | Transformation, Bacterial | X-Ray Diffraction | Protein Tyrosine Phosphatases, Non-Receptor - genetics | Acids, Heterocyclic - chemical synthesis | Cloning, Molecular | Copper - metabolism | Protein Tyrosine Phosphatase, Non-Receptor Type 1 - genetics | Acids, Heterocyclic - pharmacology | Recombinant Proteins - metabolism | Recombinant Proteins - antagonists & inhibitors | Enzyme Inhibitors - pharmacology | Protein Tyrosine Phosphatase, Non-Receptor Type 1 - antagonists & inhibitors | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - antagonists & inhibitors | Models, Molecular | Recombinant Proteins - genetics | Chelating Agents - pharmacology | Protein Tyrosine Phosphatase, Non-Receptor Type 2 - genetics | Potentiometry | Protein Tyrosine Phosphatase, Non-Receptor Type 6 - genetics | Protein Tyrosine Phosphatase, Non-Receptor Type 2 - metabolism | Protein Tyrosine Phosphatase, Non-Receptor Type 1 - metabolism | Protein Tyrosine Phosphatase, Non-Receptor Type 6 - metabolism | Signal Transduction - drug effects | Protein Tyrosine Phosphatases, Non-Receptor - metabolism | Protein Tyrosine Phosphatase, Non-Receptor Type 2 - antagonists & inhibitors | Protein Tyrosine Phosphatase, Non-Receptor Type 6 - antagonists & inhibitors | Ligands | Signal Transduction - physiology | Kinetics | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - genetics | Chelating Agents - chemical synthesis | Protein Tyrosine Phosphatases, Non-Receptor - antagonists & inhibitors | Tyrosine | Phenols | Phosphatases | Analysis | Index Medicus
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
4. Full Text SHP-1 phosphatase activity counteracts increased T cell receptor affinity
by Hebeisen, Michael and Baitsch, Lukas and Presotto, Danilo and Baumgaertner, Petra and Romero, Pedro and Michielin, Olivier and Speiser, Daniel E and Rufer, Nathalie
The Journal of clinical investigation, ISSN 0021-9738, 03/2013, Volume 123, Issue 3, pp. 1044 - 1065
Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine | Phosphorylation | Humans | Transcriptome | MicroRNAs - metabolism | Extracellular Signal-Regulated MAP Kinases - metabolism | Programmed Cell Death 1 Receptor - physiology | Signal Transduction - immunology | ZAP-70 Protein-Tyrosine Kinase - metabolism | Cell Line | HLA-A2 Antigen - immunology | Immunotherapy, Adoptive | Antigens, Neoplasm - immunology | Lymphocyte Activation | Programmed Cell Death 1 Receptor - metabolism | Membrane Proteins - immunology | Protein Tyrosine Phosphatase, Non-Receptor Type 6 - genetics | Receptors, Antigen, T-Cell, alpha-beta - genetics | CD8-Positive T-Lymphocytes - physiology | CD8-Positive T-Lymphocytes - enzymology | Protein Tyrosine Phosphatase, Non-Receptor Type 6 - metabolism | Down-Regulation - immunology | Protein Tyrosine Phosphatase, Non-Receptor Type 6 - antagonists & inhibitors | Antimony Sodium Gluconate - pharmacology | Protein Binding | MicroRNAs - genetics | Protein Processing, Post-Translational | Receptors, Antigen, T-Cell, alpha-beta - metabolism | CD8-Positive T-Lymphocytes - immunology | Programmed Cell Death 1 Receptor - genetics | Antigen receptors, T cell | Receptors | Phosphatases | Physiological aspects | Cellular immunity | Genetic aspects | Research | Gene expression | T cells | Index Medicus | Abridged Index Medicus
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
5. Full Text Mutant KRAS-driven cancers depend on PTPN11/SHP2 phosphatase
by Ruess, Dietrich A and Heynen, Guus J and Ciecielski, Katrin J and Ai, Jiaoyu and Berninger, Alexandra and Kabacaoglu, Derya and Görgülü, Kivanc and Dantes, Zahra and Wörmann, Sonja M and Diakopoulos, Kalliope N and Karpathaki, Angeliki F and Kowalska, Marlena and Kaya-Aksoy, Ezgi and Song, Liang and Van Der Laan, Eveline A. Zeeuw and López-Alberca, María P and Nazaré, Marc and Reichert, Maximilian and Saur, Dieter and Erkan, Mert M and Hopt, Ulrich T and Sainz, Bruno and Birchmeier, Walter and Schmid, Roland M and Lesina, Marina and Algül, Hana
Nature medicine, ISSN 1078-8956, 07/2018, Volume 24, Issue 7, pp. 954 - 960
Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Cell Biology | Research & Experimental Medicine | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - metabolism | Pancreatic Neoplasms - metabolism | Proto-Oncogene Proteins p21(ras) - genetics | Humans | Lung Neoplasms - metabolism | Pancreatic Neoplasms - pathology | Mitogen-Activated Protein Kinase Kinases - antagonists & inhibitors | Lung Neoplasms - pathology | Mutation - genetics | Carcinogenesis - metabolism | Disease Progression | Carcinogenesis - pathology | Mitogen-Activated Protein Kinase Kinases - metabolism | Animals | Protein Kinase Inhibitors - therapeutic use | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - deficiency | Cell Line, Tumor | Mice | Protein Kinase Inhibitors - pharmacology | Tyrosine | Care and treatment | Cellular signal transduction | Genetic aspects | Research | Gene expression | Cancer | Adenocarcinoma | Animal models | Xenotransplantation | Lung cancer | Phosphatase | Carcinogenesis | K-Ras protein | Proteins | Signal transduction | Carcinogens | Allosteric properties | Clonal deletion | Organoids | Dependence | Xenografts | Protein-tyrosine kinase receptors | Inhibition | Pancreas | Protein-tyrosine kinase | MAP kinase | Tumor cell lines | Signaling | Tumors | Protein-tyrosine-phosphatase | Index Medicus
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
6. Full Text Capillarisin inhibits constitutive and inducible STAT3 activation through induction of SHP-1 and SHP-2 tyrosine phosphatases
by Lee, Jong Hyun and Chiang, Shu Yuan and Nam, Dongwoo and Chung, Won-Seok and Lee, Junhee and Na, Young-Soon and Sethi, Gautam and Ahn, Kwang Seok
Cancer letters, ISSN 0304-3835, 2013, Volume 345, Issue 1, pp. 140 - 148
Hematology, Oncology and Palliative Medicine | Capillarisin | PTP | STAT3 | Multiple myeloma | Apoptosis | Life Sciences & Biomedicine | Oncology | Science & Technology | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - metabolism | Apoptosis - drug effects | Humans | Multiple Myeloma - metabolism | Protein Tyrosine Phosphatase, Non-Receptor Type 6 - biosynthesis | Protein Tyrosine Phosphatase, Non-Receptor Type 6 - genetics | Multiple Myeloma - drug therapy | Multiple Myeloma - pathology | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - biosynthesis | Protein Tyrosine Phosphatase, Non-Receptor Type 6 - metabolism | Signal Transduction - drug effects | Cell Line, Tumor | Enzyme Induction - drug effects | Cell Proliferation - drug effects | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - genetics | Chromones - pharmacology | Multiple Myeloma - genetics | STAT3 Transcription Factor - metabolism | Tyrosine | Phenols | Phosphatases | Vascular endothelial growth factor | Index Medicus
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
7. Full Text Uncoupling ITIM receptor G6b-B from tyrosine phosphatases Shp1 and Shp2 disrupts murine platelet homeostasis
by Geer, Mitchell J and van Geffen, Johanna P and Gopalasingam, Piraveen and Vogtle, Timo and Smith, Christopher W and Heising, Silke and Kuijpers, Marijke J. E and Tullemans, Bibian M. E and Jarvis, Gavin E and Eble, Johannes A and Jeeves, Mark and Overduin, Michael and Heemskerk, Johan W. M and Mazharian, Alexana and Senis, Yotis A
Blood, ISSN 0006-4971, 09/2018, Volume 132, Issue 13, pp. 1413 - 1425
THROMBOCYTOPENIA | ACTIVATION | MICE | PROTEIN | PHOSPHORYLATION | Life Sciences & Biomedicine | Hematology | Science & Technology | Blood Platelets - pathology | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - metabolism | Phosphorylation | Receptors, Immunologic - chemistry | Signal Transduction | Mice, Inbred C57BL | Homeostasis | Models, Molecular | Mice, Transgenic | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - chemistry | Thrombocytopenia - pathology | Protein Tyrosine Phosphatase, Non-Receptor Type 6 - chemistry | Thrombocytopenia - metabolism | Protein Interaction Maps | src Homology Domains | Thrombocytopenia - genetics | Point Mutation | Animals | Protein Tyrosine Phosphatase, Non-Receptor Type 6 - metabolism | Blood Platelets - metabolism | Mice | Receptors, Immunologic - genetics | Binding Sites | Receptors, Immunologic - metabolism | 37 | 35 | Platelets and Thrombopoiesis
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
8. Full Text Protein tyrosine phosphatases – from housekeeping enzymes to master regulators of signal transduction
by Tonks, Nicholas K
The FEBS journal, ISSN 1742-464X, 01/2013, Volume 280, Issue 2, pp. 346 - 378
kinase | tyrosine phosphatase | cancer | drug discovery | signal transduction | diabetes | Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Pregnancy | Catalytic Domain | Phosphorylation | Protein Tyrosine Phosphatase, Non-Receptor Type 1 - metabolism | Signal Transduction | Humans | Models, Molecular | Crystallography, X-Ray | Female | Placenta - enzymology | Protein Tyrosine Phosphatase, Non-Receptor Type 1 - genetics | Protein Tyrosine Phosphatase, Non-Receptor Type 1 - chemistry | Tyrosine | Enzymes | Phosphatases | Home economics | Physiological aspects | Phenols | Hypoglycemic agents | Proteins | Signal transduction | Biochemistry | Index Medicus
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights