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Circulation, ISSN 0009-7322, 2012, Volume 126, Issue 7, pp. 830 - 839
Journal Article
Journal Article
Science, ISSN 0036-8075, 6/2004, Volume 304, Issue 5678, pp. 1800 - 1804
Pathogenic mycobacteria resist lysosomal delivery after uptake into macrophages, allowing them to survive intracellularly. We found that the eukaryotic-like... 
Bacteriophages | Mycobacterium | Phagosomes | Lysosomes | Antibodies | Bacteria | Electrophoresis | Reports | Infections | Macrophages | Organelles | TUBERCULOSIS PHAGOSOME | PHAGOSOME MATURATION | ARREST | FUSION | BIOGENESIS | MULTIDISCIPLINARY SCIENCES | SEQUENCE | EARLY ENDOSOMES | MICE | INHIBITORS | INTRACELLULAR SURVIVAL | Phagosomes - microbiology | Phagosomes - enzymology | Phagosomes - physiology | Cyclic GMP-Dependent Protein Kinases - metabolism | Lysosomes - physiology | Mycobacterium smegmatis - pathogenicity | Mycobacterium tuberculosis - drug effects | Cyclic GMP-Dependent Protein Kinases - genetics | Mycobacterium tuberculosis - pathogenicity | Mycobacterium bovis - drug effects | Cyclic GMP-Dependent Protein Kinases - antagonists & inhibitors | Mycobacterium bovis - enzymology | Gene Deletion | Mycobacterium bovis - pathogenicity | Mycobacterium smegmatis - enzymology | Macrophages - microbiology | Amides - pharmacology | Cell Line | Macrophages - ultrastructure | Vacuoles - microbiology | Mycobacterium smegmatis - genetics | Signal Transduction | Enzyme Inhibitors - pharmacology | Thiophenes - pharmacology | Animals | Lysosomes - microbiology | Mycobacterium tuberculosis - enzymology | Macrophages - drug effects | Mice | Mycobacterium bovis - growth & development | Mycobacterium smegmatis - physiology | Mycobacterium tuberculosis - growth & development | Physiological aspects | Tuberculosis | Bacterial infections | Research | Mycobacteria | Pathogens | Molecules | Microbiology | Bacterial proteins
Journal Article
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, ISSN 0066-4804, 09/2019, Volume 63, Issue 9
Tuberculosis (TB) is a global health concern, and this situation has further worsened due to the emergence of drug-resistant strains and the failure of BCG... 
NU-6027 | SURVIVAL | B PKNB | serine threonine protein kinases | DRUG DISCOVERY | apoptosis | MICROBIOLOGY | ACTIVATION MECHANISM | IDENTIFICATION | RESISTANT | IN-VITRO | Mycobacterium tuberculosis | ACTIVE TUBERCULOSIS | PHARMACOLOGY & PHARMACY | SERINE/THREONINE KINASE
Journal Article
Circulation Research, ISSN 0009-7330, 01/2009, Volume 104, Issue 1, pp. 87 - 94
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 2017, Volume 292, Issue 39, pp. 16093 - 16108
Protein kinase G (PknG), a thioredoxin-fold-containing eukaryotic-like serine/threonine protein kinase, is a virulence factor in Mycobacterium tuberculosis,... 
IN-VITRO | HOMEOSTASIS | METABOLISM | GENE | PERSISTENCE | BIOCHEMISTRY & MOLECULAR BIOLOGY | GROWTH | ADAPTATION | HYPOXIC RESPONSE | STARVATION | EXPRESSION | Isoniazid - pharmacology | Granuloma - metabolism | Bacterial Proteins - chemistry | Stress, Physiological | Antigens, Bacterial - genetics | Mycobacterium tuberculosis - drug effects | Protein Processing, Post-Translational - drug effects | Gene Deletion | Mycobacterium tuberculosis - physiology | Female | Latent Tuberculosis - physiopathology | Phosphorylation - drug effects | Mycobacterium tuberculosis - metabolism | Granuloma - etiology | Protein-Serine-Threonine Kinases - metabolism | Granuloma - microbiology | Guinea Pigs | Microbial Viability - drug effects | Bacterial Proteins - genetics | Protein-Serine-Threonine Kinases - genetics | Antibiotics, Antitubercular - pharmacology | Metabolomics - methods | Amino Acid Motifs | Latent Tuberculosis - metabolism | Point Mutation | Animals | Bacterial Proteins - metabolism | Protein-Serine-Threonine Kinases - chemistry | Kinetics | Latent Tuberculosis - microbiology | Antigens, Bacterial - metabolism | Amino Acid Substitution | Mycobacterium tuberculosis - growth & development | hypoxia | serine | redox signaling | Microbiology | Mycobacterium tuberculosis | thioredoxin | threonine protein kinase | mycobacteria
Journal Article
Journal Article
Journal Article
Circulation, ISSN 0009-7322, 07/2013, Volume 128, Issue 4, pp. 365 - 376
BACKGROUND—Proteasome functional insufficiency is implicated in a large subset of cardiovascular diseases and may play an important role in their pathogenesis.... 
desmin | proteasome inhibitors | cardiomyopathies | cyclic GMP-dependent protein kinase | proteins | SYSTEM | CARDIAC & CARDIOVASCULAR SYSTEMS | HEART-FAILURE | QUALITY-CONTROL | DILATED CARDIOMYOPATHY | 26S PROTEASOME | INHIBITION | DESMIN-RELATED CARDIOMYOPATHY | CARDIAC PROTEINOPATHY | PERIPHERAL VASCULAR DISEASE | MICE | POSTTRANSLATIONAL MODIFICATION | Proteostasis Deficiencies - metabolism | RNA, Small Interfering - genetics | Humans | Cyclic GMP-Dependent Protein Kinase Type I - genetics | Male | Green Fluorescent Proteins - genetics | Sulfones - pharmacology | Cardiovascular Diseases - genetics | Cyclic GMP-Dependent Protein Kinases - metabolism | Cyclic GMP-Dependent Protein Kinases - genetics | Myocytes, Cardiac - enzymology | Sildenafil Citrate | Cyclic GMP-Dependent Protein Kinase Type I - metabolism | Adenoviridae - genetics | Phosphodiesterase 5 Inhibitors - pharmacology | Cardiovascular Diseases - metabolism | Myocytes, Cardiac - cytology | Purines - pharmacology | Cells, Cultured | Rats | Mice, Transgenic | Enzyme Activation - drug effects | Piperazines - pharmacology | Protein Processing, Post-Translational - physiology | Proteostasis Deficiencies - genetics | Animals | Desmin - metabolism | Mice | Proteasome Endopeptidase Complex - metabolism | Enzyme Activation - physiology | Proteins | Physiological aspects | Research | Ubiquitin-proteasome system | Cardiovascular diseases | Protein kinases | desmin-related cardiomyopathy | proteasome | misfolded proteins | Protein kinase G
Journal Article
01/2013
Nitric oxide synthase (NOS) is regulated by protein-protein interactions. We had earlier shown that PKG inhibits activated NOS in endothelial cells and... 
Protein kinase G | Nitric oxide synthase
Web Resource
03/2012
Background: Nitric oxide synthase (NOS) is negatively regulated by protein-protein interactions with caveolin-1 before extracellular activating signals release... 
caveolin-1 | protein kinase G | nitric oxide synthase
Web Resource
Nature Communications, ISSN 2041-1723, 12/2019, Volume 10, Issue 1, pp. 1 - 13
People heterozygous for an activating mutation in protein kinase G1 (PRKG1, p.Arg177Gln) develop thoracic aortic aneurysms and dissections (TAAD) as young... 
Oxidative stress | Marfan's syndrome | Protein kinase G | Aneurysm | Acetylcysteine | Aneurysms | Smooth muscle | Vitamin B12 | Kinases | Proteins | Antioxidants | Protein folding | Aorta | Degeneration | Age | Young adults | Free radicals | Elastin | Muscles | Thorax | Cyanocobalamin | Pathology | Protein kinase | Coronary vessels | Mice | Mutation | Apoptosis
Journal Article