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Journal of Biological Chemistry, ISSN 0021-9258, 06/2010, Volume 285, Issue 26, pp. 19833 - 19841
There has been much interest in the chloroplast-encoded large subunit of ribulose-1,5-bisphosphate carboxylase/oxygenase ( Rubisco) as a target for engineering... 
CO2/O-2 SPECIFICITY | THERMAL-STABILITY | SUBSTRATE-SPECIFICITY FACTOR | 1,5-BISPHOSPHATE CARBOXYLASE | CATALYTIC-PROPERTIES | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | ESCHERICHIA-COLI | CHLOROPLAST RIBULOSE-1,5-BISPHOSPHATE CARBOXYLASE/OXYGENASE | RIBULOSE-BISPHOSPHATE CARBOXYLASE | CONCENTRATING MECHANISMS | Temperature | Arabidopsis - enzymology | Protein Engineering - methods | DNA, Complementary - genetics | Ribulose-Bisphosphate Carboxylase - genetics | Molecular Sequence Data | Recombinant Fusion Proteins - metabolism | Chlamydomonas - ultrastructure | Protein Subunits - metabolism | Base Sequence | Chlamydomonas - genetics | Plasmids - genetics | Algal Proteins - genetics | Plant Proteins - metabolism | Protein Subunits - genetics | Transformation, Genetic | Chlamydomonas - growth & development | Enzyme Stability | Microscopy, Electron | Blotting, Western | Arabidopsis - genetics | Gene Expression Regulation, Enzymologic | Plant Proteins - genetics | Ribulose-Bisphosphate Carboxylase - metabolism | Recombinant Fusion Proteins - genetics | Helianthus - enzymology | Kinetics | Mutation | Photosynthesis | Algal Proteins - metabolism | Helianthus - genetics | Pyrenoid | Ribulosebisphosphate Carboxylase | Chlamydomonas | Enzyme Mechanisms | Oxygenase | Plant Biology | CO2-concentrating Mechanism | Genetic Engineering | Protein Targeting | Evolution | Enzymology | Chloroplast
Journal Article
Nature, ISSN 0028-0836, 06/2015, Volume 522, Issue 7557, pp. 450 - 454
The anaphase-promoting complex (APC/C) is a multimeric RING E3 ubiquitin ligase that controls chromosome segregation and mitotic exit. Its regulation by... 
E3 LIGASE | ANAPHASE-PROMOTING COMPLEX | ACTIVATION | PHOSPHORYLATION | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | MITOTIC REGULATION | CONJUGATING ENZYME | CHAIN ELONGATION | REVEALS | SUBUNIT | Phosphorylation | Ubiquitin - ultrastructure | Cadherins - metabolism | Humans | Apc11 Subunit, Anaphase-Promoting Complex-Cyclosome - chemistry | Ubiquitin - metabolism | Cell Cycle Proteins - ultrastructure | Substrate Specificity | Apc10 Subunit, Anaphase-Promoting Complex-Cyclosome - ultrastructure | Structure-Activity Relationship | Anaphase-Promoting Complex-Cyclosome - ultrastructure | Protein Subunits - metabolism | Ubiquitin-Conjugating Enzymes - chemistry | Apc1 Subunit, Anaphase-Promoting Complex-Cyclosome - metabolism | Cell Cycle Proteins - chemistry | Apc3 Subunit, Anaphase-Promoting Complex-Cyclosome - chemistry | Ubiquitination | Apc8 Subunit, Anaphase-Promoting Complex-Cyclosome - metabolism | Cadherins - chemistry | Cytoskeletal Proteins - metabolism | Lysine - metabolism | Anaphase-Promoting Complex-Cyclosome - chemistry | Cadherins - ultrastructure | Apc10 Subunit, Anaphase-Promoting Complex-Cyclosome - metabolism | Catalytic Domain | F-Box Proteins - metabolism | Apc3 Subunit, Anaphase-Promoting Complex-Cyclosome - metabolism | F-Box Proteins - chemistry | Cell Cycle Proteins - metabolism | Ubiquitin - chemistry | Models, Molecular | Ubiquitin-Conjugating Enzymes - ultrastructure | Cytoskeletal Proteins - chemistry | Apc1 Subunit, Anaphase-Promoting Complex-Cyclosome - chemistry | Apc8 Subunit, Anaphase-Promoting Complex-Cyclosome - chemistry | Cryoelectron Microscopy | F-Box Proteins - ultrastructure | Ubiquitin-Conjugating Enzymes - metabolism | Protein Binding | Protein Subunits - chemistry | Apc10 Subunit, Anaphase-Promoting Complex-Cyclosome - chemistry | Anaphase-Promoting Complex-Cyclosome - metabolism | Apc11 Subunit, Anaphase-Promoting Complex-Cyclosome - metabolism | Apc1 Subunit, Anaphase-Promoting Complex-Cyclosome - ultrastructure | Apc8 Subunit, Anaphase-Promoting Complex-Cyclosome - ultrastructure | Ubiquitin | Physiological aspects | Structure | Ubiquitin-proteasome system | Ligases | Proteins | Peptides | Molecular structure | Cyclin-dependent kinases | Cell division | Kinases | Gene expression
Journal Article
Nature Reviews Cancer, ISSN 1474-175X, 02/2012, Volume 12, Issue 2, pp. 121 - 132
It is only recently that the full importance of nuclear factor-kappa B (NF-kappa B) signalling to cancer development has been understood. Although much... 
CROSS-TALK | TARGET GENE-EXPRESSION | ONCOLOGY | DEPENDENT TRANSCRIPTION | MOUSE MODEL | PUTATIVE TUMOR-SUPPRESSOR | DOWN-REGULATION | POSTTRANSLATIONAL MODIFICATIONS | CELL-GROWTH | MICE LACKING | NEGATIVE REGULATOR | NF-kappa B - chemistry | Neoplasms - physiopathology | Genes, Tumor Suppressor | Humans | NF-kappa B - physiology
Journal Article
Biochemical Pharmacology, ISSN 0006-2952, 05/2016, Volume 107, pp. 59 - 66
Gα inhibitor UBO-QIC (FR900359) is becoming an important pharmacological tool, but its selectivity against other G proteins and their subunits, especially βγ,... 
UBO-QIC | Gαq inhibitor | GPCR | FR900359 | Gβγ subunits | G protein | inhibitor | GTP-Binding Protein alpha Subunits, Gi-Go - agonists | GTP-Binding Protein alpha Subunits, Gi-Go - genetics | Receptor, Muscarinic M2 - agonists | Receptor, Muscarinic M2 - genetics | Cricetulus | Humans | GTP-Binding Protein beta Subunits - antagonists & inhibitors | GTP-Binding Protein gamma Subunits - antagonists & inhibitors | Depsipeptides - pharmacology | GTP-Binding Protein alpha Subunits, Gq-G11 - chemistry | GTP-Binding Protein gamma Subunits - agonists | HEK293 Cells | Platelet Aggregation Inhibitors - pharmacology | Receptor, Muscarinic M2 - antagonists & inhibitors | GTP-Binding Protein beta Subunits - metabolism | GTP-Binding Protein alpha Subunits, Gq-G11 - metabolism | Proto-Oncogene Proteins c-akt - metabolism | Receptor, Adenosine A1 - genetics | CHO Cells | Pertussis Toxin - pharmacology | Recombinant Proteins - metabolism | GTP-Binding Protein gamma Subunits - metabolism | Receptor, Muscarinic M2 - metabolism | Enzyme Inhibitors - pharmacology | GTP-Binding Protein beta Subunits - agonists | Recombinant Proteins - chemistry | GTP-Binding Protein alpha Subunits, Gq-G11 - antagonists & inhibitors | Receptor, Adenosine A1 - chemistry | Receptor, Adenosine A1 - metabolism | Animals | MAP Kinase Signaling System - drug effects | GTP-Binding Protein alpha Subunits, Gi-Go - antagonists & inhibitors | Signal Transduction - drug effects | Models, Biological | Proto-Oncogene Proteins c-akt - agonists | GTP-Binding Protein alpha Subunits, Gi-Go - metabolism | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | Gβγsubunits
Journal Article
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 03/2013, Volume 288, Issue 9, pp. 6763 - 6776
Journal Article
Journal Article