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1. Full Text Quality over quantity: optimizing co-translational protein folding with non-‘optimal’ synonymous codons
by Jacobson, Giselle N and Clark, Patricia L
Current Opinion in Structural Biology, ISSN 0959-440X, 06/2016, Volume 38, pp. 102 - 110
Protein folding occurs on a time scale similar to peptide bond formation by the ribosome, which has long sparked speculation that altering translation rate... 
RIBOSOMAL EXIT TUNNEL | ELONGATION RATES | MESSENGER-RNA | USAGE | BIOCHEMISTRY & MOLECULAR BIOLOGY | IN-VIVO | ESCHERICHIA-COLI | GENE-EXPRESSION | SECONDARY STRUCTURE | MUTATIONS | REVEALS | CELL BIOLOGY | Ribosomes - metabolism | Protein Biosynthesis | Codon - genetics | Proteins - chemistry | Humans | Protein Folding | Codon | translation rate | ribosome | aggregation | rare codons | non-native folding intermediate | kinetic stability
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2. Full Text Quality before Quantity: Inspecting CFTR
by Mou, Hongmei
Developmental Cell, ISSN 1534-5807, 03/2018, Volume 44, Issue 6, pp. 655 - 656
CFTR biosynthesis is highly dynamic. In this issue of , show that RFFL serves as a CFTR conformation scrutinizer at the plasma membrane. It recognizes... 
DEGRADATION | DEVELOPMENTAL BIOLOGY | DEFECT | CELL BIOLOGY | Proteins | Physiological aspects | Cystic fibrosis | Children's hospitals
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3. Full Text Effects of Atorvastatin (80 mg) Therapy on Quantity of Epicardial Adipose Tissue in Patients Undergoing Pulmonary Vein Isolation for Atrial Fibrillation
by Soucek, Filip, MD and Covassin, Naima, PhD and Singh, Prachi, PhD and Ruzek, Lukas, MD and Kara, Tomas, MD, PhD and Suleiman, Mahmoud, MD and Lerman, Amir, MD and Koestler, Celeste, RN and Friedman, Paul A., MD and Lopez-Jimenez, Francisco, MD and Somers, Virend K., MD, PhD
American Journal of Cardiology, The, ISSN 0002-9149, 2015, Volume 116, Issue 9, pp. 1443 - 1446
Epicardial adipose tissue (EAT) has been recognized as a sensitive marker of cardiometabolic risk. Recent evidence suggests efficacy of long-term statin... 
Cardiovascular | FAT | CELLS | CARDIAC & CARDIOVASCULAR SYSTEMS | METAANALYSIS | STATINS | Predictive Value of Tests | Prospective Studies | Follow-Up Studies | Humans | Middle Aged | Male | Tomography, X-Ray Computed | Pericardium - metabolism | C-Reactive Protein - metabolism | Sensitivity and Specificity | Cholesterol, LDL - blood | Female | Pericardium - diagnostic imaging | C-Reactive Protein - drug effects | Atrial Fibrillation - diagnosis | Atorvastatin Calcium - therapeutic use | Body Mass Index | Double-Blind Method | Atrial Fibrillation - drug therapy | Cholesterol, LDL - drug effects | Treatment Outcome | Biomarkers - blood | Atrial Fibrillation - blood | Anticholesteremic Agents - therapeutic use | Pulmonary Veins - surgery | Adipose Tissue - drug effects | Adipose tissues | Care and treatment | Atrial fibrillation | Cardiac patients | Low density lipoproteins | Coronary heart disease | Public finance | Cardiovascular agents | Antilipemic agents | Cardiac arrhythmia | Heart attacks | Cardiology | Cholesterol | Statins | Cardiometabolic risk | Statin | Epicardial adipose tissue
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4. Full Text Quality and quantity control at the endoplasmic reticulum
by Hegde, Ramanujan S and Ploegh, Hidde L
Current Opinion in Cell Biology, ISSN 0955-0674, 2010, Volume 22, Issue 4, pp. 437 - 446
The endoplasmic reticulum (ER) is the site of maturation for secretory and membrane proteins that together make up about one third of the cellular proteome.... 
Internal Medicine | ERAD | COMPLEX | PROTEIN | MISFOLDED GLYCOPROTEINS | ANCHORED UBIQUITIN LIGASE | SIGNAL PEPTIDE PEPTIDASE | DEGRADATION PATHWAY | RETRO-TRANSLOCATION | N-LINKED GLYCANS | UNCONVENTIONAL SECRETION | CELL BIOLOGY | Animals | Metabolic Networks and Pathways | Humans | Stress, Physiological | Endoplasmic Reticulum - metabolism | Cytosol - metabolism | Protein Processing, Post-Translational | Physiological aspects | Proteolysis | Membrane proteins
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5. Full Text Quantity and source of dietary protein influence metabolite production by gut microbiota and rectal mucosa gene expression: a randomized, parallel, double-blind trial in overweight humans
by Beaumont, Martin and Portune, Kevin Joseph and Steuer, Nils and Lan, Annaïg and Cerrudo, Victor and Audebert, Marc and Dumont, Florent and Mancano, Giulia and Khodorova, Nadezda and Andriamihaja, Mireille and Airinei, Gheorghe and Tomé, Daniel and Benamouzig, Robert and Davila, Anne-Marie and Claus, Sandrine Paule and Sanz, Yolanda and Blachier, François
The American Journal of Clinical Nutrition, ISSN 0002-9165, 10/2017, Volume 106, Issue 4, pp. 1005 - 1019
Abstract Background: Although high-protein diets (HPDs) are frequently consumed for body-weight control, little is known about the consequences for gut... 
Bacterial metabolites | Gut microbiota | High-protein diet | Overweight humans | Transcriptome | Dietary protein | Protein source | Large intestine mucosa | transcriptome | ULCERATIVE-COLITIS | LUMINAL ENVIRONMENT | BARRIER FUNCTION | high-protein diet | gut microbiota | overweight humans | NUTRITION & DIETETICS | bacterial metabolites | INFLAMMATORY-BOWEL-DISEASE | protein source | large intestine mucosa | P-CRESOL | dietary protein | HEALTH | MEAT PROTEIN | COLONIC EPITHELIAL-CELLS | PHYSIOPATHOLOGICAL CONSEQUENCES | Obesity - diet therapy | Dietary Proteins - administration & dosage | Intestinal Mucosa - metabolism | Humans | Homeostasis | Male | Amino Acids - metabolism | Dietary Proteins - metabolism | Intestine, Large - metabolism | Intestine, Large - microbiology | Dietary Proteins - pharmacology | Adult | DNA, Bacterial - analysis | Female | Feces | RNA, Ribosomal, 16S | Diet, Carbohydrate-Restricted | Rectum - microbiology | Bacteria - metabolism | Double-Blind Method | Rectum - metabolism | Gastrointestinal Microbiome | Intestinal Mucosa - microbiology | Bacteria - genetics | Soybean Proteins - pharmacology | Caseins - pharmacology | Physiological aspects | Microbiota (Symbiotic organisms) | Health aspects | Intestinal mucosa
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6. Full Text When quality beats quantity: Decision theory, drug discovery, and the reproducibility crisis
by Scannell, Jack W and Bosley, Jim
PLoS ONE, ISSN 1932-6203, 02/2016, Volume 11, Issue 2, pp. e0147215 - e0147215
A striking contrast runs through the last 60 years of biopharmaceutical discovery, research, and development. Huge scientific and technological gains should... 
QUESTIONS | IMPROVE | COST EFFICIENCY | OPTIMIZE | BIOMEDICAL-RESEARCH | MODELS | SUCCESS RATES | MULTIDISCIPLINARY SCIENCES | PRODUCTIVITY | VALIDATION | CHALLENGES | Models, Theoretical | Reproducibility of Results | Drug Discovery - economics | Humans | Biopharmaceutics - trends | Decision Theory | Research | False Positive Reactions | High-Throughput Screening Assays | Efficiency | Biopharmaceutics - methods | Cost-Benefit Analysis | Quality Control | Drugs | Toxicity | Correlation coefficients | Drug development | Proteins | Scientometrics | Historical account | Constraint modelling | Biocompatibility | Libraries | Drug therapy | Productivity | Correlation coefficient | Computer simulation | Research & development--R&D | Decision making | Astrobiology | FDA approval | Medical screening | Screening | Molecular modelling | Reproducibility | Decision theory | Drug discovery | Cancer | Pharmaceuticals | Index Medicus | Research & development | R&D
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7. Full Text Effect of hydraulic retention time on nitrogen removal and functional gene quantity/transcription in biochar packed reactors at 5 °C: A control-strategy study
by He, Su and Ding, Lili and Pan, Yao and Hu, Haidong and Ye, Lin and Ren, Hongqiang
Bioresource Technology, ISSN 0960-8524, 09/2018, Volume 264, pp. 400 - 405
This study investigated the effect of hydraulic retention time (HRT = 8, 12, 16, and 24 h) on effluent dissolved organic nitrogen (DON), dissolved total... 
Poly-β-hydroxybutyrate (PHB) | Nitrogen removal | Hydraulic retention time | Biochar packed reactor | Low temperature | Genetic research | Muscle proteins | Genes | Analysis | Adenosine triphosphate
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8. Full Text Response of benthic foraminifera to organic matter quantity and quality and bioavailable concentrations of metals in Aveiro Lagoon (Portugal)
by Martins, Maria Virgínia Alves and Silva, Frederico and Laut, Lazaro L. M and Frontalini, Fabrizio and Clemente, Iara M. M. M and Miranda, Paulo and Figueira, Rubens and Sousa, Silvia H. M and Dias, João M. Alveirinho
PLoS ONE, ISSN 1932-6203, 02/2015, Volume 10, Issue 2, pp. e0118077 - e0118077
This work analyses the distribution of living benthic foraminiferal assemblages of surface sediments in different intertidal areas of Ria de Aveiro (Portugal),... 
OXYGEN | TROPHIC STATE | MERCURY | COASTAL SEDIMENTS | POLLUTION | HEAVY-METALS | MULTIDISCIPLINARY SCIENCES | ESTUARY RIA | ASSEMBLAGES | WATER-QUALITY | MARINE | Seawater - analysis | Environmental Monitoring - methods | Foraminifera - chemistry | Water Pollutants, Chemical - chemistry | Biological Availability | Seawater - chemistry | Biodiversity | Portugal | Water Pollution, Chemical - analysis | Metals - chemistry | Geologic Sediments - analysis | Geologic Sediments - chemistry | Environment | Enrichment | Pollution levels | Organic matter | Pollution load | Pollution index | Toxicity | Ecosystems | Metals | Metal concentrations | Adaptability | Lipids | Biopolymers | Proteins | Pollution | Quality | Scholarly publishing | Coastal environments | Species | Carbohydrates | Food sources | Intertidal areas | Sediment pollution | Bioavailability | Sediments | Environmental stress | Environmental conditions | Sensitivity | Geobiology | Reproduction (biology) | Index Medicus
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9. Full Text The influence of male ejaculate quantity on female fitness: a meta‐analysis
by South, Adam and Lewis, Sara M
Biological Reviews, ISSN 1464-7931, 05/2011, Volume 86, Issue 2, pp. 299 - 309
Although the primary function of mating is gamete transfer, male ejaculates contain numerous other substances that are produced by accessory glands and... 
polyandry | nuptial gifts | seminal fluid proteins | spermatophores | female fecundity | Polyandry | Female fecundity | Nuptial gifts | Seminal fluid proteins | Spermatophores | LIFETIME REPRODUCTIVE SUCCESS | SEXUAL CONFLICT | BEETLE CALLOSOBRUCHUS-MACULATUS | MALE MATING HISTORY | EUROPEAN CORN-BORER | MALE ACCESSORY-GLANDS | BIOLOGY | MALE-DERIVED NUTRIENTS | DROSOPHILA-MELANOGASTER FEMALES | Biological Evolution | Female | Male | Animals | Genetic Fitness | Semen Analysis | Women's fitness | Usage | Fertility | Ejaculation | Physiological aspects | Influence | Research | Courtship of animals | Methods | Meta-analysis
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